Polygenic Score (PGS) ID: PGS002035

Predicted Trait
Reported Trait Dementia
Mapped Trait(s) dementia (MONDO_0001627)
Additional Trait Information psychiatric disorders
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_290.1
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 39,752
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011147 PSS009297|
European Ancestry|
19,618 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.0425 [0.0285, 0.0564] sex, age, birth date, deprivation index, 16 PCs —
PPM011148 PSS009071|
European Ancestry|
4,070 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.0206 [-0.0102, 0.0513] sex, age, birth date, deprivation index, 16 PCs —
PPM011149 PSS008625|
European Ancestry|
6,562 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.0343 [0.0101, 0.0585] sex, age, birth date, deprivation index, 16 PCs —
PPM011150 PSS008399|
Greater Middle Eastern Ancestry|
1,186 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.0658 [0.0084, 0.1227] sex, age, birth date, deprivation index, 16 PCs —
PPM011151 PSS008179|
South Asian Ancestry|
6,222 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.0453 [0.0205, 0.0701] sex, age, birth date, deprivation index, 16 PCs —
PPM011152 PSS007964|
East Asian Ancestry|
1,802 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.0494 [0.003, 0.0956] sex, age, birth date, deprivation index, 16 PCs —
PPM011153 PSS007745|
African Ancestry|
2,441 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.044 [0.0042, 0.0837] sex, age, birth date, deprivation index, 16 PCs —
PPM011154 PSS008849|
African Ancestry|
3,852 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Dementias — — Partial Correlation (partial-r): 0.04 [0.0083, 0.0715] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008399 — — 1,186 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009071 — — 4,070 individuals — European Poland (NE Europe) UKB —
PSS008625 — — 6,562 individuals — European Italy (South Europe) UKB —
PSS009297 — — 19,618 individuals — European UK (+ Ireland) UKB —
PSS008179 — — 6,222 individuals — South Asian India (South Asia) UKB —
PSS008849 — — 3,852 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007964 — — 1,802 individuals — East Asian China (East Asia) UKB —
PSS007745 — — 2,441 individuals — African American or Afro-Caribbean Carribean UKB —