PGS Publication: PGP000722

Publication Information (EuropePMC)
Title Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study.
PubMed ID 37918457(Europe PMC)
doi 10.1016/j.amepre.2023.10.017
Publication Date Oct. 31, 2023
Journal Am J Prev Med
Author(s) Yuan S, Dan L, Zhang Y, Wu J, Zhao J, Kivipelto M, Chen J, Ludvigsson JF, Li X, Larsson SC.
Released in PGS Catalog: April 17, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001775
(PRS39_AD)
 PGP000255 |
Ebenau JL et al. Alzheimers Dement (Amst) (2021)
 Alzheimer's disease Alzheimer disease 39
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001775/ScoringFiles/PGS001775.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022528 PGS001775
(PRS39_AD)
 PSS011985|
European Ancestry|
458,181 individuals
 PGP000722 |
Yuan S et al. Am J Prev Med (2023)
|Ext.		 Reported Trait: Incident dementia — — Hazard ratio (HR, high vs low quintile): 1.51 [1.42, 1.67] age, sex, Townsend deprivation index, educational attainment, BMI, physical activity, diet, smoking status, alcohol consumption, baseline hypertension, baseline stroke, history of dementia, depression —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011985 — —
[
  • 6,415 cases
  • , 451,766 controls
]
 — European — UKB —