| Predicted Trait | |
| Reported Trait | PR interval |
| Mapped Trait(s) | PR interval (EFO_0004462) |
| Score Construction | |
| PGS Name | PRS743_PR |
| Development Method | |
| Name | Clumping and Thresholding (C+T) |
| Parameters | r^2 = 0.1 in a 250kb region, p = 5e-8, imputation quality > 0.6 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 743 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000236 |
| Citation (link to publication) | Ntalla I et al. Nat Commun (2020) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 92.8% Hispanic or Latin American: 4.4% African: 2.8% 292,566 individuals (100%) |
| PGS Evaluation | European: 100% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST010321 Europe PMC: 32439900 |
271,570 individuals | European | 35 cohorts
|
GWAS Catalog: GCST010321 Europe PMC: 32439900 |
8,173 individuals | African American or Afro-Caribbean | 35 cohorts
|
GWAS Catalog: GCST010321 Europe PMC: 32439900 |
12,823 individuals | Hispanic or Latin American | 35 cohorts
|
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM002674 | PSS001175| European Ancestry| 309,269 individuals |
PGP000236 | Ntalla I et al. Nat Commun (2020) |
Reported Trait: Atrial fibrillation | OR: 0.94 β: -0.058 (0.009) |
— | — | Baseline age, sex, genotyping array, trait-related principal components | — |
| PPM002675 | PSS001178| European Ancestry| 290,252 individuals |
PGP000236 | Ntalla I et al. Nat Commun (2020) |
Reported Trait: Distal conduction disease | β: 0.105 (0.019) OR: 1.11 |
— | — | Baseline age, sex, genotyping array, trait-related principal components | — |
| PPM002676 | PSS001176| European Ancestry| 309,041 individuals |
PGP000236 | Ntalla I et al. Nat Commun (2020) |
Reported Trait: Atrioventricular preexcitation | OR: 0.83 β: -0.191 (0.057) |
— | — | Baseline age, sex, genotyping array, trait-related principal components | — |
| PPM002677 | PSS001177| European Ancestry| 309,246 individuals |
PGP000236 | Ntalla I et al. Nat Commun (2020) |
Reported Trait: Coronary artery disease | OR: 0.99 β: -0.014 (0.007) |
— | — | Baseline age, sex, genotyping array, trait-related principal components | — |
| PPM002678 | PSS001182| European Ancestry| 309,270 individuals |
PGP000236 | Ntalla I et al. Nat Commun (2020) |
Reported Trait: Pacemaker | OR: 1.06 β: 0.056 (0.016) |
— | — | Baseline age, sex, genotyping array, trait-related principal components | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS001175 | Cases were individuals with atrial fibrillation. Disease status was ascertained based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23. | — | [
|
— | European | — | UKB | — |
| PSS001176 | Cases were individuals with atrioventricular preexcitation. Disease status was ascertained based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23. | — | [
|
— | European | — | UKB | — |
| PSS001177 | Cases were individuals with congential artery disease. Disease status was ascertained based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23. | — | [
|
— | European | — | UKB | — |
| PSS001178 | Cases were individuals with distal conduction disease. Disease status was ascertained based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23. | — | [
|
— | European | — | UKB | — |
| PSS001182 | Cases were individuals with a pacemaker. Disease status was ascertained based on data from baseline interviews, hospital diagnosis codes (ICD-9 and ICD-10), cause of death codes (ICD-10), and operation codes. Details of individual selections and disease definitions are described in Supplementary Data 23. | — | [
|
— | European | — | UKB | — |