Polygenic Score (PGS) ID: PGS001520

Predicted Trait
Reported Trait Position of the pulse wave peak
Mapped Trait(s) arterial stiffness measurement (EFO_0004517)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI4198
Released in PGS Catalog: Nov. 25, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI4198
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,358
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
107,773 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 107,773 individuals European UKB — — — white British ancestry Training + validation cohort (train_val)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007120 PSS007336|
African Ancestry|
3,863 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.05763 [0.04663, 0.06862]
Incremental R2 (full-covars): -0.00367
PGS R2 (no covariates): 3e-05 [-0.00023, 0.00029]		 age, sex, UKB array type, Genotype PCs —
PPM007121 PSS007337|
East Asian Ancestry|
807 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.0542 [0.03334, 0.07507]
Incremental R2 (full-covars): -0.00065
PGS R2 (no covariates): 0.00041 [-0.0015, 0.00231]		 age, sex, UKB array type, Genotype PCs —
PPM007122 PSS007338|
European Ancestry|
11,021 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.09762 [0.09061, 0.10462]
Incremental R2 (full-covars): 0.00071
PGS R2 (no covariates): 0.00137 [0.00045, 0.00229]		 age, sex, UKB array type, Genotype PCs —
PPM007123 PSS007339|
South Asian Ancestry|
5,226 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.03074 [0.02321, 0.03826]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.00076 [-0.00046, 0.00198]		 age, sex, UKB array type, Genotype PCs —
PPM007124 PSS007340|
European Ancestry|
26,777 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.07148 [0.06773, 0.07522]
Incremental R2 (full-covars): 0.00342
PGS R2 (no covariates): 0.00338 [0.00251, 0.00426]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007336 — — 3,863 individuals — African unspecified — UKB —
PSS007337 — — 807 individuals — East Asian — UKB —
PSS007338 — — 11,021 individuals — European non-white British ancestry UKB —
PSS007339 — — 5,226 individuals — South Asian — UKB —
PSS007340 — — 26,777 individuals — European white British ancestry UKB Testing cohort (heldout set)