Polygenic Score (PGS) ID: PGS001180

Predicted Trait
Reported Trait Lung function (FEV1/FVC)
Mapped Trait(s) FEV/FVC ratio (EFO_0004713)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI1003063
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI1003063
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 15,141
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
247,074 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 247,074 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008589 PSS004771|
African Ancestry|
5,852 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.01124 [0.00614, 0.01633]
Incremental R2 (full-covars): -0.00411
PGS R2 (no covariates): 0.00217 [-0.00009, 0.00443]		 age, sex, UKB array type, Genotype PCs —
PPM008590 PSS004772|
East Asian Ancestry|
1,587 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.04374 [0.02479, 0.06269]
Incremental R2 (full-covars): 0.02108
PGS R2 (no covariates): 0.02152 [0.00792, 0.03513]		 age, sex, UKB array type, Genotype PCs —
PPM008591 PSS004773|
European Ancestry|
22,763 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.09646 [0.08949, 0.10343]
Incremental R2 (full-covars): 0.04766
PGS R2 (no covariates): 0.05063 [0.04532, 0.05593]		 age, sex, UKB array type, Genotype PCs —
PPM008592 PSS004774|
South Asian Ancestry|
7,136 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.04322 [0.03442, 0.05203]
Incremental R2 (full-covars): 0.01609
PGS R2 (no covariates): 0.01838 [0.01249, 0.02427]		 age, sex, UKB array type, Genotype PCs —
PPM008593 PSS004775|
European Ancestry|
61,887 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.11465 [0.11013, 0.11918]
Incremental R2 (full-covars): 0.05769
PGS R2 (no covariates): 0.06034 [0.05685, 0.06382]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004771 — — 5,852 individuals — African unspecified — UKB —
PSS004772 — — 1,587 individuals — East Asian — UKB —
PSS004773 — — 22,763 individuals — European non-white British ancestry UKB —
PSS004774 — — 7,136 individuals — South Asian — UKB —
PSS004775 — — 61,887 individuals — European white British ancestry UKB Testing cohort (heldout set)