Polygenic Score (PGS) ID: PGS000913

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: Oct. 7, 2021
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Score Details

Score Construction
PGS Name ukb_sbp_prs
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,098,015
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000240
Citation (link to publication) Vaura F et al. Hypertension (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
361,194 individuals (100%)
PGS Evaluation
European: 100%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Neale Lab UKB GWAS (round 2)
 361,194 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002970 PSS001446|
European Ancestry|
218,754 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Early onset incident hypertension (< 55 years) HR: 1.54 [1.53, 1.56] — Hazard Ratio (HR, top 2.5% vs middle 60%): 2.62 [2.48, 2.77] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002971 PSS001446|
European Ancestry|
218,754 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Late onset incident hypertension (≥55 years) HR: 1.31 [1.29, 1.32] — Hazard Ratio (HR, top 2.5% vs middle 60%): 1.68 [1.57, 1.81] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002977 PSS001448|
European Ancestry|
218,792 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident cardiovascular disease — — Hazard Ratio (HR, top 2.5% vs middle 60%): 1.3 [1.22, 1.39] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002978 PSS001447|
European Ancestry|
218,792 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident coronary heart disease HR: 1.15 [1.13, 1.17] — Hazard Ratio (HR, top 2.5% vs middle 60%): 1.33 [1.23, 1.44] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002979 PSS001449|
European Ancestry|
212,884 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident stroke — — Hazard Ratio (HR, top 2.5% vs middle 60%): 1.29 [1.16, 1.44] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002981 PSS001447|
European Ancestry|
218,792 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident coronary heart disease — C-index: 0.743 — Clinical atherosclerotic cardiovascular disease risk score (age, sex, total cholesterol, high density lipoprotein, antihypertensive medication, diabetes, current smoking) —
PPM002982 PSS001449|
European Ancestry|
212,884 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident stroke — C-index: 0.732 — Clinical atherosclerotic cardiovascular disease risk score (age, sex, total cholesterol, high density lipoprotein, antihypertensive medication, diabetes, current smoking) —
PPM002969 PSS001446|
European Ancestry|
218,754 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident hypertension HR: 1.42 [1.41, 1.43] — Hazard Ratio (HR, top 2.5% vs middle 60%): 2.19 [2.1, 2.29] Sex, collection year, genotyping batch, PCs(1-10) —
PPM002975 PSS001450|
European Ancestry|
9,906 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident hypertension — C-index: 0.802 — Age, sex, systolic blood pressure, diastolic blood pressure, body mass index, diabetes, current smoking —
PPM002980 PSS001448|
European Ancestry|
218,792 individuals
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Reported Trait: Incident cardiovascular disease — C-index: 0.731 — Clinical atherosclerotic cardiovascular disease risk score (age, sex, total cholesterol, high density lipoprotein, antihypertensive medication, diabetes, current smoking) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001446 Cases were individuals with incident hypertension. Hypertension was defined as persistently high systemic arterial blood pressure based on multiple blood pressure readings (consistent systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) or medical expenses reimbursement history. Diagnoses were based on the International Classification of Diseases (ICD) 8 codes (I1[0-3]/I15/I674) , ICD-9 codes (I1[0-3]/I15/I674), and ICD-10 codes (I1[0-3]/I15/I674). Of the 55,917 cases, 27,361 had early-onset incident hypertension, whilst 28,556 had late-onset incident hypertension. Early-onset and late-onset hypertension were defined as age of onset <55 and ≥55 years, respectively. —
[
  • 55,917 cases
  • , 162,837 controls
]
 — European
(Finnish)		 — FinnGen —
PSS001447 Cases were individuals with incident coronary heart disease (CHD). CHD was defined as Major coronary heart disease event: coronary revascularization (angioplasty or bypass grafting) or myocardial infarction. Diagnoses were based on the International Classification of Diseases (ICD) 8 codes (410/4110) , ICD-9 codes (410), and ICD-10 codes (I200/I21/I22). —
[
  • 21,012 cases
  • , 197,780 controls
]
,
44.0 % Male samples
 Mean = 58.0 years European
(Finnish)		 — FinnGen —
PSS001448 Cases were individuals with incident cardiovascular disease (CVD). CVD was defined as ard cardiovascular diseases: coronary heart disease or stroke. —
[
  • 29,350 cases
  • , 189,442 controls
]
,
44.0 % Male samples
 Mean = 58.0 years European
(Finnish)		 — FinnGen —
PSS001449 Cases were individuals with incident stroke. Stroke was defined as stroke, excluding subarachnoid hemorrhage. Diagnoses were based on the International Classification of Diseases (ICD) 8 codes (431/433/434/436) , ICD-9 codes (431/4330A/4331A/4339A/4340A/4341A/4349A/436), and ICD-10 codes (I61/I63/I64 (excluding I636)). —
[
  • 11,734 cases
  • , 201,150 controls
]
 — European
(Finnish)		 — FinnGen —
PSS001450 Cases were individuals with incident hypertension. Hypertension was defined as persistently high systemic arterial blood pressure based on multiple blood pressure readings (consistent systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) or medical expenses reimbursement history. Diagnoses were based on the International Classification of Diseases (ICD) 8 codes (I1[0-3]/I15/I674) , ICD-9 codes (I1[0-3]/I15/I674), and ICD-10 codes (I1[0-3]/I15/I674). —
[
  • 725 cases
  • , 9,181 controls
]
 — European
(Finnish)		 — FINRISK —