Trait: psoriasis

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000676
Description An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp. [NCIT: P378]
Trait category
Immune system disorder
Synonyms 20 synonyms
  • OTHER PSORIASIS
  • Other and unspecified pityriasis
  • Other psoriasis and similar disorders
  • Other psoriasis and similar disorders (disorder)
  • Other psoriasis and similar disorders excluding psoriatic arthropathy
  • PITYRIASIS NEC & NOS
  • PSORIAS RELATED DIS NEC
  • PUSTULAR PSORIASIS OF PALMS SOLES
  • PUSTULOSIS OF PALMS SOLES
  • Palmoplantaris Pustulosis
  • Psoriases
  • Psoriasis and similar disorders
  • Psoriasis and similar disorders (disorder)
  • Psoriasis and similar disorders (navigational concept)
  • Psoriasis and similar disorders NOS
  • Psoriasis and similar disorders NOS (disorder)
  • Pustular Psoriasis of Palms and Soles
  • Pustulosis Palmaris et Plantaris
  • Pustulosis of Palms and Soles
  • psoriasis
Mapped terms 24 mapped terms
  • DOID:8893
  • ICD10:L40
  • ICD10CM:L40
  • ICD9:696
  • ICD9:696.1
  • ICD9:696.5
  • ICD9:696.8
  • MEDGEN:10997
  • MESH:D011565
  • MONDO:0005083
  • MeSH:D011565
  • MedDRA:10037153
  • NCIT:C3346
  • NCIt:C3346
  • OMIM:177900
  • OMIM:602723
  • OMIM:605606
  • OMIM:612599
  • OMIM:614070
  • OMIMPS:177900
  • SCTID:9014002
  • SNOMEDCT:9014002
  • UMLS:C0033860
  • icd11.foundation:63698555

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001312
(GBE_HC38)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Psoriasis psoriasis 204
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001312/ScoringFiles/PGS001312.txt.gz
PGS001313
(GBE_HC1159)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Psoriasis (time-to-event) psoriasis 578
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001313/ScoringFiles/PGS001313.txt.gz
PGS001871
(portability-PLR_696.4)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Psoriasis psoriasis 264
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001871/ScoringFiles/PGS001871.txt.gz
PGS002083
(portability-ldpred2_696.4)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Psoriasis psoriasis 71,744
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002083/ScoringFiles/PGS002083.txt.gz
PGS002293
(PRS62_psoriasis)
 PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
 Psoriasis psoriasis 62
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002293/ScoringFiles/PGS002293.txt.gz
PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002344/ScoringFiles/PGS002344.txt.gz
PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 6,879
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002416/ScoringFiles/PGS002416.txt.gz
PGS002465
(disease_PSORIASIS.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 21,483
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002465/ScoringFiles/PGS002465.txt.gz
PGS002514
(disease_PSORIASIS.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 96,453
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002514/ScoringFiles/PGS002514.txt.gz
PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 1,348
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002563/ScoringFiles/PGS002563.txt.gz
PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 643
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002612/ScoringFiles/PGS002612.txt.gz
PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 283,128
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002661/ScoringFiles/PGS002661.txt.gz
PGS002710
(disease_PSORIASIS.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 566,839
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002710/ScoringFiles/PGS002710.txt.gz
PGS004260
(GenoBoost_psoriasis_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 900
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004260/ScoringFiles/PGS004260.txt.gz
PGS004261
(GenoBoost_psoriasis_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004261/ScoringFiles/PGS004261.txt.gz
PGS004262
(GenoBoost_psoriasis_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004262/ScoringFiles/PGS004262.txt.gz
PGS004263
(GenoBoost_psoriasis_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004263/ScoringFiles/PGS004263.txt.gz
PGS004264
(GenoBoost_psoriasis_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 110
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004264/ScoringFiles/PGS004264.txt.gz
PGS004315
(GRS-ALL)
 PGP000547 |
Bui A et al. Front Genet (2023)
 Psoriasis psoriasis 88
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004315/ScoringFiles/PGS004315.txt.gz
PGS004316
(GRS-HLA)
 PGP000547 |
Bui A et al. Front Genet (2023)
 Psoriasis psoriasis 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004316/ScoringFiles/PGS004316.txt.gz
PGS004317
(GRS-noHLA)
 PGP000547 |
Bui A et al. Front Genet (2023)
 Psoriasis psoriasis 77
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004317/ScoringFiles/PGS004317.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009053 PGS001312
(GBE_HC38)
 PSS004471|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.73107 [0.60624, 0.85591] R²: 0.06593
Incremental AUROC (full-covars): 0.0282
PGS R2 (no covariates): 0.01927
PGS AUROC (no covariates): 0.62557 [0.48848, 0.76266]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009054 PGS001312
(GBE_HC38)
 PSS004472|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.88867 [0.80531, 0.97202] R²: 0.24575
Incremental AUROC (full-covars): 0.01187
PGS R2 (no covariates): 0.00399
PGS AUROC (no covariates): 0.57774 [0.40533, 0.75016]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009055 PGS001312
(GBE_HC38)
 PSS004473|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.68424 [0.65757, 0.71091] R²: 0.05057
Incremental AUROC (full-covars): 0.0981
PGS R2 (no covariates): 0.04137
PGS AUROC (no covariates): 0.66409 [0.63596, 0.69222]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009056 PGS001312
(GBE_HC38)
 PSS004474|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.6849 [0.63397, 0.73584] R²: 0.0448
Incremental AUROC (full-covars): 0.052
PGS R2 (no covariates): 0.02087
PGS AUROC (no covariates): 0.64825 [0.59861, 0.6979]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009057 PGS001312
(GBE_HC38)
 PSS004475|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.69754 [0.68165, 0.71343] R²: 0.05574
Incremental AUROC (full-covars): 0.14505
PGS R2 (no covariates): 0.05226
PGS AUROC (no covariates): 0.69158 [0.6754, 0.70775]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009058 PGS001313
(GBE_HC1159)
 PSS004158|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.69906 [0.60273, 0.7954] R²: 0.04185
Incremental AUROC (full-covars): 0.01899
PGS R2 (no covariates): 0.00732
PGS AUROC (no covariates): 0.62223 [0.54291, 0.70154]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009059 PGS001313
(GBE_HC1159)
 PSS004159|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.72306 [0.61623, 0.82989] R²: 0.09162
Incremental AUROC (full-covars): 0.00222
PGS R2 (no covariates): 0.00378
PGS AUROC (no covariates): 0.48492 [0.37014, 0.5997]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009060 PGS001313
(GBE_HC1159)
 PSS004160|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.66545 [0.64532, 0.68558] R²: 0.04468
Incremental AUROC (full-covars): 0.07449
PGS R2 (no covariates): 0.0337
PGS AUROC (no covariates): 0.64565 [0.62471, 0.66658]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009061 PGS001313
(GBE_HC1159)
 PSS004161|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.63418 [0.59417, 0.67419] R²: 0.0236
Incremental AUROC (full-covars): 0.05154
PGS R2 (no covariates): 0.0123
PGS AUROC (no covariates): 0.60455 [0.56482, 0.64428]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009062 PGS001313
(GBE_HC1159)
 PSS004162|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.67543 [0.66285, 0.68801] R²: 0.05117
Incremental AUROC (full-covars): 0.13853
PGS R2 (no covariates): 0.04966
PGS AUROC (no covariates): 0.6729 [0.66027, 0.68553]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009857 PGS001871
(portability-PLR_696.4)
 PSS009347|
European Ancestry|
19,615 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0636 [0.0497, 0.0775] sex, age, birth date, deprivation index, 16 PCs —
PPM009858 PGS001871
(portability-PLR_696.4)
 PSS009121|
European Ancestry|
4,059 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.107 [0.0764, 0.1374] sex, age, birth date, deprivation index, 16 PCs —
PPM009859 PGS001871
(portability-PLR_696.4)
 PSS008675|
European Ancestry|
6,554 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0404 [0.0162, 0.0646] sex, age, birth date, deprivation index, 16 PCs —
PPM009860 PGS001871
(portability-PLR_696.4)
 PSS008449|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0463 [-0.0112, 0.1035] sex, age, birth date, deprivation index, 16 PCs —
PPM009861 PGS001871
(portability-PLR_696.4)
 PSS008229|
South Asian Ancestry|
6,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0327 [0.0077, 0.0577] sex, age, birth date, deprivation index, 16 PCs —
PPM009862 PGS001871
(portability-PLR_696.4)
 PSS008010|
East Asian Ancestry|
1,784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0079 [-0.0388, 0.0545] sex, age, birth date, deprivation index, 16 PCs —
PPM009863 PGS001871
(portability-PLR_696.4)
 PSS007794|
African Ancestry|
2,398 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0357 [-0.0045, 0.0757] sex, age, birth date, deprivation index, 16 PCs —
PPM009864 PGS001871
(portability-PLR_696.4)
 PSS008898|
African Ancestry|
3,834 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): -0.0065 [-0.0382, 0.0252] sex, age, birth date, deprivation index, 16 PCs —
PPM011525 PGS002083
(portability-ldpred2_696.4)
 PSS009347|
European Ancestry|
19,615 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0632 [0.0493, 0.0771] sex, age, birth date, deprivation index, 16 PCs —
PPM011526 PGS002083
(portability-ldpred2_696.4)
 PSS009121|
European Ancestry|
4,059 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.1153 [0.0847, 0.1456] sex, age, birth date, deprivation index, 16 PCs —
PPM011527 PGS002083
(portability-ldpred2_696.4)
 PSS008675|
European Ancestry|
6,554 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.041 [0.0168, 0.0652] sex, age, birth date, deprivation index, 16 PCs —
PPM011529 PGS002083
(portability-ldpred2_696.4)
 PSS008229|
South Asian Ancestry|
6,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.03 [0.005, 0.055] sex, age, birth date, deprivation index, 16 PCs —
PPM011530 PGS002083
(portability-ldpred2_696.4)
 PSS008010|
East Asian Ancestry|
1,784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0119 [-0.0348, 0.0585] sex, age, birth date, deprivation index, 16 PCs —
PPM011531 PGS002083
(portability-ldpred2_696.4)
 PSS007794|
African Ancestry|
2,398 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0375 [-0.0027, 0.0776] sex, age, birth date, deprivation index, 16 PCs —
PPM011532 PGS002083
(portability-ldpred2_696.4)
 PSS008898|
African Ancestry|
3,834 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): -0.0166 [-0.0483, 0.0152] sex, age, birth date, deprivation index, 16 PCs —
PPM011528 PGS002083
(portability-ldpred2_696.4)
 PSS008449|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0458 [-0.0117, 0.1031] sex, age, birth date, deprivation index, 16 PCs —
PPM013020 PGS002293
(PRS62_psoriasis)
 PSS009651|
European Ancestry|
345,672 individuals
 PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
 Reported Trait: Incident psoriasis HR: 4.625 [2.92, 7.348] — Odds Ratio (OR, poor lifestyle and high genetic risk): 4.625 [2.92, 7.348]
Population-attributable fraction of genetic risk: 0.13 [0.032, 0.218]		 Age, sex, education, Townsend Index, and region, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry —
PPM013109 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013158 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013207 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013256 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0035 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013397 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013446 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013495 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013544 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013593 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013642 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013691 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013740 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013789 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013838 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013887 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013936 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013985 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014034 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014083 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014132 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014181 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014230 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014279 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014328 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014377 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014426 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014475 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.007 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014524 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0034 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014622 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014671 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014720 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014573 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM020328 PGS004260
(GenoBoost_psoriasis_0)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66908 Covariate-adjusted pseudo-R2: 0.04239
AUPRC: 0.04468		 age, sex, PC1-10 —
PPM020329 PGS004261
(GenoBoost_psoriasis_1)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.67722 Covariate-adjusted pseudo-R2: 0.04563
AUPRC: 0.0457		 age, sex, PC1-10 —
PPM020330 PGS004262
(GenoBoost_psoriasis_2)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66916 Covariate-adjusted pseudo-R2: 0.04211
AUPRC: 0.0431		 age, sex, PC1-10 —
PPM020331 PGS004263
(GenoBoost_psoriasis_3)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.67205 Covariate-adjusted pseudo-R2: 0.04423
AUPRC: 0.04681		 age, sex, PC1-10 —
PPM020332 PGS004264
(GenoBoost_psoriasis_4)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66842 Covariate-adjusted pseudo-R2: 0.04356
AUPRC: 0.04551		 age, sex, PC1-10 —
PPM020383 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Family history of psoriasis OR: 1.02 [1.0, 1.04] — R²: 0.0067 — —
PPM020384 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of psoriasis onset OR: 0.71 [0.59, 0.85] — R²: 0.023 — —
PPM020386 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of type1 psoriasis onset OR: 0.82 [0.59, 0.85] — R²: 0.0206 — —
PPM020388 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis severity OR: 1.02 [1.0, 1.06] — R²: 0.061 — —
PPM020390 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Total number of locations ever affected by psoriasis OR: 1.16 [1.11, 1.21] — R²: 0.061 — —
PPM020393 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Initial presentation of psoriasis at elbow or knee OR: 0.97 [0.94, 0.99] — — — —
PPM020396 PGS004315
(GRS-ALL)
 PSS011348|
European Ancestry|
345 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis in genital area β: -0.037 (0.016) — — — —
PPM020385 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of psoriasis onset OR: 0.46 [0.34, 0.63] — R²: 0.0398 — —
PPM020387 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of type1 psoriasis onset OR: 0.69 [0.56, 0.86] — R²: 0.0216 — —
PPM020389 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis severity OR: 1.09 [1.03, 1.15] — R²: 0.077 — —
PPM020391 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Total number of locations ever affected by psoriasis OR: 1.34 [1.24, 1.45] — R²: 0.077 — —
PPM020394 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Initial presentation of psoriasis at elbow or knee OR: 0.92 [0.88, 0.96] — — — —
PPM020392 PGS004317
(GRS-noHLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis in genital area OR: 0.97 [0.94, 1.0] — — — —
PPM020395 PGS004317
(GRS-noHLA)
 PSS011348|
European Ancestry|
345 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis in genital area β: -0.038 (0.019) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004158 — —
[
  • 32 cases
  • , 6,465 controls
]
 — African unspecified — UKB —
PSS004159 — —
[
  • 22 cases
  • , 1,682 controls
]
 — East Asian — UKB —
PSS004160 — —
[
  • 723 cases
  • , 24,182 controls
]
 — European non-white British ancestry UKB —
PSS004161 — —
[
  • 186 cases
  • , 7,645 controls
]
 — South Asian — UKB —
PSS004162 — —
[
  • 1,956 cases
  • , 65,469 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008010 — — 1,784 individuals — East Asian China (East Asia) UKB —
PSS008675 — — 6,554 individuals — European Italy (South Europe) UKB —
PSS007794 — — 2,398 individuals — African American or Afro-Caribbean Carribean UKB —
PSS011347 — —
[
  • 1,277 cases
  • , 66,151 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011348 — — 345 individuals,
52.0 % Male samples
 Mean = 49.0 years
Sd = 16.0 years		 European — UCSF —
PSS011349 — — 654 individuals,
48.0 % Male samples
 Mean = 41.0 years
Sd = 14.0 years		 European — NR —
PSS004471 — —
[
  • 19 cases
  • , 6,478 controls
]
 — African unspecified — UKB —
PSS004472 — —
[
  • 10 cases
  • , 1,694 controls
]
 — East Asian — UKB —
PSS008449 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS004473 — —
[
  • 416 cases
  • , 24,489 controls
]
 — European non-white British ancestry UKB —
PSS009347 — — 19,615 individuals — European UK (+ Ireland) UKB —
PSS004474 — —
[
  • 108 cases
  • , 7,723 controls
]
 — South Asian — UKB —
PSS004475 — —
[
  • 1,146 cases
  • , 66,279 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS009651 — Median = 10.88 years 345,672 individuals,
48.0 % Male samples
 Mean = 56.53 years
Sd = 8.06 years		 European — UKB —
PSS009819 — — 6,503 individuals — African unspecified — UKB —
PSS009820 — — 922 individuals — East Asian — UKB —
PSS009821 — — 43,505 individuals — European Non-British European UKB —
PSS009822 — — 8,098 individuals — South Asian — UKB —
PSS009121 — — 4,059 individuals — European Poland (NE Europe) UKB —
PSS008229 — — 6,161 individuals — South Asian India (South Asia) UKB —
PSS008898 — — 3,834 individuals — African unspecified Nigeria (West Africa) UKB —