Polygenic Score (PGS) ID: PGS002628

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name disease_ASTHMA_DIAGNOSED.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 205,286
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
337,071 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 337,071 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014491 PSS009690|
South Asian Ancestry|
7,942 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0106 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014344 PSS009687|
African Ancestry|
6,423 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0059 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014393 PSS009688|
East Asian Ancestry|
905 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0006 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014442 PSS009689|
European Ancestry|
43,398 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Asthma — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0253 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009687 — — 6,423 individuals — African unspecified — UKB —
PSS009688 — — 905 individuals — East Asian — UKB —
PSS009689 — — 43,398 individuals — European Non-British European UKB —
PSS009690 — — 7,942 individuals — South Asian — UKB —