| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0004462 |
| Description | A PR interval is an electrocardiography measurement which measures from the beginning of the P wave... to the beginning of the QRS complex in the heart's electrical cycleShow more |
| Trait category |
Cardiovascular measurement
|
| Synonym | PQ interval |
| Mapped terms |
2 mapped terms
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Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
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|---|---|---|---|---|---|---|
| PGS000735 (PRS_PR) | PGP000144 | Tadros R et al. Eur Heart J (2019) | PR interval | PR interval | 44 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000735/ScoringFiles/PGS000735.txt.gz |
| PGS000904 (PRS582_PR) | PGP000236 | Ntalla I et al. Nat Commun (2020) | PR interval | PR interval | 582 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000904/ScoringFiles/PGS000904.txt.gz |
| PGS000905 (PRS743_PR) | PGP000236 | Ntalla I et al. Nat Commun (2020) | PR interval | PR interval | 743 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000905/ScoringFiles/PGS000905.txt.gz |
| PGS001521 (GBE_INI22330) | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | PQ interval | PR interval | 391 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001521/ScoringFiles/PGS001521.txt.gz |
| PGS001904 (portability-PLR_ECG_PQ_interval) | PGP000263 | Privé F et al. Am J Hum Genet (2022) | PQ interval | PR interval | 826 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001904/ScoringFiles/PGS001904.txt.gz |
| PGS002118 (portability-ldpred2_ECG_PQ_interval) | PGP000263 | Privé F et al. Am J Hum Genet (2022) | PQ interval | PR interval | 413,539 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002118/ScoringFiles/PGS002118.txt.gz |
| PGS003499 (cont-decay-ECG_PQ_interval) | PGP000457 | Ding Y et al. bioRxiv (2022) |Pre | PQ interval | PR interval | 979,739 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003499/ScoringFiles/PGS003499.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
|
PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001750 | PGS000735 (PRS_PR) | PSS000906| European Ancestry| 1,193 individuals | PGP000144 | Tadros R et al. Eur Heart J (2019) | Reported Trait: Baseline PR in non SCN5A mutation carriers | — | — | Correlation coefficent (r): 0.23 | — | — |
| PPM001752 | PGS000735 (PRS_PR) | PSS000906| European Ancestry| 1,193 individuals | PGP000144 | Tadros R et al. Eur Heart J (2019) | Reported Trait: PR slope in non SCN5A mutation carriers | β: 0.16 (0.08) | — | Correlation coefficient (r): 0.09 | — | — |
| PPM001754 | PGS000735 (PRS_PR) | PSS000904| European Ancestry| 1,257 individuals | PGP000144 | Tadros R et al. Eur Heart J (2019) | Reported Trait: PR slope | β: 0.22 (0.08) | — | — | — | — |
| PPM001759 | PGS000735 (PRS_PR) | PSS000905| European Ancestry| 1,185 individuals | PGP000144 | Tadros R et al. Eur Heart J (2019) | Reported Trait: Ajmaline-induced Type I Brugada syndrome electrocardiogram | OR: 1.017 [1.013, 1.022] | — | — | — | — |
| PPM002666 | PGS000904 (PRS582_PR) | PSS001175| European Ancestry| 309,269 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Atrial fibrillation | OR: 0.95 β: -0.047 (0.009) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002667 | PGS000904 (PRS582_PR) | PSS001178| European Ancestry| 290,252 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Distal conduction disease | OR: 1.11 β: 0.103 (0.019) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002668 | PGS000904 (PRS582_PR) | PSS001176| European Ancestry| 309,041 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Atrioventricular preexcitation | OR: 0.85 β: -0.168 (0.057) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002669 | PGS000904 (PRS582_PR) | PSS001179| European Ancestry| 309,241 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Implantable cardioverter defibrillator | OR: 1.09 β: 0.086 (0.04) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002670 | PGS000904 (PRS582_PR) | PSS001180| European Ancestry| 309,246 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Mitral valve prolapse | OR: 1.1 β: 0.093 (0.044) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002671 | PGS000904 (PRS582_PR) | PSS001181| European Ancestry| 305,471 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Non-ischemic cardiomyopathy | OR: 0.95 β: -0.051 (0.024) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002672 | PGS000904 (PRS582_PR) | PSS001182| European Ancestry| 309,270 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Pacemaker | OR: 1.06 β: 0.062 (0.016) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002673 | PGS000904 (PRS582_PR) | PSS001183| European Ancestry| 309,255 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Valve disease | OR: 1.03 β: 0.03 (0.013) | — | — | Baseline age, sex, genotyping array, trait-related principal components | Only 581 SNPs from the 582 SNP PRS were utilised. 1 SNP was not included due to low imputation quali... ty.Show more |
| PPM002674 | PGS000905 (PRS743_PR) | PSS001175| European Ancestry| 309,269 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Atrial fibrillation | OR: 0.94 β: -0.058 (0.009) | — | — | Baseline age, sex, genotyping array, trait-related principal components | — |
| PPM002675 | PGS000905 (PRS743_PR) | PSS001178| European Ancestry| 290,252 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Distal conduction disease | β: 0.105 (0.019) OR: 1.11 | — | — | Baseline age, sex, genotyping array, trait-related principal components | — |
| PPM002676 | PGS000905 (PRS743_PR) | PSS001176| European Ancestry| 309,041 individuals | PGP000236 | Ntalla I et al. Nat Commun (2020) | Reported Trait: Atrioventricular preexcitation | OR: 0.83 β: -0.191 (0.057) | — | — | Baseline age, sex, genotyping array, trait-related principal components | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS000904 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼... 1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.12Show more | — | 1,257 individuals | — | European | — | Amsterdam | — |
| PSS000905 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼... 1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.15Show more | — | 1,185 individuals | — | European | — | Amsterdam | — |
| PSS000906 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼... 1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.13Show more | — | 1,193 individuals | — | European | — | Amsterdam | — |
| PSS001175 | Cases were individuals with atrial fibrillation. Disease status was ascertained based on data from b... aseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001176 | Cases were individuals with atrioventricular preexcitation. Disease status was ascertained based on ... data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001177 | Cases were individuals with congential artery disease. Disease status was ascertained based on data ... from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001178 | Cases were individuals with distal conduction disease. Disease status was ascertained based on data ... from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001179 | Cases were individuals with implantable cardioverter defibrillators. Disease status was ascertained ... based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001180 | Cases were individuals with mitral valve prolapse. Disease status was ascertained based on data from... baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001181 | Cases were individuals with non-ischemic cardiomyopathy. Disease status was ascertained based on dat... a from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001182 | Cases were individuals with a pacemaker. Disease status was ascertained based on data from baseline ... interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS001183 | Cases were individuals with valve disease. Disease status was ascertained based on data from baselin... e interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more | — | [
| — | European | — | UKB | — |
| PSS004966 | — | — | 120 individuals | — | African unspecified | — | UKB | — |
| PSS004967 | — | — | 68 individuals | — | East Asian | — | UKB | — |
| PSS004968 | — | — | 834 individuals | — | European | non-white British ancestry | UKB | — |