Polygenic Score (PGS) ID: PGS001783

Predicted Trait
Reported Trait Chronic obstructive pulmonary disease
Mapped Trait(s) chronic obstructive pulmonary disease (EFO_0000341)
Released in PGS Catalog: Sept. 8, 2022
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Terms and Licenses
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Score Details

Score Construction
PGS Name 1kgeur_gbmi_COPD_pst_eff_a1_b0.5_phiauto
Development Method
Name PRS-CS-auto
Parameters effective sample size and other defualt parameters
Variants
Original Genome Build GRCh37
Number of Variants 884,139
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000262
Citation (link to publication) Wang Y et al. Cell Genom (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 71.5%
East Asian: 23.7%
African: 2.1%
Additional Asian Ancestries: 1.6%
Additional Diverse Ancestries: 1.1%
1,392,366 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 1,978 cases
  • , 27,704 controls
]
 African unspecified G&H
—
[
  • 1,503 cases
  • , 13,583 controls
]
 Native American 6 cohorts
  • BioMe
  • ,BioVU
  • ,CCPM
  • ,MGI
  • ,UCLA
  • ,UKB
—
[
  • 19,044 cases
  • , 310,689 controls
]
 East Asian BioMe, CCPM, UCLA
—
[
  • 58,559 cases
  • , 937,358 controls
]
 European BBJ, CKB, TWB, UCLA
—
[
  • 484 cases
  • , 21,464 controls
]
 Asian unspecified 14 cohorts
  • BioMe
  • ,BioVU
  • ,CCPM
  • ,EB
  • ,FinnGen
  • ,GS:SFHS
  • ,HUNT
  • ,LifeLines
  • ,MGBB
  • ,MGI
  • ,QSKIN
  • ,UCLA
  • ,UKB
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009312 PSS007694|
European Ancestry|
7,128 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Chronic obstructive pulmonary disease — AUROC: 0.74 Nagelkerke's R2 (covariates regressed out): 0.03809 sex,age, 20PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007694 — —
[
  • 132 cases
  • , 6,995 controls
]
 — European — CanPath —