Trait: arterial stiffness measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004517
Description An Arterial stiffness measurement is the information output of a non invasive pulse wave velocity assay. Arterial stiffness is a predictor of cardiovascular mortality
Trait category
Cardiovascular measurement
Synonym arterial stiffness

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001519
(GBE_INI4199)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Position of pulse wave notch arterial stiffness measurement 693
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001519/ScoringFiles/PGS001519.txt.gz
PGS001520
(GBE_INI4198)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Position of the pulse wave peak arterial stiffness measurement 1,358
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001520/ScoringFiles/PGS001520.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007125 PGS001519
(GBE_INI4199)
 PSS007341|
African Ancestry|
3,863 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of pulse wave notch — — R²: 0.02994 [0.02178, 0.0381]
Incremental R2 (full-covars): 0.00194
PGS R2 (no covariates): 0.00226 [-0.00004, 0.00457]		 age, sex, UKB array type, Genotype PCs —
PPM007126 PGS001519
(GBE_INI4199)
 PSS007342|
East Asian Ancestry|
807 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of pulse wave notch — — R²: 0.02934 [0.01358, 0.04509]
Incremental R2 (full-covars): 0.0026
PGS R2 (no covariates): 0.00283 [-0.0022, 0.00785]		 age, sex, UKB array type, Genotype PCs —
PPM007127 PGS001519
(GBE_INI4199)
 PSS007343|
European Ancestry|
11,021 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of pulse wave notch — — R²: 0.02545 [0.02159, 0.02931]
Incremental R2 (full-covars): 0.00502
PGS R2 (no covariates): 0.00515 [0.00337, 0.00692]		 age, sex, UKB array type, Genotype PCs —
PPM007128 PGS001519
(GBE_INI4199)
 PSS007344|
South Asian Ancestry|
5,226 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of pulse wave notch — — R²: 0.04794 [0.03871, 0.05717]
Incremental R2 (full-covars): 0.00501
PGS R2 (no covariates): 0.0043 [0.00141, 0.00719]		 age, sex, UKB array type, Genotype PCs —
PPM007129 PGS001519
(GBE_INI4199)
 PSS007345|
European Ancestry|
26,777 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of pulse wave notch — — R²: 0.03558 [0.03284, 0.03833]
Incremental R2 (full-covars): 0.00809
PGS R2 (no covariates): 0.00826 [0.0069, 0.00962]		 age, sex, UKB array type, Genotype PCs —
PPM007120 PGS001520
(GBE_INI4198)
 PSS007336|
African Ancestry|
3,863 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.05763 [0.04663, 0.06862]
Incremental R2 (full-covars): -0.00367
PGS R2 (no covariates): 3e-05 [-0.00023, 0.00029]		 age, sex, UKB array type, Genotype PCs —
PPM007121 PGS001520
(GBE_INI4198)
 PSS007337|
East Asian Ancestry|
807 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.0542 [0.03334, 0.07507]
Incremental R2 (full-covars): -0.00065
PGS R2 (no covariates): 0.00041 [-0.0015, 0.00231]		 age, sex, UKB array type, Genotype PCs —
PPM007122 PGS001520
(GBE_INI4198)
 PSS007338|
European Ancestry|
11,021 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.09762 [0.09061, 0.10462]
Incremental R2 (full-covars): 0.00071
PGS R2 (no covariates): 0.00137 [0.00045, 0.00229]		 age, sex, UKB array type, Genotype PCs —
PPM007123 PGS001520
(GBE_INI4198)
 PSS007339|
South Asian Ancestry|
5,226 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.03074 [0.02321, 0.03826]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.00076 [-0.00046, 0.00198]		 age, sex, UKB array type, Genotype PCs —
PPM007124 PGS001520
(GBE_INI4198)
 PSS007340|
European Ancestry|
26,777 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Position of the pulse wave peak — — R²: 0.07148 [0.06773, 0.07522]
Incremental R2 (full-covars): 0.00342
PGS R2 (no covariates): 0.00338 [0.00251, 0.00426]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007336 — — 3,863 individuals — African unspecified — UKB —
PSS007337 — — 807 individuals — East Asian — UKB —
PSS007338 — — 11,021 individuals — European non-white British ancestry UKB —
PSS007339 — — 5,226 individuals — South Asian — UKB —
PSS007340 — — 26,777 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007341 — — 3,863 individuals — African unspecified — UKB —
PSS007342 — — 807 individuals — East Asian — UKB —
PSS007343 — — 11,021 individuals — European non-white British ancestry UKB —
PSS007344 — — 5,226 individuals — South Asian — UKB —
PSS007345 — — 26,777 individuals — European white British ancestry UKB Testing cohort (heldout set)