PGS Publication: PGP000719

Publication Information (EuropePMC)
Title Diabetes status, genetic susceptibility, and incident arrhythmias: A prospective cohort study of 457,151 participants.
PubMed ID 38458077(Europe PMC)
doi 10.1016/j.dsx.2024.102971
Publication Date March 1, 2024
Journal Diabetes Metab Syndr
Author(s) Dai L, Zuo Y, Lv Y, Zeng H, Chen L.
Released in PGS Catalog: April 17, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005171
(PRS142_AF)
 PGP000719 |
Dai L et al. Diabetes Metab Syndr (2024)
 Atrial fibrillation atrial fibrillation 142
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005171/ScoringFiles/PGS005171.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022493 PGS005171
(PRS142_AF)
 PSS011973|
Multi-ancestry (including European)|
457,151 individuals
 PGP000719 |
Dai L et al. Diabetes Metab Syndr (2024)
 Reported Trait: Atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 2.56 [2.47, 2.65] age, sex, genotyping array, and the first 10 principal components of ancestry —
PPM022494 PGS005171
(PRS142_AF)
 PSS011973|
Multi-ancestry (including European)|
457,151 individuals
 PGP000719 |
Dai L et al. Diabetes Metab Syndr (2024)
 Reported Trait: Atrial fibrillation x diabetes status interaction — — Hazard ratio (HR, with diabetes and high PRS vs. without diabetes and low PRS): 3.04 [2.81, 3.28] age at baseline, sex, Townsend deprivation index, assessment centers, smoking status, alcohol consumption frequency, physical activity, BMI, hypertension, dyslipidemia, sleep apnea, genotyping array, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011973 — — 411,749 individuals,
43.8 % Male samples
 Mean = 56.1 years
Sd = 8.1 years		 European — UKB —
PSS011973 — — 45,402 individuals,
43.8 % Male samples
 Mean = 56.1 years
Sd = 8.1 years		 Not reported — UKB —