Trait: atrial fibrillation

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000275
Description A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC) [NCIT: P378]
Trait category
Cardiovascular disease
Synonyms 14 synonyms
  • A-fib
  • AF
  • AF - Atrial fibrillation
  • AFib
  • Atrial Fibrillations
  • Atrial fibrillation (disorder)
  • Auricular Fibrillation
  • Auricular Fibrillations
  • Fibrillation, Atrial
  • Fibrillation, Auricular
  • Fibrillations, Atrial
  • Fibrillations, Auricular
  • atrial fibrillation
  • atrial fibrillation (disease)
Mapped terms 20 mapped terms
  • DOID:0060224
  • HP:0005110
  • ICD10:I48
  • ICD9:427.31
  • MEDGEN:445
  • MESH:D001281
  • MONDO:0004981
  • MeSH:D001281
  • MedDRA:10003658
  • NANDO:2100051
  • NANDO:2200226
  • NCIT:C50466
  • NCIt:C50466
  • OMIM:611819
  • OMIM:613120
  • OMIM:615770
  • SCTID:49436004
  • SNOMEDCT:49436004
  • UMLS:C0004238
  • icd11.foundation:171698302

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000016
(GPS_AF)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Atrial fibrillation atrial fibrillation 6,730,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000016/ScoringFiles/PGS000016.txt.gz - Check Terms/Licenses
PGS000035
(PRS_AF)
 PGP000022 |
Weng LC et al. Circulation (2017)
 Atrial fibrillation atrial fibrillation 1,168
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000035/ScoringFiles/PGS000035.txt.gz
PGS000331
(PRS_AF)
 PGP000100 |
Mars N et al. Nat Med (2020)
 Atrial fibrillation atrial fibrillation 6,183,494
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000331/ScoringFiles/PGS000331.txt.gz
PGS000338
(GRS97_AF)
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Atrial fibrillation atrial fibrillation 97
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000338/ScoringFiles/PGS000338.txt.gz
PGS000727
(AF_PGS)
 PGP000137 |
Ritchie SC et al. Nat Metab (2021)
 Atrial fibrillation atrial fibrillation 2,210,336
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000727/ScoringFiles/PGS000727.txt.gz
PGS001339
(GBE_HC964)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Atrial fibrillation and flutter (time-to-event) atrial fibrillation,
atrial flutter		 2,142
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001339/ScoringFiles/PGS001339.txt.gz
PGS001340
(GBE_HC281)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Atrial fibrillation atrial fibrillation 2,955
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001340/ScoringFiles/PGS001340.txt.gz
PGS001356
(AF_AnnoPred_PRS)
 PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
 Atrial fibrillation atrial fibrillation 2,996,793
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001356/ScoringFiles/PGS001356.txt.gz
PGS001841
(portability-PLR_427.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Atrial fibrillation and flutter atrial fibrillation,
atrial flutter		 3,980
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001841/ScoringFiles/PGS001841.txt.gz
PGS002050
(portability-ldpred2_427.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Atrial fibrillation and flutter atrial fibrillation,
atrial flutter		 554,908
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002050/ScoringFiles/PGS002050.txt.gz
PGS002756
(Atrial_fibrillation_prscs)
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Atrial fibrillation atrial fibrillation 1,091,491
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002756/ScoringFiles/PGS002756.txt.gz
PGS002773
(GTG_AF_maxCT)
 PGP000365 |
Wong CK et al. PLoS One (2022)
 Incident atrial fibrillation atrial fibrillation 265
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002773/ScoringFiles/PGS002773.txt.gz - Check Terms/Licenses
PGS002774
(GTG_AF_SCT)
 PGP000365 |
Wong CK et al. PLoS One (2022)
 Incident atrial fibrillation atrial fibrillation 216,837
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002774/ScoringFiles/PGS002774.txt.gz - Check Terms/Licenses
PGS002814
(AF-PRS)
 PGP000392 |
Miyazawa K et al. Nat Genet (2023)
 Atrial fibrillation atrial fibrillation 4,520
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002814/ScoringFiles/PGS002814.txt.gz
PGS003461
(GRS162_AF)
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Atrial fibrillation atrial fibrillation 162
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003461/ScoringFiles/PGS003461.txt.gz
PGS003761
(PRS165_AF)
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Atrial fibrillation atrial fibrillation 165
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003761/ScoringFiles/PGS003761.txt.gz
PGS004186
(afib_1)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Atrial fibrillation atrial fibrillation 3,082
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004186/ScoringFiles/PGS004186.txt.gz
PGS004187
(afib_2)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Atrial fibrillation atrial fibrillation 5,118
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004187/ScoringFiles/PGS004187.txt.gz
PGS004188
(afib_3)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Atrial fibrillation atrial fibrillation 2,420
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004188/ScoringFiles/PGS004188.txt.gz
PGS004189
(afib_4)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Atrial fibrillation atrial fibrillation 3,434
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004189/ScoringFiles/PGS004189.txt.gz
PGS004190
(afib_5)
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Atrial fibrillation atrial fibrillation 1,972
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004190/ScoringFiles/PGS004190.txt.gz
PGS004290
(GenoBoost_atrial_fibrillation_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 3,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004290/ScoringFiles/PGS004290.txt.gz
PGS004291
(GenoBoost_atrial_fibrillation_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 3,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004291/ScoringFiles/PGS004291.txt.gz
PGS004292
(GenoBoost_atrial_fibrillation_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 700
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004292/ScoringFiles/PGS004292.txt.gz
PGS004293
(GenoBoost_atrial_fibrillation_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 2,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004293/ScoringFiles/PGS004293.txt.gz
PGS004294
(GenoBoost_atrial_fibrillation_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 2,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004294/ScoringFiles/PGS004294.txt.gz
PGS004440
(disease.Atrial_fibrillation.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Atrial fibrillation atrial fibrillation 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004440/ScoringFiles/PGS004440.txt.gz
PGS004461
(disease.I48.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 I48 (Atrial fibrillation and flutter) atrial fibrillation 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004461/ScoringFiles/PGS004461.txt.gz
PGS004510
(meta.Atrial_fibrillation.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Atrial fibrillation atrial fibrillation 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004510/ScoringFiles/PGS004510.txt.gz
PGS004531
(meta.I48.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 I48 (Atrial fibrillation and flutter) atrial fibrillation 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004531/ScoringFiles/PGS004531.txt.gz
PGS004612
(PRSECG_AI)
 PGP000591 |
Wang X et al. Circ Genom Precis Med (2023)
 ECG-AI predicted 5-year risk of atrial fibrillation atrial fibrillation 1,117,399
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004612/ScoringFiles/PGS004612.txt.gz
PGS004613
(PRSCHARGE_AF)
 PGP000591 |
Wang X et al. Circ Genom Precis Med (2023)
 CHARGE-AF predicted 5-year risk of atrial fibrillation atrial fibrillation 1,117,400
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004613/ScoringFiles/PGS004613.txt.gz
PGS004705
(afib_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Atrial Fibrillation atrial fibrillation 3,575,124
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004705/ScoringFiles/PGS004705.txt.gz
PGS004706
(afib_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Atrial Fibrillation atrial fibrillation 3,576,958
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004706/ScoringFiles/PGS004706.txt.gz
PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 785,779
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004878/ScoringFiles/PGS004878.txt.gz
PGS004905
(PRS155_AF)
 PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
 Atrial fibrillation atrial fibrillation 155
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004905/ScoringFiles/PGS004905.txt.gz
PGS004920
(GRS166_AF)
 PGP000652 |
Wang N et al. Eur Heart J (2021)
 Atrial fibrillation atrial fibrillation 166
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004920/ScoringFiles/PGS004920.txt.gz
PGS004929
(AF_Ldpred2_combined)
 PGP000665 |
Moreno-Grau S et al. Human Genomics (2024)
 Atrial fibrillation atrial fibrillation 178,814
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004929/ScoringFiles/PGS004929.txt.gz
PGS005060
(Phe_427_21_ldpred_AFRss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005060/ScoringFiles/PGS005060.txt.gz
PGS005061
(Phe_427_21_ldpred_EURss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005061/ScoringFiles/PGS005061.txt.gz
PGS005062
(Phe_427_21_ldpred_HISss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005062/ScoringFiles/PGS005062.txt.gz
PGS005063
(Phe_427_21_ldpred_METAss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005063/ScoringFiles/PGS005063.txt.gz
PGS005064
(Phe_427_21_ldpred_METAss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005064/ScoringFiles/PGS005064.txt.gz
PGS005065
(Phe_427_21_ldpred_METAss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005065/ScoringFiles/PGS005065.txt.gz
PGS005066
(Phe_427_21_prscs_AFRss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005066/ScoringFiles/PGS005066.txt.gz
PGS005067
(Phe_427_21_prscs_EURss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005067/ScoringFiles/PGS005067.txt.gz
PGS005068
(Phe_427_21_prscs_HISss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005068/ScoringFiles/PGS005068.txt.gz
PGS005069
(Phe_427_21_prscs_METAss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005069/ScoringFiles/PGS005069.txt.gz
PGS005070
(Phe_427_21_prscs_METAss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005070/ScoringFiles/PGS005070.txt.gz
PGS005071
(Phe_427_21_prscs_METAss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005071/ScoringFiles/PGS005071.txt.gz
PGS005072
(Phe_427_21_prscsx_METAweight)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Atrial fibrillation (PheCode 427.21) atrial fibrillation 1,273,891
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005072/ScoringFiles/PGS005072.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000385 PGS000016
(GPS_AF)
 PSS000217|
European Ancestry|
10,303 individuals
 PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.		 Reported Trait: Atrial Fibrillation (personal history) OR: 1.277 [1.12, 1.46] AUROC: 0.78 — age, sex —
PPM000025 PGS000016
(GPS_AF)
 PSS000013|
European Ancestry|
288,978 individuals
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Reported Trait: Atrial fibrillation — AUROC: 0.77 [0.76, 0.77] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.029 age; sex; Ancestry PC 1-4; genotyping chip —
PPM000389 PGS000016
(GPS_AF)
 PSS000217|
European Ancestry|
10,303 individuals
 PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.		 Reported Trait: Atrial Fibrillation (personal history) — AUROC: 0.57 — — —
PPM002019 PGS000016
(GPS_AF)
 PSS000998|
Ancestry Not Reported|
368 individuals
 PGP000182 |
Tadros R et al. Nat Genet (2021)
|Ext.		 Reported Trait: Atrial fibrillation or atrial flutter in individuals with a pathogenic or likely pathogenic sarcomeric variant HR: 1.5 [1.17, 1.91]
β: 0.402 (0.124)		 — — Genetic relatedness matrix, sex —
PPM014988 PGS000016
(GPS_AF)
 PSS009946|
European Ancestry|
36,662 individuals
 PGP000368 |
Marston NA et al. Eur Heart J (2022)
|Ext.		 Reported Trait: Atrial fibrillation HR: 1.4 [1.32, 1.49] — — — —
PPM014989 PGS000016
(GPS_AF)
 PSS009947|
Multi-ancestry (excluding European)|
4,873 individuals
 PGP000368 |
Marston NA et al. Eur Heart J (2022)
|Ext.		 Reported Trait: Atrial fibrillation HR: 2.15 [1.57, 2.95] — — — —
PPM015520 PGS000016
(GPS_AF)
 PSS009971|
Multi-ancestry (including European)|
36,422 individuals
 PGP000381 |
Hao L et al. Nat Med (2022)
|Ext.		 Reported Trait: Atrial fibrillation OR: 2.37 [2.12, 2.64] — — 4 genetic PCs —
PPM020706 PGS000016
(GPS_AF)
 PSS011375|
Multi-ancestry (including European)|
95 individuals
 PGP000565 |
Al-Kaisey A et al. Heart Rhythm (2023)
|Ext.		 Reported Trait: Complex signals on electrogram — — beta (PRS above mean vs PRS below mean): 0.24 Age, sex, persistent atrial fibrillation, atrial fibrillation duration —
PPM020704 PGS000016
(GPS_AF)
 PSS011375|
Multi-ancestry (including European)|
95 individuals
 PGP000565 |
Al-Kaisey A et al. Heart Rhythm (2023)
|Ext.		 Reported Trait: Arrhythmia-free survival following catheter ablation — — Hazard ratio (HR, PRS above mean vs PRS below mean): 1.8 [0.9, 3.3] — —
PPM020705 PGS000016
(GPS_AF)
 PSS011375|
Multi-ancestry (including European)|
95 individuals
 PGP000565 |
Al-Kaisey A et al. Heart Rhythm (2023)
|Ext.		 Reported Trait: Left atrial conduction heterogeneity on electrogram — — beta (PRS above mean vs PRS below mean): 0.26 [0.02, 0.55] Age, sex, persistent atrial fibrillation, atrial fibrillation duration —
PPM021345 PGS000016
(GPS_AF)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Cardiovascular death, stroke, hospitalization for worsening of HF, or acute coronary syndrome HR: 0.99 [0.88, 1.11] — — — —
PPM021346 PGS000016
(GPS_AF)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Stroke HR: 1.1 [0.83, 1.45] — — — —
PPM021347 PGS000016
(GPS_AF)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Recurrent atrial fibrillation HR: 1.08 [1.0, 1.16] — — — —
PPM000079 PGS000035
(PRS_AF)
 PSS000053|
Multi-ancestry (including European)|
4,606 individuals
 PGP000022 |
Weng LC et al. Circulation (2017)
 Reported Trait: Incident atrial fibrillation HR: 1.14 [1.11, 1.16] — — Clinical risk (CHARGE-AF Score: height, weight, systolic and diastolic blood pressure, current smoking status, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure), age, sex, genotyping array, 1 PC of ancestry Unadjusted for Competing Risk of Death
PPM020778 PGS000035
(PRS_AF)
 PSS011403|
Multi-ancestry (including European)|
3,335 individuals
 PGP000586 |
Khurshid S et al. Circ Genom Precis Med (2021)
|Ext.		 Reported Trait: Incident atrial fibrillation HR: 1.49 [1.3, 1.71] C-index: 0.617 [0.574, 0.66] R²: 0.016 [0.004, 0.027] — —
PPM020775 PGS000035
(PRS_AF)
 PSS011406|
Multi-ancestry (including European)|
473,681 individuals
 PGP000586 |
Khurshid S et al. Circ Genom Precis Med (2021)
|Ext.		 Reported Trait: Incident atrial fibrillation HR: 1.34 [1.31, 1.37] C-index: 0.584 [0.577, 0.59] R²: 0.004 [0.004, 0.005] — —
PPM020776 PGS000035
(PRS_AF)
 PSS011404|
European Ancestry|
10,560 individuals
 PGP000586 |
Khurshid S et al. Circ Genom Precis Med (2021)
|Ext.		 Reported Trait: Incident atrial fibrillation HR: 1.48 [1.31, 1.66] C-index: 0.615 [0.579, 0.65] R²: 0.011 [0.004, 0.018] — —
PPM020777 PGS000035
(PRS_AF)
 PSS011405|
Multi-ancestry (including European)|
55,517 individuals
 PGP000586 |
Khurshid S et al. Circ Genom Precis Med (2021)
|Ext.		 Reported Trait: Incident atrial fibrillation HR: 1.28 [1.21, 1.35] C-index: 0.569 [0.554, 0.584] R²: 0.003 [0.002, 0.005] — —
PPM000898 PGS000331
(PRS_AF)
 PSS000439|
European Ancestry|
10,561 individuals
 PGP000100 |
Mars N et al. Nat Med (2020)
 Reported Trait: Incident atrial fibrillation — C-index: 0.734 — CHARGE-AF calculator (age, height, weight, SBP, DBP, smoking status, blood-pressure-lowering medication, diabetes, heart failure and history of myocardial infarction), FINRISK cohort, genotyping array/batch, 10 ancestry PCs 5-year risk
PPM000893 PGS000331
(PRS_AF)
 PSS000439|
European Ancestry|
10,561 individuals
 PGP000100 |
Mars N et al. Nat Med (2020)
 Reported Trait: Incident atrial fibrillation HR: 1.62 [1.54, 1.7] C-index: 0.751 — age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs 5-year risk
PPM000888 PGS000331
(PRS_AF)
 PSS000442|
European Ancestry|
135,300 individuals
 PGP000100 |
Mars N et al. Nat Med (2020)
 Reported Trait: Atrial fibrillation (incident and prevalent cases) HR: 1.62 [1.59, 1.65] — — genotyping array/batch, 10 ancestry PCs, stratified by sex —
PPM000916 PGS000338
(GRS97_AF)
 PSS000462|
European Ancestry|
3,759 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation OR: 2.13 [1.86, 2.44] — — age, sex, PCs (1-10) of ancestry —
PPM000913 PGS000338
(GRS97_AF)
 PSS000462|
European Ancestry|
3,759 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation OR: 2.12 [1.84, 2.45] — — age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry —
PPM000917 PGS000338
(GRS97_AF)
 PSS000461|
European Ancestry|
2,262 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.12 [1.77, 2.54] — — age, sex, PCs (1-10) of ancestry —
PPM000915 PGS000338
(GRS97_AF)
 PSS000460|
European Ancestry|
530 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 2.02 [1.37, 2.99] — — age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry —
PPM000914 PGS000338
(GRS97_AF)
 PSS000461|
European Ancestry|
2,262 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.08 [1.72, 2.5] — — age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry —
PPM000920 PGS000338
(GRS97_AF)
 PSS000462|
European Ancestry|
3,759 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation — AUROC: 0.721 [0.704, 737.0] — PCs (1-10) of ancestry, CHARGE-AF risk factors (age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, myocardial infarction, diabetes) —
PPM000919 PGS000338
(GRS97_AF)
 PSS000462|
European Ancestry|
3,759 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation — AUROC: 0.606 [0.588, 0.624] — PCs (1-10) of ancestry —
PPM000918 PGS000338
(GRS97_AF)
 PSS000460|
European Ancestry|
530 individuals
 PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
 Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 1.82 [1.28, 2.59] — — age, sex, PCs (1-10) of ancestry —
PPM001668 PGS000727
(AF_PGS)
 PSS000867|
European Ancestry|
3,087 individuals
 PGP000137 |
Ritchie SC et al. Nat Metab (2021)
 Reported Trait: Incident atrial fibrillation HR: 1.72 [1.2, 2.47] — — age, sex, 10 genetic PCs —
PPM009181 PGS001339
(GBE_HC964)
 PSS004746|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.75135 [0.70951, 0.7932] R²: 0.09804
Incremental AUROC (full-covars): -0.00345
PGS R2 (no covariates): 0.00273
PGS AUROC (no covariates): 0.53955 [0.48964, 0.58946]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009182 PGS001339
(GBE_HC964)
 PSS004747|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.8247 [0.75141, 0.898] R²: 0.15451
Incremental AUROC (full-covars): 0.0187
PGS R2 (no covariates): 0.01158
PGS AUROC (no covariates): 0.59663 [0.46689, 0.72636]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009183 PGS001339
(GBE_HC964)
 PSS004748|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.77656 [0.76352, 0.7896] R²: 0.14023
Incremental AUROC (full-covars): 0.02188
PGS R2 (no covariates): 0.02447
PGS AUROC (no covariates): 0.613 [0.59591, 0.6301]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009184 PGS001339
(GBE_HC964)
 PSS004749|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.73999 [0.70422, 0.77576] R²: 0.09669
Incremental AUROC (full-covars): -0.00357
PGS R2 (no covariates): 0.00629
PGS AUROC (no covariates): 0.56035 [0.51988, 0.60082]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009185 PGS001339
(GBE_HC964)
 PSS004750|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.76362 [0.75604, 0.7712] R²: 0.133
Incremental AUROC (full-covars): 0.02354
PGS R2 (no covariates): 0.0246
PGS AUROC (no covariates): 0.6108 [0.60113, 0.62048]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009186 PGS001340
(GBE_HC281)
 PSS004413|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial fibrillation — AUROC: 0.75367 [0.71087, 0.79646] R²: 0.10139
Incremental AUROC (full-covars): -0.00517
PGS R2 (no covariates): 0.00295
PGS AUROC (no covariates): 0.5427 [0.49184, 0.59356]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009187 PGS001340
(GBE_HC281)
 PSS004414|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial fibrillation — AUROC: 0.82329 [0.75147, 0.89511] R²: 0.15391
Incremental AUROC (full-covars): 0.01729
PGS R2 (no covariates): 0.01132
PGS AUROC (no covariates): 0.5932 [0.45826, 0.72815]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009188 PGS001340
(GBE_HC281)
 PSS004415|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial fibrillation — AUROC: 0.77562 [0.76201, 0.78924] R²: 0.13687
Incremental AUROC (full-covars): 0.02036
PGS R2 (no covariates): 0.02331
PGS AUROC (no covariates): 0.61305 [0.59537, 0.63074]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009189 PGS001340
(GBE_HC281)
 PSS004416|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial fibrillation — AUROC: 0.73506 [0.69832, 0.7718] R²: 0.09299
Incremental AUROC (full-covars): -0.00714
PGS R2 (no covariates): 0.00594
PGS AUROC (no covariates): 0.56086 [0.51842, 0.60331]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009190 PGS001340
(GBE_HC281)
 PSS004417|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial fibrillation — AUROC: 0.76157 [0.75368, 0.76945] R²: 0.12768
Incremental AUROC (full-covars): 0.02194
PGS R2 (no covariates): 0.02239
PGS AUROC (no covariates): 0.60727 [0.59722, 0.61733]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005188 PGS001356
(AF_AnnoPred_PRS)
 PSS003604|
European Ancestry|
178,651 individuals
 PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
 Reported Trait: Atrial fibrillation — AUROC: 0.6321 — Age, sex, PCs(1-10) —
PPM009619 PGS001841
(portability-PLR_427.2)
 PSS009087|
European Ancestry|
3,980 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0701 [0.039, 0.101] sex, age, birth date, deprivation index, 16 PCs —
PPM009620 PGS001841
(portability-PLR_427.2)
 PSS008641|
European Ancestry|
6,397 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0741 [0.0496, 0.0984] sex, age, birth date, deprivation index, 16 PCs —
PPM009621 PGS001841
(portability-PLR_427.2)
 PSS008415|
Greater Middle Eastern Ancestry|
1,151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.091 [0.0329, 0.1485] sex, age, birth date, deprivation index, 16 PCs —
PPM009622 PGS001841
(portability-PLR_427.2)
 PSS008195|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0436 [0.0182, 0.0688] sex, age, birth date, deprivation index, 16 PCs —
PPM009623 PGS001841
(portability-PLR_427.2)
 PSS007977|
East Asian Ancestry|
1,768 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0317 [-0.0153, 0.0784] sex, age, birth date, deprivation index, 16 PCs —
PPM009624 PGS001841
(portability-PLR_427.2)
 PSS007760|
African Ancestry|
2,381 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0464 [0.0061, 0.0866] sex, age, birth date, deprivation index, 16 PCs —
PPM009625 PGS001841
(portability-PLR_427.2)
 PSS008864|
African Ancestry|
3,769 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0414 [0.0094, 0.0733] sex, age, birth date, deprivation index, 16 PCs —
PPM009618 PGS001841
(portability-PLR_427.2)
 PSS009313|
European Ancestry|
19,230 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.1026 [0.0885, 0.1165] sex, age, birth date, deprivation index, 16 PCs —
PPM011263 PGS002050
(portability-ldpred2_427.2)
 PSS009087|
European Ancestry|
3,980 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0689 [0.0379, 0.0999] sex, age, birth date, deprivation index, 16 PCs —
PPM011264 PGS002050
(portability-ldpred2_427.2)
 PSS008641|
European Ancestry|
6,397 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0839 [0.0594, 0.1082] sex, age, birth date, deprivation index, 16 PCs —
PPM011265 PGS002050
(portability-ldpred2_427.2)
 PSS008415|
Greater Middle Eastern Ancestry|
1,151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0983 [0.0402, 0.1557] sex, age, birth date, deprivation index, 16 PCs —
PPM011266 PGS002050
(portability-ldpred2_427.2)
 PSS008195|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.043 [0.0177, 0.0683] sex, age, birth date, deprivation index, 16 PCs —
PPM011267 PGS002050
(portability-ldpred2_427.2)
 PSS007977|
East Asian Ancestry|
1,768 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.041 [-0.0059, 0.0877] sex, age, birth date, deprivation index, 16 PCs —
PPM011268 PGS002050
(portability-ldpred2_427.2)
 PSS007760|
African Ancestry|
2,381 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0475 [0.0072, 0.0877] sex, age, birth date, deprivation index, 16 PCs —
PPM011269 PGS002050
(portability-ldpred2_427.2)
 PSS008864|
African Ancestry|
3,769 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0418 [0.0098, 0.0737] sex, age, birth date, deprivation index, 16 PCs —
PPM011262 PGS002050
(portability-ldpred2_427.2)
 PSS009313|
European Ancestry|
19,230 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.1034 [0.0894, 0.1174] sex, age, birth date, deprivation index, 16 PCs —
PPM014956 PGS002756
(Atrial_fibrillation_prscs)
 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation OR: 1.87 [1.79, 1.96] — — age, sex, 10 PCs, technical covariates —
PPM014973 PGS002773
(GTG_AF_maxCT)
 PSS009940|
European Ancestry|
12,306 individuals
 PGP000365 |
Wong CK et al. PLoS One (2022)
 Reported Trait: Incident atrial fibrillation OR: 1.41 [1.35, 1.48] AUROC: 0.599 [0.585, 0.613] — — —
PPM014974 PGS002774
(GTG_AF_SCT)
 PSS009940|
European Ancestry|
12,306 individuals
 PGP000365 |
Wong CK et al. PLoS One (2022)
 Reported Trait: Incident atrial fibrillation OR: 1.49 [1.42, 1.57] AUROC: 0.613 [0.599, 0.626] — — —
PPM015602 PGS002814
(AF-PRS)
 PSS009995|
East Asian Ancestry|
24,147 individuals
 PGP000392 |
Miyazawa K et al. Nat Genet (2023)
 Reported Trait: Atrial fibrillation OR: 1.94332
β: 0.66		 AUROC: 0.74 Nagelkerke’s pseudo R2: 0.14 age, sex, and the top 20 PCs We assessed the PRS performance using logistic regression model adjusted for covariates using glm in R.
PPM017265 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 2.54 [2.26, 2.85] — —
PPM017267 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics delayed acrophase HR: 2.69 [2.18, 3.33] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017268 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low Pseudo-F HR: 2.55 [2.04, 3.18] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017269 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low mesor HR: 3.67 [2.97, 4.54] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017266 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low amplitude HR: 3.87 [3.07, 4.87] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM018558 PGS003761
(PRS165_AF)
 PSS011022|
Multi-ancestry (including European)|
84,206 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 7.32 [3.02, 17.7] sex —
PPM018559 PGS003761
(PRS165_AF)
 PSS011023|
Multi-ancestry (including European)|
117,520 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 8.41 [4.37, 16.2] sex —
PPM018560 PGS003761
(PRS165_AF)
 PSS011024|
Multi-ancestry (including European)|
147,178 individuals
 PGP000484 |
Zhang J et al. BMC Med (2023)
 Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden — — Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 4.12 [2.76, 6.14] sex —
PPM020119 PGS004186
(afib_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Atrial fibrillation — AUROC: 0.73831 — year of birth, sex —
PPM020120 PGS004186
(afib_1)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Atrial fibrillation — AUROC: 0.73501 — year of birth, sex —
PPM020121 PGS004187
(afib_2)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Atrial fibrillation — AUROC: 0.74377 — year of birth, sex —
PPM020122 PGS004188
(afib_3)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Atrial fibrillation — AUROC: 0.73914 — year of birth, sex —
PPM020123 PGS004189
(afib_4)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Atrial fibrillation — AUROC: 0.74461 — year of birth, sex —
PPM020124 PGS004190
(afib_5)
 PSS011296|
European Ancestry|
45,334 individuals
 PGP000520 |
Raben TG et al. Sci Rep (2023)
 Reported Trait: Hypertension — AUROC: 0.69573 — year of birth, sex —
PPM020358 PGS004290
(GenoBoost_atrial_fibrillation_0)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75753 Covariate-adjusted pseudo-R2: 0.03378
AUPRC: 0.75753		 age, sex, PC1-10 —
PPM020359 PGS004291
(GenoBoost_atrial_fibrillation_1)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75566 Covariate-adjusted pseudo-R2: 0.03105
AUPRC: 0.75566		 age, sex, PC1-10 —
PPM020360 PGS004292
(GenoBoost_atrial_fibrillation_2)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75591 Covariate-adjusted pseudo-R2: 0.03151
AUPRC: 0.75591		 age, sex, PC1-10 —
PPM020361 PGS004293
(GenoBoost_atrial_fibrillation_3)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75627 Covariate-adjusted pseudo-R2: 0.03251
AUPRC: 0.75627		 age, sex, PC1-10 —
PPM020362 PGS004294
(GenoBoost_atrial_fibrillation_4)
 PSS011337|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Atrial fibrillation — AUROC: 0.75648 Covariate-adjusted pseudo-R2: 0.03265
AUPRC: 0.75648		 age, sex, PC1-10 —
PPM020555 PGS004440
(disease.Atrial_fibrillation.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Atrial fibrillation OR: 1.28672 — — — —
PPM020576 PGS004461
(disease.I48.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: I48 (Atrial fibrillation and flutter) OR: 1.34588 — — — —
PPM020625 PGS004510
(meta.Atrial_fibrillation.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Atrial fibrillation OR: 1.2456 — — — —
PPM020646 PGS004531
(meta.I48.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: I48 (Atrial fibrillation and flutter) OR: 1.27953 — — — —
PPM020787 PGS004612
(PRSECG_AI)
 PSS011412|
Multi-ancestry (including European)|
424,411 individuals
 PGP000591 |
Wang X et al. Circ Genom Precis Med (2023)
 Reported Trait: 5-year incident atrial fibrillation HR: 1.07 [1.04, 1.09] C-index: 0.738 — Age at enrollment, sex, genotyping array, 20 PCs of ancestry —
PPM020788 PGS004613
(PRSCHARGE_AF)
 PSS011412|
Multi-ancestry (including European)|
424,411 individuals
 PGP000591 |
Wang X et al. Circ Genom Precis Med (2023)
 Reported Trait: 5-year incident atrial fibrillation HR: 1.12 [1.09, 1.14] C-index: 0.739 — Age at enrollment, sex, genotyping array, 20 PCs of ancestry —
PPM020930 PGS004705
(afib_PRSmix_eur)
 PSS011465|
European Ancestry|
9,462 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Atrial Fibrillation — — Incremental R2 (Full model versus model with only covariates): 0.042 [0.034, 0.05] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020931 PGS004706
(afib_PRSmixPlus_eur)
 PSS011465|
European Ancestry|
9,462 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Atrial Fibrillation — — Incremental R2 (Full model versus model with only covariates): 0.044 [0.036, 0.053] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM021204 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011542|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.55 [1.48, 1.62] C-index: 0.63 [0.61, 0.64] — PCs 1-10 —
PPM021205 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011540|
European Ancestry|
44,186 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.42 [1.29, 1.56] — — PCs 1-10 —
PPM021202 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011544|
European Ancestry|
32,089 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.36 [1.32, 1.39] C-index: 0.59 [0.58, 0.6] — PCs 1-10 —
PPM021203 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011543|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.68 [1.64, 1.73] C-index: 0.65 [0.64, 0.65] — PCs 1-10 —
PPM021206 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011541|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.62 [1.5, 1.75] C-index: 0.66 [0.63, 0.68] — PCs 1-10 —
PPM021207 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011539|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.61 [1.6, 1.63] C-index: 0.62 [0.62, 0.62] — PCs 1-10 —
PPM021208 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011538|
European Ancestry|
148,312 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.56 [1.52, 1.6] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021355 PGS004905
(PRS155_AF)
 PSS011700|
Multi-ancestry (including European)|
401,251 individuals
 PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
 Reported Trait: Incident atrial fibrillation HR: 2.145 [2.085, 2.205] — — Age, sex, ethnicity, education, employment, alcohol consumption status, smoking status, healthy diet score, physical activity, BMI, hypertension, hyperlipidemia, diabetes, genotyping batch, 10 PCs —
PPM021391 PGS004920
(GRS166_AF)
 PSS011724|
European Ancestry|
193,819 individuals
 PGP000652 |
Wang N et al. Eur Heart J (2021)
 Reported Trait: Atrial fibrillation HR: 2.68 [2.53, 2.84] — — Age, sex, ethnicity, Townsend index, education, smoking status, BMI <25.0 kg/m2, physical activity goal (≥150 min/week of moderate intensity, ≥75 min/week of vigorous intensity, or an equivalent combination), dietary score ≥4 proposed in previous studies, total cholesterol <5.18 mmol/L without using lipid-lowering medication, glycated haemoglobin <5.7% (39 mmol/mol) and no history of diabetes, blood pressure <120/<80 mmHg without using blood pressure-lowering medication —
PPM021716 PGS004929
(AF_Ldpred2_combined)
 PSS011762|
European Ancestry|
8,417 individuals
 PGP000665 |
Moreno-Grau S et al. Human Genomics (2024)
 Reported Trait: Atrial fibrillation OR: 1.44 [1.28, 1.63] AUROC: 0.71 — — —
PPM021938 PGS005060
(Phe_427_21_ldpred_AFRss_afrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.231 [1.08, 1.4] C-index: 0.81914 — age, sex, 20 PCs —
PPM021944 PGS005060
(Phe_427_21_ldpred_AFRss_afrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.208 [1.16, 1.26] C-index: 0.80875 — age, sex, 20 PCs —
PPM021950 PGS005060
(Phe_427_21_ldpred_AFRss_afrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.246 [1.11, 1.39] C-index: 0.74621 — age, sex, 20 PCs —
PPM021940 PGS005061
(Phe_427_21_ldpred_EURss_eurld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.223 [1.06, 1.42] C-index: 0.82015 — age, sex, 20 PCs —
PPM021946 PGS005061
(Phe_427_21_ldpred_EURss_eurld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.639 [1.57, 1.71] C-index: 0.82287 — age, sex, 20 PCs —
PPM021952 PGS005061
(Phe_427_21_ldpred_EURss_eurld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.13 [1.03, 1.24] C-index: 0.74445 — age, sex, 20 PCs —
PPM021939 PGS005062
(Phe_427_21_ldpred_HISss_amrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.232 [1.08, 1.4] C-index: 0.8194 — age, sex, 20 PCs —
PPM021945 PGS005062
(Phe_427_21_ldpred_HISss_amrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.206 [1.16, 1.26] C-index: 0.80897 — age, sex, 20 PCs —
PPM021951 PGS005062
(Phe_427_21_ldpred_HISss_amrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.069 [0.96, 1.19] C-index: 0.7432 — age, sex, 20 PCs —
PPM021935 PGS005063
(Phe_427_21_ldpred_METAss_afrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.378 [1.22, 1.56] C-index: 0.82471 — age, sex, 20 PCs —
PPM021941 PGS005063
(Phe_427_21_ldpred_METAss_afrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.619 [1.55, 1.69] C-index: 0.82332 — age, sex, 20 PCs —
PPM021947 PGS005063
(Phe_427_21_ldpred_METAss_afrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.235 [1.12, 1.37] C-index: 0.74798 — age, sex, 20 PCs —
PPM021936 PGS005064
(Phe_427_21_ldpred_METAss_amrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.317 [1.17, 1.48] C-index: 0.82283 — age, sex, 20 PCs —
PPM021948 PGS005064
(Phe_427_21_ldpred_METAss_amrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.185 [1.08, 1.3] C-index: 0.74675 — age, sex, 20 PCs —
PPM021942 PGS005064
(Phe_427_21_ldpred_METAss_amrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.497 [1.44, 1.56] C-index: 0.81963 — age, sex, 20 PCs —
PPM021937 PGS005065
(Phe_427_21_ldpred_METAss_eurld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.352 [1.19, 1.54] C-index: 0.82367 — age, sex, 20 PCs —
PPM021943 PGS005065
(Phe_427_21_ldpred_METAss_eurld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.67 [1.6, 1.74] C-index: 0.82526 — age, sex, 20 PCs —
PPM021949 PGS005065
(Phe_427_21_ldpred_METAss_eurld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.282 [1.16, 1.42] C-index: 0.74939 — age, sex, 20 PCs —
PPM021856 PGS005066
(Phe_427_21_prscs_AFRss_afrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.238 [1.09, 1.41] C-index: 0.74525 — age, sex, 20 PCs —
PPM021842 PGS005066
(Phe_427_21_prscs_AFRss_afrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.215 [1.06, 1.39] C-index: 0.81844 — age, sex, 20 PCs —
PPM021849 PGS005066
(Phe_427_21_prscs_AFRss_afrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.164 [1.12, 1.21] C-index: 0.8076 — age, sex, 20 PCs —
PPM021858 PGS005067
(Phe_427_21_prscs_EURss_eurld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.183 [1.08, 1.3] C-index: 0.74595 — age, sex, 20 PCs —
PPM021844 PGS005067
(Phe_427_21_prscs_EURss_eurld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.344 [1.18, 1.53] C-index: 0.82419 — age, sex, 20 PCs —
PPM021851 PGS005067
(Phe_427_21_prscs_EURss_eurld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.734 [1.66, 1.81] C-index: 0.82758 — age, sex, 20 PCs —
PPM021857 PGS005068
(Phe_427_21_prscs_HISss_amrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.074 [0.96, 1.2] C-index: 0.74301 — age, sex, 20 PCs —
PPM021843 PGS005068
(Phe_427_21_prscs_HISss_amrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.167 [1.02, 1.34] C-index: 0.81866 — age, sex, 20 PCs —
PPM021850 PGS005068
(Phe_427_21_prscs_HISss_amrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.146 [1.1, 1.2] C-index: 0.80732 — age, sex, 20 PCs —
PPM021839 PGS005069
(Phe_427_21_prscs_METAss_afrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.344 [1.18, 1.53] C-index: 0.82333 — age, sex, 20 PCs —
PPM021846 PGS005069
(Phe_427_21_prscs_METAss_afrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.578 [1.51, 1.65] C-index: 0.82183 — age, sex, 20 PCs —
PPM021853 PGS005069
(Phe_427_21_prscs_METAss_afrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.191 [1.08, 1.31] C-index: 0.74595 — age, sex, 20 PCs —
PPM021847 PGS005070
(Phe_427_21_prscs_METAss_amrld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.685 [1.61, 1.76] C-index: 0.82621 — age, sex, 20 PCs —
PPM021854 PGS005070
(Phe_427_21_prscs_METAss_amrld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.226 [1.11, 1.36] C-index: 0.74683 — age, sex, 20 PCs —
PPM021840 PGS005070
(Phe_427_21_prscs_METAss_amrld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.396 [1.23, 1.58] C-index: 0.82598 — age, sex, 20 PCs —
PPM021841 PGS005071
(Phe_427_21_prscs_METAss_eurld)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.397 [1.23, 1.59] C-index: 0.82533 — age, sex, 20 PCs —
PPM021848 PGS005071
(Phe_427_21_prscs_METAss_eurld)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.693 [1.62, 1.77] C-index: 0.82616 — age, sex, 20 PCs —
PPM021855 PGS005071
(Phe_427_21_prscs_METAss_eurld)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.261 [1.14, 1.4] C-index: 0.74915 — age, sex, 20 PCs —
PPM021859 PGS005072
(Phe_427_21_prscsx_METAweight)
 PSS011800|
African Ancestry|
8,952 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.232 [1.11, 1.36] C-index: 0.74713 — age, sex, 20 PCs —
PPM021845 PGS005072
(Phe_427_21_prscsx_METAweight)
 PSS011810|
Hispanic or Latin American Ancestry|
6,775 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.414 [1.25, 1.6] C-index: 0.82572 — age, sex, 20 PCs —
PPM021852 PGS005072
(Phe_427_21_prscsx_METAweight)
 PSS011820|
European Ancestry|
25,409 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Atrial fibrillation OR: 1.684 [1.61, 1.76] C-index: 0.82639 — age, sex, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011698 — — 1,567 individuals — European — EAST-AFNET4 —
PSS011700 — Median = 11.9 years
[
  • 17,096 cases
  • , 358,680 controls
]
 — European — UKB —
PSS011700 — Median = 11.9 years
[
  • 252 cases
  • , 9,451 controls
]
 — Not reported — UKB —
PSS011700 — Median = 11.9 years
[
  • 240 cases
  • , 8,458 controls
]
 — Asian unspecified — UKB —
PSS011700 — Median = 11.9 years
[
  • 143 cases
  • , 6,931 controls
]
 — African unspecified — UKB —
PSS008195 — — 6,001 individuals — South Asian India (South Asia) UKB —
PSS000013 Atrial fibrillation ascertainment was based on self-report of atrial fibrillation, atrial flutter, or cardioversion in an interview with a trained nurse, an ICD-9 code of 427.3 or ICD-10 code of I48.X in hospitalization records, or a history of a percutaneous ablation or cardioversion based on the OPCS-4 coded procedure (K57.1, K62.1, K62.2, K62.3, or K 62.4), as performed previously —
[
  • 4,576 cases
  • , 284,402 controls
]
 — European — UKB UKB Phase 2
PSS004746 — —
[
  • 136 cases
  • , 6,361 controls
]
 — African unspecified — UKB —
PSS004747 — —
[
  • 24 cases
  • , 1,680 controls
]
 — East Asian — UKB —
PSS004748 — —
[
  • 1,090 cases
  • , 23,815 controls
]
 — European non-white British ancestry UKB —
PSS004749 — —
[
  • 200 cases
  • , 7,631 controls
]
 — South Asian — UKB —
PSS004750 — —
[
  • 3,483 cases
  • , 63,942 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS011724 — —
[
  • 3,832 cases
  • , 189,987 controls
]
 — European — UKB —
PSS000998 All individuals were carriers of a pathogenic or likely pathogenic variant (MYBPC3 truncating variant, MYBPC3 non-truncating variant, MYH7 variant, MYL2 variant, other genetic variant). Cases included individuals who had experienced atrial fibrillation, defined as: time to atrial fibrillation or flutter. —
[
  • 70 cases
  • , 298 controls
]
 — Not reported — ERSPC —
PSS000439 National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9. —
[
  • 229 cases
  • , 10,332 controls
]
,
47.3 % Male samples
 Mean (Age At Baseline) = 48.0 years European
(Finnish)		 — FINRISK FINRISK surveys from 1992, 1997, 2002 and 2007
PSS000442 National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9. —
[
  • 12,809 cases
  • , 122,491 controls
]
,
43.7 % Male samples
 Mean (Age At Baseline) = 59.2 years
Sd = 16.6 years		 European
(Finnish)		 — FinnGen —
PSS007760 — — 2,381 individuals — African American or Afro-Caribbean Carribean UKB —
PSS011465 — — 9,462 individuals — European — AllofUs —
PSS000460 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. HFpEF defined as LVEF >/= 50% —
[
  • 307 cases
  • , 223 controls
]
 — European — BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000461 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.HFrEF defined as LVEF <40% —
[
  • 1,125 cases
  • , 1,137 controls
]
 — European — BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000462 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. —
[
  • 1,976 cases
  • , 1,783 controls
]
,
70.0 % Male samples
 Mean = 72.8 years
Sd = 11.5 years		 European — BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS009313 — — 19,230 individuals — European UK (+ Ireland) UKB —
PSS011296 22,667 sibling pairs — 45,334 individuals — European — UKB —
PSS000053 Participants were classified as having AF if an arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records during a median 9.4 years of follow-up. —
[
  • 580 cases
  • , 4,026 controls
]
,
45.9 % Male samples
 — European, NR FHS is principally composed of individuals of European ancestry FHS Samples were obtained from the following FHS cohorts: Original, Offspring, and Third Generation. Participants were eligible for inclusion if they were AF free at an average age of 55.
PSS000217 Phenotypic information was self-reported by the individual through an online, interactive health history tool —
[
  • 239 cases
  • , 10,064 controls
]
,
17.1 % Male samples
 — European — CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS011762 — — 8,417 individuals — European — BBofA —
PSS008864 — — 3,769 individuals — African unspecified Nigeria (West Africa) UKB —
PSS000867 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I48 Median = 6.9 years
[
  • 33 cases
  • , 3,054 controls
]
,
51.0 % Male samples
 Median = 44.0 years
IQR = [30.5, 54.7] years		 European — INTERVAL —
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —
PSS009940 We used the disease definitions described in the supplement of Said et al (2018). PMID: 29955826 —
[
  • 2,051 cases
  • , 10,255 controls
]
,
46.0 % Male samples
 European — UKB —
PSS009946 — — 36,662 individuals,
75.0 % Male samples
 Mean = 64.1 years European — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 674 individuals — Asian unspecified — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 791 individuals — East Asian — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 687 individuals — South Asian — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 2,721 individuals — Hispanic or Latin American
(Mixed American)		 — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS004413 — —
[
  • 132 cases
  • , 6,365 controls
]
 — African unspecified — UKB —
PSS004414 — —
[
  • 24 cases
  • , 1,680 controls
]
 — East Asian — UKB —
PSS004415 — —
[
  • 1,017 cases
  • , 23,888 controls
]
 — European non-white British ancestry UKB —
PSS004416 — —
[
  • 189 cases
  • , 7,642 controls
]
 — South Asian — UKB —
PSS004417 — —
[
  • 3,228 cases
  • , 64,197 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008415 — — 1,151 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS011337 — —
[
  • 5,085 cases
  • , 62,343 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011538 — —
[
  • 5,454 cases
  • , 142,858 controls
]
 — European — EB —
PSS011539 — —
[
  • 42,166 cases
  • , 369,924 controls
]
 — European — FinnGen —
PSS009971 — — 30,716 individuals — European — MGBB —
PSS009971 — — 1,807 individuals — African unspecified
(Black)		 — MGBB —
PSS009971 — — 786 individuals — Asian unspecified — MGBB —
PSS009971 — — 3,113 individuals — Other — MGBB —
PSS011542 — —
[
  • 1,852 cases
  • , 27,575 controls
]
 — European — GEL —
PSS011544 — —
[
  • 5,982 cases
  • , 26,107 controls
]
 — European — MGBB —
PSS011540 — —
[
  • 401 cases
  • , 43,785 controls
]
 — European — G&H —
PSS011541 — —
[
  • 656 cases
  • , 6,362 controls
]
 — European — GS:SFHS —
PSS011543 — —
[
  • 4,962 cases
  • , 64,753 controls
]
 — European — HUNT —
PSS011364 — — 56,192 individuals — European — UKB —
PSS007977 — — 1,768 individuals — East Asian China (East Asia) UKB —
PSS011800 — —
[
  • 473 cases
  • , 8,479 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS011810 — —
[
  • 309 cases
  • , 6,466 controls
]
 — Hispanic or Latin American — AllofUs —
PSS011375 — — 93 individuals — European Admixed European (n=3) NR —
PSS011375 — — 1 individuals — East Asian — NR —
PSS011375 — — 1 individuals — South Asian Admixed South Asian (n=1) NR —
PSS009995 ICD48 —
[
  • 2,953 cases
  • , 21,194 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS011820 — —
[
  • 3,038 cases
  • , 22,371 controls
]
 — European — AllofUs —
PSS003604 — —
[
  • 4,025 cases
  • , 174,626 controls
]
 Mean = 56.81 years European — UKB —
PSS010183 Incident AF was defined as International Classification of Diseases (ICD) edition 10 (codes I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9) and operative procedures (codes K62.1, K62.2, K62.3, K62.4) Median = 6.16 years 62,927 individuals,
43.87 % Male samples
 Mean = 62.48 years European — UKB —
PSS011403 Cases were individuals with atrial fibrillation (AF). Individuals were classified as having AF if the arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records. Study investigators reviewed all available records to determine dates of AF. Two physicians adjudicated first-detected AF events. —
[
  • 183 cases
  • , 3,152 controls
]
,
44.6 % Male samples
 Mean = 59.4 years
Sd = 15.5 years		 European, Not reported — FHS —
PSS011404 Cases were individuals with atrial fibrillation (AF). Cases were identified using ICD-10 code: I48 and ICD-9 code: 427.3. —
[
  • 299 cases
  • , 10,331 controls
]
,
47.7 % Male samples
 Mean = 57.0 years
Sd = 7.4 years		 European — FINRISK —
PSS011405 Cases were individuals with atrial fibrillation (AF). AF was defined as a clinically reported finding of AF or atrial flutter from a 12- lead ECG or a diagnosis of AF or atrial flutter applied to two or more inpatient or outpatient encounters or on the patient problem list from the institutional electronic health record. Diagnosis codes used to define AF included ICD10: I48.0, I48.1, I48.2, I48.3 and I48.91); ICD9: 427.31; and 92 separate internal codes. —
[
  • 1,336 cases
  • , 54,181 controls
]
,
34.2 % Male samples
 Mean = 47.3 years
Sd = 15.2 years		 European, Not reported — MyCode —
PSS011406 Cases were individuals with atrial fibrillation (AF). Cases were identified using using self-report, ICD 9/10 codes, or cause of death records and where available, codes for specific AF-related procedures (e.g., percutaneous transluminal ablation of pulmonary vein) were also utilized in the AF definition. The complete list of clinical factor definitions is shown in supplemental Table I. —
[
  • 7,192 cases
  • , 466,489 controls
]
,
45.3 % Male samples
 Mean = 56.9 years
Sd = 8.1 years		 European, Not reported — UKB Possible sample overlap between this dataset and the dataset used to develop/train PGS000035.
PSS009087 — — 3,980 individuals — European Poland (NE Europe) UKB —
PSS011412 — — 370,121 individuals — European — UKB —
PSS011412 — — 54,290 individuals — Not reported — UKB —
PSS011022 — — 75,886 individuals European — UKB —
PSS011022 — — 8,320 individuals Not reported — UKB —
PSS011023 — — 110,737 individuals European — UKB —
PSS011023 — — 6,783 individuals Not reported — UKB —
PSS011024 — — 142,614 individuals European — UKB —
PSS011024 — — 4,564 individuals Not reported — UKB —
PSS008641 — — 6,397 individuals — European Italy (South Europe) UKB —