PGS Publication: PGP000699

Publication Information (EuropePMC)
Title Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study.
PubMed ID 37846527(Europe PMC)
doi 10.1111/dom.15334
Publication Date Oct. 17, 2023
Journal Diabetes Obes Metab
Author(s) Li S, Zhang T, Yang H, Chang Q, Zhao Y, Chen L, Zhao L, Xia Y.
Released in PGS Catalog: Dec. 16, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000210
(LF279)
 PGP000086 |
Shrine N et al. Nat Genet (2019)
 Lung function (FEV1/FVC) FEV/FVC ratio 279
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000210/ScoringFiles/PGS000210.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022298 PGS000210
(LF279)
 PSS011909|
European Ancestry|
287,868 individuals
 PGP000699 |
Li S et al. Diabetes Obes Metab (2023)
|Ext.		 Reported Trait: Chronic obstructive pulmonary disease — — Hazard ratio (HR, high vs low PGS tertile): 1.17 [1.1, 1.24] Age, sex, body mass index, height, household income, education level, Townsend deprivation index, physical activity, family history of diseases (hypertension, cardiovascular disease, and diabetes), smoking status, drinking status, healthy diet score, passive smoking, air pollution, family history of COPD, baseline forced expiratory volume in 1s / forced vital capacity ratio, asthma, metabolic syndrome, 10 PCs, genotype batch —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011909 — Mean = 9.24 years
[
  • 5,877 cases
  • , 281,991 controls
]
,
44.26 % Male samples
 — European — UKB —