Polygenic Score (PGS) ID: PGS005171

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: April 17, 2025
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Score Details

Score Construction
PGS Name PRS142_AF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 142
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000719
Citation (link to publication) Dai L et al. Diabetes Metab Syndr (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022493 PSS011973|
Multi-ancestry (including European)|
457,151 individuals
 PGP000719 |
Dai L et al. Diabetes Metab Syndr (2024)
 Reported Trait: Atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 2.56 [2.47, 2.65] age, sex, genotyping array, and the first 10 principal components of ancestry —
PPM022494 PSS011973|
Multi-ancestry (including European)|
457,151 individuals
 PGP000719 |
Dai L et al. Diabetes Metab Syndr (2024)
 Reported Trait: Atrial fibrillation x diabetes status interaction — — Hazard ratio (HR, with diabetes and high PRS vs. without diabetes and low PRS): 3.04 [2.81, 3.28] age at baseline, sex, Townsend deprivation index, assessment centers, smoking status, alcohol consumption frequency, physical activity, BMI, hypertension, dyslipidemia, sleep apnea, genotyping array, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011973 — — 411,749 individuals,
43.8 % Male samples
 Mean = 56.1 years
Sd = 8.1 years		 European — UKB —
PSS011973 — — 45,402 individuals,
43.8 % Male samples
 Mean = 56.1 years
Sd = 8.1 years		 Not reported — UKB —