PGS Publication: PGP000638

Publication Information (EuropePMC)
Title Air pollution, genetic susceptibility, and the risk of atrial fibrillation: A large prospective cohort study.
PubMed ID 37523535(Europe PMC)
doi 10.1073/pnas.2302708120
Publication Date July 31, 2023
Journal Proc Natl Acad Sci U S A
Author(s) Ma Y, Su B, Li D, Cui F, Tang L, Wang J, Tian Y, Zheng X.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004905
(PRS155_AF)
 PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
 Atrial fibrillation atrial fibrillation 155
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004905/ScoringFiles/PGS004905.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021355 PGS004905
(PRS155_AF)
 PSS011700|
Multi-ancestry (including European)|
401,251 individuals
 PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
 Reported Trait: Incident atrial fibrillation HR: 2.145 [2.085, 2.205] — — Age, sex, ethnicity, education, employment, alcohol consumption status, smoking status, healthy diet score, physical activity, BMI, hypertension, hyperlipidemia, diabetes, genotyping batch, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011700 — Median = 11.9 years
[
  • 17,096 cases
  • , 358,680 controls
]
 — European — UKB —
PSS011700 — Median = 11.9 years
[
  • 252 cases
  • , 9,451 controls
]
 — Not reported — UKB —
PSS011700 — Median = 11.9 years
[
  • 240 cases
  • , 8,458 controls
]
 — Asian unspecified — UKB —
PSS011700 — Median = 11.9 years
[
  • 143 cases
  • , 6,931 controls
]
 — African unspecified — UKB —