Polygenic Score (PGS) ID: PGS003461

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name GRS162_AF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 162
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000454
Citation (link to publication) Yang L et al. NPJ Digit Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017265 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 2.54 [2.26, 2.85] — —
PPM017267 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics delayed acrophase HR: 2.69 [2.18, 3.33] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017268 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low Pseudo-F HR: 2.55 [2.04, 3.18] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017269 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low mesor HR: 3.67 [2.97, 4.54] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017266 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low amplitude HR: 3.87 [3.07, 4.87] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010183 Incident AF was defined as International Classification of Diseases (ICD) edition 10 (codes I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9) and operative procedures (codes K62.1, K62.2, K62.3, K62.4) Median = 6.16 years 62,927 individuals,
43.87 % Male samples
 Mean = 62.48 years European — UKB —