| Predicted Trait | |
| Reported Trait | Atrial fibrillation |
| Mapped Trait(s) | atrial fibrillation (EFO_0000275) |
| Score Construction | |
| PGS Name | GRS162_AF |
| Development Method | |
| Name | Genome-wide significant SNPs |
| Parameters | NR |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 162 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000454 |
| Citation (link to publication) | Yang L et al. NPJ Digit Med (2023) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 1,030,836 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST006414 Europe PMC: 30061737 | 1,030,836 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM017265 | PSS010183| European Ancestry| 62,927 individuals | PGP000454 | Yang L et al. NPJ Digit Med (2023) | Reported Trait: Incident atrial fibrillation | — | — | Hazard ratio (HR, high vs low tertile): 2.54 [2.26, 2.85] | — | — |
| PPM017266 | PSS010183| European Ancestry| 62,927 individuals | PGP000454 | Yang L et al. NPJ Digit Med (2023) | Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low amplitude | HR: 3.87 [3.07, 4.87] | — | — | Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre,... education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep durationShow more | — |
| PPM017267 | PSS010183| European Ancestry| 62,927 individuals | PGP000454 | Yang L et al. NPJ Digit Med (2023) | Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics delayed acrophase | HR: 2.69 [2.18, 3.33] | — | — | Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre,... education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep durationShow more | — |
| PPM017268 | PSS010183| European Ancestry| 62,927 individuals | PGP000454 | Yang L et al. NPJ Digit Med (2023) | Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low Pseudo-F | HR: 2.55 [2.04, 3.18] | — | — | Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre,... education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep durationShow more | — |
| PPM017269 | PSS010183| European Ancestry| 62,927 individuals | PGP000454 | Yang L et al. NPJ Digit Med (2023) | Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low mesor | HR: 3.67 [2.97, 4.54] | — | — | Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre,... education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep durationShow more | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS010183 | Incident AF was defined as International Classification of Diseases (ICD) edition 10 (codes I48, I48... .0, I48.1, I48.2, I48.3, I48.4, I48.9) and operative procedures (codes K62.1, K62.2, K62.3, K62.4)Show more | Median = 6.16 years | 62,927 individuals, 43.87 % Male samples | Mean = 62.48 years | European | — | UKB | — |