PGS Publication: PGP000546

Publication Information (EuropePMC)
Title A polygenic score method boosted by non-additive models.
PubMed ID 38811555(Europe PMC)
doi 10.1038/s41467-024-48654-x
Publication Date May 29, 2024
Journal Nat Commun
Author(s) Ohta R, Tanigawa Y, Suzuki Y, Kellis M, Morishita S.
Released in PGS Catalog: June 12, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004289
(GenoBoost_alzheimer_s_disease_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Alzheimer's disease Alzheimer disease 40
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004289/ScoringFiles/PGS004289.txt.gz
PGS004288
(GenoBoost_alzheimer_s_disease_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Alzheimer's disease Alzheimer disease 200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004288/ScoringFiles/PGS004288.txt.gz
PGS004286
(GenoBoost_alzheimer_s_disease_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Alzheimer's disease Alzheimer disease 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004286/ScoringFiles/PGS004286.txt.gz
PGS004259
(GenoBoost_rheumatoid_arthritis_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004259/ScoringFiles/PGS004259.txt.gz
PGS004258
(GenoBoost_rheumatoid_arthritis_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004258/ScoringFiles/PGS004258.txt.gz
PGS004261
(GenoBoost_psoriasis_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004261/ScoringFiles/PGS004261.txt.gz
PGS004262
(GenoBoost_psoriasis_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004262/ScoringFiles/PGS004262.txt.gz
PGS004255
(GenoBoost_rheumatoid_arthritis_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004255/ScoringFiles/PGS004255.txt.gz
PGS004257
(GenoBoost_rheumatoid_arthritis_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004257/ScoringFiles/PGS004257.txt.gz
PGS004283
(GenoBoost_all-cause_dementia_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 All-cause dementia dementia 90
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004283/ScoringFiles/PGS004283.txt.gz
PGS004284
(GenoBoost_all-cause_dementia_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 All-cause dementia dementia 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004284/ScoringFiles/PGS004284.txt.gz
PGS004285
(GenoBoost_alzheimer_s_disease_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Alzheimer's disease Alzheimer disease 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004285/ScoringFiles/PGS004285.txt.gz
PGS004292
(GenoBoost_atrial_fibrillation_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 700
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004292/ScoringFiles/PGS004292.txt.gz
PGS004293
(GenoBoost_atrial_fibrillation_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 2,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004293/ScoringFiles/PGS004293.txt.gz
PGS004294
(GenoBoost_atrial_fibrillation_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 2,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004294/ScoringFiles/PGS004294.txt.gz
PGS004296
(GenoBoost_breast_cancer_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Breast cancer breast carcinoma 80
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004296/ScoringFiles/PGS004296.txt.gz
PGS004297
(GenoBoost_breast_cancer_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Breast cancer breast carcinoma 90
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004297/ScoringFiles/PGS004297.txt.gz
PGS004309
(GenoBoost_coronary_artery_disease_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Coronary artery disease coronary artery disease 3,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004309/ScoringFiles/PGS004309.txt.gz
PGS004303
(GenoBoost_colorectal_cancer_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004303/ScoringFiles/PGS004303.txt.gz
PGS004305
(GenoBoost_coronary_artery_disease_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Coronary artery disease coronary artery disease 3,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004305/ScoringFiles/PGS004305.txt.gz
PGS004310
(GenoBoost_type_2_diabetes_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 7,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004310/ScoringFiles/PGS004310.txt.gz
PGS004312
(GenoBoost_type_2_diabetes_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 7,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004312/ScoringFiles/PGS004312.txt.gz
PGS004313
(GenoBoost_type_2_diabetes_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 8,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004313/ScoringFiles/PGS004313.txt.gz
PGS004300
(GenoBoost_colorectal_cancer_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 70
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004300/ScoringFiles/PGS004300.txt.gz
PGS004302
(GenoBoost_colorectal_cancer_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 300
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004302/ScoringFiles/PGS004302.txt.gz
PGS004301
(GenoBoost_colorectal_cancer_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 600
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004301/ScoringFiles/PGS004301.txt.gz
PGS004276
(GenoBoost_asthma_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004276/ScoringFiles/PGS004276.txt.gz
PGS004277
(GenoBoost_asthma_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004277/ScoringFiles/PGS004277.txt.gz
PGS004278
(GenoBoost_asthma_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004278/ScoringFiles/PGS004278.txt.gz
PGS004279
(GenoBoost_asthma_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 5,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004279/ScoringFiles/PGS004279.txt.gz
PGS004280
(GenoBoost_all-cause_dementia_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 All-cause dementia dementia 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004280/ScoringFiles/PGS004280.txt.gz
PGS004281
(GenoBoost_all-cause_dementia_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 All-cause dementia dementia 110
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004281/ScoringFiles/PGS004281.txt.gz
PGS004282
(GenoBoost_all-cause_dementia_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 All-cause dementia dementia 40
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004282/ScoringFiles/PGS004282.txt.gz
PGS004291
(GenoBoost_atrial_fibrillation_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 3,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004291/ScoringFiles/PGS004291.txt.gz
PGS004295
(GenoBoost_breast_cancer_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Breast cancer breast carcinoma 140
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004295/ScoringFiles/PGS004295.txt.gz
PGS004299
(GenoBoost_breast_cancer_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Breast cancer breast carcinoma 70
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004299/ScoringFiles/PGS004299.txt.gz
PGS004307
(GenoBoost_coronary_artery_disease_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Coronary artery disease coronary artery disease 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004307/ScoringFiles/PGS004307.txt.gz
PGS004308
(GenoBoost_coronary_artery_disease_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Coronary artery disease coronary artery disease 1,500
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004308/ScoringFiles/PGS004308.txt.gz
PGS004263
(GenoBoost_psoriasis_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004263/ScoringFiles/PGS004263.txt.gz
PGS004267
(GenoBoost_gout_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Gout gout 1,500
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004267/ScoringFiles/PGS004267.txt.gz
PGS004268
(GenoBoost_gout_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Gout gout 70
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004268/ScoringFiles/PGS004268.txt.gz
PGS004269
(GenoBoost_gout_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Gout gout 70
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004269/ScoringFiles/PGS004269.txt.gz
PGS004270
(GenoBoost_inflammatory_bowel_disease_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Inflammatory bowel disease inflammatory bowel disease 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004270/ScoringFiles/PGS004270.txt.gz
PGS004271
(GenoBoost_inflammatory_bowel_disease_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Inflammatory bowel disease inflammatory bowel disease 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004271/ScoringFiles/PGS004271.txt.gz
PGS004272
(GenoBoost_inflammatory_bowel_disease_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Inflammatory bowel disease inflammatory bowel disease 100
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004272/ScoringFiles/PGS004272.txt.gz
PGS004264
(GenoBoost_psoriasis_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 110
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004264/ScoringFiles/PGS004264.txt.gz
PGS004265
(GenoBoost_gout_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Gout gout 80
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004265/ScoringFiles/PGS004265.txt.gz
PGS004266
(GenoBoost_gout_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Gout gout 200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004266/ScoringFiles/PGS004266.txt.gz
PGS004273
(GenoBoost_inflammatory_bowel_disease_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Inflammatory bowel disease inflammatory bowel disease 110
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004273/ScoringFiles/PGS004273.txt.gz
PGS004287
(GenoBoost_alzheimer_s_disease_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Alzheimer's disease Alzheimer disease 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004287/ScoringFiles/PGS004287.txt.gz
PGS004290
(GenoBoost_atrial_fibrillation_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 3,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004290/ScoringFiles/PGS004290.txt.gz
PGS004298
(GenoBoost_breast_cancer_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Breast cancer breast carcinoma 900
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004298/ScoringFiles/PGS004298.txt.gz
PGS004304
(GenoBoost_colorectal_cancer_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 700
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004304/ScoringFiles/PGS004304.txt.gz
PGS004306
(GenoBoost_coronary_artery_disease_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Coronary artery disease coronary artery disease 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004306/ScoringFiles/PGS004306.txt.gz
PGS004274
(GenoBoost_inflammatory_bowel_disease_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Inflammatory bowel disease inflammatory bowel disease 40
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004274/ScoringFiles/PGS004274.txt.gz
PGS004311
(GenoBoost_type_2_diabetes_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 4,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004311/ScoringFiles/PGS004311.txt.gz
PGS004314
(GenoBoost_type_2_diabetes_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 6,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004314/ScoringFiles/PGS004314.txt.gz
PGS004256
(GenoBoost_rheumatoid_arthritis_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004256/ScoringFiles/PGS004256.txt.gz
PGS004260
(GenoBoost_psoriasis_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 900
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004260/ScoringFiles/PGS004260.txt.gz
PGS004275
(GenoBoost_asthma_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Asthma asthma 5,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004275/ScoringFiles/PGS004275.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020363 PGS004295
(GenoBoost_breast_cancer_0)
 PSS011338|
European Ancestry|
36,380 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Breast cancer — AUROC: 0.64123 Covariate-adjusted pseudo-R2: 0.02653
AUPRC: 0.64123		 age, sex, PC1-10 —
PPM020324 PGS004256
(GenoBoost_rheumatoid_arthritis_1)
 PSS011342|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Rheumatoid arthritis — AUROC: 0.66212 Covariate-adjusted pseudo-R2: 0.01305
AUPRC: 0.04649		 age, sex, PC1-10 —
PPM020325 PGS004257
(GenoBoost_rheumatoid_arthritis_2)
 PSS011342|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Rheumatoid arthritis — AUROC: 0.66087 AUPRC: 0.04561
Covariate-adjusted pseudo-R2: 0.01191		 age, sex, PC1-10 —
PPM020326 PGS004258
(GenoBoost_rheumatoid_arthritis_3)
 PSS011342|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Rheumatoid arthritis — AUROC: 0.6639 Covariate-adjusted pseudo-R2: 0.01382
AUPRC: 0.04737		 age, sex, PC1-10 —
PPM020327 PGS004259
(GenoBoost_rheumatoid_arthritis_4)
 PSS011342|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Rheumatoid arthritis — AUROC: 0.66128 Covariate-adjusted pseudo-R2: 0.01258
AUPRC: 0.04632		 age, sex, PC1-10 —
PPM020328 PGS004260
(GenoBoost_psoriasis_0)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66908 Covariate-adjusted pseudo-R2: 0.04239
AUPRC: 0.04468		 age, sex, PC1-10 —
PPM020329 PGS004261
(GenoBoost_psoriasis_1)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.67722 Covariate-adjusted pseudo-R2: 0.04563
AUPRC: 0.0457		 age, sex, PC1-10 —
PPM020330 PGS004262
(GenoBoost_psoriasis_2)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66916 Covariate-adjusted pseudo-R2: 0.04211
AUPRC: 0.0431		 age, sex, PC1-10 —
PPM020331 PGS004263
(GenoBoost_psoriasis_3)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.67205 Covariate-adjusted pseudo-R2: 0.04423
AUPRC: 0.04681		 age, sex, PC1-10 —
PPM020332 PGS004264
(GenoBoost_psoriasis_4)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66842 Covariate-adjusted pseudo-R2: 0.04356
AUPRC: 0.04551		 age, sex, PC1-10 —
PPM020333 PGS004265
(GenoBoost_gout_0)
 PSS011346|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Gout — AUROC: 0.79753 Covariate-adjusted pseudo-R2: 0.0401
AUPRC: 0.09881		 age, sex, PC1-10 —
PPM020334 PGS004266
(GenoBoost_gout_1)
 PSS011346|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Gout — AUROC: 0.79833 Covariate-adjusted pseudo-R2: 0.04118
AUPRC: 0.10129		 age, sex, PC1-10 —
PPM020335 PGS004267
(GenoBoost_gout_2)
 PSS011346|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Gout — AUROC: 0.79692 Covariate-adjusted pseudo-R2: 0.03951
AUPRC: 0.09791		 age, sex, PC1-10 —
PPM020336 PGS004268
(GenoBoost_gout_3)
 PSS011346|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Gout — AUROC: 0.79783 Covariate-adjusted pseudo-R2: 0.03962
AUPRC: 0.09837		 age, sex, PC1-10 —
PPM020337 PGS004269
(GenoBoost_gout_4)
 PSS011346|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Gout — AUROC: 0.7987 Covariate-adjusted pseudo-R2: 0.04172
AUPRC: 0.10081		 age, sex, PC1-10 —
PPM020339 PGS004271
(GenoBoost_inflammatory_bowel_disease_1)
 PSS011341|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Inflammatory bowel disease — AUROC: 0.57758 Covariate-adjusted pseudo-R2: 0.00673
AUPRC: 0.01694		 age, sex, PC1-10 —
PPM020340 PGS004272
(GenoBoost_inflammatory_bowel_disease_2)
 PSS011341|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Inflammatory bowel disease — AUROC: 0.58326 Covariate-adjusted pseudo-R2: 0.00796
AUPRC: 0.0168		 age, sex, PC1-10 —
PPM020341 PGS004273
(GenoBoost_inflammatory_bowel_disease_3)
 PSS011341|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Inflammatory bowel disease — AUROC: 0.58873 Covariate-adjusted pseudo-R2: 0.00874
AUPRC: 0.01624		 age, sex, PC1-10 —
PPM020342 PGS004274
(GenoBoost_inflammatory_bowel_disease_4)
 PSS011341|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Inflammatory bowel disease — AUROC: 0.5879 Covariate-adjusted pseudo-R2: 0.00872
AUPRC: 0.01705		 age, sex, PC1-10 —
PPM020343 PGS004275
(GenoBoost_asthma_0)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.613 Covariate-adjusted pseudo-R2: 0.03314
AUPRC: 0.20819		 age, sex, PC1-10 —
PPM020344 PGS004276
(GenoBoost_asthma_1)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.60893 Covariate-adjusted pseudo-R2: 0.03015
AUPRC: 0.20397		 age, sex, PC1-10 —
PPM020345 PGS004277
(GenoBoost_asthma_2)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.60862 Covariate-adjusted pseudo-R2: 0.02971
AUPRC: 0.2033		 age, sex, PC1-10 —
PPM020346 PGS004278
(GenoBoost_asthma_3)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.61057 Covariate-adjusted pseudo-R2: 0.03076
AUPRC: 0.20281		 age, sex, PC1-10 —
PPM020347 PGS004279
(GenoBoost_asthma_4)
 PSS011344|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Asthma — AUROC: 0.61262 Covariate-adjusted pseudo-R2: 0.03191
AUPRC: 0.205		 age, sex, PC1-10 —
PPM020349 PGS004281
(GenoBoost_all-cause_dementia_1)
 PSS011345|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: All-cause dementia — AUROC: 0.81897 Covariate-adjusted pseudo-R2: 0.03418
AUPRC: 0.81897		 age, sex, PC1-10 —
PPM020350 PGS004282
(GenoBoost_all-cause_dementia_2)
 PSS011345|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: All-cause dementia — AUROC: 0.81837 Covariate-adjusted pseudo-R2: 0.03323
AUPRC: 0.81837		 age, sex, PC1-10 —
PPM020351 PGS004283
(GenoBoost_all-cause_dementia_3)
 PSS011345|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: All-cause dementia — AUROC: 0.81816 Covariate-adjusted pseudo-R2: 0.03381
AUPRC: 0.81816		 age, sex, PC1-10 —
PPM020352 PGS004284
(GenoBoost_all-cause_dementia_4)
 PSS011345|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: All-cause dementia — AUROC: 0.81886 Covariate-adjusted pseudo-R2: 0.03415
AUPRC: 0.81886		 age, sex, PC1-10 —
PPM020353 PGS004285
(GenoBoost_alzheimer_s_disease_0)
 PSS011336|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Alzheimer's disease — AUROC: 0.8336 Covariate-adjusted pseudo-R2: 0.0421
AUPRC: 0.8336		 age, sex, PC1-10 —
PPM020354 PGS004286
(GenoBoost_alzheimer_s_disease_1)
 PSS011336|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Alzheimer's disease — AUROC: 0.8321 Covariate-adjusted pseudo-R2: 0.04019
AUPRC: 0.8321		 age, sex, PC1-10 —
PPM020355 PGS004287
(GenoBoost_alzheimer_s_disease_2)
 PSS011336|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Alzheimer's disease — AUROC: 0.83179 Covariate-adjusted pseudo-R2: 0.04182
AUPRC: 0.83179		 age, sex, PC1-10 —
PPM020357 PGS004289
(GenoBoost_alzheimer_s_disease_4)
 PSS011336|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Alzheimer's disease — AUROC: 0.83162 Covariate-adjusted pseudo-R2: 0.04076
AUPRC: 0.83162		 age, sex, PC1-10 —
PPM020358 PGS004290
(GenoBoost_atrial_fibrillation_0)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75753 Covariate-adjusted pseudo-R2: 0.03378
AUPRC: 0.75753		 age, sex, PC1-10 —
PPM020359 PGS004291
(GenoBoost_atrial_fibrillation_1)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75566 Covariate-adjusted pseudo-R2: 0.03105
AUPRC: 0.75566		 age, sex, PC1-10 —
PPM020360 PGS004292
(GenoBoost_atrial_fibrillation_2)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75591 Covariate-adjusted pseudo-R2: 0.03151
AUPRC: 0.75591		 age, sex, PC1-10 —
PPM020361 PGS004293
(GenoBoost_atrial_fibrillation_3)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75627 Covariate-adjusted pseudo-R2: 0.03251
AUPRC: 0.75627		 age, sex, PC1-10 —
PPM020366 PGS004298
(GenoBoost_breast_cancer_3)
 PSS011338|
European Ancestry|
36,380 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Breast cancer — AUROC: 0.64169 Covariate-adjusted pseudo-R2: 0.02726
AUPRC: 0.64169		 age, sex, PC1-10 —
PPM020367 PGS004299
(GenoBoost_breast_cancer_4)
 PSS011338|
European Ancestry|
36,380 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Breast cancer — AUROC: 0.63627 Covariate-adjusted pseudo-R2: 0.02431
AUPRC: 0.63627		 age, sex, PC1-10 —
PPM020368 PGS004300
(GenoBoost_colorectal_cancer_0)
 PSS011340|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Colorectal cancer — AUROC: 0.66861 Covariate-adjusted pseudo-R2: 0.00382
AUPRC: 0.66861		 age, sex, PC1-10 —
PPM020369 PGS004301
(GenoBoost_colorectal_cancer_1)
 PSS011340|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Colorectal cancer — AUROC: 0.66747 Covariate-adjusted pseudo-R2: 0.0036
AUPRC: 0.66747		 age, sex, PC1-10 —
PPM020370 PGS004302
(GenoBoost_colorectal_cancer_2)
 PSS011340|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Colorectal cancer — AUROC: 0.66658 Covariate-adjusted pseudo-R2: 0.00253
AUPRC: 0.66658		 age, sex, PC1-10 —
PPM020371 PGS004303
(GenoBoost_colorectal_cancer_3)
 PSS011340|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Colorectal cancer — AUROC: 0.66945 Covariate-adjusted pseudo-R2: 0.00423
AUPRC: 0.66945		 age, sex, PC1-10 —
PPM020372 PGS004304
(GenoBoost_colorectal_cancer_4)
 PSS011340|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Colorectal cancer — AUROC: 0.66807 Covariate-adjusted pseudo-R2: 0.00325
AUPRC: 0.66807		 age, sex, PC1-10 —
PPM020373 PGS004305
(GenoBoost_coronary_artery_disease_0)
 PSS011339|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Coronary artery disease — AUROC: 0.75531 Covariate-adjusted pseudo-R2: 0.02237
AUPRC: 0.75531		 age, sex, PC1-10 —
PPM020375 PGS004307
(GenoBoost_coronary_artery_disease_2)
 PSS011339|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Coronary artery disease — AUROC: 0.75669 Covariate-adjusted pseudo-R2: 0.0242
AUPRC: 0.75669		 age, sex, PC1-10 —
PPM020376 PGS004308
(GenoBoost_coronary_artery_disease_3)
 PSS011339|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Coronary artery disease — AUROC: 0.75454 Covariate-adjusted pseudo-R2: 0.02173
AUPRC: 0.75454		 age, sex, PC1-10 —
PPM020377 PGS004309
(GenoBoost_coronary_artery_disease_4)
 PSS011339|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Coronary artery disease — AUROC: 0.75719 Covariate-adjusted pseudo-R2: 0.02427
AUPRC: 0.75719		 age, sex, PC1-10 —
PPM020378 PGS004310
(GenoBoost_type_2_diabetes_0)
 PSS011343|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Type 2 diabetes — AUROC: 0.70295 Covariate-adjusted pseudo-R2: 0.03816
AUPRC: 0.70295		 age, sex, PC1-10 —
PPM020379 PGS004311
(GenoBoost_type_2_diabetes_1)
 PSS011343|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Type 2 diabetes — AUROC: 0.70067 Covariate-adjusted pseudo-R2: 0.03626
AUPRC: 0.70067		 age, sex, PC1-10 —
PPM020380 PGS004312
(GenoBoost_type_2_diabetes_2)
 PSS011343|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Type 2 diabetes — AUROC: 0.7011 Covariate-adjusted pseudo-R2: 0.03779
AUPRC: 0.7011		 age, sex, PC1-10 —
PPM020381 PGS004313
(GenoBoost_type_2_diabetes_3)
 PSS011343|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Type 2 diabetes — AUROC: 0.70228 Covariate-adjusted pseudo-R2: 0.03838
AUPRC: 0.70228		 age, sex, PC1-10 —
PPM020382 PGS004314
(GenoBoost_type_2_diabetes_4)
 PSS011343|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Type 2 diabetes — AUROC: 0.70378 Covariate-adjusted pseudo-R2: 0.03925
AUPRC: 0.70378		 age, sex, PC1-10 —
PPM020362 PGS004294
(GenoBoost_atrial_fibrillation_4)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75648 Covariate-adjusted pseudo-R2: 0.03265
AUPRC: 0.75648		 age, sex, PC1-10 —
PPM020323 PGS004255
(GenoBoost_rheumatoid_arthritis_0)
 PSS011342|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Rheumatoid arthritis — AUROC: 0.66209 Covariate-adjusted pseudo-R2: 0.01285
AUPRC: 0.04621		 age, sex, PC1-10 —
PPM020338 PGS004270
(GenoBoost_inflammatory_bowel_disease_0)
 PSS011341|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Inflammatory bowel disease — AUROC: 0.57093 Covariate-adjusted pseudo-R2: 0.00624
AUPRC: 0.01652		 age, sex, PC1-10 —
PPM020348 PGS004280
(GenoBoost_all-cause_dementia_0)
 PSS011345|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: All-cause dementia — AUROC: 0.81926 Covariate-adjusted pseudo-R2: 0.03533
AUPRC: 0.07827		 age, sex, PC1-10 —
PPM020356 PGS004288
(GenoBoost_alzheimer_s_disease_3)
 PSS011336|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Alzheimer's disease — AUROC: 0.83004 Covariate-adjusted pseudo-R2: 0.03836
AUPRC: 0.83004		 age, sex, PC1-10 —
PPM020364 PGS004296
(GenoBoost_breast_cancer_1)
 PSS011338|
European Ancestry|
36,380 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Breast cancer — AUROC: 0.64037 Covariate-adjusted pseudo-R2: 0.02541
AUPRC: 0.64037		 age, sex, PC1-10 —
PPM020365 PGS004297
(GenoBoost_breast_cancer_2)
 PSS011338|
European Ancestry|
36,380 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Breast cancer — AUROC: 0.64119 Covariate-adjusted pseudo-R2: 0.02635
AUPRC: 0.64119		 age, sex, PC1-10 —
PPM020374 PGS004306
(GenoBoost_coronary_artery_disease_1)
 PSS011339|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Coronary artery disease — AUROC: 0.75619 Covariate-adjusted pseudo-R2: 0.02397
AUPRC: 0.75619		 age, sex, PC1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011336 — —
[
  • 437 cases
  • , 66,991 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011337 — —
[
  • 5,085 cases
  • , 62,343 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011338 — —
[
  • 2,964 cases
  • , 33,416 controls
]
,
0.0 % Male samples
 — European
(White British)		 — UKB —
PSS011339 — —
[
  • 4,575 cases
  • , 62,853 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011340 — —
[
  • 1,306 cases
  • , 66,122 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011341 — —
[
  • 763 cases
  • , 66,665 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011342 — —
[
  • 1,563 cases
  • , 65,865 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011343 — —
[
  • 5,089 cases
  • , 62,339 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011344 — —
[
  • 9,565 cases
  • , 57,863 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011345 — —
[
  • 1,001 cases
  • , 66,427 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011346 — —
[
  • 1,848 cases
  • , 65,580 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011347 — —
[
  • 1,277 cases
  • , 66,151 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —