PGS Publication: PGP000368

Publication Information (EuropePMC)
Title A polygenic risk score predicts atrial fibrillation in cardiovascular disease.
PubMed ID 35980763(Europe PMC)
doi 10.1093/eurheartj/ehac460
Publication Date Aug. 18, 2022
Journal Eur Heart J
Author(s) Marston NA, Garfinkel AC, Kamanu FK, Melloni GM, Roselli C, Jarolim P, Berg DD, Bhatt DL, Bonaca MP, Cannon CP, Giugliano RP, O'Donoghue ML, Raz I, Scirica BM, Braunwald E, Morrow DA, Ellinor PT, Lubitz SA, Sabatine MS, Ruff CT.
Released in PGS Catalog: Sept. 29, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000016
(GPS_AF)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Atrial fibrillation atrial fibrillation 6,730,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000016/ScoringFiles/PGS000016.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014988 PGS000016
(GPS_AF)
 PSS009946|
European Ancestry|
36,662 individuals
 PGP000368 |
Marston NA et al. Eur Heart J (2022)
|Ext.		 Reported Trait: Atrial fibrillation HR: 1.4 [1.32, 1.49] — — — —
PPM014989 PGS000016
(GPS_AF)
 PSS009947|
Multi-ancestry (excluding European)|
4,873 individuals
 PGP000368 |
Marston NA et al. Eur Heart J (2022)
|Ext.		 Reported Trait: Atrial fibrillation HR: 2.15 [1.57, 2.95] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009946 — — 36,662 individuals,
75.0 % Male samples
 Mean = 64.1 years European — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 674 individuals — Asian unspecified — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 791 individuals — East Asian — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 687 individuals — South Asian — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS009947 — — 2,721 individuals — Hispanic or Latin American
(Mixed American)		 — FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52 —