PGS Publication: PGP000709

Publication Information (EuropePMC)
Title Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation.
PubMed ID 38016806(Europe PMC)
doi 10.1136/heartjnl-2023-323333
Publication Date April 15, 2024
Journal Heart
Author(s) Frederiksen TC, Christiansen MK, Benjamin EJ, Overvad K, Olsen A, Andersen MK, Hansen T, Grarup N, Jensen HK, Dahm CC.
Released in PGS Catalog: Feb. 26, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005159
(GRS142_AF)
 PGP000709 |
Frederiksen TC et al. Heart (2024)
 Atrial fibrillation atrial fibrillation 142
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005159/ScoringFiles/PGS005159.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022385 PGS005159
(GRS142_AF)
 PSS011934|
European Ancestry|
3,094 individuals
 PGP000709 |
Frederiksen TC et al. Heart (2024)
 Reported Trait: Atrial fibrillation — — Hazard ratio (HR, high vs low tertile): 4.27 [3.61, 5.06] age, sex, educational level, heart failure, stroke, diabetes mellitus, and myocardial infarction at baseline —
PPM022386 PGS005159
(GRS142_AF)
 PSS011934|
European Ancestry|
3,094 individuals
 PGP000709 |
Frederiksen TC et al. Heart (2024)
 Reported Trait: Atrial fibrillation x lifestyle status interaction — — Hazard ratio (HR, poor lifestyle and high PRS vs. ideal lifestyle and low PRS): 11.33 [6.15, 20.85] age, sex, educational level, heart failure, stroke, diabetes mellitus, myocardial infarction and for competing risk of death —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011934 — — 3,094 individuals,
64.0 % Male samples
 — European
(Denmark)		 — DCH —