| Publication Information (EuropePMC) | |
| Title | Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. |
| PubMed ID | 40050429(Europe PMC) |
| doi | 10.1038/s41588-024-02072-3 |
| Publication Date | March 6, 2025 |
| Journal | Nat Genet |
| Author(s) | Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M, Nafissi NA, Natale A, Nazarian S, Ostrowski SR, Pak HN, Pang S, Pedersen OB, Pedersen NL, Pereira AC, Pirruccello JP, Preuss M, Psaty BM, Pullinger CR, Rader DJ, Rämö JT, Ridker PM, Rienstra M, Risch L, Roden DM, Rotter JI, Sabatine MS, Schunkert H, Shah SH, Shim J, Shoemaker MB, Simonson B, Sinner MF, Smit RAJ, Smith JA, Smith NL, Smith JG, Soliman EZ, Sørensen E, Sotoodehnia N, Strbian D, Stricker BH, Teder-Laving M, Sun YV, Thériault S, Thorolfsdottir RB, Thorsteinsdottir U, Tveit A, van der Harst P, van Meurs J, Wang B, Weiss S, Wells QS, Weng LC, Wilson PW, Xiao L, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Zhao W, Zhou X, Zöllner S, BioBank Japan Project, Regeneron Genetics Center, DBDS Genomic Consortium, Ruff CT, Bundgaard H, Willer C, Stefansson K, Ellinor PT. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS005168 (PRSAF) |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Atrial fibrillation | atrial fibrillation | 382,963 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005168/ScoringFiles/PGS005168.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM022406 | PGS005168 (PRSAF) |
PSS011945| European Ancestry| 52,757 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Atrial fibrillation | HR: 1.6663 β: 0.5106 (0.0206) |
C-index: 0.8718 [0.8657, 0.878] | — | age, age^2, sex, geno_array, CHARGE-AF | — |
| PPM022407 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Atrial fibrillation | HR: 1.6005 β: 0.4703 (0.0096) |
C-index: 0.7895 [0.7855, 0.7936] | — | age, age^2, sex, geno_array, CHARGE-AF | — |
| PPM022408 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Heart Failure | β: 0.173 (0.0094) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022409 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Dilated cardiomyopathy | β: 0.2 (0.0349) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022410 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Atrial fibrillation or flutter | β: 0.5568 (0.0068) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022411 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Supraventricular arrhythmia | β: 0.3159 (0.0152) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022412 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Ventricular arrhythmia | β: 0.112 (0.015) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022413 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Ventricular arrhythmia Sudden cardiac death | β: 0.0748 (0.0214) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022414 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Bradyarrhythmia | β: 0.0937 (0.0084) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022415 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Bradyarrhythmia AV block or distal conduction disease | β: 0.0628 (0.0099) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022416 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Bradyarrhythmia Pacemaker | β: 0.1296 (0.0116) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022417 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Aortic valve disease | β: 0.0619 (0.0123) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022418 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Mitral valve disease | β: 0.1804 (0.0113) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022419 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Tricuspid valve disease | β: 0.2134 (0.0155) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022420 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Peripheral vascular disease | β: 0.0608 (0.0122) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022421 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Venous thromboembolism | β: 0.0395 (0.008) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022422 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Ischemic stroke | β: 0.1436 (0.0147) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022423 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Stroke | β: 0.0901 (0.0101) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022424 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Coronary Artery Disease | β: 0.0373 (0.0069) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022425 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Myocardial Infarction | β: 0.0449 (0.0083) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022427 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Hypertension | β: 0.0474 (0.0035) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022428 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Diabetes Type 2 | β: 0.0278 (0.0062) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022429 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Hyperthyroidism | β: 0.0746 (0.0137) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022430 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Hypothyroidism | β: 0.0341 (0.0063) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022431 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Gout | β: 0.0457 (0.0103) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022432 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Asthma | β: 0.0172 (0.0046) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022433 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Diverticular disease | β: 0.0286 (0.0051) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022434 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Chronic kidney disease | β: 0.0701 (0.009) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022435 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Osteoarthritis | β: 0.02 (0.004) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022436 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Sleep apnea | β: 0.0579 (0.0116) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022437 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Pneumonia | β: 0.0447 (0.0067) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022438 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Height | β: 0.2656 (0.0101) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022440 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Body mass index | β: 0.0928 (0.0076) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022426 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Hypercholesterolemia | β: 0.0302 (0.0041) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022439 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Weight | β: 0.5037 (0.0225) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022441 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Diastolic blood pressure | β: 0.0823 (0.016) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022442 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: High density lipoprotein | β: -0.0041 (0.0006) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022443 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Low density lipoprotein | β: -0.0103 (0.0014) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022444 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Triglycerides | β: -0.0064 (0.0016) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022445 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: P-wave duration | β: -0.4988 (0.0918) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022446 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: QRS-duration | β: -0.3295 (0.0736) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022447 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Left ventricular end-diastolic volume | β: 0.5077 (0.1366) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022448 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Left ventricular end-systolic volume | β: 0.4055 (0.0814) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022449 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Left ventricular ejection fraction | β: -0.0016 (0.0003) | — | — | age, sex, genotyping array, PCs 1-5 | — |
| PPM022450 | PGS005168 (PRSAF) |
PSS011946| European Ancestry| 246,683 individuals |
PGP000712 | Roselli C et al. Nat Genet (2025) |
Reported Trait: Descending Aorta Diameter | β: 0.0046 (0.001) | — | — | age, sex, genotyping array, PCs 1-5 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011945 | — | — | [
|
— | European | — | HUNT | — |
| PSS011946 | — | — | [
|
— | European | — | UKB | — |