Polygenic Score (PGS) ID: PGS004878

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: June 27, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name INTERVENE_MegaPRS_Atrial_fibrillation
Development Method
Name megaprs.auto
Parameters bolt, p=0.02, f2=0.5
Variants
Original Genome Build GRCh37
Number of Variants 785,779
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000618
Citation (link to publication) Jermy B et al. Nat Commun (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 91.4%
East Asian: 6.3%
African: 1.5%
Hispanic or Latin American: 0.9%
588,190 individuals (100%)
Score Development/Training
European: 100%
404 individuals (100%)
PGS Evaluation
European: 100%
7 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006061
Europe PMC: 29892015
 537,409 individuals European NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 36,792 individuals East Asian
(Japanese)		 NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 8,967 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 5,022 individuals Hispanic or Latin American NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 404 individuals European 1000G — — — non-Finnish Europeans —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021204 PSS011542|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.55 [1.48, 1.62] C-index: 0.63 [0.61, 0.64] — PCs 1-10 —
PPM021205 PSS011540|
European Ancestry|
44,186 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.42 [1.29, 1.56] — — PCs 1-10 —
PPM021202 PSS011544|
European Ancestry|
32,089 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.36 [1.32, 1.39] C-index: 0.59 [0.58, 0.6] — PCs 1-10 —
PPM021203 PSS011543|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.68 [1.64, 1.73] C-index: 0.65 [0.64, 0.65] — PCs 1-10 —
PPM021206 PSS011541|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.62 [1.5, 1.75] C-index: 0.66 [0.63, 0.68] — PCs 1-10 —
PPM021207 PSS011539|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.61 [1.6, 1.63] C-index: 0.62 [0.62, 0.62] — PCs 1-10 —
PPM021208 PSS011538|
European Ancestry|
148,312 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.56 [1.52, 1.6] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011538 — —
[
  • 5,454 cases
  • , 142,858 controls
]
 — European — EB —
PSS011539 — —
[
  • 42,166 cases
  • , 369,924 controls
]
 — European — FinnGen —
PSS011540 — —
[
  • 401 cases
  • , 43,785 controls
]
 — European — G&H —
PSS011541 — —
[
  • 656 cases
  • , 6,362 controls
]
 — European — GS:SFHS —
PSS011542 — —
[
  • 1,852 cases
  • , 27,575 controls
]
 — European — GEL —
PSS011543 — —
[
  • 4,962 cases
  • , 64,753 controls
]
 — European — HUNT —
PSS011544 — —
[
  • 5,982 cases
  • , 26,107 controls
]
 — European — MGBB —