| Trait Information | |
| Identifier | MONDO_0001627 |
| Description | Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders. [NCIT: P378] | Trait category |
Neurological disorder
|
| Synonyms |
2 synonyms
|
| Mapped terms |
11 mapped terms
|
| Child trait(s) | 3 child traits |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000025 (GRS) |
PGP000015 | Chouraki V et al. J Alzheimers Dis (2016) |
Alzheimer's disease | Alzheimer disease | 19 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000025/ScoringFiles/PGS000025.txt.gz |
| PGS000026 (PHS) |
PGP000016 | Desikan RS et al. PLoS Med (2017) |
Alzheimer's disease | Alzheimer disease | 33 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000026/ScoringFiles/PGS000026.txt.gz | |
| PGS000053 (ALZ21_NIA-LOAD) |
PGP000039 | Tosto G et al. Neurology (2017) |
Alzheimer's disease (late onset) | late-onset Alzheimer's disease | 21 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000053/ScoringFiles/PGS000053.txt.gz |
| PGS000054 (ALZ21_EFIGA) |
PGP000039 | Tosto G et al. Neurology (2017) |
Alzheimer's disease (late onset) | late-onset Alzheimer's disease | 21 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000054/ScoringFiles/PGS000054.txt.gz |
| PGS000334 (GRSfull_22) |
PGP000101 | Zhang Q et al. Nat Commun (2020) |
Late-onset Alzheimer’s disease | late-onset Alzheimer's disease | 22 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000334/ScoringFiles/PGS000334.txt.gz |
| PGS000779 (PGS7_AD) |
PGP000183 | Zhou X et al. Alzheimers Dement (Amst) (2020) |
Alzheimer's disease | Alzheimer disease | 7 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000779/ScoringFiles/PGS000779.txt.gz | |
| PGS000811 (AD-PRS_39) |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Alzheimer's disease | Alzheimer disease | 39 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000811/ScoringFiles/PGS000811.txt.gz |
| PGS000812 (AD-PRS_57) |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Alzheimer's disease | Alzheimer disease | 57 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000812/ScoringFiles/PGS000812.txt.gz |
| PGS000823 (GRS23_AD) |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Alzheimer's disease | Alzheimer disease | 23 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000823/ScoringFiles/PGS000823.txt.gz |
| PGS000876 (PRS31_AD) |
PGP000222 | Leonenko G et al. Ann Clin Transl Neurol (2019) |
Alzheimer's disease | Alzheimer disease | 31 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000876/ScoringFiles/PGS000876.txt.gz |
| PGS000898 (PRS39_AD) |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Alzheimer's disease | Alzheimer disease | 40 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000898/ScoringFiles/PGS000898.txt.gz | |
| PGS000929 (GBE_HC1583) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
All-cause dementia (algorithmically-defined) | dementia | 6 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000929/ScoringFiles/PGS000929.txt.gz |
| PGS000945 (GBE_HC710) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Dementia in Alzheimer's disease (time-to-event) | dementia, Alzheimer disease |
26 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000945/ScoringFiles/PGS000945.txt.gz |
| PGS000946 (GBE_HC713) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Unspecified dementia (time-to-event) | dementia | 9 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000946/ScoringFiles/PGS000946.txt.gz |
| PGS001179 (GBE_HC711) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Vascular dementia (time-to-event) | vascular dementia | 7 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001179/ScoringFiles/PGS001179.txt.gz |
| PGS001348 (GBE_HC1584) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Alzheimer's disease (algorithmically-defined) | Alzheimer disease | 15 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001348/ScoringFiles/PGS001348.txt.gz |
| PGS001349 (GBE_HC807) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Alzheimer's disease (time-to-event) | Alzheimer disease | 6 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001349/ScoringFiles/PGS001349.txt.gz |
| PGS001775 (PRS39_AD) |
PGP000255 | Ebenau JL et al. Alzheimers Dement (Amst) (2021) |
Alzheimer's disease | Alzheimer disease | 39 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001775/ScoringFiles/PGS001775.txt.gz |
| PGS001827 (portability-PLR_290.1) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Dementia | dementia | 33 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001827/ScoringFiles/PGS001827.txt.gz |
| PGS001828 (portability-PLR_290.11) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Alzheimer's disease | Alzheimer disease | 38 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001828/ScoringFiles/PGS001828.txt.gz |
| PGS002035 (portability-ldpred2_290.1) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Dementia | dementia | 39,752 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002035/ScoringFiles/PGS002035.txt.gz |
| PGS002249 (AD_PRS_0.5) |
PGP000276 | Lourida I et al. JAMA (2019) |
Alzheimer's disease | Alzheimer disease | 249,273 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002249/ScoringFiles/PGS002249.txt.gz |
| PGS002280 (GRS83_AD) |
PGP000309 | Bellenguez C et al. Nat Genet (2022) |
Alzheimer's disease | Alzheimer disease | 83 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002280/ScoringFiles/PGS002280.txt.gz |
| PGS002289 (GRS23_AD) |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Late-onset Alzheimer's disease | late-onset Alzheimer's disease | 23 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002289/ScoringFiles/PGS002289.txt.gz |
| PGS002731 (oA-PRS) |
PGP000339 | Xicota L et al. Neurology (2022) |
Alzheimer's disease | Alzheimer disease | 17 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002731/ScoringFiles/PGS002731.txt.gz | |
| PGS002753 (Alzheimer_s_disease_prscs) |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Alzheimer's disease | Alzheimer disease | 1,092,011 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002753/ScoringFiles/PGS002753.txt.gz |
| PGS003334 (PRS_dementia) |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Dementia | dementia | 27 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003334/ScoringFiles/PGS003334.txt.gz |
| PGS003440 (GRS11_nonapoeAD) |
PGP000444 | Petrican R et al. Sci Rep (2023) |
Alzheimer's disease in non APOE | APOE carrier status, Alzheimer disease |
11 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003440/ScoringFiles/PGS003440.txt.gz |
| PGS003441 (GRS28_AD) |
PGP000444 | Petrican R et al. Sci Rep (2023) |
Alzheimer's disease | Alzheimer disease | 28 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003441/ScoringFiles/PGS003441.txt.gz |
| PGS003574 (GRS_Dementia21) |
PGP000459 | Mukadam N et al. PLoS One (2022) |
Alzheimer's disease (late onset) | Alzheimer disease | 21 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003574/ScoringFiles/PGS003574.txt.gz |
| PGS003953 (AD_Bellenguez) |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 1,937 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003953/ScoringFiles/PGS003953.txt.gz |
| PGS003954 (AD_FINNGEN) |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 81 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003954/ScoringFiles/PGS003954.txt.gz |
| PGS003955 (AD_Jun) |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 85 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003955/ScoringFiles/PGS003955.txt.gz |
| PGS003956 (AD_Kunkle_AFR) |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 157 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003956/ScoringFiles/PGS003956.txt.gz |
| PGS003957 (AD_Kunkle) |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 12,002 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003957/ScoringFiles/PGS003957.txt.gz |
| PGS003958 (AD_Unweighted_PRSsum) |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 14,109 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003958/ScoringFiles/PGS003958.txt.gz |
| PGS003992 (dbslmm.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 1,136,212 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003992/ScoringFiles/PGS003992.txt.gz |
| PGS004008 (lassosum.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 5,663 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004008/ScoringFiles/PGS004008.txt.gz |
| PGS004034 (ldpred2.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 1,046,908 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004034/ScoringFiles/PGS004034.txt.gz |
| PGS004062 (megaprs.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 691,136 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004062/ScoringFiles/PGS004062.txt.gz |
| PGS004092 (prscs.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 1,109,233 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004092/ScoringFiles/PGS004092.txt.gz |
| PGS004116 (pt_clump.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 58 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004116/ScoringFiles/PGS004116.txt.gz |
| PGS004146 (sbayesr.auto.GCST90012877.AD) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Alzheimer's disease | Alzheimer disease | 915,771 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004146/ScoringFiles/PGS004146.txt.gz |
| PGS004227 (ad_apoe_gw_pgs) |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 15 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004227/ScoringFiles/PGS004227.txt.gz |
| PGS004228 (ad_apoe_0.1_pgs) |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 8,863 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004228/ScoringFiles/PGS004228.txt.gz |
| PGS004229 (ad_noapoe_0.1_pgs) |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Alzheimer's disease | Alzheimer disease | 8,858 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004229/ScoringFiles/PGS004229.txt.gz |
| PGS004280 (GenoBoost_all-cause_dementia_0) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
All-cause dementia | dementia | 30 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004280/ScoringFiles/PGS004280.txt.gz |
| PGS004281 (GenoBoost_all-cause_dementia_1) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
All-cause dementia | dementia | 110 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004281/ScoringFiles/PGS004281.txt.gz |
| PGS004282 (GenoBoost_all-cause_dementia_2) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
All-cause dementia | dementia | 40 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004282/ScoringFiles/PGS004282.txt.gz |
| PGS004283 (GenoBoost_all-cause_dementia_3) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
All-cause dementia | dementia | 90 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004283/ScoringFiles/PGS004283.txt.gz |
| PGS004284 (GenoBoost_all-cause_dementia_4) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
All-cause dementia | dementia | 50 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004284/ScoringFiles/PGS004284.txt.gz |
| PGS004285 (GenoBoost_alzheimer_s_disease_0) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Alzheimer's disease | Alzheimer disease | 20 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004285/ScoringFiles/PGS004285.txt.gz |
| PGS004286 (GenoBoost_alzheimer_s_disease_1) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Alzheimer's disease | Alzheimer disease | 10 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004286/ScoringFiles/PGS004286.txt.gz |
| PGS004287 (GenoBoost_alzheimer_s_disease_2) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Alzheimer's disease | Alzheimer disease | 30 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004287/ScoringFiles/PGS004287.txt.gz |
| PGS004288 (GenoBoost_alzheimer_s_disease_3) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Alzheimer's disease | Alzheimer disease | 200 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004288/ScoringFiles/PGS004288.txt.gz |
| PGS004289 (GenoBoost_alzheimer_s_disease_4) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Alzheimer's disease | Alzheimer disease | 40 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004289/ScoringFiles/PGS004289.txt.gz |
| PGS004318 (PRS29_dementia) |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Dementia | dementia | 29 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004318/ScoringFiles/PGS004318.txt.gz |
| PGS004588 (PRS39_Eur) |
PGP000567 | Jung SH et al. JAMA Netw Open (2022) |
Alzheimer's disease | Alzheimer disease | 39 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004588/ScoringFiles/PGS004588.txt.gz | |
| PGS004589 (PRS80_trans) |
PGP000567 | Jung SH et al. JAMA Netw Open (2022) |
Alzheimer's disease | Alzheimer disease | 80 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004589/ScoringFiles/PGS004589.txt.gz | |
| PGS004590 (PRS363_rand_eff) |
PGP000569 | Lake J et al. Mol Psychiatry (2023) |
Alzheimer's disease | Alzheimer disease | 363 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004590/ScoringFiles/PGS004590.txt.gz |
| PGS004600 (PRS_AD83) |
PGP000578 | Tomassen J et al. BMC Neurol (2022) |
Alzheimer's disease | Alzheimer disease | 83 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004600/ScoringFiles/PGS004600.txt.gz |
| PGS004863 (PRS74_AD) |
PGP000609 | Sleiman PM et al. Alzheimers Dement (2023) |
Alzheimer's disease | Alzheimer disease | 74 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004863/ScoringFiles/PGS004863.txt.gz |
| PGS004898 (PRS_AD) |
PGP000624 | Vasiljevic E et al. Alzheimers Dement (2023) |
Alzheimer's disease | Alzheimer disease | 44 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004898/ScoringFiles/PGS004898.txt.gz |
| PGS004918 (PRS8_Synapse) |
PGP000649 | Lawingco T et al. Neurobiol Aging (2020) |
Late-onset Alzheimers disease (based on SNPs in genes involved in synaptic function) | late-onset Alzheimer's disease | 8 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004918/ScoringFiles/PGS004918.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000051 | PGS000025 (GRS) |
PSS000034| European Ancestry| 4,353 individuals |
PGP000015 | Chouraki V et al. J Alzheimers Dis (2016) |
Reported Trait: Incident Alzheimer's disease in APOE Ɛ4 carriers | HR: 1.24 [1.15, 1.34] | — | ΔC-index between models with and without GRS: 0.0112 [0.0015, 0.0208] | age at baseline, sex, education level | HRs are derived from a meta-analysis of studies (adjusted for study center, and participant relatedness) |
| PPM000052 | PGS000025 (GRS) |
PSS000035| European Ancestry| 15,334 individuals |
PGP000015 | Chouraki V et al. J Alzheimers Dis (2016) |
Reported Trait: Incident Alzheimer's disease in APOE Ɛ4 non-carriers | HR: 1.13 [1.08, 1.18] | — | ΔC-index between models with and without GRS: 0.0018 [-0.0003, 0.0039] | age at baseline, sex, education level | HRs are derived from a meta-analysis of studies (adjusted for study center, and participant relatedness) |
| PPM000050 | PGS000025 (GRS) |
PSS000033| European Ancestry| 19,687 individuals |
PGP000015 | Chouraki V et al. J Alzheimers Dis (2016) |
Reported Trait: Incident Alzheimer's disease | HR: 1.17 [1.13, 1.21] | — | ΔC-index between models with and without GRS: 0.0043 [0.0019, 0.0067] | age at baseline, sex, education level, APOE Ɛ4 status | HRs are derived from a meta-analysis of studies (adjusted for study center, and participant relatedness) |
| PPM000053 | PGS000026 (PHS) |
PSS000036| European Ancestry| 17,956 individuals |
PGP000016 | Desikan RS et al. PLoS Med (2017) |
Reported Trait: Alzheimer disease | — | — | r (correlation between between binned quantiles of PHS-predicted and empirical age of AD onset): 0.9 | APOE risk alleles (e2 and e4), age, sex, genetic PCs 1-5 | — |
| PPM002504 | PGS000026 (PHS) |
PSS001127| European Ancestry| 8,415 individuals |
PGP000222 | Leonenko G et al. Ann Clin Transl Neurol (2019) |Ext. |
Reported Trait: Age at Alzheimer's disease onset | β: 0.11 (0.02) | — | — | Gender, PCs (1-3), APOE(ε2 + ε4) | Due to SNP availability issues in the dataset, only 25 out of the 31 variants in Desikan et al's polygenic hazard score (PGS000026) were used. No APOE alleles were included |
| PPM014811 | PGS000026 (PHS) |
PSS009898| Ancestry Not Reported| 780 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in neocortical region | β: 19.98 [14.3, 25.7] | — | — | — | — |
| PPM014812 | PGS000026 (PHS) |
PSS009898| Ancestry Not Reported| 780 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in posterior cingulate region | β: 25.54 [18.4, 32.6] | — | — | — | — |
| PPM014814 | PGS000026 (PHS) |
PSS009900| Ancestry Not Reported| 278 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in neocortical region (in APOE E4 carriers) | β: 25.28 [17.4, 33.2] | — | — | — | — |
| PPM014815 | PGS000026 (PHS) |
PSS009900| Ancestry Not Reported| 278 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in posterior cingulate region (in APOE E4 carriers) | β: 33.06 [23.3, 42.8] | — | — | — | — |
| PPM014816 | PGS000026 (PHS) |
PSS009900| Ancestry Not Reported| 278 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in frontal cortex region (in APOE E4 carriers) | β: 26.63 [18.0, 35.3] | — | — | — | — |
| PPM014817 | PGS000026 (PHS) |
PSS009899| Ancestry Not Reported| 502 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in neocortical region (in APOE E4 non-carriers) | β: 12.61 [3.9, 21.3] | — | — | — | — |
| PPM014818 | PGS000026 (PHS) |
PSS009899| Ancestry Not Reported| 502 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in posterior cingulate region (in APOE E4 non-carriers) | β: 14.28 [3.42, 25.1] | — | — | — | — |
| PPM014819 | PGS000026 (PHS) |
PSS009899| Ancestry Not Reported| 502 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in frontal cortex region (in APOE E4 non-carriers) | β: 13.62 [4.24, 23.0] | — | — | — | — |
| PPM014813 | PGS000026 (PHS) |
PSS009898| Ancestry Not Reported| 780 individuals |
PGP000340 | Vacher M et al. BMC Genomics (2022) |Ext. |
Reported Trait: Aβ-amyloid deposition in frontal cortex region | β: 21.19 [15.0, 27.4] | — | — | — | — |
| PPM000137 | PGS000053 (ALZ21_NIA-LOAD) |
PSS000085| European Ancestry| 4,792 individuals |
PGP000039 | Tosto G et al. Neurology (2017) |
Reported Trait: Alzheimer's disease (age-at-onset) | β: -0.7 (0.15) years | — | — | — | — |
| PPM000133 | PGS000053 (ALZ21_NIA-LOAD) |
PSS000085| European Ancestry| 4,792 individuals |
PGP000039 | Tosto G et al. Neurology (2017) |
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) | OR: 1.29 [1.21, 1.37] | — | — | Age, sex | — |
| PPM000134 | PGS000053 (ALZ21_NIA-LOAD) |
PSS000085| European Ancestry| 4,792 individuals |
PGP000039 | Tosto G et al. Neurology (2017) |
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) | OR: 1.29 [1.21, 1.38] | — | — | Age, sex, APOE e4 | — |
| PPM000138 | PGS000054 (ALZ21_EFIGA) |
PSS000084| Hispanic or Latin American Ancestry| 3,324 individuals |
PGP000039 | Tosto G et al. Neurology (2017) |
Reported Trait: Alzheimer's disease (age-at-onset) | β: -0.86 (0.15) years | — | — | — | — |
| PPM000135 | PGS000054 (ALZ21_EFIGA) |
PSS000084| Hispanic or Latin American Ancestry| 3,324 individuals |
PGP000039 | Tosto G et al. Neurology (2017) |
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) | OR: 1.73 [1.57, 1.93] | — | — | Age, sex | — |
| PPM000136 | PGS000054 (ALZ21_EFIGA) |
PSS000084| Hispanic or Latin American Ancestry| 3,324 individuals |
PGP000039 | Tosto G et al. Neurology (2017) |
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) | OR: 1.71 [1.55, 1.9] | — | — | Age, sex, APOE e4 | — |
| PPM000901 | PGS000334 (GRSfull_22) |
PSS000449| European Ancestry| 3,810 individuals |
PGP000101 | Zhang Q et al. Nat Commun (2020) |
Reported Trait: Late-onset Alzheimer’s disease | — | — | R²: 0.191 [0.131, 0.269] | — | R2 = variance explained on the liability scale |
| PPM002022 | PGS000779 (PGS7_AD) |
PSS001005| East Asian Ancestry| 112 individuals |
PGP000183 | Zhou X et al. Alzheimers Dement (Amst) (2020) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.612 | Beta (β, top 33.3% vs bottom 33.3%): 1.485 (0.602) | Age, sex | — |
| PPM002023 | PGS000779 (PGS7_AD) |
PSS001006| European Ancestry| 2,696 individuals |
PGP000183 | Zhou X et al. Alzheimers Dement (Amst) (2020) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.717 | Beta (β, top 33.3% vs bottom 33.3%): 2.283 (1.021) | Age, sex, PCs(1-5) | — |
| PPM002140 | PGS000811 (AD-PRS_39) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia in APOE ɛ4 non-carriers | HR: 1.22 [1.1, 1.35] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002143 | PGS000811 (AD-PRS_39) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia in APOE ɛ4 non-carriers aged between 70 and 94 | HR: 1.16 [1.01, 1.34] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002144 | PGS000811 (AD-PRS_39) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia in APOE ɛ4 non-carriers aged 95 years or above | HR: 1.28 [1.1, 1.5] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002145 | PGS000811 (AD-PRS_39) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia in APOE ɛ4 carriers aged 95 years or above | HR: 0.62 [0.41, 0.95] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002141 | PGS000812 (AD-PRS_57) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia | HR: 1.09 [1.01, 1.19] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002142 | PGS000812 (AD-PRS_57) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia in APOE ɛ4 non-carriers | HR: 1.15 [1.05, 1.27] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002146 | PGS000812 (AD-PRS_57) |
PSS001052| European Ancestry| 2,052 individuals |
PGP000196 | Najar J et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Incident dementia in individuals aged 95 or above | HR: 1.15 [1.01, 1.32] | — | — | Age at blood sampling, birth year, sex, PCs(1-10) | — |
| PPM002216 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident dementia at age 85 in individuals homozygous for APOE ε4 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.00022 | Mortality | — |
| PPM002218 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident dementia at age 90 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 5.20e-13 | Mortality | — |
| PPM002219 | PGS000823 (GRS23_AD) |
PSS001081| European Ancestry| 12,978 individuals |
PGP000208 | Riaz M et al. Aging Cell (2021) |Ext. |
Reported Trait: Incident all-cause dementia | — | — | Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.76] | Age at enrolment, sex | — |
| PPM002220 | PGS000823 (GRS23_AD) |
PSS001081| European Ancestry| 12,978 individuals |
PGP000208 | Riaz M et al. Aging Cell (2021) |Ext. |
Reported Trait: Incident all-cause dementia | — | — | Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.77] | Age at enrolment, sex, competing risk of death | — |
| PPM002215 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident Alzheimer's disease at age 80 in individuals homozygous for APOE ε4 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.0056 | Non-Alzheimer's disease dementia, mortality | — |
| PPM002217 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident Alzheimer's disease at age 85 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 7.90e-14 | Non-Alzheimer's disease dementia, mortality | — |
| PPM002214 | PGS000823 (GRS23_AD) |
PSS001080| European Ancestry| 12,255 individuals |
PGP000207 | van der Lee SJ et al. Lancet Neurol (2018) |
Reported Trait: Incident Alzheimer's disease at age 85 in individuals homozygous for APOE ε4 | — | — | Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.0085 | Non-Alzheimer's disease dementia, mortality | — |
| PPM002505 | PGS000876 (PRS31_AD) |
PSS001127| European Ancestry| 8,415 individuals |
PGP000222 | Leonenko G et al. Ann Clin Transl Neurol (2019) |
Reported Trait: Age at Alzheimer's disease onset | β: 0.13 (0.02) | — | — | Gender, PCs (1-3), APOE(ε2 + ε4) | Due to SNP availability issues in the dataset, only 25 out of the 31 variants used to construct the polygenic risk score were used. |
| PPM002506 | PGS000876 (PRS31_AD) |
PSS001125| European Ancestry| 9,903 individuals |
PGP000222 | Leonenko G et al. Ann Clin Transl Neurol (2019) |
Reported Trait: Age at Alzheimer's disease onset | β: 0.28 (0.04) | — | — | Gender, PCs (1-3), APOE ε2, APOE ε4 | — |
| PPM002507 | PGS000876 (PRS31_AD) |
PSS001126| European Ancestry| 4,100 individuals |
PGP000222 | Leonenko G et al. Ann Clin Transl Neurol (2019) |
Reported Trait: Age at Alzheimer's disease onset in individuals above the age of 55 | β: 0.29 (0.03) | — | — | Gender, PCs (1-3), APOE ε2, APOE ε4 | — |
| PPM002634 | PGS000898 (PRS39_AD) |
PSS001167| European Ancestry| 2,394 individuals |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Reported Trait: Alzheimer's disease (clinically confirmed) | OR: 1.3 [1.18, 1.44] | — | — | PCs(1-4) | — |
| PPM002635 | PGS000898 (PRS39_AD) |
PSS001167| European Ancestry| 2,394 individuals |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Reported Trait: Alzheimer's disease (pathologically confirmed) | OR: 1.38 [1.21, 1.58] | — | — | PCs(1-4) | — |
| PPM002636 | PGS000898 (PRS39_AD) |
PSS001167| European Ancestry| 2,394 individuals |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Reported Trait: Alzheimer's disease (pathologically confirmed, males) | OR: 1.33 [1.13, 1.56] | — | — | PCs(1-4) | — |
| PPM002637 | PGS000898 (PRS39_AD) |
PSS001167| European Ancestry| 2,394 individuals |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Reported Trait: Alzheimer's disease (pathologically confirmed, females) | OR: 1.32 [1.19, 1.47] | — | — | PCs(1-4) | — |
| PPM002638 | PGS000898 (PRS39_AD) |
PSS001167| European Ancestry| 2,394 individuals |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Reported Trait: Early-onset Alzheimer's disease (< 65 years) | OR: 1.58 [1.22, 2.05] | — | — | PCs(1-4) | — |
| PPM002639 | PGS000898 (PRS39_AD) |
PSS001167| European Ancestry| 2,394 individuals |
PGP000231 | de Rojas I et al. Nat Commun (2021) |
Reported Trait: Late-onset Alzheimer's disease (> 85 years) | OR: 1.29 [1.1, 1.51] | — | — | PCs(1-4) | — |
| PPM007472 | PGS000929 (GBE_HC1583) |
PSS004302| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD all cause dementia | — | AUROC: 0.87071 [0.81635, 0.92507] | R²: 0.20833 Incremental AUROC (full-covars): 0.0113 PGS R2 (no covariates): 0.01979 PGS AUROC (no covariates): 0.61107 [0.52126, 0.70088] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007473 | PGS000929 (GBE_HC1583) |
PSS004303| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD all cause dementia | — | AUROC: 0.95182 [0.90381, 0.99984] | R²: 0.22288 Incremental AUROC (full-covars): 0.00617 PGS R2 (no covariates): 0.01638 PGS AUROC (no covariates): 0.54656 [0.0, 1.0] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007474 | PGS000929 (GBE_HC1583) |
PSS004304| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD all cause dementia | — | AUROC: 0.81502 [0.78, 0.85005] | R²: 0.12968 Incremental AUROC (full-covars): 0.00636 PGS R2 (no covariates): 0.01492 PGS AUROC (no covariates): 0.59229 [0.54215, 0.64242] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007475 | PGS000929 (GBE_HC1583) |
PSS004305| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD all cause dementia | — | AUROC: 0.82116 [0.74776, 0.89457] | R²: 0.1345 Incremental AUROC (full-covars): 0.00919 PGS R2 (no covariates): 0.02074 PGS AUROC (no covariates): 0.56393 [0.44983, 0.67804] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007476 | PGS000929 (GBE_HC1583) |
PSS004306| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD all cause dementia | — | AUROC: 0.81557 [0.79434, 0.8368] | R²: 0.11649 Incremental AUROC (full-covars): 0.02294 PGS R2 (no covariates): 0.02346 PGS AUROC (no covariates): 0.62703 [0.59629, 0.65777] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007551 | PGS000945 (GBE_HC710) |
PSS004614| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE dementia in alzheimer's disease | — | AUROC: 0.98515 [0.97381, 0.9965] | R²: 0.33632 Incremental AUROC (full-covars): 0.00807 PGS R2 (no covariates): 0.02667 PGS AUROC (no covariates): 0.7414 [0.59579, 0.88702] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007552 | PGS000945 (GBE_HC710) |
PSS004615| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE dementia in alzheimer's disease | — | AUROC: 0.8807 [0.81377, 0.94763] | R²: 0.16889 Incremental AUROC (full-covars): 0.0235 PGS R2 (no covariates): 0.04331 PGS AUROC (no covariates): 0.66609 [0.55451, 0.77766] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007553 | PGS000945 (GBE_HC710) |
PSS004616| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE dementia in alzheimer's disease | — | AUROC: 0.9584 [0.92052, 0.99629] | R²: 0.25982 Incremental AUROC (full-covars): 0.0131 PGS R2 (no covariates): 0.0675 PGS AUROC (no covariates): 0.67849 [0.36185, 0.99513] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007554 | PGS000945 (GBE_HC710) |
PSS004617| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE dementia in alzheimer's disease | — | AUROC: 0.8916 [0.86249, 0.9207] | R²: 0.16679 Incremental AUROC (full-covars): 0.05458 PGS R2 (no covariates): 0.06543 PGS AUROC (no covariates): 0.75273 [0.69847, 0.80699] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007555 | PGS000946 (GBE_HC713) |
PSS004622| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE unspecified dementia | — | AUROC: 0.82014 [0.73087, 0.90941] | R²: 0.13536 Incremental AUROC (full-covars): 0.02407 PGS R2 (no covariates): 0.01431 PGS AUROC (no covariates): 0.57071 [0.42666, 0.71476] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007556 | PGS000946 (GBE_HC713) |
PSS004624| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE unspecified dementia | — | AUROC: 0.82275 [0.77979, 0.86571] | R²: 0.12092 Incremental AUROC (full-covars): 0.00342 PGS R2 (no covariates): 0.00838 PGS AUROC (no covariates): 0.57672 [0.50856, 0.64487] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007557 | PGS000946 (GBE_HC713) |
PSS004625| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE unspecified dementia | — | AUROC: 0.90804 [0.86257, 0.9535] | R²: 0.20027 Incremental AUROC (full-covars): 0.0061 PGS R2 (no covariates): 0.0151 PGS AUROC (no covariates): 0.56115 [0.41165, 0.71066] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM007558 | PGS000946 (GBE_HC713) |
PSS004626| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE unspecified dementia | — | AUROC: 0.83545 [0.80839, 0.8625] | R²: 0.11896 Incremental AUROC (full-covars): 0.02339 PGS R2 (no covariates): 0.02543 PGS AUROC (no covariates): 0.64149 [0.59989, 0.68308] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008585 | PGS001179 (GBE_HC711) |
PSS004618| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE vascular dementia | — | AUROC: 0.89609 [0.78011, 1.0] | R²: 0.23133 Incremental AUROC (full-covars): -0.00271 PGS R2 (no covariates): 0.00098 PGS AUROC (no covariates): 0.45314 [0.26337, 0.6429] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008586 | PGS001179 (GBE_HC711) |
PSS004619| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE vascular dementia | — | AUROC: 0.86436 [0.80883, 0.91989] | R²: 0.14328 Incremental AUROC (full-covars): 0.00289 PGS R2 (no covariates): 0.00776 PGS AUROC (no covariates): 0.59245 [0.49395, 0.69095] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008587 | PGS001179 (GBE_HC711) |
PSS004620| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE vascular dementia | — | AUROC: 0.83842 [0.72824, 0.9486] | R²: 0.14604 Incremental AUROC (full-covars): 0.00843 PGS R2 (no covariates): 0.0135 PGS AUROC (no covariates): 0.61894 [0.47358, 0.76431] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008588 | PGS001179 (GBE_HC711) |
PSS004621| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE vascular dementia | — | AUROC: 0.82562 [0.78593, 0.86531] | R²: 0.10475 Incremental AUROC (full-covars): 0.00707 PGS R2 (no covariates): 0.01123 PGS AUROC (no covariates): 0.61306 [0.55366, 0.67245] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009221 | PGS001348 (GBE_HC1584) |
PSS004307| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD alzheimer's disease | — | AUROC: 0.96694 [0.94819, 0.98568] | R²: 0.31464 Incremental AUROC (full-covars): 0.01598 PGS R2 (no covariates): 0.04322 PGS AUROC (no covariates): 0.69389 [0.49462, 0.89316] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009222 | PGS001348 (GBE_HC1584) |
PSS004309| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD alzheimer's disease | — | AUROC: 0.8626 [0.81314, 0.91206] | R²: 0.15552 Incremental AUROC (full-covars): 0.03113 PGS R2 (no covariates): 0.05179 PGS AUROC (no covariates): 0.66389 [0.57085, 0.75693] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009223 | PGS001348 (GBE_HC1584) |
PSS004310| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD alzheimer's disease | — | AUROC: 0.91522 [0.82612, 1.0] | R²: 0.23563 Incremental AUROC (full-covars): 0.0091 PGS R2 (no covariates): 0.01731 PGS AUROC (no covariates): 0.59348 [0.39906, 0.7879] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009224 | PGS001348 (GBE_HC1584) |
PSS004311| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: AD alzheimer's disease | — | AUROC: 0.8686 [0.84242, 0.89478] | R²: 0.1517 Incremental AUROC (full-covars): 0.05292 PGS R2 (no covariates): 0.05685 PGS AUROC (no covariates): 0.72349 [0.67813, 0.76886] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009225 | PGS001349 (GBE_HC807) |
PSS004632| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE alzheimer's disease | — | AUROC: 0.96248 [0.93046, 0.9945] | R²: 0.31063 Incremental AUROC (full-covars): 0.00757 PGS R2 (no covariates): 0.03204 PGS AUROC (no covariates): 0.63583 [0.42385, 0.84781] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009226 | PGS001349 (GBE_HC807) |
PSS004634| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE alzheimer's disease | — | AUROC: 0.86841 [0.82079, 0.91602] | R²: 0.16057 Incremental AUROC (full-covars): 0.03323 PGS R2 (no covariates): 0.05188 PGS AUROC (no covariates): 0.67961 [0.58969, 0.76952] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009227 | PGS001349 (GBE_HC807) |
PSS004635| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE alzheimer's disease | — | AUROC: 0.9136 [0.8364, 0.9908] | R²: 0.24293 Incremental AUROC (full-covars): 0.00891 PGS R2 (no covariates): 0.01019 PGS AUROC (no covariates): 0.53145 [0.34417, 0.71873] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009228 | PGS001349 (GBE_HC807) |
PSS004636| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE alzheimer's disease | — | AUROC: 0.8666 [0.84246, 0.89075] | R²: 0.15418 Incremental AUROC (full-covars): 0.04665 PGS R2 (no covariates): 0.05271 PGS AUROC (no covariates): 0.71238 [0.66844, 0.75632] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009238 | PGS001775 (PRS39_AD) |
PSS007663| European Ancestry| 532 individuals |
PGP000255 | Ebenau JL et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Other dementia (excluding all-type dementia and Alzheimer's disease) | HR: 0.5 [0.3, 0.9] | — | — | Age, sex, population substructure, Mini-Mental State Examination (predictor: APOE ε4 allele or normalized PRS, outcome: clinical progression to dementia) | — |
| PPM009237 | PGS001775 (PRS39_AD) |
PSS007663| European Ancestry| 532 individuals |
PGP000255 | Ebenau JL et al. Alzheimers Dement (Amst) (2021) |
Reported Trait: Alzheimer's disease dementia | HR: 1.7 [1.1, 2.8] | — | — | Age, sex, population substructure, Mini-Mental State Examination (predictor: APOE ε4 allele or normalized PRS, outcome: clinical progression to dementia) | — |
| PPM009509 | PGS001827 (portability-PLR_290.1) |
PSS009297| European Ancestry| 19,618 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0455 [0.0315, 0.0595] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009510 | PGS001827 (portability-PLR_290.1) |
PSS009071| European Ancestry| 4,070 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.025 [-0.0058, 0.0558] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009511 | PGS001827 (portability-PLR_290.1) |
PSS008625| European Ancestry| 6,562 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0324 [0.0081, 0.0565] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009512 | PGS001827 (portability-PLR_290.1) |
PSS008399| Greater Middle Eastern Ancestry| 1,186 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0695 [0.0122, 0.1264] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009513 | PGS001827 (portability-PLR_290.1) |
PSS008179| South Asian Ancestry| 6,222 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.046 [0.0211, 0.0708] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009514 | PGS001827 (portability-PLR_290.1) |
PSS007964| East Asian Ancestry| 1,802 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0477 [0.0013, 0.094] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009515 | PGS001827 (portability-PLR_290.1) |
PSS007745| African Ancestry| 2,441 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0445 [0.0047, 0.0842] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009516 | PGS001827 (portability-PLR_290.1) |
PSS008849| African Ancestry| 3,852 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0522 [0.0206, 0.0837] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009517 | PGS001828 (portability-PLR_290.11) |
PSS009298| European Ancestry| 19,563 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.0482 [0.0342, 0.0622] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009519 | PGS001828 (portability-PLR_290.11) |
PSS008626| European Ancestry| 6,544 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.0354 [0.0111, 0.0596] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009520 | PGS001828 (portability-PLR_290.11) |
PSS008400| Greater Middle Eastern Ancestry| 1,183 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.0684 [0.011, 0.1254] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009521 | PGS001828 (portability-PLR_290.11) |
PSS008180| South Asian Ancestry| 6,205 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.0283 [0.0034, 0.0532] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009522 | PGS001828 (portability-PLR_290.11) |
PSS007965| East Asian Ancestry| 1,802 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.045 [-0.0015, 0.0912] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009523 | PGS001828 (portability-PLR_290.11) |
PSS007746| African Ancestry| 2,429 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.0414 [0.0015, 0.0812] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009524 | PGS001828 (portability-PLR_290.11) |
PSS008850| African Ancestry| 3,836 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): 0.0338 [0.002, 0.0654] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009518 | PGS001828 (portability-PLR_290.11) |
PSS009072| European Ancestry| 4,062 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | — | — | Partial Correlation (partial-r): -0.0098 [-0.0406, 0.021] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011147 | PGS002035 (portability-ldpred2_290.1) |
PSS009297| European Ancestry| 19,618 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0425 [0.0285, 0.0564] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011148 | PGS002035 (portability-ldpred2_290.1) |
PSS009071| European Ancestry| 4,070 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0206 [-0.0102, 0.0513] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011149 | PGS002035 (portability-ldpred2_290.1) |
PSS008625| European Ancestry| 6,562 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0343 [0.0101, 0.0585] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011150 | PGS002035 (portability-ldpred2_290.1) |
PSS008399| Greater Middle Eastern Ancestry| 1,186 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0658 [0.0084, 0.1227] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011151 | PGS002035 (portability-ldpred2_290.1) |
PSS008179| South Asian Ancestry| 6,222 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0453 [0.0205, 0.0701] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011152 | PGS002035 (portability-ldpred2_290.1) |
PSS007964| East Asian Ancestry| 1,802 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.0494 [0.003, 0.0956] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011153 | PGS002035 (portability-ldpred2_290.1) |
PSS007745| African Ancestry| 2,441 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.044 [0.0042, 0.0837] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011154 | PGS002035 (portability-ldpred2_290.1) |
PSS008849| African Ancestry| 3,852 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Dementias | — | — | Partial Correlation (partial-r): 0.04 [0.0083, 0.0715] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012797 | PGS002249 (AD_PRS_0.5) |
PSS009559| European Ancestry| 196,383 individuals |
PGP000276 | Lourida I et al. JAMA (2019) |
Reported Trait: Incident dementia | — | — | Hazard Ratio (HR, high vs. low genetic risk): 1.91 [1.64, 2.23] | Age, sex, education, socioeconomic status, relatedness, number of alleles, weighted lifestyle categories | — |
| PPM012798 | PGS002249 (AD_PRS_0.5) |
PSS009559| European Ancestry| 196,383 individuals |
PGP000276 | Lourida I et al. JAMA (2019) |
Reported Trait: Incident dementia in individuals with high genetic risk | — | — | Incidence (%): 1.23 [1.13, 1.35] Incidence (%, individuals with unfavourable lifestyle): 1.78 [1.38, 2.28] Incidence (%, individuals with favourable lifestyle): 1.13 [1.01, 1.26] |
— | — |
| PPM020316 | PGS002249 (AD_PRS_0.5) |
PSS011330| European Ancestry| 196,368 individuals |
PGP000543 | Klee M et al. Am J Prev Med (2023) |Ext. |
Reported Trait: Incident dementia with area-level socioeconomic deprivation | — | — | Hazard ratio (HR, high deprivation and PRS in top quintile vs. low-moderate deprivation and PRS in bottom quintile): 2.31 [1.84, 2.91] | 20 first PCs, third-degree relatedness, number of alleles used to compute PRS, age, sex, education, marital status, healthy lifestyle, depressive symptoms in the last 2 weeks, individual-level deprivation | — |
| PPM020317 | PGS002249 (AD_PRS_0.5) |
PSS011330| European Ancestry| 196,368 individuals |
PGP000543 | Klee M et al. Am J Prev Med (2023) |Ext. |
Reported Trait: Incident dementia with individual-level socioeconomic deprivation | — | — | Hazard ratio (HR, high deprivation and PRS in top quintile vs. low-moderate deprivation and PRS in bottom quintile): 4.06 [2.63, 6.26] | 20 first PCs, third-degree relatedness, number of alleles used to compute PRS, age, sex, education, marital status, healthy lifestyle, depressive symptoms in the last 2 weeks, area-level deprivation | — |
| PPM020431 | PGS002249 (AD_PRS_0.5) |
PSS011359| European Ancestry| 60,298 individuals |
PGP000556 | Shannon OM et al. BMC Med (2023) |Ext. |
Reported Trait: Dementia | — | — | Hazard ratio (HR, top vs bottom PRS quintile): 1.224 [1.102, 1.36] | — | — |
| PPM020432 | PGS002249 (AD_PRS_0.5) |
PSS011359| European Ancestry| 60,298 individuals |
PGP000556 | Shannon OM et al. BMC Med (2023) |Ext. |
Reported Trait: Dementia x MedDiet adherence (MEDAS score) interaction | HR: 1.042 [1.003, 1.082] | — | — | — | — |
| PPM012966 | PGS002280 (GRS83_AD) |
PSS009635| European Ancestry| 17,545 individuals |
PGP000309 | Bellenguez C et al. Nat Genet (2022) |
Reported Trait: Conversion to Alzheimer disease | HR: 1.076 [1.064, 1.088] | — | Hazard Ratio (HR; highest vs. lowest decile): 1.93 [1.75, 2.13] | Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components | Fixed-effect meta-analysis |
| PPM012967 | PGS002280 (GRS83_AD) |
PSS009634| European Ancestry| 4,114 individuals |
PGP000309 | Bellenguez C et al. Nat Genet (2022) |
Reported Trait: Conversion to Alzheimer disease (in mild cognitive impairment) | HR: 1.056 [1.04, 1.072] | — | Hazard Ratio (HR; highest vs. lowest decile): 1.63 [1.42, 1.87] | Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components | Fixed-effect meta-analysis |
| PPM012968 | PGS002280 (GRS83_AD) |
PSS009635| European Ancestry| 17,545 individuals |
PGP000309 | Bellenguez C et al. Nat Genet (2022) |
Reported Trait: Conversion to Alzheimer disease within 5 years | — | — | NRI (net reclassification improvement): 0.248 [0.159, 0.336] Delta C-index: 0.002 [0.0004, 0.004] |
Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components | Fixed-effect meta-analysis |
| PPM012969 | PGS002280 (GRS83_AD) |
PSS009635| European Ancestry| 17,545 individuals |
PGP000309 | Bellenguez C et al. Nat Genet (2022) |
Reported Trait: Conversion to Alzheimer disease within 3 years (in mild cognitive impairment) | — | — | NRI (net reclassification improvement): 0.232 [0.14, 0.325] Delta C-index: 0.007 [0.001, 0.012] |
Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components | Fixed-effect meta-analysis |
| PPM022295 | PGS002280 (GRS83_AD) |
PSS011907| European Ancestry| 3,285 individuals |
PGP000698 | Gorijala P et al. Alzheimers Dement (2023) |Ext. |
Reported Trait: Sporadic early-onset Alzheimer's disease | — | — | Odds ratio (OR, high vs low PGS tertile): 2.56 [1.95, 3.39] | Sex | — |
| PPM022296 | PGS002280 (GRS83_AD) |
PSS011906| European Ancestry| 4,303 individuals |
PGP000698 | Gorijala P et al. Alzheimers Dement (2023) |Ext. |
Reported Trait: Familial late-onset Alzheimer's disease | — | — | Odds ratio (OR, high vs low PGS tertile): 2.31 [1.97, 2.72] | Sex | — |
| PPM022297 | PGS002280 (GRS83_AD) |
PSS011908| European Ancestry| 5,149 individuals |
PGP000698 | Gorijala P et al. Alzheimers Dement (2023) |Ext. |
Reported Trait: Sporadic late-onset Alzheimer's disease | — | — | Odds ratio (OR, high vs low PGS tertile): 1.67 [1.46, 1.91] | Sex | — |
| PPM012991 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 1 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.3 | — | — |
| PPM012992 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) no. of incorrect in person round 1 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.4 | — | — |
| PPM012993 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) time to complete online round 1 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 3.5 | — | — |
| PPM012994 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 2 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.5 | — | — |
| PPM012995 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Numeric memory (short-term memory and attention) no. of correct online x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 8.8 | — | — |
| PPM012996 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Symbol digit substitution (processing speed) no. of correct in person x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.8 | — | — |
| PPM012997 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Symbol digit substitution (processing speed) no. attempted in person x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.7 | — | — |
| PPM012998 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Symbol digit substitution (processing speed) time to complete 10 substitutions online x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.5 | — | — |
| PPM012999 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Symbol digit substitution (processing speed) no. of correct online x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.4 | — | — |
| PPM013000 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Symbol digit substitution (processing speed) no. attempted online x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.0 | — | — |
| PPM012988 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) no. of correct online round 1 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 11.5 | — | — |
| PPM012989 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 1 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 7.9 | — | — |
| PPM012990 | PGS002289 (GRS23_AD) |
PSS009642| European Ancestry| 497,087 individuals |
PGP000316 | Zimmerman SC et al. JAMA Netw Open (2022) |
Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 2 x age interaction | — | — | Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 9.4 | — | — |
| PPM014809 | PGS002731 (oA-PRS) |
PSS009897| Ancestry Not Reported| 228 individuals |
PGP000339 | Xicota L et al. Neurology (2022) |
Reported Trait: Amyloid burden | OR: 3.38 [1.02, 11.63] | — | — | — | — |
| PPM014810 | PGS002731 (oA-PRS) |
PSS009897| Ancestry Not Reported| 228 individuals |
PGP000339 | Xicota L et al. Neurology (2022) |
Reported Trait: Amyloid burden in E4 carriers | OR: 44.94 [3.03, 1277.0] | — | — | — | — |
| PPM014953 | PGS002753 (Alzheimer_s_disease_prscs) |
PSS009939| European Ancestry| 39,444 individuals |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Reported Trait: Alzheimer's disease | OR: 1.64 [1.5, 1.79] | — | — | age, sex, 10 PCs, technical covariates | — |
| PPM016153 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident Alzheimer’s Disease | — | — | Hazard ratio (HR, high vs low tertile): 1.75 [1.58, 1.93] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016154 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident vascular dementia | — | — | Hazard ratio (HR, high vs low tertile): 1.55 [1.32, 1.82] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016155 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident dementia without cardiometabolic diseases | — | — | Hazard ratio (HR, high vs low tertile): 1.6 [1.48, 1.73] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016156 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident Alzheimer’s Disease without cardiometabolic diseases | — | — | Hazard ratio (HR, high vs low tertile): 1.84 [1.64, 2.07] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016152 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident dementia | — | — | Hazard ratio (HR, high vs low tertile): 1.5 [1.41, 1.6] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016157 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident vascular dementia without cardiometabolic diseases | — | — | Hazard ratio (HR, high vs low tertile): 1.63 [1.31, 2.03] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016158 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident dementia with cardiometabolic diseases | — | — | Hazard ratio (HR, high vs low tertile): 2.62 [2.36, 2.91] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016159 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident Alzheimer’s Disease with cardiometabolic diseases | — | — | Hazard ratio (HR, high vs low tertile): 2.38 [2.02, 2.81] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM016160 | PGS003334 (PRS_dementia) |
PSS010051| European Ancestry| 204,646 individuals |
PGP000402 | Chen Y et al. Arch Gerontol Geriatr (2022) |
Reported Trait: Incident vascular dementia with cardiometabolic diseases | — | — | Hazard ratio (HR, high vs low tertile): 4.45 [3.47, 5.71] | Sex, age, education levels, socioeconomic status, body mass index (BMI), smoking status, alcohol intake frequency, physical activity, diet pattern, hypertension, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and C-reactive protein (CRP), and the first 10 principal components of ancestry | — |
| PPM017176 | PGS003440 (GRS11_nonapoeAD) |
PSS010155| Ancestry Not Reported| 117 individuals |
PGP000444 | Petrican R et al. Sci Rep (2023) |
Reported Trait: Fluid cognition via cortical thickness in adoptees | β: 0.008 (0.005) | — | — | — | — |
| PPM017177 | PGS003440 (GRS11_nonapoeAD) |
PSS010156| Ancestry Not Reported| 4,382 individuals |
PGP000444 | Petrican R et al. Sci Rep (2023) |
Reported Trait: Fluid cognition via cortical thickness in non-adoptees | β: 0.0001 (0.001) | — | — | — | — |
| PPM017178 | PGS003441 (GRS28_AD) |
PSS010155| Ancestry Not Reported| 117 individuals |
PGP000444 | Petrican R et al. Sci Rep (2023) |
Reported Trait: Fluid cognition via cortical thickness in adoptees | β: 0.011 (0.006) | — | — | — | — |
| PPM017179 | PGS003441 (GRS28_AD) |
PSS010156| Ancestry Not Reported| 4,382 individuals |
PGP000444 | Petrican R et al. Sci Rep (2023) |
Reported Trait: Fluid cognition via cortical thickness in non-adoptees | β: -0.001 (0.001) | — | — | — | — |
| PPM018176 | PGS003574 (GRS_Dementia21) |
PSS010944| Multi-ancestry (including European)| 378,471 individuals |
PGP000459 | Mukadam N et al. PLoS One (2022) |
Reported Trait: Dementia | OR: 1.21 [1.18, 1.24] | — | — | age, sex, ethnic group, PRS*ethnicity | Excluding APOE variants |
| PPM018175 | PGS003574 (GRS_Dementia21) |
PSS010944| Multi-ancestry (including European)| 378,471 individuals |
PGP000459 | Mukadam N et al. PLoS One (2022) |
Reported Trait: Dementia | OR: 1.73 [1.69, 1.77] | — | — | age, sex, ethnic group, PRS*ethnicity | — |
| PPM019088 | PGS003953 (AD_Bellenguez) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment | OR: 1.06 [0.96, 1.18] | — | — | age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts | — |
| PPM019090 | PGS003953 (AD_Bellenguez) |
PSS011179| Multi-ancestry (including European)| 23,157 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment (with Alzheimer's disease) | OR: 1.13 (0.04) | — | — | two SNPs defining the APOE alleles | — |
| PPM019084 | PGS003954 (AD_FINNGEN) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment | OR: 1.19 [1.06, 1.33] | — | — | age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts | — |
| PPM019085 | PGS003955 (AD_Jun) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment | OR: 1.15 [1.01, 1.31] | — | — | age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts | — |
| PPM019092 | PGS003955 (AD_Jun) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Cognititve function (G-Factor change) | β: -0.03 [-0.06, -0.01] | — | — | — | — |
| PPM019094 | PGS003955 (AD_Jun) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Cognititve function (SEVLT recall change) | β: -0.09 [-0.17, -0.01] | — | — | — | — |
| PPM019087 | PGS003956 (AD_Kunkle_AFR) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment | OR: 1.14 [1.02, 1.28] | — | — | age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts | — |
| PPM019096 | PGS003956 (AD_Kunkle_AFR) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Cognititve function (SEVLT recall change) | β: -0.08 [-0.17, 0.0] | — | — | — | — |
| PPM019086 | PGS003957 (AD_Kunkle) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment | OR: 1.34 [1.05, 1.71] | — | — | age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts | — |
| PPM019095 | PGS003957 (AD_Kunkle) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Cognititve function (SEVLT recall change) | β: -0.2 [-0.4, 0.0] | — | — | — | — |
| PPM019089 | PGS003958 (AD_Unweighted_PRSsum) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Mild cognitive impairment | OR: 1.28 [1.12, 1.46] | — | — | age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL‑INCA visit, sex, study center, 5 principal components, and APOE‑E4 and APOE‑E2 allele counts | — |
| PPM019091 | PGS003958 (AD_Unweighted_PRSsum) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Cognititve function (SEVLT recall change) | β: -0.13 [-0.24, -0.02] | — | — | APOE alleles | — |
| PPM019093 | PGS003958 (AD_Unweighted_PRSsum) |
PSS011180| Hispanic or Latin American Ancestry| 4,189 individuals |
PGP000503 | Sofer T et al. Alzheimers Res Ther (2023) |
Reported Trait: Cognititve function (G-Factor change) | β: -0.04 [-0.06, -0.01] | — | — | — | — |
| PPM019922 | PGS003992 (dbslmm.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.36764 [1.25914746, 1.48548255] β: 0.31309 [0.23043487, 0.39573967] |
AUROC: 0.58889 [0.56427113, 0.61350965] | R²: 0.0149 [0.00821494, 0.02493823] | 0 | beta = log(or)/sd_pgs |
| PPM019923 | PGS003992 (dbslmm.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.33446 [1.31203429, 1.35726497] β: 0.28853 [0.27157882, 0.30547162] |
AUROC: 0.58137 [0.57651307, 0.5862179] | R²: 0.01256 [0.01098677, 0.01400605] | 0 | beta = log(or)/sd_pgs |
| PPM019924 | PGS003992 (dbslmm.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.59974 [1.52182949, 1.6816393] β: 0.46984 [0.41991323, 0.51976909] |
AUROC: 0.6315 [0.61718444, 0.64582464] | R²: 0.03367 [0.02663668, 0.04154769] | 0 | beta = log(or)/sd_pgs |
| PPM019937 | PGS004008 (lassosum.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.42671 [1.32526095, 1.53593273] β: 0.35537 [0.28160939, 0.42913784] |
AUROC: 0.59847 [0.57332316, 0.62362478] | R²: 0.02435 [0.01341092, 0.03701681] | 0 | beta = log(or)/sd_pgs |
| PPM019938 | PGS004008 (lassosum.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.48397 [1.46157064, 1.50671708] β: 0.39472 [0.37951164, 0.40993316] |
AUROC: 0.61454 [0.60960208, 0.61948354] | R²: 0.02982 [0.02725224, 0.03259812] | 0 | beta = log(or)/sd_pgs |
| PPM019939 | PGS004008 (lassosum.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.73288 [1.65911417, 1.80992965] β: 0.54979 [0.50628383, 0.59328798] |
AUROC: 0.66293 [0.64863592, 0.6772318] | R²: 0.06348 [0.05374272, 0.0761614] | 0 | beta = log(or)/sd_pgs |
| PPM019928 | PGS004034 (ldpred2.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.45859 [1.35624817, 1.56865365] β: 0.37747 [0.30472219, 0.4502177] |
AUROC: 0.60532 [0.5803355, 0.63030351] | R²: 0.02833 [0.01664267, 0.04228284] | 0 | beta = log(or)/sd_pgs |
| PPM019929 | PGS004034 (ldpred2.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.5321 [1.50892339, 1.55564048] β: 0.42664 [0.41139641, 0.44188734] |
AUROC: 0.6237 [0.61877662, 0.62862975] | R²: 0.0349 [0.03207661, 0.03776512] | 0 | beta = log(or)/sd_pgs |
| PPM019930 | PGS004034 (ldpred2.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.78882 [1.71250526, 1.86854552] β: 0.58156 [0.53795736, 0.62516033] |
AUROC: 0.67205 [0.65778828, 0.68630804] | R²: 0.07132 [0.06110042, 0.08413551] | 0 | beta = log(or)/sd_pgs |
| PPM019931 | PGS004062 (megaprs.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.46172 [1.35265857, 1.57957283] β: 0.37961 [0.30207197, 0.45715445] |
AUROC: 0.60579 [0.58137466, 0.63020687] | R²: 0.02494 [0.01482857, 0.03780255] | 0 | beta = log(or)/sd_pgs |
| PPM019933 | PGS004062 (megaprs.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.73895 [1.66108385, 1.82046629] β: 0.55328 [0.50747031, 0.59909267] |
AUROC: 0.66036 [0.64617344, 0.67454912] | R²: 0.05664 [0.04705507, 0.0684223] | 0 | beta = log(or)/sd_pgs |
| PPM019932 | PGS004062 (megaprs.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.48022 [1.45673427, 1.50408347] β: 0.39219 [0.37619713, 0.40818372] |
AUROC: 0.61101 [0.6061323, 0.6158922] | R²: 0.02634 [0.02407498, 0.02873899] | 0 | beta = log(or)/sd_pgs |
| PPM019934 | PGS004092 (prscs.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.50751 [1.39408288, 1.63015587] β: 0.41046 [0.33223677, 0.48867563] |
AUROC: 0.61363 [0.58940298, 0.63785059] | R²: 0.02861 [0.0178852, 0.04157816] | 0 | beta = log(or)/sd_pgs |
| PPM019935 | PGS004092 (prscs.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.48977 [1.46572255, 1.51421327] β: 0.39862 [0.38234833, 0.41489601] |
AUROC: 0.61238 [0.60749418, 0.61727359] | R²: 0.02623 [0.02395749, 0.02862116] | 0 | beta = log(or)/sd_pgs |
| PPM019936 | PGS004092 (prscs.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.77852 [1.69732301, 1.86359553] β: 0.57578 [0.52905231, 0.6225077] |
AUROC: 0.66492 [0.65074397, 0.67909054] | R²: 0.05886 [0.04942013, 0.07017009] | 0 | beta = log(or)/sd_pgs |
| PPM019919 | PGS004116 (pt_clump.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.27295 [1.16877898, 1.38640714] β: 0.24134 [0.1559596, 0.32671561] |
AUROC: 0.57002 [0.54493965, 0.59509681] | R²: 0.00829 [0.00313542, 0.01593775] | 0 | beta = log(or)/sd_pgs |
| PPM019920 | PGS004116 (pt_clump.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.2393 [1.21794864, 1.26102083] β: 0.21454 [0.197168, 0.23192158] |
AUROC: 0.5606 [0.55574503, 0.56545085] | R²: 0.00659 [0.00548578, 0.00774337] | 0 | beta = log(or)/sd_pgs |
| PPM019921 | PGS004116 (pt_clump.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.44592 [1.3726573, 1.52309192] β: 0.36875 [0.3167485, 0.42074243] |
AUROC: 0.60208 [0.58755709, 0.61660009] | R²: 0.01898 [0.01397656, 0.02489353] | 0 | beta = log(or)/sd_pgs |
| PPM019927 | PGS004146 (sbayesr.auto.GCST90012877.AD) |
PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.79245 [1.71513669, 1.87323956] β: 0.58358 [0.53949278, 0.62766932] |
AUROC: 0.67094 [0.65667793, 0.68519515] | R²: 0.06987 [0.05877563, 0.08216167] | 0 | beta = log(or)/sd_pgs |
| PPM019925 | PGS004146 (sbayesr.auto.GCST90012877.AD) |
PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.48544 [1.37939815, 1.59962905] β: 0.39571 [0.32164728, 0.46977176] |
AUROC: 0.60796 [0.58278903, 0.63313316] | R²: 0.03003 [0.01833361, 0.04547365] | 0 | beta = log(or)/sd_pgs |
| PPM019926 | PGS004146 (sbayesr.auto.GCST90012877.AD) |
PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: AD | OR: 1.52213 [1.49865179, 1.54596874] β: 0.42011 [0.40456589, 0.43565073] |
AUROC: 0.62099 [0.61607908, 0.6259011] | R²: 0.03241 [0.02967044, 0.03503408] | 0 | beta = log(or)/sd_pgs |
| PPM020218 | PGS004227 (ad_apoe_gw_pgs) |
PSS011307| Ancestry Not Reported| 1,638 individuals |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Reported Trait: Alzheimer's disease biomarker (1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1) | β: -0.06101 [-0.108607308, -0.013407489] | — | — | — | — |
| PPM020220 | PGS004227 (ad_apoe_gw_pgs) |
PSS011307| Ancestry Not Reported| 1,638 individuals |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Reported Trait: Alzheimer's disease biomarker (palmitoyl-myristoyl-glycerol (16:0/14:0) [1]) | β: -0.0502 [-0.098164771, -0.002232543] | — | — | — | — |
| PPM020219 | PGS004227 (ad_apoe_gw_pgs) |
PSS011307| Ancestry Not Reported| 1,638 individuals |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Reported Trait: Alzheimer's disease biomarker (palmitoyl-palmitoyl-glycerol (16:0/16:0) [1]) | β: -0.0559 [-0.103719741, -0.008088708] | — | — | — | — |
| PPM020221 | PGS004228 (ad_apoe_0.1_pgs) |
PSS011307| Ancestry Not Reported| 1,638 individuals |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Reported Trait: Alzheimer's disease biomarker (docosapentaenoate (DPA; 22:5n3)) | β: -0.05808 [-0.106496039, -0.009669554] | — | — | — | — |
| PPM020223 | PGS004229 (ad_noapoe_0.1_pgs) |
PSS011307| Ancestry Not Reported| 1,638 individuals |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Reported Trait: Alzheimer's disease biomarker (linolenate (18:3n3 or 3n6)) | β: -0.05431 [-0.103025695, -0.005590157] | — | — | — | — |
| PPM020222 | PGS004229 (ad_noapoe_0.1_pgs) |
PSS011307| Ancestry Not Reported| 1,638 individuals |
PGP000527 | Green RE et al. Alzheimers Res Ther (2023) |
Reported Trait: Alzheimer's disease biomarker (docosapentaenoate (DPA; 22:5n3)) | β: -0.07733 [-0.125825807, -0.028839878] | — | — | — | — |
| PPM020348 | PGS004280 (GenoBoost_all-cause_dementia_0) |
PSS011345| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: All-cause dementia | — | AUROC: 0.81926 | Covariate-adjusted pseudo-R2: 0.03533 AUPRC: 0.07827 |
age, sex, PC1-10 | — |
| PPM020349 | PGS004281 (GenoBoost_all-cause_dementia_1) |
PSS011345| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: All-cause dementia | — | AUROC: 0.81897 | Covariate-adjusted pseudo-R2: 0.03418 AUPRC: 0.81897 |
age, sex, PC1-10 | — |
| PPM020350 | PGS004282 (GenoBoost_all-cause_dementia_2) |
PSS011345| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: All-cause dementia | — | AUROC: 0.81837 | Covariate-adjusted pseudo-R2: 0.03323 AUPRC: 0.81837 |
age, sex, PC1-10 | — |
| PPM020351 | PGS004283 (GenoBoost_all-cause_dementia_3) |
PSS011345| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: All-cause dementia | — | AUROC: 0.81816 | Covariate-adjusted pseudo-R2: 0.03381 AUPRC: 0.81816 |
age, sex, PC1-10 | — |
| PPM020352 | PGS004284 (GenoBoost_all-cause_dementia_4) |
PSS011345| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: All-cause dementia | — | AUROC: 0.81886 | Covariate-adjusted pseudo-R2: 0.03415 AUPRC: 0.81886 |
age, sex, PC1-10 | — |
| PPM020353 | PGS004285 (GenoBoost_alzheimer_s_disease_0) |
PSS011336| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.8336 | Covariate-adjusted pseudo-R2: 0.0421 AUPRC: 0.8336 |
age, sex, PC1-10 | — |
| PPM020354 | PGS004286 (GenoBoost_alzheimer_s_disease_1) |
PSS011336| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.8321 | Covariate-adjusted pseudo-R2: 0.04019 AUPRC: 0.8321 |
age, sex, PC1-10 | — |
| PPM020355 | PGS004287 (GenoBoost_alzheimer_s_disease_2) |
PSS011336| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.83179 | Covariate-adjusted pseudo-R2: 0.04182 AUPRC: 0.83179 |
age, sex, PC1-10 | — |
| PPM020356 | PGS004288 (GenoBoost_alzheimer_s_disease_3) |
PSS011336| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.83004 | Covariate-adjusted pseudo-R2: 0.03836 AUPRC: 0.83004 |
age, sex, PC1-10 | — |
| PPM020357 | PGS004289 (GenoBoost_alzheimer_s_disease_4) |
PSS011336| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.83162 | Covariate-adjusted pseudo-R2: 0.04076 AUPRC: 0.83162 |
age, sex, PC1-10 | — |
| PPM020398 | PGS004318 (PRS29_dementia) |
PSS011350| Multi-ancestry (including European)| 57,688 individuals |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Reported Trait: Alzheimer's disease | — | — | Hazard ratio (HR, high vs low PRS tertile): 4.11 [3.71, 4.54] | Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation | — |
| PPM020399 | PGS004318 (PRS29_dementia) |
PSS011350| Multi-ancestry (including European)| 57,688 individuals |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Reported Trait: Vascular dementia | — | — | Hazard ratio (HR, high vs low PRS tertile): 2.43 [2.15, 2.75] | Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation | — |
| PPM020400 | PGS004318 (PRS29_dementia) |
PSS011350| Multi-ancestry (including European)| 57,688 individuals |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Reported Trait: Dementia with high laxatives exposure | — | — | Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 4.09 [3.48, 4.81] | Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation | — |
| PPM020401 | PGS004318 (PRS29_dementia) |
PSS011350| Multi-ancestry (including European)| 57,688 individuals |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Reported Trait: Alzheimer's disease with high laxatives exposure | — | — | Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 4.62 [3.56, 6.0] | Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation | — |
| PPM020402 | PGS004318 (PRS29_dementia) |
PSS011350| Multi-ancestry (including European)| 57,688 individuals |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Reported Trait: Vascular dementia with high laxatives exposure | — | — | Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 3.27 [2.37, 4.51] | Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation | — |
| PPM020397 | PGS004318 (PRS29_dementia) |
PSS011350| Multi-ancestry (including European)| 57,688 individuals |
PGP000548 | Feng J et al. BMC Geriatr (2023) |
Reported Trait: Dementia | — | — | Hazard ratio (HR, high vs low PRS tertile): 2.76 [2.6, 2.93] | Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation | — |
| PPM020711 | PGS004588 (PRS39_Eur) |
PSS011377| East Asian Ancestry| 379 individuals |
PGP000567 | Jung SH et al. JAMA Netw Open (2022) |
Reported Trait: Alzheimer's disease dementia | OR: 1.85 [1.05, 3.32] | — | — | Sex, age, education year, 4 PCs, APOE ε4 status | — |
| PPM020712 | PGS004589 (PRS80_trans) |
PSS011377| East Asian Ancestry| 379 individuals |
PGP000567 | Jung SH et al. JAMA Netw Open (2022) |
Reported Trait: Alzheimer's disease dementia | OR: 2.09 [1.09, 4.04] | — | — | Sex, age, education year, 4 PCs, APOE ε4 status | — |
| PPM020719 | PGS004590 (PRS363_rand_eff) |
PSS011381| Multi-ancestry (including European)| 368 individuals |
PGP000569 | Lake J et al. Mol Psychiatry (2023) |
Reported Trait: Alzheimer's disease | — | AUROC: 0.68 | R²: 0.0044 | Age, sex, 5 PCs | — |
| PPM020755 | PGS004600 (PRS_AD83) |
PSS011392| European Ancestry| 276 individuals |
PGP000578 | Tomassen J et al. BMC Neurol (2022) |
Reported Trait: Memory function over time | β: -0.04 (0.01) | — | — | age, sex, center, education | — |
| PPM020756 | PGS004600 (PRS_AD83) |
PSS011392| European Ancestry| 276 individuals |
PGP000578 | Tomassen J et al. BMC Neurol (2022) |
Reported Trait: Positive amyloid-beta status | OR: 1.43 [1.02, 2.0] | — | — | age, sex, center, education | — |
| PPM021094 | PGS004863 (PRS74_AD) |
PSS011524| East Asian Ancestry| 528 individuals |
PGP000609 | Sleiman PM et al. Alzheimers Dement (2023) |
Reported Trait: Cortical amyloid positivity | OR: 1.186 [0.992, 1.418] | AUROC: 0.751 [0.705, 0.796] | — | APOE haplotype, age, sex, 3 PCs | — |
| PPM021095 | PGS004863 (PRS74_AD) |
PSS011525| East Asian Ancestry| 696 individuals |
PGP000609 | Sleiman PM et al. Alzheimers Dement (2023) |
Reported Trait: Clinical Dementia Rating global score ≥ 1 | OR: 1.04 [0.871, 1.243] | AUROC: 0.637 [0.586, 0.689] | — | APOE haplotype, age, sex, 3 PCs | — |
| PPM021096 | PGS004863 (PRS74_AD) |
PSS011522| South Asian Ancestry| 718 individuals |
PGP000609 | Sleiman PM et al. Alzheimers Dement (2023) |
Reported Trait: All-cause dementia | OR: 1.11 [0.94, 1.33] | AUROC: 0.69 [0.62, 0.76] | — | APOE haplotype, age, sex, 3 PCs | — |
| PPM021097 | PGS004863 (PRS74_AD) |
PSS011523| East Asian Ancestry| 2,000 individuals |
PGP000609 | Sleiman PM et al. Alzheimers Dement (2023) |
Reported Trait: Alzheimer's disease or mild cognitive impairment | OR: 1.12 | AUROC: 0.625 [0.601, 0.65] | — | APOE haplotype, age, sex, 3 PCs | — |
| PPM021098 | PGS004863 (PRS74_AD) |
PSS011526| European Ancestry| 229,265 individuals |
PGP000609 | Sleiman PM et al. Alzheimers Dement (2023) |
Reported Trait: Alzheimer's disease or dementia | OR: 1.003 [0.99, 1.007] | AUROC: 0.746 [0.738, 0.754] | — | APOE haplotype, age, sex, 3 PCs | — |
| PPM021281 | PGS004898 (PRS_AD) |
PSS011676| European Ancestry| 1,135 individuals |
PGP000624 | Vasiljevic E et al. Alzheimers Dement (2023) |
Reported Trait: Immediate learning | β: -0.07 [-0.12, -0.02] | — | — | Sex, years of education, testing practice effects | — |
| PPM021282 | PGS004898 (PRS_AD) |
PSS011676| European Ancestry| 1,135 individuals |
PGP000624 | Vasiljevic E et al. Alzheimers Dement (2023) |
Reported Trait: Delayed recall | β: -0.07 [-0.12, -0.02] | — | — | Sex, years of education, testing practice effects | — |
| PPM021283 | PGS004898 (PRS_AD) |
PSS011676| European Ancestry| 1,135 individuals |
PGP000624 | Vasiljevic E et al. Alzheimers Dement (2023) |
Reported Trait: Executive function | β: -0.06 [-0.11, -0.01] | — | — | Sex, years of education, testing practice effects | — |
| PPM021284 | PGS004898 (PRS_AD) |
PSS011676| European Ancestry| 1,135 individuals |
PGP000624 | Vasiljevic E et al. Alzheimers Dement (2023) |
Reported Trait: Preclinical Alzheimer Cognitive Composite (PACC3) | β: -0.08 [-0.13, -0.04] | — | — | Sex, years of education, testing practice effects | — |
| PPM021384 | PGS004918 (PRS8_Synapse) |
PSS011719| European Ancestry| 136 individuals |
PGP000649 | Lawingco T et al. Neurobiol Aging (2020) |
Reported Trait: Late-onset Alzheimer's disease | — | AUROC: 0.731 | — | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS008179 | — | — | 6,222 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS008180 | — | — | 6,205 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS011906 | — | — | [
|
— | European | — | NIA-LOAD | — |
| PSS011907 | — | — | [
|
— | European | — | ADNI, Knight-ADRC | — |
| PSS011908 | — | — | [
|
— | European | — | ADNI, Knight-ADRC | — |
| PSS001167 | Cases were individuals with pathologically or clinically diagnosed Alzheimer's disease (AD). Of the 1008 AD cases, 332 had been confirmed pathologically whilst 676 had been confirmed clinically. Pathological AD was confirmed by the Biobanc Hospital Clínic–IDIBAPS, whilst clinical diagnosis of AD was based on clinical criteria from Fundació ACE. | — | [ ,
29.2 % Male samples |
— | European (Spanish) |
— | EADB | — |
| PSS011213 | — | — | [
|
— | European | — | EB | — |
| PSS011719 | Samples used in this study were extracted from autopsied brain tissue. Samples were taken from cognitively normal individuals witth a dementia rating of 0 (controls) and from late-onset Alzheimer's disease (LOAD) patients who had a clinical diagnosis of dementia due to AD and neuropathological confirmation of AD. | — | [ ,
39.0 % Male samples |
— | European | — | BfDR | — |
| PSS011226 | G6_AD_WIDE, ICD10: G30|F00, ICD9: 3310 | — | [
|
— | European | — | FinnGen | — |
| PSS009897 | — | — | 228 individuals, 49.6 % Male samples |
Mean = 76.62 years Sd = 4.55 years |
Not reported | — | ADNI | — |
| PSS009898 | CN/MCI/AD: [573/124/83] | — | 780 individuals | — | Not reported | — | NR | AIBL |
| PSS009899 | CN/MCI/AD: [412/66/24] | — | 502 individuals | — | Not reported | — | NR | AIBL |
| PSS009900 | CN/MCI/AD: [161/58/59] | — | 278 individuals | — | Not reported | — | NR | AIBL |
| PSS011252 | — | — | [
|
— | European | — | HUNT | — |
| PSS001005 | Cases include individuals with Alzheimer's disease (AD) The phenotypes of the participants were determined on the basis of the most recent diagnostic records (until December 2019). | — | [ ,
54.29 % Male samples |
— | East Asian (Chinese) |
— | NR | Participants recruited from the Specialist Outpatient Department of Prince of Wales Hospital. |
| PSS001006 | Cases include individuals with Alzheimer's disease (AD). Patients with definite AD have been diagnosed according to established neuropathological criteria (CERAD, Braak, Khachaturian, NIA-RI, or other established criteria). | — | [ ,
37.62 % Male samples |
— | European | — | LOAD | — |
| PSS000033 | Most of the studies used standard screening procedures based on history, medical review, screening questions, and cognitive assessments that flagged participants with potential cognitive impairment. These participants underwent complete neurological and neuropsychological evaluation. An initial decision was made regarding the presence or absence of dementia, using the DSM-IV criteria; a diagnosis of possible, probable, or definite AD was made as a second step using NINCDS-ADRDA (National Institute of Neurological Disorders and Stroke Alzheimer’s Disease and Related Disorders Association) criteria. | — | [
|
— | European | — | 8 cohorts
|
As one SNP (rs9271192) was missing in FHS, WHICAP, and Rotterdam because of poor imputation quality, an 18 SNP-based GRS was computed in these cohorts. As the samples used in this project were partially overlapping with the ones used in the original IGAP study, we ran an additional IGAP meta-analysis after excluding those and did not find significant changes in the estimations of HRs for the SNPs considered |
| PSS000034 | Most of the studies used standard screening procedures based on history, medical review, screening questions, and cognitive assessments that flagged participants with potential cognitive impairment. These participants underwent complete neurological and neuropsychological evaluation. An initial decision was made regarding the presence or absence of dementia, using the DSM-IV criteria; a diagnosis of possible, probable, or definite AD was made as a second step using NINCDS-ADRDA (National Institute of Neurological Disorders and Stroke Alzheimer’s Disease and Related Disorders Association) criteria. | — | 4,353 individuals | — | European | — | 8 cohorts
|
As one SNP (rs9271192) was missing in FHS, WHICAP, and Rotterdam because of poor imputation quality, an 18 SNP-based GRS was computed in these cohorts. As the samples used in this project were partially overlapping with the ones used in the original IGAP study, we ran an additional IGAP meta-analysis after excluding those and did not find significant changes in the estimations of HRs for the SNPs considered |
| PSS000035 | Most of the studies used standard screening procedures based on history, medical review, screening questions, and cognitive assessments that flagged participants with potential cognitive impairment. These participants underwent complete neurological and neuropsychological evaluation. An initial decision was made regarding the presence or absence of dementia, using the DSM-IV criteria; a diagnosis of possible, probable, or definite AD was made as a second step using NINCDS-ADRDA (National Institute of Neurological Disorders and Stroke Alzheimer’s Disease and Related Disorders Association) criteria. | — | 15,334 individuals | — | European | — | 8 cohorts
|
As one SNP (rs9271192) was missing in FHS, WHICAP, and Rotterdam because of poor imputation quality, an 18 SNP-based GRS was computed in these cohorts. As the samples used in this project were partially overlapping with the ones used in the original IGAP study, we ran an additional IGAP meta-analysis after excluding those and did not find significant changes in the estimations of HRs for the SNPs considered |
| PSS010051 | Adults aged 37-73 free of dementia at baseline. International Classification of Diseases (ICD-10) codes was used to define all-cause dementia (ICD-10 codes: F00, F01, F02, F03, F05.1, G30, G31.1, G31.8), Alzheimer’s dementia (AD) (ICD-10 codes: F00, G30), and vascular dementia (VaD) (ICD-10 codes: F01). | — | [ ,
46.9 % Male samples |
Mean = 64.1 years | European | — | UKB | 5,750 (2.8%) all-cause dementia, 2,432 (1.2%) AD, and 936 (0.5%) VaD |
| PSS000036 | Cases are patients with clinically diagnosed AD and compared to cognitively normal older individuals | — | [ ,
40.51 % Male samples |
— | European | — | ADGC | ADGC Phase 2 |
| PSS007745 | — | — | 2,441 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS007746 | — | — | 2,429 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS000449 | — | — | [ ,
54.7 % Male samples |
Mean (Cases) = 77.6 years Sd (Cases) = 7.6 years |
European | — | ABIL | — |
| PSS000449 | — | — | [ ,
44.4 % Male samples |
Mean (Cases) = 86.8 years Sd (Cases) = 4.6 years |
European | — | MAS | — |
| PSS000449 | — | — | [ ,
47.0 % Male samples |
Mean (Cases) = 64.4 years Sd (Cases) = 4.5 years |
European | — | UKB | — |
| PSS009297 | — | — | 19,618 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS009298 | — | — | 19,563 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS004302 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004303 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004304 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004305 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004306 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS004307 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004309 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004310 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004311 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009634 | — | — | 4,114 individuals | — | European | — | ADC | DCN, FACE, HAN, UAN, UHA, AMC, ZIM |
| PSS009635 | — | — | 17,545 individuals | — | European | — | 3C, FHS, MAS, RS | AgeCoDe, VITA |
| PSS009642 | G30.1 Alzheimer’s disease with late onset | — | 497,087 individuals, 45.9 % Male samples |
Mean = 57.1 years Sd = 7.9 years |
European | — | UKB | — |
| PSS008849 | — | — | 3,852 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008850 | — | — | 3,836 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS011307 | — | — | 1,638 individuals, 49.6 % Male samples |
— | Not reported | — | NSHD | Outcomes tested were metabolite levels generated by Metabolon Inc, and metabolite modules generated using this data. All outcome (metabolite) data were collected at the 60-64 wave of the NSHD. |
| PSS009939 | — | — | 39,444 individuals | — | European (Finnish) |
— | FinnGen | — |
| PSS011522 | — | — | [
|
— | South Asian (Pakistani, Bangladeshi) |
— | G&H | — |
| PSS011524 | — | — | [
|
— | East Asian (Korean) |
— | BICWALZS | — |
| PSS011525 | — | — | [
|
— | East Asian (Korean) |
— | BICWALZS | — |
| PSS011523 | — | — | [
|
— | East Asian (Japanese) |
— | NCGG | — |
| PSS011526 | — | — | [
|
— | European (British) |
— | UKB | — |
| PSS008399 | — | — | 1,186 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS008400 | — | — | 1,183 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS000084 | EFIGA recruited patients from families multiply affected by LOAD, but of Caribbean Hispanic ancestry from the Dominican Republic and New York. Families were recruited after confirming diagnoses in the probands. Family members with dementia were also interviewed and neurologically evaluated. Clinical diagnoses were made in a consensus diagnostic conference by a panel of neurologists, neuropsychologists, and psychiatrists. Detailed description is available elsewhere.14 For these family-based studies, we included data from families for which their members (1) were 60 years or older at the time of enrollment; (2) had a diagnosis of probable or possible LOAD according to National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association (NINDS-ADRDA) criteria; (3) had available pedigree information and covariates. | — | [ ,
34.0 % Male samples |
— | Hispanic or Latin American | Samples are described as "Carribbean Hispanic" | EFIGA | — |
| PSS000085 | Selection criteria included (1) a proband who received a dianosis of definite or probable late onset Alzheimer's Disease (LOAD) with age at onset of at least 60 years; (2) a full sibling with definite, probable, or possible LOAD with age at onset after 60 years; (3) a related family member (first-,second-,or third-degree relative) of theaffected sibling pair and 60 years or older if unaffected, or 50 years or older if dianosed with LOAD or mild cognitive impairment (MCI) | — | [ ,
38.0 % Male samples |
— | European | — | NIA-LOAD | — |
| PSS011330 | — | — | 196,368 individuals, 47.3 % Male samples |
Mean = 64.1 years Sd = 2.9 years |
European | — | UKB | — |
| PSS010944 | ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. | — | [ ,
46.2 % Male samples |
Mean = 56.8 years | European (white British) |
— | UKB | — |
| PSS010944 | ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. | — | [ ,
54.2 % Male samples |
Mean = 53.4 years | South Asian | — | UKB | — |
| PSS010944 | ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. | — | [ ,
43.6 % Male samples |
Mean = 51.9 years | African unspecified (Black) |
— | UKB | — |
| PSS011336 | — | — | [ ,
46.0 % Male samples |
— | European (White British) |
— | UKB | — |
| PSS011179 | — | — | 1,005 individuals | — | African unspecified | — | MGBB | — |
| PSS011179 | — | — | 306 individuals | — | Asian unspecified | — | MGBB | — |
| PSS011179 | — | — | 20,348 individuals | — | European | — | MGBB | — |
| PSS011179 | — | — | 614 individuals | — | Hispanic or Latin American | — | MGBB | — |
| PSS011179 | — | — | 884 individuals | — | Not reported | — | MGBB | — |
| PSS011180 | — | — | 4,189 individuals | Mean = 63.0 years | Hispanic or Latin American (Central American, South American, Mexican, Cuban, Dominican, Puerto-Rican) |
— | SOL | SOL-INCA: Study of Latinos-Investigation of Neurocognitive Aging |
| PSS011345 | — | — | [ ,
46.0 % Male samples |
— | European (White British) |
— | UKB | — |
| PSS011350 | — | — | 53,447 individuals | — | European | — | UKB | Mean age of full combined ancestry cohort = 58 years |
| PSS011350 | — | — | 1,118 individuals | — | African unspecified | — | UKB | Mean age of full combined ancestry cohort = 58 years |
| PSS011350 | — | — | 3,123 individuals | — | Asian unspecified, Not reported | — | UKB | Mean age of full combined ancestry cohort = 58 years |
| PSS011359 | Alzheimer's (ICD10: F00, F00.0, F00.1, F00.2, F00.9, G30, G30.0, G30.1, G30.8, G30.9), Vascular dementia (ICD10: F01, F01.0, F01.1, F01.2, F01.3, F01.8, F01.9, I67.3), Frontotemporal dementia (ICD10: F02.0, G31.0), all-cause dementia (ICD10: A81.0, F02, F02.1, F02.2, F02.3, F02.4, F02.8, F03, F05.1, F10.6, G31.1, G31.8) | Mean = 9.1 years Sd = 1.7 years |
60,298 individuals, 51.5 % Male samples |
Mean = 63.8 years Sd = 2.7 years |
European | — | UKB | — |
| PSS007964 | — | — | 1,802 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS007965 | — | — | 1,802 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS001052 | The diagnosis of dementia at each examination was based on Diagnostic and Statistical Manual of Mental Disorders Third Edition‐Revised (DSM‐III‐R) criteria, using information from neuropsychiatric examinations and close informant interviews. Dementia diagnoses for individuals lost to follow‐up were based on information obtained from the Swedish Inpatient Registry until 2012. Age of dementia onset was based on information provided by close informants, the examinations, and the Swedish Inpatient Register. If no information could be obtained from these sources, the age of onset was determined as the mid‐point between the last examination at which dementia criteria were not fulfilled and the first with a dementia diagnosis. Information on deaths during follow‐up was obtained from the Swedish Population Registry until December 31, 2016. Of the 605 dementia cases, 182 were carriers of an APOE ɛ4 allele. | Mean = 7.2 years Sd = 4.7 years |
[
|
European | — | NR | Gothenburg H70 Birth Cohort studies | |
| PSS010155 | — | — | 117 individuals, 50.0 % Male samples |
Mean = 9.96 years | Not reported | — | NR | ABCD |
| PSS010156 | — | — | 4,382 individuals, 50.0 % Male samples |
Mean = 9.94 years | Not reported | — | NR | ABCD |
| PSS011377 | — | — | [ ,
39.3 % Male samples |
Mean = 69.8 years Sd = 9.3 years |
East Asian (Korean) |
— | BICWALZS, PREMIER | — |
| PSS011381 | — | — | [
|
— | European, Native American, African unspecified | — | TANGL | — |
| PSS001080 | Cases included incident Alzheimer's disease (AD) and other types of incident dementia. Of the 1,609 dementia cases, 1,262 were individuals with AD and 347 were individuals with other types of dementia excluding AD. A consensus panel led by a consultant neurologist established the final diagnosis according to standard criteria for dementia (Diagnostic and Statistical Manual of Mental Disorders III-revised) and Alzheimer’s disease (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association). Of the total 12,255 individuals, APOE genotypes were available for 11,375. From those genotyped, 261 individuals were homozygous for APOE ε4 (ε4/ε4). Of the 261 ε4/ε4 individuals, 72 had AD whilst 11 had other types of dementia excluding AD. | Median = 10.9 years | [ ,
41.5 % Male samples |
European (Dutch) |
— | RS | — | |
| PSS001081 | Cases were individuals with incident-all cause dementia. Dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Diagnosis date was recorded as date of trigger. Dementia cases were sub-classified into either 'probable Alzheimer's Disease (AD)', 'possible AD' or 'non-dementia AD' using the 2011 NIA-Alzheimer's Association core clinical criteria. Of the 324 cases, 143 were classified as 'probable AD', 176 were classified as 'possible AD' and 5 were classified as 'non-AD related dementia'. | Median = 4.5 years IQR = [2.1, 5.7] years |
[ ,
45.0 % Male samples |
Mean = 75.05 years Sd = 4.2 years |
European | — | ASPREE | — |
| PSS011392 | Used the following tests to assess memory performance: the total immediate recall and delayed recall of the Rey Auditory Verbal Learning Test (RAVLT), the twenty minute recall of the Rey Complex Figure Test (RCFT), the total errors of the Cambridge Neuropsychological Test Automated Battery (CANTAB) Paired Associate Learning (PAL) test, and the total score of the Face Name Associated Memory Examination (FNAME) names and occupations delayed recall. | Mean = 2.0 years Sd = 0.4 years |
276 individuals, 37.0 % Male samples |
Mean = 74.7 years Sd = 9.7 years |
European | — | ACPRC, NTR | Cognitively unimpaired. Includes 97 complete twin pairs. |
| PSS009071 | — | — | 4,070 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS009072 | — | — | 4,062 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS007663 | Cases were individuals with dementia. Of the 82 cases with dementia, 41 had all-type dementia, 25 had Alzheimer's disease (AD) dementia and 16 had other types of dementia. | — | [
|
— | European | — | AmDem, SCIENCe | — |
| PSS009559 | AD: F00, F00.0, F00.1, F00.2, F00.9, G30, G30.0, G30.1, G30.8, G30.9 VaD: F01, F01.0, F01.1, F01.2, F01.3, F01.8, F01.9, I67.3 FTD: F02.0, G31.0, Other codes for all-cause dementia: A81.0, F02, F02.1, F02.2, F02.3, F02.4, F02.8, F03, F05.1, F10.6, G31.1, G31.8 | Median = 8.0 years | [ ,
47.3 % Male samples |
Mean = 64.1 years | European | — | UKB | — |
| PSS004614 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004615 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004616 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004617 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS004618 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004619 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004620 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004621 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS004622 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004624 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004625 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004626 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS004632 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004634 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004635 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004636 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS011676 | — | — | 1,135 individuals, 30.0 % Male samples |
Mean = 59.0 years Sd = 6.0 years |
European | — | WRAP | — |
| PSS008625 | — | — | 6,562 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS008626 | — | — | 6,544 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS001125 | Cases included individuals with Alzheimer's disease. | — | [
|
— | European | — | 11 cohorts
|
— |
| PSS001126 | All individuals were aged 55 and above. Cases include individuals with Alzheimer's disease. | — | [
|
— | European | — | 11 cohorts
|
— |
| PSS001127 | Cases included individuals with Alzheimer's disease. | — | [
|
— | European | — | 11 cohorts
|
— |