Predicted Trait | |
Reported Trait | Asthma |
Mapped Trait(s) | asthma (MONDO_0004979) |
Score Construction | |
PGS Name | 1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto |
Development Method | |
Name | PRS-CS-auto |
Parameters | effective sample size and other defualt parameters |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 909,990 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000262 |
Citation (link to publication) | Wang Y et al. Cell Genom (2023) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
— | [
|
African unspecified | 7 cohorts
|
— | [
|
Native American | BioMe, BioVU, CCPM, MGI, UCLA |
— | [
|
East Asian | BioMe, CCPM, UCLA |
— | [
|
European | BBJ, CKB, TWB, UCLA |
— | [
|
Asian unspecified | EB, FinnGen |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM009307 | PSS007706| East Asian Ancestry| 2,633 individuals |
PGP000262 | Wang Y et al. Cell Genom (2023) |
Reported Trait: Asthma | — | AUROC: 0.679 | Nagelkerke's R2 (covariates regressed out): 0.00679 | sex,age,age2,age*sex,age^2*sex, 20PCs | — |
PPM009308 | PSS007698| African Ancestry| 6,152 individuals |
PGP000262 | Wang Y et al. Cell Genom (2023) |
Reported Trait: Asthma | — | AUROC: 0.627 | Nagelkerke's R2 (covariates regressed out): 0.00814 | sex,age,age2,age*sex,age^2*sex, 20PCs | — |
PPM009291 | PSS007710| European Ancestry| 351,578 individuals |
PGP000262 | Wang Y et al. Cell Genom (2023) |
Reported Trait: Asthma | — | AUROC: 0.64 | Nagelkerke's R2 (covariates regressed out): 0.03517 | sex,age,age2,age*sex,age^2*sex, 20PCs | — |
PPM009301 | PSS007701| Additional Diverse Ancestries| 965 individuals |
PGP000262 | Wang Y et al. Cell Genom (2023) |
Reported Trait: Asthma | — | AUROC: 0.796 | Nagelkerke's R2 (covariates regressed out): 0.0895 | sex,age,age2,age*sex,age^2*sex, 20PCs | — |
PPM009302 | PSS007720| Greater Middle Eastern Ancestry| 1,529 individuals |
PGP000262 | Wang Y et al. Cell Genom (2023) |
Reported Trait: Asthma | — | AUROC: 0.689 | Nagelkerke's R2 (covariates regressed out): 0.03763 | sex,age,age2,age*sex,age^2*sex, 20PCs | — |
PPM009303 | PSS007702| Additional Asian Ancestries| 8,101 individuals |
PGP000262 | Wang Y et al. Cell Genom (2023) |
Reported Trait: Asthma | — | AUROC: 0.651 | Nagelkerke's R2 (covariates regressed out): 0.02455 | sex,age,age2,age*sex,age^2*sex, 20PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS007702 | — | — | [
|
— | Asian unspecified | Central and South Asian | UKB | — |
PSS007706 | — | — | [
|
— | East Asian | — | UKB | — |
PSS007710 | — | — | [
|
— | European | — | UKB | — |
PSS007720 | — | — | [
|
— | Greater Middle Eastern (Middle Eastern, North African or Persian) | — | UKB | — |
PSS007698 | — | — | [
|
— | African unspecified | Africa or admixed-ancestry diaspora | UKB | — |
PSS007701 | — | — | [
|
— | Other admixed ancestry (Admixed American) |
— | UKB | — |