PGS Publication: PGP000208

Publication Information (EuropePMC)
Title Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population.
PubMed ID 34041846(Europe PMC)
doi 10.1111/acel.13384
Publication Date May 26, 2021
Journal Aging Cell
Author(s) Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebra R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P.
Released in PGS Catalog: July 29, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000823
(GRS23_AD)
 PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
 Alzheimer's disease Alzheimer disease 23
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000823/ScoringFiles/PGS000823.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002219 PGS000823
(GRS23_AD)
 PSS001081|
European Ancestry|
12,978 individuals
 PGP000208 |
Riaz M et al. Aging Cell (2021)
|Ext.		 Reported Trait: Incident all-cause dementia — — Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.76] Age at enrolment, sex —
PPM002220 PGS000823
(GRS23_AD)
 PSS001081|
European Ancestry|
12,978 individuals
 PGP000208 |
Riaz M et al. Aging Cell (2021)
|Ext.		 Reported Trait: Incident all-cause dementia — — Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.77] Age at enrolment, sex, competing risk of death —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001081 Cases were individuals with incident-all cause dementia. Dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Diagnosis date was recorded as date of trigger. Dementia cases were sub-classified into either 'probable Alzheimer's Disease (AD)', 'possible AD' or 'non-dementia AD' using the 2011 NIA-Alzheimer's Association core clinical criteria. Of the 324 cases, 143 were classified as 'probable AD', 176 were classified as 'possible AD' and 5 were classified as 'non-AD related dementia'. Median = 4.5 years
IQR = [2.1, 5.7] years
[
  • 324 cases
  • , 12,654 controls
]
,
45.0 % Male samples
 Mean = 75.05 years
Sd = 4.2 years		 European — ASPREE —