Trait: atrial flutter

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003911
Description A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) [NCIT: P378]
Trait category
Cardiovascular disease
Synonyms 9 synonyms
  • Atrial Flutters
  • Auricular Flutter
  • Auricular Flutters
  • Flutter, Atrial
  • Flutter, Auricular
  • Flutters, Atrial
  • Flutters, Auricular
  • atrial flutter
  • atrial flutter (disease)
Mapped terms 15 mapped terms
  • HP:0004749
  • ICD9:427.32
  • MEDGEN:13955
  • MESH:D001282
  • MONDO:0005310
  • MeSH:D001282
  • MedDRA:10003662
  • NANDO:2100050
  • NANDO:2200218
  • NANDO:2200225
  • NCIT:C51224
  • NCIt:C51224
  • SCTID:5370000
  • SNOMEDCT:5370000
  • UMLS:C0004239

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001263
(GBE_HC440)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Atrial flutter atrial flutter 2,087
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001263/ScoringFiles/PGS001263.txt.gz
PGS001339
(GBE_HC964)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Atrial fibrillation and flutter (time-to-event) atrial fibrillation,
atrial flutter		 2,142
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001339/ScoringFiles/PGS001339.txt.gz
PGS001841
(portability-PLR_427.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Atrial fibrillation and flutter atrial fibrillation,
atrial flutter		 3,980
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001841/ScoringFiles/PGS001841.txt.gz
PGS002050
(portability-ldpred2_427.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Atrial fibrillation and flutter atrial fibrillation,
atrial flutter		 554,908
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002050/ScoringFiles/PGS002050.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008820 PGS001263
(GBE_HC440)
 PSS004501|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial flutter — AUROC: 0.76033 [0.71757, 0.80309] R²: 0.10534
Incremental AUROC (full-covars): 0.00055
PGS R2 (no covariates): 0.00351
PGS AUROC (no covariates): 0.54665 [0.4962, 0.5971]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008821 PGS001263
(GBE_HC440)
 PSS004502|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial flutter — AUROC: 0.82631 [0.7516, 0.90103] R²: 0.15678
Incremental AUROC (full-covars): 0.02031
PGS R2 (no covariates): 0.01354
PGS AUROC (no covariates): 0.59968 [0.4662, 0.73316]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008822 PGS001263
(GBE_HC440)
 PSS004503|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial flutter — AUROC: 0.78179 [0.76842, 0.79516] R²: 0.1422
Incremental AUROC (full-covars): 0.02171
PGS R2 (no covariates): 0.02517
PGS AUROC (no covariates): 0.61716 [0.59934, 0.63498]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008823 PGS001263
(GBE_HC440)
 PSS004504|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial flutter — AUROC: 0.73743 [0.69955, 0.77531] R²: 0.09462
Incremental AUROC (full-covars): -0.00059
PGS R2 (no covariates): 0.00793
PGS AUROC (no covariates): 0.57035 [0.52788, 0.61283]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008824 PGS001263
(GBE_HC440)
 PSS004505|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Atrial flutter — AUROC: 0.76368 [0.75572, 0.77165] R²: 0.12819
Incremental AUROC (full-covars): 0.02207
PGS R2 (no covariates): 0.02215
PGS AUROC (no covariates): 0.60821 [0.59797, 0.61845]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009181 PGS001339
(GBE_HC964)
 PSS004746|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.75135 [0.70951, 0.7932] R²: 0.09804
Incremental AUROC (full-covars): -0.00345
PGS R2 (no covariates): 0.00273
PGS AUROC (no covariates): 0.53955 [0.48964, 0.58946]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009182 PGS001339
(GBE_HC964)
 PSS004747|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.8247 [0.75141, 0.898] R²: 0.15451
Incremental AUROC (full-covars): 0.0187
PGS R2 (no covariates): 0.01158
PGS AUROC (no covariates): 0.59663 [0.46689, 0.72636]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009183 PGS001339
(GBE_HC964)
 PSS004748|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.77656 [0.76352, 0.7896] R²: 0.14023
Incremental AUROC (full-covars): 0.02188
PGS R2 (no covariates): 0.02447
PGS AUROC (no covariates): 0.613 [0.59591, 0.6301]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009184 PGS001339
(GBE_HC964)
 PSS004749|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.73999 [0.70422, 0.77576] R²: 0.09669
Incremental AUROC (full-covars): -0.00357
PGS R2 (no covariates): 0.00629
PGS AUROC (no covariates): 0.56035 [0.51988, 0.60082]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009185 PGS001339
(GBE_HC964)
 PSS004750|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE atrial fibrillation and flutter — AUROC: 0.76362 [0.75604, 0.7712] R²: 0.133
Incremental AUROC (full-covars): 0.02354
PGS R2 (no covariates): 0.0246
PGS AUROC (no covariates): 0.6108 [0.60113, 0.62048]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009619 PGS001841
(portability-PLR_427.2)
 PSS009087|
European Ancestry|
3,980 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0701 [0.039, 0.101] sex, age, birth date, deprivation index, 16 PCs —
PPM009620 PGS001841
(portability-PLR_427.2)
 PSS008641|
European Ancestry|
6,397 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0741 [0.0496, 0.0984] sex, age, birth date, deprivation index, 16 PCs —
PPM009621 PGS001841
(portability-PLR_427.2)
 PSS008415|
Greater Middle Eastern Ancestry|
1,151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.091 [0.0329, 0.1485] sex, age, birth date, deprivation index, 16 PCs —
PPM009622 PGS001841
(portability-PLR_427.2)
 PSS008195|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0436 [0.0182, 0.0688] sex, age, birth date, deprivation index, 16 PCs —
PPM009623 PGS001841
(portability-PLR_427.2)
 PSS007977|
East Asian Ancestry|
1,768 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0317 [-0.0153, 0.0784] sex, age, birth date, deprivation index, 16 PCs —
PPM009624 PGS001841
(portability-PLR_427.2)
 PSS007760|
African Ancestry|
2,381 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0464 [0.0061, 0.0866] sex, age, birth date, deprivation index, 16 PCs —
PPM009625 PGS001841
(portability-PLR_427.2)
 PSS008864|
African Ancestry|
3,769 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0414 [0.0094, 0.0733] sex, age, birth date, deprivation index, 16 PCs —
PPM009618 PGS001841
(portability-PLR_427.2)
 PSS009313|
European Ancestry|
19,230 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.1026 [0.0885, 0.1165] sex, age, birth date, deprivation index, 16 PCs —
PPM011263 PGS002050
(portability-ldpred2_427.2)
 PSS009087|
European Ancestry|
3,980 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0689 [0.0379, 0.0999] sex, age, birth date, deprivation index, 16 PCs —
PPM011264 PGS002050
(portability-ldpred2_427.2)
 PSS008641|
European Ancestry|
6,397 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0839 [0.0594, 0.1082] sex, age, birth date, deprivation index, 16 PCs —
PPM011265 PGS002050
(portability-ldpred2_427.2)
 PSS008415|
Greater Middle Eastern Ancestry|
1,151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0983 [0.0402, 0.1557] sex, age, birth date, deprivation index, 16 PCs —
PPM011266 PGS002050
(portability-ldpred2_427.2)
 PSS008195|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.043 [0.0177, 0.0683] sex, age, birth date, deprivation index, 16 PCs —
PPM011267 PGS002050
(portability-ldpred2_427.2)
 PSS007977|
East Asian Ancestry|
1,768 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.041 [-0.0059, 0.0877] sex, age, birth date, deprivation index, 16 PCs —
PPM011268 PGS002050
(portability-ldpred2_427.2)
 PSS007760|
African Ancestry|
2,381 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0475 [0.0072, 0.0877] sex, age, birth date, deprivation index, 16 PCs —
PPM011269 PGS002050
(portability-ldpred2_427.2)
 PSS008864|
African Ancestry|
3,769 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.0418 [0.0098, 0.0737] sex, age, birth date, deprivation index, 16 PCs —
PPM011262 PGS002050
(portability-ldpred2_427.2)
 PSS009313|
European Ancestry|
19,230 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Atrial fibrillation and flutter — — Partial Correlation (partial-r): 0.1034 [0.0894, 0.1174] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008641 — — 6,397 individuals — European Italy (South Europe) UKB —
PSS008864 — — 3,769 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009087 — — 3,980 individuals — European Poland (NE Europe) UKB —
PSS007977 — — 1,768 individuals — East Asian China (East Asia) UKB —
PSS007760 — — 2,381 individuals — African American or Afro-Caribbean Carribean UKB —
PSS004746 — —
[
  • 136 cases
  • , 6,361 controls
]
 — African unspecified — UKB —
PSS004747 — —
[
  • 24 cases
  • , 1,680 controls
]
 — East Asian — UKB —
PSS004748 — —
[
  • 1,090 cases
  • , 23,815 controls
]
 — European non-white British ancestry UKB —
PSS004749 — —
[
  • 200 cases
  • , 7,631 controls
]
 — South Asian — UKB —
PSS004750 — —
[
  • 3,483 cases
  • , 63,942 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008415 — — 1,151 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009313 — — 19,230 individuals — European UK (+ Ireland) UKB —
PSS004501 — —
[
  • 128 cases
  • , 6,369 controls
]
 — African unspecified — UKB —
PSS004502 — —
[
  • 24 cases
  • , 1,680 controls
]
 — East Asian — UKB —
PSS004503 — —
[
  • 983 cases
  • , 23,922 controls
]
 — European non-white British ancestry UKB —
PSS004504 — —
[
  • 186 cases
  • , 7,645 controls
]
 — South Asian — UKB —
PSS004505 — —
[
  • 3,114 cases
  • , 64,311 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008195 — — 6,001 individuals — South Asian India (South Asia) UKB —