Polygenic Score (PGS) ID: PGS000905

Predicted Trait
Reported Trait PR interval
Mapped Trait(s) PR interval (EFO_0004462)
Released in PGS Catalog: Sept. 17, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS743_PR
Development Method
Name Clumping and Thresholding (C+T)
Parameters r^2 = 0.1 in a 250kb region, p = 5e-8, imputation quality > 0.6
Variants
Original Genome Build GRCh37
Number of Variants 743
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000236
Citation (link to publication) Ntalla I et al. Nat Commun (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 92.8%
Hispanic or Latin American: 4.4%
African: 2.8%
292,566 individuals (100%)
PGS Evaluation
European: 100%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST010321
Europe PMC: 32439900
271,570 individualsEuropean35 cohorts
  • AGES
  • ,AMISH
  • ,ARIC
  • ,BRIGHT
  • ,BioMe
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-SPLIT
  • ,ERF
  • ,FHS
  • ,FINCAVAS
  • ,GS:SFHS
  • ,Health2000
  • ,INGI-Carlantino
  • ,INGI-FVG
  • ,JHS
  • ,KORA
  • ,LifeLines
  • ,MESA
  • ,MICROS
  • ,NEO
  • ,ORCADES
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,RS
  • ,SHIP
  • ,SardiNIA
  • ,TwinsUK
  • ,UKB
  • ,ULSAM
  • ,WHI
  • ,YFS
  • ,deCODE
GWAS Catalog: GCST010321
Europe PMC: 32439900
8,173 individualsAfrican American or Afro-Caribbean35 cohorts
  • AGES
  • ,AMISH
  • ,ARIC
  • ,BRIGHT
  • ,BioMe
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-SPLIT
  • ,ERF
  • ,FHS
  • ,FINCAVAS
  • ,GS:SFHS
  • ,Health2000
  • ,INGI-Carlantino
  • ,INGI-FVG
  • ,JHS
  • ,KORA
  • ,LifeLines
  • ,MESA
  • ,MICROS
  • ,NEO
  • ,ORCADES
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,RS
  • ,SHIP
  • ,SardiNIA
  • ,TwinsUK
  • ,UKB
  • ,ULSAM
  • ,WHI
  • ,YFS
  • ,deCODE
GWAS Catalog: GCST010321
Europe PMC: 32439900
12,823 individualsHispanic or Latin American35 cohorts
  • AGES
  • ,AMISH
  • ,ARIC
  • ,BRIGHT
  • ,BioMe
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-SPLIT
  • ,ERF
  • ,FHS
  • ,FINCAVAS
  • ,GS:SFHS
  • ,Health2000
  • ,INGI-Carlantino
  • ,INGI-FVG
  • ,JHS
  • ,KORA
  • ,LifeLines
  • ,MESA
  • ,MICROS
  • ,NEO
  • ,ORCADES
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,RS
  • ,SHIP
  • ,SardiNIA
  • ,TwinsUK
  • ,UKB
  • ,ULSAM
  • ,WHI
  • ,YFS
  • ,deCODE
Showing 1 to 3 of 3 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002674PSS001175|
European Ancestry|
309,269 individuals
PGP000236 |
Ntalla I et al. Nat Commun (2020)
Reported Trait: Atrial fibrillationOR: 0.94
β: -0.058 (0.009)
Baseline age, sex, genotyping array, trait-related principal components
PPM002675PSS001178|
European Ancestry|
290,252 individuals
PGP000236 |
Ntalla I et al. Nat Commun (2020)
Reported Trait: Distal conduction diseaseβ: 0.105 (0.019)
OR: 1.11
Baseline age, sex, genotyping array, trait-related principal components
PPM002676PSS001176|
European Ancestry|
309,041 individuals
PGP000236 |
Ntalla I et al. Nat Commun (2020)
Reported Trait: Atrioventricular preexcitationOR: 0.83
β: -0.191 (0.057)
Baseline age, sex, genotyping array, trait-related principal components
PPM002677PSS001177|
European Ancestry|
309,246 individuals
PGP000236 |
Ntalla I et al. Nat Commun (2020)
Reported Trait: Coronary artery diseaseOR: 0.99
β: -0.014 (0.007)
Baseline age, sex, genotyping array, trait-related principal components
PPM002678PSS001182|
European Ancestry|
309,270 individuals
PGP000236 |
Ntalla I et al. Nat Commun (2020)
Reported Trait: PacemakerOR: 1.06
β: 0.056 (0.016)
Baseline age, sex, genotyping array, trait-related principal components
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001175Cases were individuals with atrial fibrillation. Disease status was ascertained based on data from b... aseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more
[
  • 14,812 cases
  • , 294,457 controls
]
EuropeanUKB
PSS001176Cases were individuals with atrioventricular preexcitation. Disease status was ascertained based on ... data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more
[
  • 307 cases
  • , 308,734 controls
]
EuropeanUKB
PSS001177Cases were individuals with congential artery disease. Disease status was ascertained based on data ... from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more
[
  • 27,072 cases
  • , 282,174 controls
]
EuropeanUKB
PSS001178Cases were individuals with distal conduction disease. Disease status was ascertained based on data ... from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more
[
  • 2,789 cases
  • , 287,463 controls
]
EuropeanUKB
PSS001182Cases were individuals with a pacemaker. Disease status was ascertained based on data from baseline ... interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23.Show more
[
  • 3,975 cases
  • , 305,295 controls
]
EuropeanUKB
Showing 1 to 5 of 5 rows