Polygenic Score (PGS) ID: PGS001396

Predicted Trait
Reported Trait Frequency of unenthusiasm / disinterest in last 2 weeks
Mapped Trait(s) emotional symptom measurement (EFO_0007803)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/QT_FC1002060
Released in PGS Catalog: Nov. 25, 2021
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Score Details

Score Construction
PGS Name GBE_QT_FC1002060
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 2,431
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
261,941 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 261,941 individuals European UKB — — — white British ancestry Training + validation cohort (train_val)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007245 PSS007581|
African Ancestry|
5,837 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of unenthusiasm / disinterest in last 2 weeks — — R²: 0.00813 [0.00379, 0.01248]
Incremental R2 (full-covars): -0.00053
PGS R2 (no covariates): 0.00015 [-0.00044, 0.00073]		 age, sex, UKB array type, Genotype PCs —
PPM007246 PSS007582|
East Asian Ancestry|
1,496 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of unenthusiasm / disinterest in last 2 weeks — — R²: 0.02489 [0.01031, 0.03947]
Incremental R2 (full-covars): -0.00242
PGS R2 (no covariates): 0.0007 [-0.00181, 0.00321]		 age, sex, UKB array type, Genotype PCs —
PPM007247 PSS007583|
European Ancestry|
23,872 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of unenthusiasm / disinterest in last 2 weeks — — R²: 0.023 [0.01932, 0.02668]
Incremental R2 (full-covars): 0.00212
PGS R2 (no covariates): 0.00251 [0.00127, 0.00376]		 age, sex, UKB array type, Genotype PCs —
PPM007248 PSS007584|
South Asian Ancestry|
6,548 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of unenthusiasm / disinterest in last 2 weeks — — R²: 0.00941 [0.00515, 0.01366]
Incremental R2 (full-covars): -0.00072
PGS R2 (no covariates): 0.0 [-0.00005, 0.00005]		 age, sex, UKB array type, Genotype PCs —
PPM007249 PSS007585|
European Ancestry|
65,413 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of unenthusiasm / disinterest in last 2 weeks — — R²: 0.01367 [0.01193, 0.01541]
Incremental R2 (full-covars): 0.00193
PGS R2 (no covariates): 0.00206 [0.00138, 0.00274]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007581 — — 5,837 individuals — African unspecified — UKB —
PSS007582 — — 1,496 individuals — East Asian — UKB —
PSS007583 — — 23,872 individuals — European non-white British ancestry UKB —
PSS007584 — — 6,548 individuals — South Asian — UKB —
PSS007585 — — 65,413 individuals — European white British ancestry UKB Testing cohort (heldout set)