Trait: FEV/FVC ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004713
Trait category
Other measurement
Synonyms 3 synonyms
  • FEV/FEC ratio
  • FEV/FVC
  • FEV1/FVC

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000210
(LF279)
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Lung function (FEV1/FVC) FEV/FVC ratio 279
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000210/ScoringFiles/PGS000210.txt.gz
PGS001180
(GBE_INI1003063)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Lung function (FEV1/FVC) FEV/FVC ratio 15,141
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001180/ScoringFiles/PGS001180.txt.gz
PGS001801
(PRS_Ratio)
 PGP000264 |
Moll M et al. Lancet Respir Med (2020)
 FEV1/FVC ratio FEV/FVC ratio 1,232,916
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001801/ScoringFiles/PGS001801.txt.gz
PGS002326
(lung_FEV1FVCzSMOKE.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002326/ScoringFiles/PGS002326.txt.gz
PGS002398
(lung_FEV1FVCzSMOKE.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 12,645
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002398/ScoringFiles/PGS002398.txt.gz
PGS002447
(lung_FEV1FVCzSMOKE.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 33,367
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002447/ScoringFiles/PGS002447.txt.gz
PGS002496
(lung_FEV1FVCzSMOKE.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 139,123
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002496/ScoringFiles/PGS002496.txt.gz
PGS002545
(lung_FEV1FVCzSMOKE.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 4,165
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002545/ScoringFiles/PGS002545.txt.gz
PGS002594
(lung_FEV1FVCzSMOKE.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 2,609
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002594/ScoringFiles/PGS002594.txt.gz
PGS002643
(lung_FEV1FVCzSMOKE.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 508,629
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002643/ScoringFiles/PGS002643.txt.gz
PGS002692
(lung_FEV1FVCzSMOKE.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 FEV1/FVC ratio FEV/FVC ratio 985,212
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002692/ScoringFiles/PGS002692.txt.gz
PGS003465
(LDPred2_FEV1FVC)
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 FEV1/FVC ratio FEV/FVC ratio 835,705
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003465/ScoringFiles/PGS003465.txt.gz
PGS003862
(multiancestry_LF_GRS_FF_weights_EUR)
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Lung function (FEV1/FVC) FEV/FVC ratio 442
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003862/ScoringFiles/PGS003862.txt.gz
PGS003863
(multiancestry_LF_GRS_FF_weights_AFR)
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Lung function (FEV1/FVC) FEV/FVC ratio 437
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003863/ScoringFiles/PGS003863.txt.gz
PGS003864
(multiancestry_LF_GRS_FF_weights_AMR)
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Lung function (FEV1/FVC) FEV/FVC ratio 434
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003864/ScoringFiles/PGS003864.txt.gz
PGS003865
(multiancestry_LF_GRS_FF_weights_EAS)
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Lung function (FEV1/FVC) FEV/FVC ratio 406
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003865/ScoringFiles/PGS003865.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000638 PGS000210
(LF279)
 PSS000345|
East Asian Ancestry|
75,580 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.219 [1.182, 1.256] — — age, age^2, sex, height, smoking Models were stratified by geographical region and meta-analyzed. 12 Proxy SNPs were used
PPM000636 PGS000210
(LF279)
 PSS000348|
European Ancestry|
303,570 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.436 [1.411, 1.461] — — age, age^2, sex, height, smoking, 10 genetic PCs *Potential inflation (some weights are derived in a UKB GWAS)
PPM000645 PGS000210
(LF279)
 PSS000351|
East Asian Ancestry|
72,796 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.078 [-0.085, -0.071] — — age, age^2, sex, height, smoking Models were stratified by geographical region and meta-analyzed. 12 Proxy SNPs were used
PPM000647 PGS000210
(LF279)
 PSS000346|
European Ancestry|
10,894 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.546 [1.476, 1.62] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000642 PGS000210
(LF279)
 PSS000355|
European Ancestry|
303,570 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.224 [-0.227, -0.221] — — age, age^2, sex, height, smoking, 10 genetic PCs *Potential inflation (some weights are derived in a UKB GWAS)
PPM000643 PGS000210
(LF279)
 PSS000353|
Additional Diverse Ancestries|
1,208 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.176 [-0.231, -0.12] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000641 PGS000210
(LF279)
 PSS000354|
East Asian Ancestry|
1,607 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.142 [-0.191, -0.093] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000640 PGS000210
(LF279)
 PSS000357|
South Asian Ancestry|
6,358 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.181 [-0.205, -0.156] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000639 PGS000210
(LF279)
 PSS000352|
African Ancestry|
4,225 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.086 [-0.116, -0.056] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000644 PGS000210
(LF279)
 PSS000356|
Additional Diverse Ancestries|
6,033 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Lung Function (FEV1/FVC) β: -0.186 [-0.211, -0.162] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000637 PGS000210
(LF279)
 PSS000349|
Additional Diverse Ancestries|
6,033 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.506 [1.325, 1.712] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000635 PGS000210
(LF279)
 PSS000350|
South Asian Ancestry|
6,358 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.414 [1.254, 1.594] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000634 PGS000210
(LF279)
 PSS000347|
African Ancestry|
4,225 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.348 [1.152, 1.577] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM000646 PGS000210
(LF279)
 PSS000344|
African Ancestry|
2,466 individuals
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.255 [1.147, 1.374] — — age, age^2, sex, height, smoking, 10 genetic PCs —
PPM014853 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years ≥0) OR: 1.66 [1.55, 1.79]
β: 0.5096 (0.0372)		 — — — —
PPM014845 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years ≥0) OR: 1.57 [1.48, 1.67]
β: 0.4524 (0.0304)		 — — — —
PPM014846 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years ≥0) OR: 1.24 [1.14, 1.36]
β: 0.2191 (0.0436)		 — — — —
PPM014847 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years: [0,20)) OR: 1.69 [1.36, 2.11]
β: 0.5271 (0.1112)		 — — — —
PPM014848 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years: [0,20)) OR: 1.33 [1.05, 1.7]
β: 0.2872 (0.1233)		 — — — —
PPM014849 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years: [20,40)) OR: 1.64 [1.49, 1.82]
β: 0.4971 (0.0506)		 — — — —
PPM014854 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years ≥0) OR: 1.35 [1.2, 1.52]
β: 0.2994 (0.0609)		 — — — —
PPM014855 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years: [0,20)) OR: 1.85 [1.37, 2.5]
β: 0.6155 (0.1527)		 — — — —
PPM014856 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years: [0,20)) OR: 1.31 [0.87, 1.96]
β: 0.2667 (0.2061)		 — — — —
PPM014850 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years: [20,40)) OR: 1.35 [1.18, 1.53]
β: 0.2968 (0.0653)		 — — — —
PPM014851 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years ≥40) OR: 1.52 [1.4, 1.65]
β: 0.4211 (0.042)		 — — — —
PPM014859 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years ≥40) OR: 1.61 [1.46, 1.77]
β: 0.4762 (0.0488)		 — — — —
PPM014860 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years ≥40) OR: 1.18 [0.98, 1.41]
β: 0.1638 (0.0931)		 — — — —
PPM014861 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years ≥0) β: -2.8878 (0.1597) — R²: 0.0361 [0.0144, 0.0578] — —
PPM014862 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years ≥0) β: -1.2526 (0.1985) — R²: 0.0111 [-0.0214, 0.0436] — —
PPM014863 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years: [0,20)) β: -2.6173 (0.448) — R²: 0.0361 [-0.0337, 0.1059] — —
PPM014864 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years: [0,20)) β: -0.6558 (0.4221) — R²: 0.0036 [-0.0741, 0.0813] — —
PPM014865 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years: [20,40)) β: -3.2512 (0.2601) — R²: 0.0464 [0.0087, 0.0841] — —
PPM014866 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years: [20,40)) β: -1.5655 (0.2858) — R²: 0.0199 [-0.0285, 0.0683] — —
PPM014867 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years ≥40) β: -2.7449 (0.2221) — R²: 0.0315 [0.0028, 0.0602] — —
PPM014868 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1/FVC ratio (Smoking Pack-Years ≥40) β: -1.1647 (0.3587) — R²: 0.0083 [-0.045, 0.0616] — —
PPM014869 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years ≥0) β: -0.131 (0.0081) — R²: 0.0301 [0.0084, 0.0518] — —
PPM014870 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years ≥0) β: -0.036 (0.0105) — R²: 0.0028 [-0.0297, 0.0353] — —
PPM014872 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years: [0,20)) β: -0.0365 (0.024) — R²: 0.0036 [-0.0741, 0.0813] — —
PPM014873 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years: [20,40)) β: -0.1382 (0.0137) — R²: 0.0326 [-0.0051, 0.0703] — —
PPM014874 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years: [20,40)) β: -0.0518 (0.0153) — R²: 0.0063 [-0.0421, 0.0547] — —
PPM014875 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years ≥40) β: -0.1272 (0.0109) — R²: 0.0288 [0.0001, 0.0575] — —
PPM014876 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years ≥40) β: -0.0142 (0.0183) — R²: 0.0004 [-0.0529, 0.0537] — —
PPM014852 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Moderate to severe COPD (Smoking Pack-Years ≥40) OR: 1.1 [0.96, 1.26]
β: 0.0963 (0.0706)		 — — — —
PPM014857 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years: [20,40)) OR: 1.75 [1.54, 2.0]
β: 0.5621 (0.0664)		 — — — —
PPM014858 PGS000210
(LF279)
 PSS009914|
African Ancestry|
3,627 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Severe COPD (Smoking Pack-Years: [20,40)) OR: 1.5 [1.24, 1.8]
β: 0.4023 (0.0958)		 — — — —
PPM014871 PGS000210
(LF279)
 PSS009915|
European Ancestry|
8,144 individuals
 PGP000348 |
Hu X et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: FEV1 (Smoking Pack-Years: [0,20)) β: -0.1204 (0.0248) — R²: 0.0256 [-0.0442, 0.0954] — —
PPM022298 PGS000210
(LF279)
 PSS011909|
European Ancestry|
287,868 individuals
 PGP000699 |
Li S et al. Diabetes Obes Metab (2023)
|Ext.		 Reported Trait: Chronic obstructive pulmonary disease — — Hazard ratio (HR, high vs low PGS tertile): 1.17 [1.1, 1.24] Age, sex, body mass index, height, household income, education level, Townsend deprivation index, physical activity, family history of diseases (hypertension, cardiovascular disease, and diabetes), smoking status, drinking status, healthy diet score, passive smoking, air pollution, family history of COPD, baseline forced expiratory volume in 1s / forced vital capacity ratio, asthma, metabolic syndrome, 10 PCs, genotype batch —
PPM008589 PGS001180
(GBE_INI1003063)
 PSS004771|
African Ancestry|
5,852 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.01124 [0.00614, 0.01633]
Incremental R2 (full-covars): -0.00411
PGS R2 (no covariates): 0.00217 [-0.00009, 0.00443]		 age, sex, UKB array type, Genotype PCs —
PPM008590 PGS001180
(GBE_INI1003063)
 PSS004772|
East Asian Ancestry|
1,587 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.04374 [0.02479, 0.06269]
Incremental R2 (full-covars): 0.02108
PGS R2 (no covariates): 0.02152 [0.00792, 0.03513]		 age, sex, UKB array type, Genotype PCs —
PPM008591 PGS001180
(GBE_INI1003063)
 PSS004773|
European Ancestry|
22,763 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.09646 [0.08949, 0.10343]
Incremental R2 (full-covars): 0.04766
PGS R2 (no covariates): 0.05063 [0.04532, 0.05593]		 age, sex, UKB array type, Genotype PCs —
PPM008592 PGS001180
(GBE_INI1003063)
 PSS004774|
South Asian Ancestry|
7,136 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.04322 [0.03442, 0.05203]
Incremental R2 (full-covars): 0.01609
PGS R2 (no covariates): 0.01838 [0.01249, 0.02427]		 age, sex, UKB array type, Genotype PCs —
PPM008593 PGS001180
(GBE_INI1003063)
 PSS004775|
European Ancestry|
61,887 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: FEV FVC ratio — — R²: 0.11465 [0.11013, 0.11918]
Incremental R2 (full-covars): 0.05769
PGS R2 (no covariates): 0.06034 [0.05685, 0.06382]		 age, sex, UKB array type, Genotype PCs —
PPM009320 PGS001801
(PRS_Ratio)
 PSS007722|
European Ancestry|
19,229 individuals
 PGP000264 |
Moll M et al. Lancet Respir Med (2020)
 Reported Trait: Chronic obstructive pulmonary disease (moderate-to-severe) — — Odds Ratio of Combined PRS (OR): 1.81 [1.74, 1.88) Age, sex, height, smoking pack-years, PCs of genetic ancestry, study clinic, PRS_FEV1 NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-score
PPM009321 PGS001801
(PRS_Ratio)
 PSS007723|
Multi-ancestry (excluding European)|
7,122 individuals
 PGP000264 |
Moll M et al. Lancet Respir Med (2020)
 Reported Trait: Chronic obstructive pulmonary disease (moderate-to-severe) — — Odds Ratio of Combined PRS (OR): 1.42 [1.34, 1.51) Age, sex, height, smoking pack-years, PCs of genetic ancestry, study clinic, PRS_FEV1 NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-score
PPM009317 PGS001801
(PRS_Ratio)
 PSS007721|
European Ancestry|
5,175 individuals
 PGP000264 |
Moll M et al. Lancet Respir Med (2020)
 Reported Trait: GOLD spirometry grades — — Association (p-value): 2.02e-69 — —
PPM015566 PGS001801
(PRS_Ratio)
 PSS009985|
European Ancestry|
6,647 individuals
 PGP000385 |
Zhang J et al. Eur Respir J (2022)
|Ext.		 Reported Trait: Incident chronic obstructive pulmonary disease before age 50 years OR: 1.55 [1.41, 1.71] AUROC: 0.739 [0.718, 0.761] — PGS001800, early-life risk factors, principal components of genetic ancestry NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-scor
PPM015567 PGS001801
(PRS_Ratio)
 PSS009983|
African Ancestry|
2,464 individuals
 PGP000385 |
Zhang J et al. Eur Respir J (2022)
|Ext.		 Reported Trait: Incident chronic obstructive pulmonary disease before age 50 years OR: 1.23 [1.05, 1.43] AUROC: 0.635 [0.595, 0.675] — PGS001800, early-life risk factors, principal components of genetic ancestry NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-scor
PPM015568 PGS001801
(PRS_Ratio)
 PSS009984|
European Ancestry|
6,812 individuals
 PGP000385 |
Zhang J et al. Eur Respir J (2022)
|Ext.		 Reported Trait: Incident chronic obstructive pulmonary disease before age 50 years OR: 2.47 [2.12, 2.88] — — PGS001800, early-life risk factors, principal components of genetic ancestry NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-scor
PPM013091 PGS002326
(lung_FEV1FVCzSMOKE.BOLT-LMM)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0321 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013140 PGS002326
(lung_FEV1FVCzSMOKE.BOLT-LMM)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0411 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013238 PGS002326
(lung_FEV1FVCzSMOKE.BOLT-LMM)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0732 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013189 PGS002326
(lung_FEV1FVCzSMOKE.BOLT-LMM)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.1332 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013379 PGS002398
(lung_FEV1FVCzSMOKE.P+T.0.0001)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013428 PGS002398
(lung_FEV1FVCzSMOKE.P+T.0.0001)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0242 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013477 PGS002398
(lung_FEV1FVCzSMOKE.P+T.0.0001)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0766 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013526 PGS002398
(lung_FEV1FVCzSMOKE.P+T.0.0001)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0316 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013722 PGS002447
(lung_FEV1FVCzSMOKE.P+T.0.001)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0272 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013575 PGS002447
(lung_FEV1FVCzSMOKE.P+T.0.001)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013624 PGS002447
(lung_FEV1FVCzSMOKE.P+T.0.001)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0144 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013673 PGS002447
(lung_FEV1FVCzSMOKE.P+T.0.001)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0763 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013771 PGS002496
(lung_FEV1FVCzSMOKE.P+T.0.01)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013820 PGS002496
(lung_FEV1FVCzSMOKE.P+T.0.01)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0068 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013869 PGS002496
(lung_FEV1FVCzSMOKE.P+T.0.01)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0235 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013918 PGS002496
(lung_FEV1FVCzSMOKE.P+T.0.01)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0058 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013967 PGS002545
(lung_FEV1FVCzSMOKE.P+T.1e-06)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0125 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014016 PGS002545
(lung_FEV1FVCzSMOKE.P+T.1e-06)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0364 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014065 PGS002545
(lung_FEV1FVCzSMOKE.P+T.1e-06)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0635 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014114 PGS002545
(lung_FEV1FVCzSMOKE.P+T.1e-06)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.031 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014163 PGS002594
(lung_FEV1FVCzSMOKE.P+T.5e-08)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0179 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014212 PGS002594
(lung_FEV1FVCzSMOKE.P+T.5e-08)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0328 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014261 PGS002594
(lung_FEV1FVCzSMOKE.P+T.5e-08)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0551 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014310 PGS002594
(lung_FEV1FVCzSMOKE.P+T.5e-08)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0277 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014408 PGS002643
(lung_FEV1FVCzSMOKE.PolyFun-pred)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0481 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014359 PGS002643
(lung_FEV1FVCzSMOKE.PolyFun-pred)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0403 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014457 PGS002643
(lung_FEV1FVCzSMOKE.PolyFun-pred)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1362 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014506 PGS002643
(lung_FEV1FVCzSMOKE.PolyFun-pred)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0736 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014555 PGS002692
(lung_FEV1FVCzSMOKE.SBayesR)
 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0379 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014604 PGS002692
(lung_FEV1FVCzSMOKE.SBayesR)
 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0601 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014653 PGS002692
(lung_FEV1FVCzSMOKE.SBayesR)
 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.1281 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014702 PGS002692
(lung_FEV1FVCzSMOKE.SBayesR)
 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model vs. covariates alone): 0.0738 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM017275 PGS003465
(LDPred2_FEV1FVC)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index β: -0.01 (0.01) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017298 PGS003465
(LDPred2_FEV1FVC)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea β: -0.042 (0.024) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM018752 PGS003862
(multiancestry_LF_GRS_FF_weights_EUR)
 PSS011096|
European Ancestry|
320,656 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: FEV1/FVC ratio β: 0.2787 [0.2753, 0.282] — — age, age^2, sex, height, smoking, 10 genetic PCs Beta = Standard deviation (SD) change of FEV1/FVC per SD change of GRS
PPM018756 PGS003862
(multiancestry_LF_GRS_FF_weights_EUR)
 PSS011092|
European Ancestry|
11,074 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.63 [1.56, 1.71] — — age, age^2, sex, height, smoking —
PPM018753 PGS003863
(multiancestry_LF_GRS_FF_weights_AFR)
 PSS011093|
African Ancestry|
4,227 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: FEV1/FVC ratio β: 0.1534 [0.1106, 0.1961] — — age, age^2, sex, height, smoking, 10 genetic PCs Beta = Standard deviation (SD) change of FEV1/FVC per SD change of GRS
PPM018757 PGS003863
(multiancestry_LF_GRS_FF_weights_AFR)
 PSS011091|
African Ancestry|
2,886 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.23 [1.13, 1.34] — — age, age^2, sex, height, smoking —
PPM018754 PGS003864
(multiancestry_LF_GRS_FF_weights_AMR)
 PSS011094|
Hispanic or Latin American Ancestry|
2,798 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: FEV1/FVC ratio β: 0.254 [0.2163, 0.2917] — — age, age^2, sex, height, smoking, 10 genetic PCs Beta = Standard deviation (SD) change of FEV1/FVC per SD change of GRS
PPM018755 PGS003865
(multiancestry_LF_GRS_FF_weights_EAS)
 PSS011095|
East Asian Ancestry|
1,564 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: FEV1/FVC ratio β: 0.196 [0.1203, 0.2716] — — age, age^2, sex, height, smoking, 10 genetic PCs Beta = Standard deviation (SD) change of FEV1/FVC per SD change of GRS

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000352 — — 4,225 individuals — African unspecified — UKB —
PSS000353 — — 1,208 individuals — Other admixed ancestry
(Admixed African (unspecified) and European)		 — UKB —
PSS000354 — — 1,607 individuals — East Asian — UKB —
PSS000355 — — 303,570 individuals — European — UKB —
PSS000356 — — 6,033 individuals — Other admixed ancestry — UKB —
PSS000357 — — 6,358 individuals — South Asian — UKB —
PSS009915 — — 8,144 individuals — European
(Non Hispanic White)		 — COPDGene, SPIROMICS —
PSS009914 — — 3,627 individuals — African American or Afro-Caribbean
(African American)		 — COPDGene, SPIROMICS —
PSS009747 — — 4,243 individuals — African unspecified — UKB —
PSS009748 — — 679 individuals — East Asian — UKB —
PSS009750 — — 5,538 individuals — South Asian — UKB —
PSS009749 — — 34,753 individuals — European Non-British European UKB —
PSS011096 — — 320,656 individuals — European — UKB —
PSS011095 — — 1,564 individuals — East Asian — UKB —
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS, SOL —
PSS011909 — Mean = 9.24 years
[
  • 5,877 cases
  • , 281,991 controls
]
,
44.26 % Male samples
 — European — UKB —
PSS009983 Age of diagnosis was defined using age at earliest exam when moderate-to-severe COPD (modified Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade 2–4 using pre-bronchodilator spirometry) was observed. We defined COPD occurring early in life as age at diagnosis <50 year — 2,464 individuals,
57.6 % Male samples
 — African American or Afro-Caribbean
(African American)		 — COPDGene —
PSS009984 Age of diagnosis was defined using age at earliest exam when moderate-to-severe COPD (modified Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade 2–4 using pre-bronchodilator spirometry) was observed. We defined COPD occurring early in life as age at diagnosis <50 year — 6,812 individuals — European — FHS —
PSS009985 Age of diagnosis was defined using age at earliest exam when moderate-to-severe COPD (modified Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade 2–4 using pre-bronchodilator spirometry) was observed. We defined COPD occurring early in life as age at diagnosis <50 year — 6,647 individuals,
52.3 % Male samples
 — European
(Non-Hispanic White)		 — COPDGene —
PSS011094 — — 2,798 individuals — Hispanic or Latin American — UKB —
PSS007721 — — 5,175 individuals,
52.27 % Male samples
 — European — COPDGene —
PSS007722 — —
[
  • 3,065 cases
  • , 2,110 controls
]
,
52.27 % Male samples
 — European — COPDGene Fixed-effects meta-analysis
PSS007722 — —
[
  • 609 cases
  • , 1,480 controls
]
,
36.19 % Male samples
 — European — CHS Fixed-effects meta-analysis
PSS007722 — —
[
  • 1,713 cases
  • , 147 controls
]
,
66.34 % Male samples
 — European — ECLIPSE Fixed-effects meta-analysis
PSS007722 — —
[
  • 1,809 cases
  • , 946 controls
]
,
63.74 % Male samples
 — European — LHS Fixed-effects meta-analysis
PSS007722 — —
[
  • 208 cases
  • , 948 controls
]
,
47.66 % Male samples
 — European — MESA Fixed-effects meta-analysis
PSS007722 — —
[
  • 371 cases
  • , 429 controls
]
,
83.12 % Male samples
 — European — NAS, NETT Fixed-effects meta-analysis
PSS007722 — —
[
  • 127 cases
  • , 911 controls
]
,
42.87 % Male samples
 — European — RS Fixed-effects meta-analysis
PSS007722 — —
[
  • 96 cases
  • , 867 controls
]
,
46.73 % Male samples
 — European — RS Fixed-effects meta-analysis
PSS007722 — —
[
  • 131 cases
  • , 1,737 controls
]
,
43.36 % Male samples
 — European — RS Fixed-effects meta-analysis
PSS007722 — —
[
  • 988 cases
  • , 537 controls
]
,
52.85 % Male samples
 — European — SPIROMICS Fixed-effects meta-analysis
PSS007723 — —
[
  • 910 cases
  • , 1,556 controls
]
,
57.62 % Male samples
 — African American or Afro-Caribbean — COPDGene Fixed-effects meta-analysis
PSS007723 — —
[
  • 116 cases
  • , 258 controls
]
,
34.49 % Male samples
 — African American or Afro-Caribbean — CHS Fixed-effects meta-analysis
PSS007723 — —
[
  • 794 cases
  • , 1,600 controls
]
,
74.56 % Male samples
 — Not reported — NR Fixed-effects meta-analysis
PSS007723 — —
[
  • 115 cases
  • , 645 controls
]
,
46.58 % Male samples
 — African American or Afro-Caribbean — MESA Fixed-effects meta-analysis
PSS007723 — —
[
  • 31 cases
  • , 422 controls
]
,
49.89 % Male samples
 — East Asian — MESA Fixed-effects meta-analysis
PSS007723 — —
[
  • 62 cases
  • , 613 controls
]
,
47.26 % Male samples
 — Hispanic or Latin American — MESA Fixed-effects meta-analysis
PSS004771 — — 5,852 individuals — African unspecified — UKB —
PSS004772 — — 1,587 individuals — East Asian — UKB —
PSS004773 — — 22,763 individuals — European non-white British ancestry UKB —
PSS004774 — — 7,136 individuals — South Asian — UKB —
PSS004775 — — 61,887 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS011091 — —
[
  • 995 cases
  • , 1,891 controls
]
 — African unspecified — COPDGene, SPIROMICS —
PSS011092 — —
[
  • 6,746 cases
  • , 4,328 controls
]
 — European — 6 cohorts
  • COPDGene
  • ,ECLIPSE
  • ,GenKOLS
  • ,NAS
  • ,NETT
  • ,SPIROMICS
 —
PSS011093 — — 4,227 individuals — African unspecified — UKB —
PSS000344 — —
[
  • 910 cases
  • , 1,556 controls
]
 — African American or Afro-Caribbean — COPDGene —
PSS000345 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards) —
[
  • 69,567 cases
  • , 6,013 controls
]
 — East Asian
(Chinese)		 — CKB —
PSS000346 — —
[
  • 6,979 cases
  • , 3,915 controls
]
 — European — 6 cohorts
  • COPDGene
  • ,ECLIPSE
  • ,GenKOLS
  • ,NAS
  • ,NETT
  • ,SPIROMICS
 —
PSS000347 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards) —
[
  • 172 cases
  • , 4,053 controls
]
 — African unspecified — UKB —
PSS000348 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards) —
[
  • 288,467 cases
  • , 15,103 controls
]
 — European — UKB —
PSS000349 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards) —
[
  • 5,752 cases
  • , 281 controls
]
 — Other admixed ancestry — UKB —
PSS000350 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards) —
[
  • 6,046 cases
  • , 312 controls
]
 — South Asian — UKB —
PSS000351 — — 72,796 individuals — East Asian
(Chinese)		 — CKB —