PGS Publication: PGP000454

Publication Information (EuropePMC)
Title Association of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation.
PubMed ID 36869222(Europe PMC)
doi 10.1038/s41746-023-00781-3
Publication Date March 4, 2023
Journal NPJ Digit Med
Author(s) Yang L, Feng H, Ai S, Liu Y, Lei B, Chen J, Tan X, Benedict C, Wang N, Wing YK, Qi L, Zhang J.
Released in PGS Catalog: March 24, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003461
(GRS162_AF)
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Atrial fibrillation atrial fibrillation 162
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003461/ScoringFiles/PGS003461.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017265 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 2.54 [2.26, 2.85] — —
PPM017267 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics delayed acrophase HR: 2.69 [2.18, 3.33] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017268 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low Pseudo-F HR: 2.55 [2.04, 3.18] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017269 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low mesor HR: 3.67 [2.97, 4.54] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —
PPM017266 PGS003461
(GRS162_AF)
 PSS010183|
European Ancestry|
62,927 individuals
 PGP000454 |
Yang L et al. NPJ Digit Med (2023)
 Reported Trait: Incident atrial fibrillation with circadian rest-activity characteristics low amplitude HR: 3.87 [3.07, 4.87] — — Age, sex, first 10 principal components of ancestry, Townsend deprivation index, recruitment centre, education level, season of accelerometer wear, BMI categories, healthy diet score, smoking status, alcohol intake, coffee consumption, tea consumption, hypertension, diabetes, dyslipidemia, sleep efficiency, sleep duration —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010183 Incident AF was defined as International Classification of Diseases (ICD) edition 10 (codes I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9) and operative procedures (codes K62.1, K62.2, K62.3, K62.4) Median = 6.16 years 62,927 individuals,
43.87 % Male samples
 Mean = 62.48 years European — UKB —