PGS Publication: PGP000208

Publication Information (EuropePMC)
Title Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population.
PubMed ID 34041846(Europe PMC)
doi 10.1111/acel.13384
Publication Date May 26, 2021
Journal Aging Cell
Author(s) Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebr... a R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P.Show more
Released in PGS Catalog: July 29, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000823
(GRS23_AD)
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Alzheimer's diseaseAlzheimer disease23
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000823/ScoringFiles/PGS000823.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002219PGS000823
(GRS23_AD)
PSS001081|
European Ancestry|
12,978 individuals
PGP000208 |
Riaz M et al. Aging Cell (2021)
|Ext.		Reported Trait: Incident all-cause dementia——Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.76]Age at enrolment, sex—
PPM002220PGS000823
(GRS23_AD)
PSS001081|
European Ancestry|
12,978 individuals
PGP000208 |
Riaz M et al. Aging Cell (2021)
|Ext.		Reported Trait: Incident all-cause dementia——Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.77]Age at enrolment, sex, competing risk of death—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001081Cases were individuals with incident-all cause dementia. Dementia was diagnosed using Diagnostic and...  Statistical Manual of Mental Disorders, fourth edition criteria. Diagnosis date was recorded as date of trigger. Dementia cases were sub-classified into either 'probable Alzheimer's Disease (AD)', 'possible AD' or 'non-dementia AD' using the 2011 NIA-Alzheimer's Association core clinical criteria. Of the 324 cases, 143 were classified as 'probable AD', 176 were classified as 'possible AD' and 5 were classified as 'non-AD related dementia'.Show moreMedian = 4.5 years
IQR = [2.1, 5.7] years
[
  • 324 cases
  • , 12,654 controls
]
,
45.0 % Male samples
Mean = 75.05 years
Sd = 4.2 years		European—ASPREE—
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