Polygenic Score (PGS) ID: PGS005170

Predicted Trait
Reported Trait All-cause dementia
Mapped Trait(s) dementia (MONDO_0001627)
Released in PGS Catalog: April 17, 2025
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name iPRS_DEM
Development Method
Name integrative PRS of 24 component PRSs derived from LDPRED-2, C+T, PRS-CS
Parameters 24 component PRSs comprising Alzheimer's Disease, 7 European-specific and cross-ancestry stroke GWAS, 2 AD Biomarkers, 4 MRI-markers of cerebral small vessel disease, and 10 vascular risk factors. Component single-trait PRS were inputed into elastic-net penalized regression to obtain training weights. 12 single-trait PRS had a non-zero training weight.
Variants
Original Genome Build GRCh37
Number of Variants 1,320,229
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000718
Citation (link to publication) D'Aoust T et al. Alzheimers Dement (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 73.2%
Multi-ancestry (including European): 26.8%
  • European
  • East Asian
  • African
  • Hispanic or Latin American
  • South Asian
16,596,355 individuals (100%)
Score Development/Training
European: 100%
2,039 individuals (100%)
PGS Evaluation
European: 83.3%
African: 5.6%
Hispanic or Latin American: 5.6%
East Asian: 5.6%
18 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 35379992
[
  • 83,380 cases
  • , 394,702 controls
]
 European 10 cohorts
  • Bonn
  • ,CCHS
  • ,DemGene
  • ,EADB
  • ,EADI
  • ,GERAD
  • ,GR@ACE
  • ,PERADES
  • ,RS
  • ,UKB
Europe PMC: 36180795
[
  • 73,019 cases
  • , 1,197,781 controls
]
 European 32 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,PROSPER
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
Europe PMC: 36180795
[
  • 109,891 cases
  • , 1,466,039 controls
]
 European, East Asian, African unspecified, Hispanic or Latin American, South Asian 41 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,BBJ
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,CKB
  • ,COMPASS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HISAYAMA
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,JHS
  • ,KCPS
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,NOMAS
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
Europe PMC: 36180795
[
  • 62,063 cases
  • , 1,173,817 controls
]
 European 32 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,PROSPER
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
Europe PMC: 36180795
[
  • 87,766 cases
  • , 1,371,264 controls
]
 European, East Asian, African unspecified, Hispanic or Latin American, South Asian 41 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,BBJ
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,CKB
  • ,COMPASS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HISAYAMA
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,JHS
  • ,KCPS
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,NOMAS
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
Europe PMC: 36180795
[
  • 6,753 cases
  • , 460,922 controls
]
 European 32 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,PROSPER
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
Europe PMC: 36180795
[
  • 13,562 cases
  • , 632,871 controls
]
 European, East Asian, African unspecified, Hispanic or Latin American, South Asian 41 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,BBJ
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,CKB
  • ,COMPASS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HISAYAMA
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,JHS
  • ,KCPS
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,NOMAS
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
Europe PMC: 36180795
[
  • 13,066 cases
  • , 686,526 controls
]
 European, East Asian, African unspecified, Hispanic or Latin American, South Asian 41 cohorts
  • AGES
  • ,ARIC
  • ,ASPREE
  • ,BBJ
  • ,CADISP
  • ,CCHS
  • ,CHS
  • ,CKB
  • ,COMPASS
  • ,DNA_Lacunar
  • ,EB
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,FinnGen
  • ,GMC
  • ,Glasgow
  • ,HABC
  • ,HISAYAMA
  • ,HUNT
  • ,HVH
  • ,ICH
  • ,INTERSTROKE
  • ,JHS
  • ,KCPS
  • ,MDC
  • ,MESA
  • ,METASTROKE
  • ,NOMAS
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SHIP
  • ,SIFAP
  • ,SMART
  • ,SiGN
  • ,UKB
  • ,WGHS
  • ,deCODE
GWAS Catalog: GCST011947
Europe PMC: 33293549
 48,454 individuals European NR
GWAS Catalog: GCST90244151
Europe PMC: 37069360
 38,598 individuals European CHARGE, UKB
GWAS Catalog: GCST90244153
Europe PMC: 37069360
 38,903 individuals European CHARGE, UKB
GWAS Catalog: GCST90244155
Europe PMC: 37069360
 38,871 individuals European CHARGE, UKB
GWAS Catalog: GCST006628
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST006627
Europe PMC: 30224653
 757,601 individuals European NR
Europe PMC: 34887591
 1,231,289 individuals European 123 cohorts
  • AEGS1
  • ,AGES
  • ,ALSPAC
  • ,ARIC
  • ,ASCOT
  • ,ASPS
  • ,AugUR
  • ,B58C
  • ,BMES
  • ,BRIGHT
  • ,BioMe
  • ,CARDIA
  • ,CARDIOGENICS
  • ,CFS
  • ,CHIP
  • ,CHOP
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CTMM
  • ,Cilento
  • ,CoLaus
  • ,DCS
  • ,DGI
  • ,DIACORE
  • ,Danfund
  • ,EPICPotsdam
  • ,EPOZ
  • ,ERF
  • ,EUGENDA
  • ,EXCEED
  • ,EpiHealth
  • ,FHS
  • ,FINCAVAS
  • ,FINRISK
  • ,FTC
  • ,FUSION
  • ,FVG
  • ,FamHS
  • ,Fenland
  • ,GCKD
  • ,GENOA
  • ,GLACIER
  • ,GOLDN
  • ,GOMAP
  • ,GRAPHIC
  • ,GRMIC
  • ,GS:SFHS
  • ,GeneRISK
  • ,GerMIFS
  • ,GoDARTS
  • ,HABC
  • ,HCS
  • ,HELIC
  • ,HNR
  • ,HPFS
  • ,HRS
  • ,HUNT
  • ,HYPERGEN
  • ,Health2006
  • ,Hoorn
  • ,InCHIANTI
  • ,Inter99
  • ,JoCoOA
  • ,KORA
  • ,LIFE-Adult
  • ,LLFS
  • ,LOLIPOP
  • ,LURIC
  • ,MANOLIS
  • ,MESA
  • ,METSIM
  • ,MGI
  • ,MHI
  • ,MIGen
  • ,MVP
  • ,MrOS
  • ,MyCode
  • ,NBS
  • ,NEO
  • ,NESDA
  • ,NFBC66
  • ,NHS
  • ,NICOLA
  • ,NSHD
  • ,NTR
  • ,OBB
  • ,OGP
  • ,ORCADES
  • ,PARC
  • ,PHS
  • ,PMB
  • ,POPGEN
  • ,PREVEND
  • ,PROCARDIS
  • ,PROSPER
  • ,QFS
  • ,QIMR
  • ,RAINE
  • ,RISC
  • ,ROSMAP
  • ,RS
  • ,SHIP
  • ,SORBS
  • ,STRIP
  • ,SardiNIA
  • ,Steno
  • ,THISEAS
  • ,TRAILS
  • ,TwinGene
  • ,TwinsUK
  • ,UKB
  • ,UKHLS
  • ,VIKING
  • ,VIS
  • ,Vejle
  • ,WGHS
  • ,WHI
  • ,WHI-GARNET
  • ,WHI-LLS
  • ,YFS
  • ,deCODE
  • ,eMERGE
Europe PMC: 34887591
 1,244,580 individuals European 123 cohorts
  • AEGS1
  • ,AGES
  • ,ALSPAC
  • ,ARIC
  • ,ASCOT
  • ,ASPS
  • ,AugUR
  • ,B58C
  • ,BMES
  • ,BRIGHT
  • ,BioMe
  • ,CARDIA
  • ,CARDIOGENICS
  • ,CFS
  • ,CHIP
  • ,CHOP
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CTMM
  • ,Cilento
  • ,CoLaus
  • ,DCS
  • ,DGI
  • ,DIACORE
  • ,Danfund
  • ,EPICPotsdam
  • ,EPOZ
  • ,ERF
  • ,EUGENDA
  • ,EXCEED
  • ,EpiHealth
  • ,FHS
  • ,FINCAVAS
  • ,FINRISK
  • ,FTC
  • ,FUSION
  • ,FVG
  • ,FamHS
  • ,Fenland
  • ,GCKD
  • ,GENOA
  • ,GLACIER
  • ,GOLDN
  • ,GOMAP
  • ,GRAPHIC
  • ,GRMIC
  • ,GS:SFHS
  • ,GeneRISK
  • ,GerMIFS
  • ,GoDARTS
  • ,HABC
  • ,HCS
  • ,HELIC
  • ,HNR
  • ,HPFS
  • ,HRS
  • ,HUNT
  • ,HYPERGEN
  • ,Health2006
  • ,Hoorn
  • ,InCHIANTI
  • ,Inter99
  • ,JoCoOA
  • ,KORA
  • ,LIFE-Adult
  • ,LLFS
  • ,LOLIPOP
  • ,LURIC
  • ,MANOLIS
  • ,MESA
  • ,METSIM
  • ,MGI
  • ,MHI
  • ,MIGen
  • ,MVP
  • ,MrOS
  • ,MyCode
  • ,NBS
  • ,NEO
  • ,NESDA
  • ,NFBC66
  • ,NHS
  • ,NICOLA
  • ,NSHD
  • ,NTR
  • ,OBB
  • ,OGP
  • ,ORCADES
  • ,PARC
  • ,PHS
  • ,PMB
  • ,POPGEN
  • ,PREVEND
  • ,PROCARDIS
  • ,PROSPER
  • ,QFS
  • ,QIMR
  • ,RAINE
  • ,RISC
  • ,ROSMAP
  • ,RS
  • ,SHIP
  • ,SORBS
  • ,STRIP
  • ,SardiNIA
  • ,Steno
  • ,THISEAS
  • ,TRAILS
  • ,TwinGene
  • ,TwinsUK
  • ,UKB
  • ,UKHLS
  • ,VIKING
  • ,VIS
  • ,Vejle
  • ,WGHS
  • ,WHI
  • ,WHI-GARNET
  • ,WHI-LLS
  • ,YFS
  • ,deCODE
  • ,eMERGE
Europe PMC: 34887591
 1,253,277 individuals European 123 cohorts
  • AEGS1
  • ,AGES
  • ,ALSPAC
  • ,ARIC
  • ,ASCOT
  • ,ASPS
  • ,AugUR
  • ,B58C
  • ,BMES
  • ,BRIGHT
  • ,BioMe
  • ,CARDIA
  • ,CARDIOGENICS
  • ,CFS
  • ,CHIP
  • ,CHOP
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CTMM
  • ,Cilento
  • ,CoLaus
  • ,DCS
  • ,DGI
  • ,DIACORE
  • ,Danfund
  • ,EPICPotsdam
  • ,EPOZ
  • ,ERF
  • ,EUGENDA
  • ,EXCEED
  • ,EpiHealth
  • ,FHS
  • ,FINCAVAS
  • ,FINRISK
  • ,FTC
  • ,FUSION
  • ,FVG
  • ,FamHS
  • ,Fenland
  • ,GCKD
  • ,GENOA
  • ,GLACIER
  • ,GOLDN
  • ,GOMAP
  • ,GRAPHIC
  • ,GRMIC
  • ,GS:SFHS
  • ,GeneRISK
  • ,GerMIFS
  • ,GoDARTS
  • ,HABC
  • ,HCS
  • ,HELIC
  • ,HNR
  • ,HPFS
  • ,HRS
  • ,HUNT
  • ,HYPERGEN
  • ,Health2006
  • ,Hoorn
  • ,InCHIANTI
  • ,Inter99
  • ,JoCoOA
  • ,KORA
  • ,LIFE-Adult
  • ,LLFS
  • ,LOLIPOP
  • ,LURIC
  • ,MANOLIS
  • ,MESA
  • ,METSIM
  • ,MGI
  • ,MHI
  • ,MIGen
  • ,MVP
  • ,MrOS
  • ,MyCode
  • ,NBS
  • ,NEO
  • ,NESDA
  • ,NFBC66
  • ,NHS
  • ,NICOLA
  • ,NSHD
  • ,NTR
  • ,OBB
  • ,OGP
  • ,ORCADES
  • ,PARC
  • ,PHS
  • ,PMB
  • ,POPGEN
  • ,PREVEND
  • ,PROCARDIS
  • ,PROSPER
  • ,QFS
  • ,QIMR
  • ,RAINE
  • ,RISC
  • ,ROSMAP
  • ,RS
  • ,SHIP
  • ,SORBS
  • ,STRIP
  • ,SardiNIA
  • ,Steno
  • ,THISEAS
  • ,TRAILS
  • ,TwinGene
  • ,TwinsUK
  • ,UKB
  • ,UKHLS
  • ,VIKING
  • ,VIS
  • ,Vejle
  • ,WGHS
  • ,WHI
  • ,WHI-GARNET
  • ,WHI-LLS
  • ,YFS
  • ,deCODE
  • ,eMERGE
GWAS Catalog: GCST90239652
Europe PMC: 34887591
 1,320,016 individuals European 123 cohorts
  • AEGS1
  • ,AGES
  • ,ALSPAC
  • ,ARIC
  • ,ASCOT
  • ,ASPS
  • ,AugUR
  • ,B58C
  • ,BMES
  • ,BRIGHT
  • ,BioMe
  • ,CARDIA
  • ,CARDIOGENICS
  • ,CFS
  • ,CHIP
  • ,CHOP
  • ,CHRIS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CTMM
  • ,Cilento
  • ,CoLaus
  • ,DCS
  • ,DGI
  • ,DIACORE
  • ,Danfund
  • ,EPICPotsdam
  • ,EPOZ
  • ,ERF
  • ,EUGENDA
  • ,EXCEED
  • ,EpiHealth
  • ,FHS
  • ,FINCAVAS
  • ,FINRISK
  • ,FTC
  • ,FUSION
  • ,FVG
  • ,FamHS
  • ,Fenland
  • ,GCKD
  • ,GENOA
  • ,GLACIER
  • ,GOLDN
  • ,GOMAP
  • ,GRAPHIC
  • ,GRMIC
  • ,GS:SFHS
  • ,GeneRISK
  • ,GerMIFS
  • ,GoDARTS
  • ,HABC
  • ,HCS
  • ,HELIC
  • ,HNR
  • ,HPFS
  • ,HRS
  • ,HUNT
  • ,HYPERGEN
  • ,Health2006
  • ,Hoorn
  • ,InCHIANTI
  • ,Inter99
  • ,JoCoOA
  • ,KORA
  • ,LIFE-Adult
  • ,LLFS
  • ,LOLIPOP
  • ,LURIC
  • ,MANOLIS
  • ,MESA
  • ,METSIM
  • ,MGI
  • ,MHI
  • ,MIGen
  • ,MVP
  • ,MrOS
  • ,MyCode
  • ,NBS
  • ,NEO
  • ,NESDA
  • ,NFBC66
  • ,NHS
  • ,NICOLA
  • ,NSHD
  • ,NTR
  • ,OBB
  • ,OGP
  • ,ORCADES
  • ,PARC
  • ,PHS
  • ,PMB
  • ,POPGEN
  • ,PREVEND
  • ,PROCARDIS
  • ,PROSPER
  • ,QFS
  • ,QIMR
  • ,RAINE
  • ,RISC
  • ,ROSMAP
  • ,RS
  • ,SHIP
  • ,SORBS
  • ,STRIP
  • ,SardiNIA
  • ,Steno
  • ,THISEAS
  • ,TRAILS
  • ,TwinGene
  • ,TwinsUK
  • ,UKB
  • ,UKHLS
  • ,VIKING
  • ,VIS
  • ,Vejle
  • ,WGHS
  • ,WHI
  • ,WHI-GARNET
  • ,WHI-LLS
  • ,YFS
  • ,deCODE
  • ,eMERGE
GWAS Catalog: GCST004787
Europe PMC: 28714975
 63,731 individuals European, NR NR
Europe PMC: 30643251
 249,176 individuals European NR
GWAS Catalog: GCST009379
Europe PMC: 30297969
 898,130 individuals European NR
GWAS Catalog: GCST009004
Europe PMC: 30239722
 806,834 individuals European NR
GWAS Catalog: GCST90129599
Europe PMC: 36066633
 8,074 individuals European 7 cohorts
  • ACE
  • ,ADC
  • ,EADB
  • ,GH70
  • ,PAGES
  • ,TUM
  • ,UHU
GWAS Catalog: GCST90129600
Europe PMC: 36066633
 7,798 individuals European 7 cohorts
  • ACE
  • ,ADC
  • ,EADB
  • ,GH70
  • ,PAGES
  • ,TUM
  • ,UHU
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 301 cases
  • , 1,738 controls
]
,
40.0 % Male samples
 European
(French)		 3C — Mean = 73.9 years
Sd = 5.09 years		 — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022476 PSS011959|
European Ancestry|
1,414 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.04 [0.88, 1.23] — — age at baseline, age^2, 10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022477 PSS011960|
European Ancestry|
2,288 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.23 [1.07, 1.41] — — age at baseline, age^2, 10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022478 PSS011957|
European Ancestry|
2,165 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (>80 years) HR: 1.16 [1.01, 1.32] — — age at baseline, age^2, sex,10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022479 PSS011956|
European Ancestry|
3,201 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (<80 years) HR: 1.17 [0.96, 1.43] — — age at baseline, age^2, sex, 10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022480 PSS011958|
European Ancestry|
704 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (APOE E4 carriers) HR: 1.194 [0.98, 1.46] — — age at baseline, age^2, sex,10 genetic PCs Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022481 PSS011961|
European Ancestry|
2,928 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (APOE E4 non-carriers) HR: 1.13 [0.99, 1.28] — — age at baseline, age^2, sex, 10 genetic PCs Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022482 PSS011966|
European Ancestry|
2,032 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.25 [1.11, 1.42] AUROC: 0.761 — age at baseline, age^2, sex, the first 10 genetic principal components (PCs) of population stratification, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported. Prediction was assessed at 5-year follow-up using time-dependent AUC over 2,000 bootstrap replications.
PPM022483 PSS011969|
European Ancestry|
782 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.17 [0.97, 1.4] — — age at baseline, 10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022484 PSS011970|
European Ancestry|
1,250 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.3 [1.1, 1.54] — — age at baseline, 10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022486 PSS011967|
European Ancestry|
1,758 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (<80 years) HR: 1.3 [1.11, 1.52] — — age at baseline, sex, 10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022487 PSS011971|
European Ancestry|
605 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (APOE E4 carriers) HR: 1.33 [1.12, 1.58] — — age at baseline, sex,10 genetic PCs Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022488 PSS011972|
European Ancestry|
1,427 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (APOE E4 non-carriers) HR: 1.15 [0.96, 1.37] — — age at baseline, sex, 10 genetic PCs Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.
PPM022489 PSS011964|
European Ancestry|
130,797 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.28 [1.09, 1.51] — — age, sex, five genetic principal components, and APOE dosage —
PPM022490 PSS011962|
African Ancestry|
55,498 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.06 [0.75, 1.45] — — age, sex, five genetic principal components, and APOE dosage —
PPM022491 PSS011963|
East Asian Ancestry|
5,640 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 5.29 [1.43, 34.36] — — age, sex, five genetic principal components, and APOE dosage —
PPM022492 PSS011965|
Hispanic or Latin American Ancestry|
44,266 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.09 [0.78, 1.68] — — age, sex, five genetic principal components, and APOE dosage —
PPM022475 PSS011955|
European Ancestry|
3,702 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia HR: 1.15 [1.03, 1.28] AUROC: 0.756 — age at baseline, age^2, sex, the first 10 genetic principal components (PCs) of population stratification, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported. Prediction was assessed at 10-year follow-up using time-dependent AUC over 2,000 bootstrap replications.
PPM022485 PSS011968|
European Ancestry|
638 individuals
 PGP000718 |
D'Aoust T et al. Alzheimers Dement (2025)
 Reported Trait: Incident all-cause dementia (>80 years) HR: 1.13 [0.92, 1.38] — — age at baseline, sex,10 genetic PCs, and dosage of APOE ε4 and APOE ε2 alleles Fine-Gray Regression models were used, sub-distribution hazard ratios are reported.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011971 — — 605 individuals — European
(French)		 — MEMENTO —
PSS011972 — — 1,427 individuals — European
(French)		 — MEMENTO —
PSS011955 — —
[
  • 361 cases
  • , 3,341 controls
]
,
38.0 % Male samples
 Mean = 74.2 years
Sd = 5.5 years		 European
(French)		 — 3C —
PSS011956 — —
[
  • 123 cases
  • , 3,078 controls
]
 — European
(French)		 — 3C —
PSS011957 — —
[
  • 238 cases
  • , 1,927 controls
]
 — European
(French)		 — 3C —
PSS011958 — —
[
  • 90 cases
  • , 614 controls
]
 — European
(French)		 — 3C —
PSS011959 — —
[
  • 141 cases
  • , 1,273 controls
]
,
100.0 % Male samples
 — European
(French)		 — 3C —
PSS011960 — —
[
  • 220 cases
  • , 2,068 controls
]
,
0.0 % Male samples
 — European
(French)		 — 3C —
PSS011961 — —
[
  • 267 cases
  • , 2,661 controls
]
 — European
(French)		 — 3C —
PSS011962 — —
[
  • 282 cases
  • , 55,216 controls
]
,
42.0 % Male samples
 Mean = 49.0 years
Sd = 15.0 years		 African American or Afro-Caribbean — AllofUs —
PSS011963 — —
[
  • 17 cases
  • , 5,623 controls
]
,
36.0 % Male samples
 Mean = 44.0 years
Sd = 17.0 years		 East Asian — AllofUs —
PSS011964 — —
[
  • 1,274 cases
  • , 129,523 controls
]
,
40.0 % Male samples
 Mean = 56.0 years
Sd = 17.0 years		 European — AllofUs —
PSS011965 — —
[
  • 228 cases
  • , 44,038 controls
]
,
33.0 % Male samples
 Mean = 45.0 years
Sd = 16.0 years		 Hispanic or Latin American — AllofUs —
PSS011966 — —
[
  • 284 cases
  • , 1,748 controls
]
,
39.0 % Male samples
 Mean = 70.9 years
Sd = 8.62 years		 European
(French)		 — MEMENTO —
PSS011967 — —
[
  • 172 cases
  • , 1,586 controls
]
 — European
(French)		 — MEMENTO —
PSS011968 — —
[
  • 112 cases
  • , 526 controls
]
 — European
(French)		 — MEMENTO —
PSS011969 — —
[
  • 133 cases
  • , 649 controls
]
,
100.0 % Male samples
 — European
(French)		 — MEMENTO —
PSS011970 — —
[
  • 151 cases
  • , 1,099 controls
]
,
0.0 % Male samples
 — European
(French)		 — MEMENTO —