PGS Catalog - PGS005168 / Atrial fibrillation (Polygenic Score)

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
Europe PMC: 40050429	11,138 individuals [ 1,782 cases , 9,356 controls ]	African American or Afro-Caribbean	6 cohorts ARIC ,BioMe ,Broad CVDi ,CHS ,ENGAGE_AF-TIMI_48 ,MESA
Europe PMC: 40050429	148,865 individuals [ 11,350 cases , 137,515 controls ]	East Asian	BBJ, ENGAGE_AF-TIMI_48, MESA
Europe PMC: 40050429	9,439 individuals [ 1,774 cases , 7,665 controls ]	Hispanic or Latin American	BioMe, Broad CVDi, ENGAGE_AF-TIMI_48, MESA, SPHFC
Europe PMC: 40050429	631 individuals [ 218 cases , 413 controls ]	South Asian	ENGAGE_AF-TIMI_48
Europe PMC: 40050429	700,518 individuals [ 115,154 cases , 576,364 controls ]	European	33 cohorts AGES ,ARIC ,BioMe ,Broad CVDi ,CCAF ,CHB ,CHS ,EGCUT ,ENGAGE_AF-TIMI_48 ,FHS ,FinnGen ,GAPP ,GS:SFHS ,HRS ,LURIC ,MESA ,MGI ,MyCode ,Other ,PHB ,PIVUS ,PREVEND ,PROSPER ,RS ,SHIP ,SOLID-TIMI_52 ,SiGN ,TwinGene ,ULSAM ,Vanderbilt ,WGHS ,WTCCC ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM022406	PSS011945\| European Ancestry\| 52,757 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Atrial fibrillation	HR: 1.6663 β: 0.5106 (0.0206)	C-index: 0.8718 [0.8657, 0.878]	—	age, age^2, sex, geno_array, CHARGE-AF	—
PPM022407	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Atrial fibrillation	HR: 1.6005 β: 0.4703 (0.0096)	C-index: 0.7895 [0.7855, 0.7936]	—	age, age^2, sex, geno_array, CHARGE-AF	—
PPM022408	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Heart Failure	β: 0.173 (0.0094)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022409	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Dilated cardiomyopathy	β: 0.2 (0.0349)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022410	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Atrial fibrillation or flutter	β: 0.5568 (0.0068)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022411	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Supraventricular arrhythmia	β: 0.3159 (0.0152)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022412	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Ventricular arrhythmia	β: 0.112 (0.015)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022413	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Ventricular arrhythmia Sudden cardiac death	β: 0.0748 (0.0214)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022414	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Bradyarrhythmia	β: 0.0937 (0.0084)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022415	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Bradyarrhythmia AV block or distal conduction disease	β: 0.0628 (0.0099)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022416	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Bradyarrhythmia Pacemaker	β: 0.1296 (0.0116)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022417	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Aortic valve disease	β: 0.0619 (0.0123)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022418	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Mitral valve disease	β: 0.1804 (0.0113)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022419	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Tricuspid valve disease	β: 0.2134 (0.0155)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022420	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Peripheral vascular disease	β: 0.0608 (0.0122)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022421	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Venous thromboembolism	β: 0.0395 (0.008)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022422	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Ischemic stroke	β: 0.1436 (0.0147)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022423	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Stroke	β: 0.0901 (0.0101)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022424	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Coronary Artery Disease	β: 0.0373 (0.0069)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022425	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Myocardial Infarction	β: 0.0449 (0.0083)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022427	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Hypertension	β: 0.0474 (0.0035)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022428	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Diabetes Type 2	β: 0.0278 (0.0062)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022429	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Hyperthyroidism	β: 0.0746 (0.0137)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022430	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Hypothyroidism	β: 0.0341 (0.0063)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022431	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Gout	β: 0.0457 (0.0103)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022432	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Asthma	β: 0.0172 (0.0046)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022433	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Diverticular disease	β: 0.0286 (0.0051)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022434	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Chronic kidney disease	β: 0.0701 (0.009)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022435	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Osteoarthritis	β: 0.02 (0.004)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022436	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Sleep apnea	β: 0.0579 (0.0116)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022437	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Pneumonia	β: 0.0447 (0.0067)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022438	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Height	β: 0.2656 (0.0101)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022440	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Body mass index	β: 0.0928 (0.0076)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022426	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Hypercholesterolemia	β: 0.0302 (0.0041)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022439	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Weight	β: 0.5037 (0.0225)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022441	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Diastolic blood pressure	β: 0.0823 (0.016)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022442	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: High density lipoprotein	β: -0.0041 (0.0006)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022443	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Low density lipoprotein	β: -0.0103 (0.0014)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022444	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Triglycerides	β: -0.0064 (0.0016)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022445	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: P-wave duration	β: -0.4988 (0.0918)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022446	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: QRS-duration	β: -0.3295 (0.0736)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022447	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Left ventricular end-diastolic volume	β: 0.5077 (0.1366)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022448	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Left ventricular end-systolic volume	β: 0.4055 (0.0814)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022449	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Left ventricular ejection fraction	β: -0.0016 (0.0003)	—	—	age, sex, genotyping array, PCs 1-5	—
PPM022450	PSS011946\| European Ancestry\| 246,683 individuals	PGP000712 \| Roselli C et al. Nat Genet (2025)	Reported Trait: Descending Aorta Diameter	β: 0.0046 (0.001)	—	—	age, sex, genotyping array, PCs 1-5	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS011945	—	—	52,757 individuals [ 2,474 cases , 50,283 controls ]	—	European	—	HUNT	—
PSS011946	—	—	246,683 individuals [ 10,416 cases , 236,267 controls ]	—	European	—	UKB	—

Predicted Trait
Reported Trait	Atrial fibrillation
Mapped Trait(s)	atrial fibrillation (EFO_0000275)

Score Construction
PGS Name	PRSAF
Development Method
Name	PRS-CS
Parameters	LD reference panel = 1000 Genomes Europeans
Variants
Original Genome Build	hg38
Number of Variants	382,963
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000712
Citation (link to publication)	Roselli C et al. Nat Genet (2025)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 80.5% East Asian: 17.1% African: 1.3% Hispanic or Latin American: 1.1% South Asian: 0.07% 870,591 individuals (100%)
PGS Evaluation	European: 100% 2 Sample Sets

Polygenic Score (PGS) ID: PGS005168

Score Details

Development Samples

Source of Variant Associations (GWAS)

Performance Metrics

Evaluated Samples