Polygenic Score (PGS) ID: PGS001103

Predicted Trait
Reported Trait Body fat percentage (left leg)
Mapped Trait(s) body fat percentage (EFO_0007800)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI23115
Released in PGS Catalog: Oct. 21, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI23115
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 28,134
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
265,150 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 265,150 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008256 PSS005108|
European Ancestry|
24,461 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Leg fat % (L) — — R²: 0.76237 [0.75721, 0.76752]
Incremental R2 (full-covars): 0.02314
PGS R2 (no covariates): 0.01668 [0.01353, 0.01984]		 age, sex, UKB array type, Genotype PCs —
PPM008254 PSS005106|
African Ancestry|
6,304 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Leg fat % (L) — — R²: 0.80234 [0.79373, 0.81095]
Incremental R2 (full-covars): -0.00147
PGS R2 (no covariates): 0.0021 [-0.00012, 0.00432]		 age, sex, UKB array type, Genotype PCs —
PPM008255 PSS005107|
East Asian Ancestry|
1,679 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Leg fat % (L) — — R²: 0.8031 [0.78638, 0.81982]
Incremental R2 (full-covars): 2e-05
PGS R2 (no covariates): 0.01698 [0.00484, 0.02912]		 age, sex, UKB array type, Genotype PCs —
PPM008257 PSS005109|
South Asian Ancestry|
7,649 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Leg fat % (L) — — R²: 0.82056 [0.81337, 0.82776]
Incremental R2 (full-covars): 0.00571
PGS R2 (no covariates): 0.00973 [0.00541, 0.01406]		 age, sex, UKB array type, Genotype PCs —
PPM008258 PSS005110|
European Ancestry|
66,256 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Leg fat % (L) — — R²: 0.78472 [0.78184, 0.7876]
Incremental R2 (full-covars): 0.02307
PGS R2 (no covariates): 0.02257 [0.02035, 0.02479]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005106 — — 6,304 individuals — African unspecified — UKB —
PSS005107 — — 1,679 individuals — East Asian — UKB —
PSS005108 — — 24,461 individuals — European non-white British ancestry UKB —
PSS005109 — — 7,649 individuals — South Asian — UKB —
PSS005110 — — 66,256 individuals — European white British ancestry UKB Testing cohort (heldout set)