Trait: asthma

Trait Information
Identifier MONDO_0004979
Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. [EFO: 0000270]
Trait category
Other disease
Synonyms 6 synonyms
  • bronchial hyperreactivity
  • chronic obstructive asthma
  • chronic obstructive asthma with acute exacerbation
  • chronic obstructive asthma with status asthmaticus
  • exercise induced asthma
  • exercise-induced asthma
Mapped terms 12 mapped terms
  • DOID:2841
  • HP:0002099
  • ICD10CM:J45
  • ICD9:493
  • ICD9:493.81
  • ICD9:493.9
  • MEDGEN:2109
  • MESH:D001249
  • NCIT:C28397
  • SCTID:31387002
  • UMLS:C0004096
  • icd11.foundation:1656445230
Child trait(s) childhood onset asthma

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "asthma" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000037
(PGS_AST)
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Asthma asthma 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000037/ScoringFiles/PGS000037.txt.gz
PGS000799
(GRSw_TAGC)
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Asthma asthma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000799/ScoringFiles/PGS000799.txt.gz
PGS001341
(GBE_HC382)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Asthma asthma 6,430
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001341/ScoringFiles/PGS001341.txt.gz
PGS001343
(GBE_HC1581)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Asthma (algorithmically-defined) asthma 6,425
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001343/ScoringFiles/PGS001343.txt.gz
PGS001344
(GBE_BIN_FC4006152)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Asthma (diagnosed by doctor) asthma 6,139
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001344/ScoringFiles/PGS001344.txt.gz
PGS001345
(GBE_BIN22127)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Asthma (diagnosed by doctor) asthma 435
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001345/ScoringFiles/PGS001345.txt.gz
PGS001346
(GBE_HC1036)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Asthma (time-to-event) asthma 8,508
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001346/ScoringFiles/PGS001346.txt.gz
PGS001370
(GBE_INI3786)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Age asthma diagnosed asthma 922
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001370/ScoringFiles/PGS001370.txt.gz
PGS001782
(1kgeur_gbmi_Asthma_pst_eff_a1_b0.5_phiauto)
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Asthma asthma 884,043
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001782/ScoringFiles/PGS001782.txt.gz
PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Asthma asthma 909,990
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001787/ScoringFiles/PGS001787.txt.gz
PGS001849
(portability-PLR_495)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Asthma asthma 22,679
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001849/ScoringFiles/PGS001849.txt.gz
PGS002061
(portability-ldpred2_495)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Asthma asthma 793,375
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002061/ScoringFiles/PGS002061.txt.gz
PGS002248
(PRSice_asthma)
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Childhood asthma childhood onset asthma 105
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002248/ScoringFiles/PGS002248.txt.gz
PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002311/ScoringFiles/PGS002311.txt.gz
PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 920,922
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002358/ScoringFiles/PGS002358.txt.gz
PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 3,893
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002383/ScoringFiles/PGS002383.txt.gz
PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 15,843
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002432/ScoringFiles/PGS002432.txt.gz
PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 95,252
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002481/ScoringFiles/PGS002481.txt.gz
PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 817
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002530/ScoringFiles/PGS002530.txt.gz
PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 503
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002579/ScoringFiles/PGS002579.txt.gz
PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 205,286
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002628/ScoringFiles/PGS002628.txt.gz
PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Asthma asthma 934,369
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002677/ScoringFiles/PGS002677.txt.gz
PGS002727
(PRS_PA)
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Asthma asthma 985,837
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002727/ScoringFiles/PGS002727.txt.gz
PGS002754
(Asthma_prscs)
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Asthma asthma 668,286
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002754/ScoringFiles/PGS002754.txt.gz
PGS004176
(asthma_1)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Asthma asthma 5,210
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004176/ScoringFiles/PGS004176.txt.gz
PGS004177
(asthma_2)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Asthma asthma 6,770
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004177/ScoringFiles/PGS004177.txt.gz
PGS004178
(asthma_3)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Asthma asthma 4,924
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004178/ScoringFiles/PGS004178.txt.gz
PGS004179
(asthma_4)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Asthma asthma 3,963
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004179/ScoringFiles/PGS004179.txt.gz
PGS004180
(asthma_5)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Asthma asthma 3,641
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004180/ScoringFiles/PGS004180.txt.gz
PGS004252
(PRS212_asthma)
 PGP000544 |
Zhu Y et al. Ecotoxicol Environ Saf (2023)
 Asthma asthma 212
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004252/ScoringFiles/PGS004252.txt.gz
PGS004275
(GenoBoost_asthma_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 5,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004275/ScoringFiles/PGS004275.txt.gz
PGS004276
(GenoBoost_asthma_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004276/ScoringFiles/PGS004276.txt.gz
PGS004277
(GenoBoost_asthma_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004277/ScoringFiles/PGS004277.txt.gz
PGS004278
(GenoBoost_asthma_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004278/ScoringFiles/PGS004278.txt.gz
PGS004279
(GenoBoost_asthma_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 5,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004279/ScoringFiles/PGS004279.txt.gz
PGS004439
(disease.Asthma.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Asthma asthma 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004439/ScoringFiles/PGS004439.txt.gz
PGS004467
(disease.J45.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 J45 (Asthma) asthma 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004467/ScoringFiles/PGS004467.txt.gz
PGS004509
(meta.Asthma.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Asthma asthma 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004509/ScoringFiles/PGS004509.txt.gz
PGS004537
(meta.J45.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 J45 (Asthma) asthma 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004537/ScoringFiles/PGS004537.txt.gz
PGS004723
(asthma_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Asthma asthma 985,316
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004723/ScoringFiles/PGS004723.txt.gz
PGS004724
(asthma_PRSmix_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Asthma asthma 2,342,250
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004724/ScoringFiles/PGS004724.txt.gz
PGS004725
(asthma_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Asthma asthma 3,972,232
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004725/ScoringFiles/PGS004725.txt.gz
PGS004726
(asthma_PRSmixPlus_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Asthma asthma 2,342,250
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004726/ScoringFiles/PGS004726.txt.gz
PGS004877
(INTERVENE_MegaPRS_Asthma)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Asthma asthma 870,454
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004877/ScoringFiles/PGS004877.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000082 PGS000037
(PGS_AST)
 PSS000055|
European Ancestry|
880 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Asthma onset, up to age 38 years HR: 1.12 [1.01, 1.26] — — sex —
PPM000083 PGS000037
(PGS_AST)
 PSS000055|
European Ancestry|
880 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Life-course-persistent asthma RR: 1.36 [1.14, 1.63] — — sex —
PPM000084 PGS000037
(PGS_AST)
 PSS000056|
European Ancestry|
187 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Asthma onset HR: 1.17 [1.01, 1.34] AUROC: 0.61 [0.53, 0.7] — sex —
PPM000085 PGS000037
(PGS_AST)
 PSS000056|
European Ancestry|
187 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Life-course-persistent asthma RR: 1.2 [1.05, 1.38] — — sex —
PPM000086 PGS000037
(PGS_AST)
 PSS000055|
European Ancestry|
880 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Atopy (skin test for common allergen 2mm > control) RR: 1.07 [1.01, 1.14] — — sex —
PPM000087 PGS000037
(PGS_AST)
 PSS000055|
European Ancestry|
880 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Airway hyper-responsiveness to methacholine or albuterol RR: 1.16 [1.03, 1.32] — — sex —
PPM000088 PGS000037
(PGS_AST)
 PSS000055|
European Ancestry|
880 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Incompletely reversible airflow obstruction (IRAO, post-bronchodilator FEV1:FVC more than 2SD below mean) RR: 1.28 [1.04, 1.57] — — sex —
PPM000089 PGS000037
(PGS_AST)
 PSS000055|
European Ancestry|
880 individuals
 PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
 Reported Trait: Admitted to hospital for asthma RR: 1.38 [1.07, 1.79] — — sex —
PPM002079 PGS000799
(GRSw_TAGC)
 PSS001028|
European Ancestry|
427 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years OR: 1.52 [1.19, 1.96] — — — Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data.
PPM002077 PGS000799
(GRSw_TAGC)
 PSS001029|
European Ancestry|
1,858 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years OR: 1.23 [1.1, 1.38] — — — —
PPM002078 PGS000799
(GRSw_TAGC)
 PSS001029|
European Ancestry|
1,858 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years — AUROC: 0.66 — Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) —
PPM002080 PGS000799
(GRSw_TAGC)
 PSS001028|
European Ancestry|
427 individuals
 PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
 Reported Trait: Asthma ever, at age 8 years — AUROC: 0.69 — Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data.
PPM009191 PGS001341
(GBE_HC382)
 PSS004466|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma — AUROC: 0.61763 [0.59798, 0.63728] R²: 0.03727
Incremental AUROC (full-covars): 0.0081
PGS R2 (no covariates): 0.00847
PGS AUROC (no covariates): 0.55669 [0.53574, 0.57763]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009192 PGS001341
(GBE_HC382)
 PSS004467|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma — AUROC: 0.57795 [0.53557, 0.62032] R²: 0.02196
Incremental AUROC (full-covars): -0.01536
PGS R2 (no covariates): 0.00014
PGS AUROC (no covariates): 0.51559 [0.47138, 0.55979]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009193 PGS001341
(GBE_HC382)
 PSS004468|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma — AUROC: 0.63649 [0.62628, 0.6467] R²: 0.04868
Incremental AUROC (full-covars): 0.06379
PGS R2 (no covariates): 0.0373
PGS AUROC (no covariates): 0.6175 [0.60705, 0.62795]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009194 PGS001341
(GBE_HC382)
 PSS004469|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma — AUROC: 0.60865 [0.59116, 0.62614] R²: 0.03337
Incremental AUROC (full-covars): 0.03258
PGS R2 (no covariates): 0.01973
PGS AUROC (no covariates): 0.58188 [0.5641, 0.59966]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009195 PGS001341
(GBE_HC382)
 PSS004470|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma — AUROC: 0.62569 [0.61945, 0.63192] R²: 0.04404
Incremental AUROC (full-covars): 0.07406
PGS R2 (no covariates): 0.03731
PGS AUROC (no covariates): 0.61664 [0.61037, 0.62291]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009198 PGS001343
(GBE_HC1581)
 PSS004294|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: AD asthma — AUROC: 0.63661 [0.62631, 0.6469] R²: 0.04847
Incremental AUROC (full-covars): 0.06318
PGS R2 (no covariates): 0.03703
PGS AUROC (no covariates): 0.61732 [0.60678, 0.62786]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009196 PGS001343
(GBE_HC1581)
 PSS004292|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: AD asthma — AUROC: 0.61862 [0.59895, 0.63828] R²: 0.038
Incremental AUROC (full-covars): 0.00982
PGS R2 (no covariates): 0.00928
PGS AUROC (no covariates): 0.55801 [0.53701, 0.579]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009197 PGS001343
(GBE_HC1581)
 PSS004293|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: AD asthma — AUROC: 0.57145 [0.52876, 0.61414] R²: 0.02036
Incremental AUROC (full-covars): -0.02169
PGS R2 (no covariates): 2e-05
PGS AUROC (no covariates): 0.50757 [0.46343, 0.55171]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009199 PGS001343
(GBE_HC1581)
 PSS004295|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: AD asthma — AUROC: 0.61078 [0.59322, 0.62833] R²: 0.03413
Incremental AUROC (full-covars): 0.03417
PGS R2 (no covariates): 0.02015
PGS AUROC (no covariates): 0.58309 [0.56524, 0.60095]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009200 PGS001343
(GBE_HC1581)
 PSS004296|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: AD asthma — AUROC: 0.62553 [0.61925, 0.63182] R²: 0.04393
Incremental AUROC (full-covars): 0.07302
PGS R2 (no covariates): 0.03704
PGS AUROC (no covariates): 0.6162 [0.60989, 0.62251]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009201 PGS001344
(GBE_BIN_FC4006152)
 PSS003954|
African Ancestry|
4,956 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma diagnosed by doctor — AUROC: 0.64534 [0.62387, 0.66681] R²: 0.059
Incremental AUROC (full-covars): 0.00716
PGS R2 (no covariates): 0.01177
PGS AUROC (no covariates): 0.56449 [0.5415, 0.58748]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009202 PGS001344
(GBE_BIN_FC4006152)
 PSS003955|
East Asian Ancestry|
1,072 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma diagnosed by doctor — AUROC: 0.61098 [0.56503, 0.65693] R²: 0.04365
Incremental AUROC (full-covars): -0.00964
PGS R2 (no covariates): 0.00128
PGS AUROC (no covariates): 0.53103 [0.48086, 0.5812]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009203 PGS001344
(GBE_BIN_FC4006152)
 PSS003956|
European Ancestry|
19,857 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma diagnosed by doctor — AUROC: 0.66621 [0.65552, 0.67691] R²: 0.07596
Incremental AUROC (full-covars): 0.07977
PGS R2 (no covariates): 0.05973
PGS AUROC (no covariates): 0.64568 [0.63475, 0.65662]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009204 PGS001344
(GBE_BIN_FC4006152)
 PSS003957|
South Asian Ancestry|
6,229 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma diagnosed by doctor — AUROC: 0.61016 [0.59026, 0.63007] R²: 0.03328
Incremental AUROC (full-covars): 0.04929
PGS R2 (no covariates): 0.02494
PGS AUROC (no covariates): 0.59646 [0.57624, 0.61668]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009205 PGS001344
(GBE_BIN_FC4006152)
 PSS003958|
European Ancestry|
53,936 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Asthma diagnosed by doctor — AUROC: 0.65364 [0.64713, 0.66016] R²: 0.06727
Incremental AUROC (full-covars): 0.09037
PGS R2 (no covariates): 0.05689
PGS AUROC (no covariates): 0.64265 [0.63609, 0.64921]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009206 PGS001345
(GBE_BIN22127)
 PSS003676|
African Ancestry|
516 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Doctor diagnosed asthma — AUROC: 0.66261 [0.59914, 0.72609] R²: 0.07843
Incremental AUROC (full-covars): 0.01462
PGS R2 (no covariates): 0.00704
PGS AUROC (no covariates): 0.54765 [0.47414, 0.62116]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009207 PGS001345
(GBE_BIN22127)
 PSS003677|
East Asian Ancestry|
245 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Doctor diagnosed asthma — AUROC: 0.67066 [0.56822, 0.7731] R²: 0.10676
Incremental AUROC (full-covars): 0.02219
PGS R2 (no covariates): 0.03135
PGS AUROC (no covariates): 0.60951 [0.50092, 0.71811]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009208 PGS001345
(GBE_BIN22127)
 PSS003678|
European Ancestry|
5,959 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Doctor diagnosed asthma — AUROC: 0.59515 [0.57415, 0.61614] R²: 0.02426
Incremental AUROC (full-covars): 0.0264
PGS R2 (no covariates): 0.01031
PGS AUROC (no covariates): 0.56199 [0.54029, 0.58369]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009209 PGS001345
(GBE_BIN22127)
 PSS003679|
South Asian Ancestry|
707 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Doctor diagnosed asthma — AUROC: 0.63251 [0.57541, 0.68961] R²: 0.04811
Incremental AUROC (full-covars): 0.0046
PGS R2 (no covariates): 0.00714
PGS AUROC (no covariates): 0.53871 [0.47553, 0.60189]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009210 PGS001345
(GBE_BIN22127)
 PSS003680|
European Ancestry|
17,244 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Doctor diagnosed asthma — AUROC: 0.60258 [0.58999, 0.61516] R²: 0.02879
Incremental AUROC (full-covars): 0.03437
PGS R2 (no covariates): 0.01667
PGS AUROC (no covariates): 0.57923 [0.56641, 0.59204]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009215 PGS001346
(GBE_HC1036)
 PSS004088|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE asthma — AUROC: 0.62361 [0.61737, 0.62985] R²: 0.04277
Incremental AUROC (full-covars): 0.07368
PGS R2 (no covariates): 0.03644
PGS AUROC (no covariates): 0.61489 [0.60862, 0.62117]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009211 PGS001346
(GBE_HC1036)
 PSS004084|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE asthma — AUROC: 0.60891 [0.58896, 0.62886] R²: 0.03181
Incremental AUROC (full-covars): 0.00272
PGS R2 (no covariates): 0.00692
PGS AUROC (no covariates): 0.55171 [0.53052, 0.5729]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009212 PGS001346
(GBE_HC1036)
 PSS004085|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE asthma — AUROC: 0.58384 [0.54229, 0.62539] R²: 0.02359
Incremental AUROC (full-covars): -0.00999
PGS R2 (no covariates): 0.00084
PGS AUROC (no covariates): 0.52195 [0.47679, 0.5671]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009213 PGS001346
(GBE_HC1036)
 PSS004086|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE asthma — AUROC: 0.63612 [0.62588, 0.64636] R²: 0.04845
Incremental AUROC (full-covars): 0.06586
PGS R2 (no covariates): 0.03759
PGS AUROC (no covariates): 0.61803 [0.60759, 0.62848]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009214 PGS001346
(GBE_HC1036)
 PSS004087|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE asthma — AUROC: 0.6095 [0.59223, 0.62677] R²: 0.03284
Incremental AUROC (full-covars): 0.03317
PGS R2 (no covariates): 0.01873
PGS AUROC (no covariates): 0.58128 [0.56371, 0.59884]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007090 PGS001370
(GBE_INI3786)
 PSS007256|
African Ancestry|
613 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age asthma diagnosed — — R²: 0.25693 [0.23862, 0.27524]
Incremental R2 (full-covars): -0.00562
PGS R2 (no covariates): 0.00183 [-0.00025, 0.0039]		 age, sex, UKB array type, Genotype PCs —
PPM007091 PGS001370
(GBE_INI3786)
 PSS007257|
East Asian Ancestry|
120 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age asthma diagnosed — — R²: 0.16159 [0.12965, 0.19353]
Incremental R2 (full-covars): -0.02341
PGS R2 (no covariates): 0.00419 [-0.00192, 0.0103]		 age, sex, UKB array type, Genotype PCs —
PPM007092 PGS001370
(GBE_INI3786)
 PSS007258|
European Ancestry|
2,597 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age asthma diagnosed — — R²: 0.17449 [0.16593, 0.18306]
Incremental R2 (full-covars): 0.01793
PGS R2 (no covariates): 0.02331 [0.01961, 0.02702]		 age, sex, UKB array type, Genotype PCs —
PPM007093 PGS001370
(GBE_INI3786)
 PSS007259|
South Asian Ancestry|
807 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age asthma diagnosed — — R²: 0.16307 [0.14811, 0.17804]
Incremental R2 (full-covars): -0.00111
PGS R2 (no covariates): 0.00547 [0.00221, 0.00873]		 age, sex, UKB array type, Genotype PCs —
PPM007094 PGS001370
(GBE_INI3786)
 PSS007260|
European Ancestry|
7,052 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age asthma diagnosed — — R²: 0.15588 [0.15084, 0.16091]
Incremental R2 (full-covars): 0.02498
PGS R2 (no covariates): 0.02714 [0.02472, 0.02956]		 age, sex, UKB array type, Genotype PCs —
PPM009311 PGS001782
(1kgeur_gbmi_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007693|
European Ancestry|
7,128 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.659 Nagelkerke's R2 (covariates regressed out): 0.04884 sex,age, 20PCs —
PPM009307 PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007706|
East Asian Ancestry|
2,633 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.679 Nagelkerke's R2 (covariates regressed out): 0.00679 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009308 PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007698|
African Ancestry|
6,152 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.627 Nagelkerke's R2 (covariates regressed out): 0.00814 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009291 PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007710|
European Ancestry|
351,578 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.64 Nagelkerke's R2 (covariates regressed out): 0.03517 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009301 PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007701|
Additional Diverse Ancestries|
965 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.796 Nagelkerke's R2 (covariates regressed out): 0.0895 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009302 PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007720|
Greater Middle Eastern Ancestry|
1,529 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.689 Nagelkerke's R2 (covariates regressed out): 0.03763 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009303 PGS001787
(1kgeur_gbmi_leaveUKBBout_Asthma_pst_eff_a1_b0.5_phiauto)
 PSS007702|
Additional Asian Ancestries|
8,101 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Asthma — AUROC: 0.651 Nagelkerke's R2 (covariates regressed out): 0.02455 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009682 PGS001849
(portability-PLR_495)
 PSS009324|
European Ancestry|
19,551 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.1135 [0.0997, 0.1274] sex, age, birth date, deprivation index, 16 PCs —
PPM009683 PGS001849
(portability-PLR_495)
 PSS009098|
European Ancestry|
4,078 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0477 [0.017, 0.0784] sex, age, birth date, deprivation index, 16 PCs —
PPM009684 PGS001849
(portability-PLR_495)
 PSS008652|
European Ancestry|
6,537 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0847 [0.0606, 0.1088] sex, age, birth date, deprivation index, 16 PCs —
PPM009685 PGS001849
(portability-PLR_495)
 PSS008426|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0818 [0.0244, 0.1386] sex, age, birth date, deprivation index, 16 PCs —
PPM009686 PGS001849
(portability-PLR_495)
 PSS008206|
South Asian Ancestry|
6,270 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.098 [0.0734, 0.1225] sex, age, birth date, deprivation index, 16 PCs —
PPM009687 PGS001849
(portability-PLR_495)
 PSS007988|
East Asian Ancestry|
1,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0312 [-0.0153, 0.0775] sex, age, birth date, deprivation index, 16 PCs —
PPM009688 PGS001849
(portability-PLR_495)
 PSS007771|
African Ancestry|
2,462 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0528 [0.0132, 0.0923] sex, age, birth date, deprivation index, 16 PCs —
PPM009689 PGS001849
(portability-PLR_495)
 PSS008875|
African Ancestry|
3,892 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0161 [-0.0154, 0.0476] sex, age, birth date, deprivation index, 16 PCs —
PPM011350 PGS002061
(portability-ldpred2_495)
 PSS009324|
European Ancestry|
19,551 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.1184 [0.1045, 0.1322] sex, age, birth date, deprivation index, 16 PCs —
PPM011351 PGS002061
(portability-ldpred2_495)
 PSS009098|
European Ancestry|
4,078 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0394 [0.0087, 0.0701] sex, age, birth date, deprivation index, 16 PCs —
PPM011352 PGS002061
(portability-ldpred2_495)
 PSS008652|
European Ancestry|
6,537 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0945 [0.0704, 0.1185] sex, age, birth date, deprivation index, 16 PCs —
PPM011353 PGS002061
(portability-ldpred2_495)
 PSS008426|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.079 [0.0216, 0.1359] sex, age, birth date, deprivation index, 16 PCs —
PPM011354 PGS002061
(portability-ldpred2_495)
 PSS008206|
South Asian Ancestry|
6,270 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.097 [0.0723, 0.1215] sex, age, birth date, deprivation index, 16 PCs —
PPM011355 PGS002061
(portability-ldpred2_495)
 PSS007988|
East Asian Ancestry|
1,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0355 [-0.0109, 0.0818] sex, age, birth date, deprivation index, 16 PCs —
PPM011356 PGS002061
(portability-ldpred2_495)
 PSS007771|
African Ancestry|
2,462 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0521 [0.0125, 0.0916] sex, age, birth date, deprivation index, 16 PCs —
PPM011357 PGS002061
(portability-ldpred2_495)
 PSS008875|
African Ancestry|
3,892 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Asthma — — Partial Correlation (partial-r): 0.0221 [-0.0094, 0.0536] sex, age, birth date, deprivation index, 16 PCs —
PPM012792 PGS002248
(PRSice_asthma)
 PSS009557|
European Ancestry|
898 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 11 — AUROC: 0.61 — — —
PPM012793 PGS002248
(PRSice_asthma)
 PSS009558|
European Ancestry|
1,018 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 8 — AUROC: 0.65 [0.53, 0.77] — CAPE model —
PPM012791 PGS002248
(PRSice_asthma)
 PSS009558|
European Ancestry|
1,018 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 8 — AUROC: 0.61 — — —
PPM012794 PGS002248
(PRSice_asthma)
 PSS009557|
European Ancestry|
898 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 11 — AUROC: 0.71 [0.61, 0.8] — CAPE model —
PPM012795 PGS002248
(PRSice_asthma)
 PSS009558|
European Ancestry|
1,018 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 8 — AUROC: 0.85 [0.77, 0.92] — CAPP model —
PPM012796 PGS002248
(PRSice_asthma)
 PSS009557|
European Ancestry|
898 individuals
 PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
 Reported Trait: Childhood asthma by age 11 — AUROC: 0.81 [0.72, 0.89] — CAPP model —
PPM013076 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0055 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013125 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013174 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0238 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013223 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0106 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013270 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013293 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0016 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013316 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013339 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013364 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013413 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013462 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013511 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013560 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013609 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013658 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013707 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013756 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013805 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013854 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013903 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013952 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014001 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014050 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0077 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014099 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014148 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014197 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0022 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014246 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0073 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014295 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0036 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014491 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0106 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014344 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0059 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014393 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0006 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014442 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0253 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014540 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0048 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014589 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014638 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0212 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014687 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model vs. covariates alone): 0.0103 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014754 PGS002727
(PRS_PA)
 PSS009885|
East Asian Ancestry|
1,671 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.32 [0.99, 1.77] AUROC: 0.73 [0.66, 0.8] R²: 0.08 — —
PPM014755 PGS002727
(PRS_PA)
 PSS009887|
South Asian Ancestry|
8,736 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.32 [1.18, 1.48] AUROC: 0.65 [0.62, 0.68] R²: 0.03 — —
PPM014752 PGS002727
(PRS_PA)
 PSS009884|
African Ancestry|
7,818 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.43 [1.24, 1.65] AUROC: 0.66 [0.63, 0.69] R²: 0.03 — —
PPM014753 PGS002727
(PRS_PA)
 PSS009888|
Hispanic or Latin American Ancestry|
5,225 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.63 [1.36, 1.95] AUROC: 0.7 [0.67, 0.74] R²: 0.07 — —
PPM014751 PGS002727
(PRS_PA)
 PSS009886|
European Ancestry|
391,820 individuals
 PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
 Reported Trait: Pediatric asthma OR: 1.57 [1.55, 1.6] AUROC: 0.66 [0.65, 0.67] R²: 0.04 — —
PPM014954 PGS002754
(Asthma_prscs)
 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Asthma OR: 1.43 [1.39, 1.48] — — age, sex, 10 PCs, technical covariates —
PPM020109 PGS004176
(asthma_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Asthma — AUROC: 0.62651 — year of birth, sex —
PPM020110 PGS004176
(asthma_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Asthma — AUROC: 0.62694 — year of birth, sex —
PPM020111 PGS004176
(asthma_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Asthma — AUROC: 0.62779 — year of birth, sex —
PPM020112 PGS004176
(asthma_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Asthma — AUROC: 0.62504 — year of birth, sex —
PPM020113 PGS004176
(asthma_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Asthma — AUROC: 0.62557 — year of birth, sex —
PPM020318 PGS004252
(PRS212_asthma)
 PSS011331|
European Ancestry|
298,738 individuals
 PGP000544 |
Zhu Y et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident asthma HR: 1.59 [1.5, 1.69] — — age, sex, region, employment status, household income, educational level, Townsend deprivation index, smoking status, drinking status, diet, and physical activity, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry —
PPM021390 PGS004252
(PRS212_asthma)
 PSS011723|
European Ancestry|
327,124 individuals
 PGP000651 |
Liang H et al. ERJ Open Res (2023)
|Ext.		 Reported Trait: Incident asthma — — Hazard ratio (HR, high vs low PRS tertile): 1.59 [1.5, 1.73] Age, sex, education, Townsend Index, alcohol status, region, relatedness, number of alleles included in the polygenic risk score, 20 PCs —
PPM020343 PGS004275
(GenoBoost_asthma_0)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.613 Covariate-adjusted pseudo-R2: 0.03314
AUPRC: 0.20819		 age, sex, PC1-10 —
PPM020344 PGS004276
(GenoBoost_asthma_1)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.60893 Covariate-adjusted pseudo-R2: 0.03015
AUPRC: 0.20397		 age, sex, PC1-10 —
PPM020345 PGS004277
(GenoBoost_asthma_2)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.60862 Covariate-adjusted pseudo-R2: 0.02971
AUPRC: 0.2033		 age, sex, PC1-10 —
PPM020346 PGS004278
(GenoBoost_asthma_3)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.61057 Covariate-adjusted pseudo-R2: 0.03076
AUPRC: 0.20281		 age, sex, PC1-10 —
PPM020347 PGS004279
(GenoBoost_asthma_4)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.61262 Covariate-adjusted pseudo-R2: 0.03191
AUPRC: 0.205		 age, sex, PC1-10 —
PPM020554 PGS004439
(disease.Asthma.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Asthma OR: 1.37056 — — — —
PPM020582 PGS004467
(disease.J45.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: J45 (Asthma) OR: 1.32925 — — — —
PPM020624 PGS004509
(meta.Asthma.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Asthma OR: 1.40799 — — — —
PPM020652 PGS004537
(meta.J45.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: J45 (Asthma) OR: 1.40091 — — — —
PPM020948 PGS004723
(asthma_PRSmix_eur)
 PSS011465|
European Ancestry|
9,462 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Asthma — — Incremental R2 (Full model versus model with only covariates): 0.033 [0.026, 0.04] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020949 PGS004724
(asthma_PRSmix_sas)
 PSS011474|
South Asian Ancestry|
8,837 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Asthma — — Incremental R2 (Full model versus model with only covariates): 0.065 [0.055, 0.075] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020950 PGS004725
(asthma_PRSmixPlus_eur)
 PSS011465|
European Ancestry|
9,462 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Asthma — — Incremental R2 (Full model versus model with only covariates): 0.039 [0.031, 0.047] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020951 PGS004726
(asthma_PRSmixPlus_sas)
 PSS011474|
South Asian Ancestry|
8,837 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Asthma — — Incremental R2 (Full model versus model with only covariates): 0.069 [0.059, 0.08] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM021195 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011664|
European Ancestry|
33,589 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.27 [1.24, 1.3] C-index: 0.57 [0.57, 0.58] — PCs 1-10 —
PPM021196 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011663|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.48 [1.43, 1.52] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021197 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011662|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.47 [1.43, 1.52] C-index: 0.61 [0.6, 0.62] — PCs 1-10 —
PPM021198 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011660|
European Ancestry|
44,187 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.39 [1.35, 1.43] — — PCs 1-10 —
PPM021200 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011659|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.42 [1.41, 1.44] C-index: 0.61 [0.61, 0.62] — PCs 1-10 —
PPM021201 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011658|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.35 [1.33, 1.37] C-index: 0.6 [0.6, 0.6] — PCs 1-10 —
PPM021199 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011661|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.41 [1.32, 1.5] C-index: 0.6 [0.58, 0.62] — PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004292 — —
[
  • 869 cases
  • , 5,628 controls
]
 — African unspecified — UKB —
PSS004293 — —
[
  • 165 cases
  • , 1,539 controls
]
 — East Asian — UKB —
PSS004294 — —
[
  • 3,193 cases
  • , 21,712 controls
]
 — European non-white British ancestry UKB —
PSS004295 — —
[
  • 1,164 cases
  • , 6,667 controls
]
 — South Asian — UKB —
PSS004296 — —
[
  • 8,797 cases
  • , 58,628 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS001028 Cases were children with asthma ever, at age 8 years. Cases were defined using an adjusted diagnosis of asthma ever at age 8 years based on (1) 1 or more attacks of wheeze in the last 12 months or (2) inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had at least 1 of these characteristics was categorized as having asthma. —
[
  • 215 cases
  • , 212 controls
]
,
56.2 % Male samples
 — European
(Swedish)		 — BAMSE Possible sample overlap of up to 100% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS001029 Cases were children with asthma ever, at age 8 years, in which asthma was defined by the following characteristics: 1 or more attacks of wheeze in the last 12 months, 1 or more events of shortness of breath (dyspnea) in the last 12 months, or inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had 1 or more of these characteristics was categorized as having asthma. —
[
  • 792 cases
  • , 1,066 controls
]
,
51.1 % Male samples
 — European — PIAMA Possible sample overlap of up to 19% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS008652 — — 6,537 individuals — European Italy (South Europe) UKB —
PSS009557 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last —
[
  • 116 cases
  • , 782 controls
]
 — European — MAAS —
PSS009558 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last —
[
  • 144 cases
  • , 874 controls
]
 — European — MAAS —
PSS011331 — —
[
  • 5,725 cases
  • , 293,013 controls
]
,
48.2 % Male samples
 Mean = 56.62 years
Sd = 8.03 years		 European
(Irish, British)		 — UKB —
PSS011465 — — 9,462 individuals — European — AllofUs —
PSS007771 — — 2,462 individuals — African American or Afro-Caribbean Carribean UKB —
PSS007256 — — 613 individuals — African unspecified — UKB —
PSS007257 — — 120 individuals — East Asian — UKB —
PSS007258 — — 2,597 individuals — European non-white British ancestry UKB —
PSS007259 — — 807 individuals — South Asian — UKB —
PSS003676 — —
[
  • 80 cases
  • , 436 controls
]
 — African unspecified — UKB —
PSS003677 — —
[
  • 29 cases
  • , 216 controls
]
 — East Asian — UKB —
PSS003678 — —
[
  • 793 cases
  • , 5,166 controls
]
 — European non-white British ancestry UKB —
PSS003679 — —
[
  • 99 cases
  • , 608 controls
]
 — South Asian — UKB —
PSS003680 — —
[
  • 2,213 cases
  • , 15,031 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS007260 — — 7,052 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007693 — —
[
  • 1,061 cases
  • , 6,066 controls
]
 — European — CanPath —
PSS008426 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009324 — — 19,551 individuals — European UK (+ Ireland) UKB —
PSS011296 22,667 sibling pairs — 45,334 individuals — European — UKB —
PSS011658 — —
[
  • 23,157 cases
  • , 176,711 controls
]
 — European — EB —
PSS000055 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. Median = 38.0 years
Range = [0.0, 38.0] years
[
  • 305 cases
  • , 575 controls
]
,
51.0 % Male samples
 — European — DMHDS —
PSS000056 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. — 187 individuals — European — DMHDS Subset of children from DMHDS with asthma onset in childhood (before age 13 years)
PSS011660 — —
[
  • 4,032 cases
  • , 40,155 controls
]
 — European — G&H —
PSS011344 — —
[
  • 9,565 cases
  • , 57,863 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011663 — —
[
  • 3,679 cases
  • , 66,036 controls
]
 — European — HUNT —
PSS011664 — —
[
  • 8,184 cases
  • , 25,405 controls
]
 — European — MGBB —
PSS011662 — —
[
  • 4,346 cases
  • , 25,081 controls
]
 — European — GEL —
PSS011659 — —
[
  • 45,188 cases
  • , 366,902 controls
]
 — European — FinnGen —
PSS004466 — —
[
  • 871 cases
  • , 5,626 controls
]
 — African unspecified — UKB —
PSS003955 — —
[
  • 135 cases
  • , 937 controls
]
 — East Asian — UKB —
PSS003956 — —
[
  • 2,872 cases
  • , 16,985 controls
]
 — European non-white British ancestry UKB —
PSS004467 — —
[
  • 166 cases
  • , 1,538 controls
]
 — East Asian — UKB —
PSS003958 — —
[
  • 7,869 cases
  • , 46,067 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS004468 — —
[
  • 3,243 cases
  • , 21,662 controls
]
 — European non-white British ancestry UKB —
PSS004469 — —
[
  • 1,171 cases
  • , 6,660 controls
]
 — South Asian — UKB —
PSS004470 — —
[
  • 8,934 cases
  • , 58,491 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS003954 — —
[
  • 730 cases
  • , 4,226 controls
]
 — African unspecified — UKB —
PSS003957 — —
[
  • 901 cases
  • , 5,328 controls
]
 — South Asian — UKB —
PSS004088 — —
[
  • 8,933 cases
  • , 58,492 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS004084 — —
[
  • 851 cases
  • , 5,646 controls
]
 — African unspecified — UKB —
PSS004085 — —
[
  • 166 cases
  • , 1,538 controls
]
 — East Asian — UKB —
PSS004086 — —
[
  • 3,237 cases
  • , 21,668 controls
]
 — European non-white British ancestry UKB —
PSS004087 — —
[
  • 1,196 cases
  • , 6,635 controls
]
 — South Asian — UKB —
PSS007706 — —
[
  • 142 cases
  • , 2,490 controls
]
 — East Asian — UKB —
PSS007698 — —
[
  • 539 cases
  • , 5,612 controls
]
 — African unspecified Africa or admixed-ancestry diaspora UKB —
PSS007701 — —
[
  • 62 cases
  • , 902 controls
]
 — Other admixed ancestry
(Admixed American)		 — UKB —
PSS007710 — —
[
  • 26,473 cases
  • , 325,104 controls
]
 — European — UKB —
PSS007702 — —
[
  • 831 cases
  • , 7,269 controls
]
 — Asian unspecified Central and South Asian UKB —
PSS009098 — — 4,078 individuals — European Poland (NE Europe) UKB —
PSS008206 — — 6,270 individuals — South Asian India (South Asia) UKB —
PSS009687 — — 6,423 individuals — African unspecified — UKB —
PSS009688 — — 905 individuals — East Asian — UKB —
PSS009689 — — 43,398 individuals — European Non-British European UKB —
PSS009690 — — 7,942 individuals — South Asian — UKB —
PSS009885 — —
[
  • 49 cases
  • , 1,622 controls
]
 — East Asian — UKB —
PSS009887 — —
[
  • 312 cases
  • , 8,424 controls
]
 — South Asian — UKB —
PSS007720 — —
[
  • 134 cases
  • , 1,394 controls
]
 — Greater Middle Eastern (Middle Eastern, North African or Persian) — UKB —
PSS009884 — —
[
  • 310 cases
  • , 7,508 controls
]
 — African unspecified — UKB —
PSS009888 — —
[
  • 205 cases
  • , 5,020 controls
]
 — Hispanic or Latin American
(Admixed American)		 — UKB —
PSS009886 — —
[
  • 15,586 cases
  • , 376,234 controls
]
 — European — UKB —
PSS011723 — —
[
  • 6,238 cases
  • , 320,886 controls
]
,
48.1 % Male samples
 Mean = 56.6 years
Sd = 8.03 years		 European — UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —
PSS011474 — — 8,837 individuals — South Asian — G&H —
PSS008875 — — 3,892 individuals — African unspecified Nigeria (West Africa) UKB —
PSS011661 — —
[
  • 989 cases
  • , 6,029 controls
]
 — European — GS:SFHS —
PSS007988 — — 1,803 individuals — East Asian China (East Asia) UKB —