Polygenic Score (PGS) ID: PGS005159

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: Feb. 26, 2025
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Score Details

Score Construction
PGS Name GRS142_AF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 142
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000709
Citation (link to publication) Frederiksen TC et al. Heart (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022385 PSS011934|
European Ancestry|
3,094 individuals
 PGP000709 |
Frederiksen TC et al. Heart (2024)
 Reported Trait: Atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 4.27 [3.61, 5.06] age, sex, educational level, heart failure, stroke, diabetes mellitus, and myocardial infarction at baseline —
PPM022386 PSS011934|
European Ancestry|
3,094 individuals
 PGP000709 |
Frederiksen TC et al. Heart (2024)
 Reported Trait: Atrial fibrillation x lifestyle status interaction — — Hazard ratio (HR, poor lifestyle and high PRS vs. ideal lifestyle and low PRS): 11.33 [6.15, 20.85] age, sex, educational level, heart failure, stroke, diabetes mellitus, myocardial infarction and for competing risk of death —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011934 — — 3,094 individuals,
64.0 % Male samples
 — European
(Denmark)		 — DCH —