PGS Publication: PGP000618

Publication Information (EuropePMC)
Title A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.
PubMed ID 38866767(Europe PMC)
doi 10.1038/s41467-024-48938-2
Publication Date June 12, 2024
Journal Nat Commun
Author(s) Jermy B, Läll K, Wolford BN, Wang Y, Zguro K, Cheng Y, Kanai M, Kanoni S, Yang Z, Hartonen T, Monti R, Wanner J, Youssef O, Estonian Biobank research team, FinnGen, Lippert C, van Heel D, Okada Y, McCartney DL, Hayward C, Marioni RE, Furini S, Renieri A, Martin AR, Neale BM, Hveem K, Mägi R, Palotie A, Heyne H, Mars N, Ganna A, Ripatti S.
Released in PGS Catalog: June 27, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Hip osteoarthritis osteoarthritis, hip 773,587
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004882/ScoringFiles/PGS004882.txt.gz
PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Lung cancer lung carcinoma 655,479
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004884/ScoringFiles/PGS004884.txt.gz
PGS004877
(INTERVENE_MegaPRS_Asthma)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Asthma asthma 870,454
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004877/ScoringFiles/PGS004877.txt.gz
PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Breast cancer breast carcinoma 872,060
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004869/ScoringFiles/PGS004869.txt.gz
PGS004870
(INTERVENE_MegaPRS_T2D)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 930,506
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004870/ScoringFiles/PGS004870.txt.gz
PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Prostate cancer prostate carcinoma 765,876
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004872/ScoringFiles/PGS004872.txt.gz
PGS004874
(INTERVENE_MegaPRS_T1D)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Type 1 diabetes (T1D) type 1 diabetes mellitus 56,916
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004874/ScoringFiles/PGS004874.txt.gz
PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 All Cancers cancer 818,872
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004875/ScoringFiles/PGS004875.txt.gz
PGS004879
(INTERVENE_MegaPRS_CHD)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Coronary heart disease coronary artery disease 610,677
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004879/ScoringFiles/PGS004879.txt.gz
PGS004885
(INTERVENE_MegaPRS_MDD)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Major depressive disorder major depressive disorder 801,544
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004885/ScoringFiles/PGS004885.txt.gz
PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Knee osteoarthritis osteoarthritis, knee 952,133
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004883/ScoringFiles/PGS004883.txt.gz
PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Colorectal cancer colorectal carcinoma 843,248
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004880/ScoringFiles/PGS004880.txt.gz
PGS004871
(INTERVENE_MegaPRS_Gout)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Gout gout 762,621
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004871/ScoringFiles/PGS004871.txt.gz
PGS004873
(INTERVENE_MegaPRS_RA)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Rheumatoid arthritis rheumatoid arthritis 551,074
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004873/ScoringFiles/PGS004873.txt.gz
PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Appendicitis appendicitis 601,835
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004876/ScoringFiles/PGS004876.txt.gz
PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Atrial fibrillation atrial fibrillation 785,779
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004878/ScoringFiles/PGS004878.txt.gz
PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Epilepsy epilepsy 605,432
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004881/ScoringFiles/PGS004881.txt.gz
PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Melanoma melanoma 692,834
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004886/ScoringFiles/PGS004886.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021179 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011637|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 2.37 [2.31, 2.44] C-index: 0.77 [0.77, 0.78] — PCs 1-10 —
PPM021204 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011542|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.55 [1.48, 1.62] C-index: 0.63 [0.61, 0.64] — PCs 1-10 —
PPM021205 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011540|
European Ancestry|
44,186 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.42 [1.29, 1.56] — — PCs 1-10 —
PPM021136 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011557|
European Ancestry|
36,886 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.63 [1.55, 1.71] C-index: 0.63 [0.61, 0.64] — PCs 1-10 —
PPM021137 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011556|
European Ancestry|
17,370 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.48 [1.43, 1.54] C-index: 0.63 [0.62, 0.65] — PCs 1-10 —
PPM021138 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011554|
European Ancestry|
24,387 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.63 [1.42, 1.88] — — PCs 1-10 —
PPM021139 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011555|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.42 [1.3, 1.55] C-index: 0.61 [0.59, 0.64] — PCs 1-10 —
PPM021140 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011553|
European Ancestry|
230,276 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.61 [1.59, 1.64] C-index: 0.64 [0.63, 0.64] — PCs 1-10 —
PPM021141 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011552|
European Ancestry|
130,985 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.59 [1.53, 1.65] C-index: 0.63 [0.62, 0.64] — PCs 1-10 —
PPM021142 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011650|
European Ancestry|
38,343 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.42 [1.38, 1.45] C-index: 0.61 [0.6, 0.62] — PCs 1-10 —
PPM021143 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011649|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.86 [1.79, 1.93] C-index: 0.69 [0.68, 0.7] — PCs 1-10 —
PPM021144 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011648|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.87 [1.79, 1.95] C-index: 0.68 [0.67, 0.69] — PCs 1-10 —
PPM021145 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011646|
European Ancestry|
44,183 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.56 [1.51, 1.6] — — PCs 1-10 —
PPM021146 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011647|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.68 [1.55, 1.83] C-index: 0.64 [0.62, 0.67] — PCs 1-10 —
PPM021147 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011645|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.7 [1.69, 1.71] C-index: 0.66 [0.66, 0.66] — PCs 1-10 —
PPM021148 PGS004870
(INTERVENE_MegaPRS_T2D)
 PSS011644|
European Ancestry|
148,312 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T2D HR: 1.78 [1.74, 1.82] C-index: 0.67 [0.66, 0.67] — PCs 1-10 —
PPM021149 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011667|
European Ancestry|
447,332 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.87 [1.83, 1.91] — — PCs 1-10 —
PPM021150 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011666|
European Ancestry|
31,218 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.54 [1.48, 1.6] C-index: 0.63 [0.61, 0.64] — PCs 1-10 —
PPM021151 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011586|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.74 [1.63, 1.86] C-index: 0.66 [0.64, 0.68] — PCs 1-10 —
PPM021153 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011583|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 2.0 [1.77, 2.26] — — PCs 1-10 —
PPM021154 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011584|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.23 [0.98, 1.55] C-index: 0.64 [0.57, 0.71] — PCs 1-10 —
PPM021155 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011582|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.62 [1.58, 1.66] C-index: 0.64 [0.64, 0.65] — PCs 1-10 —
PPM021156 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011581|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.55 [1.52, 1.58] C-index: 0.63 [0.62, 0.64] — PCs 1-10 —
PPM021157 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011627|
European Ancestry|
204,761 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.96 [1.92, 1.99] — — PCs 1-10 —
PPM021158 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011626|
European Ancestry|
17,270 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.66 [1.59, 1.73] C-index: 0.65 [0.64, 0.66] — PCs 1-10 —
PPM021159 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011625|
European Ancestry|
32,747 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.85 [1.77, 1.93] C-index: 0.67 [0.65, 0.68] — PCs 1-10 —
PPM021160 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011624|
European Ancestry|
12,058 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.86 [1.74, 2.0] C-index: 0.68 [0.66, 0.7] — PCs 1-10 —
PPM021161 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011622|
European Ancestry|
19,798 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 2.12 [1.69, 2.66] — — PCs 1-10 —
PPM021163 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011621|
European Ancestry|
181,814 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.98 [1.94, 2.01] C-index: 0.69 [0.69, 0.7] — PCs 1-10 —
PPM021164 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011620|
European Ancestry|
68,883 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.79 [1.72, 1.87] C-index: 0.67 [0.65, 0.68] — PCs 1-10 —
PPM021165 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011635|
European Ancestry|
447,332 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 1.87 [1.76, 1.99] — — PCs 1-10 —
PPM021166 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011634|
European Ancestry|
37,986 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 2.16 [1.96, 2.37] C-index: 0.71 [0.68, 0.74] — PCs 1-10 —
PPM021167 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011633|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 1.59 [1.49, 1.68] C-index: 0.64 [0.62, 0.66] — PCs 1-10 —
PPM021168 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011632|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 2.27 [1.81, 2.84] C-index: 0.73 [0.66, 0.8] — PCs 1-10 —
PPM021169 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011630|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 2.13 [1.65, 2.75] — — PCs 1-10 —
PPM021170 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011631|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 1.83 [1.14, 2.93] C-index: 0.85 [0.77, 0.92] — PCs 1-10 —
PPM021171 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011629|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 1.65 [1.62, 1.69] C-index: 0.65 [0.65, 0.66] — PCs 1-10 —
PPM021173 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011643|
European Ancestry|
447,332 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 2.11 [1.98, 2.24] — — PCs 1-10 —
PPM021174 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011642|
European Ancestry|
32,779 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 1.41 [1.17, 1.69] C-index: 0.69 [0.64, 0.74] — PCs 1-10 —
PPM021175 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011641|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 1.43 [1.28, 1.59] C-index: 0.64 [0.61, 0.67] — PCs 1-10 —
PPM021176 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011640|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 2.09 [1.91, 2.29] C-index: 0.75 [0.72, 0.78] — PCs 1-10 —
PPM021181 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011657|
European Ancestry|
38,448 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 0.9 [0.89, 0.91] C-index: 0.53 [0.53, 0.54] — PCs 1-10 —
PPM021182 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011656|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 1.13 [1.11, 1.15] C-index: 0.54 [0.53, 0.54] — PCs 1-10 —
PPM021183 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011655|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 1.06 [1.04, 1.08] C-index: 0.54 [0.53, 0.55] — PCs 1-10 —
PPM021184 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011653|
European Ancestry|
44,177 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 1.15 [1.08, 1.23] — — PCs 1-10 —
PPM021185 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011654|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 1.1 [1.05, 1.14] C-index: 0.55 [0.53, 0.56] — PCs 1-10 —
PPM021187 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011651|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 1.15 [1.13, 1.16] C-index: 0.54 [0.53, 0.55] — PCs 1-10 —
PPM021188 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011551|
European Ancestry|
38,191 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.04 [0.96, 1.14] C-index: 0.58 [0.55, 0.61] — PCs 1-10 —
PPM021189 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011550|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.07 [1.02, 1.12] C-index: 0.54 [0.53, 0.56] — PCs 1-10 —
PPM021190 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011549|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.1 [1.01, 1.19] C-index: 0.56 [0.53, 0.58] — PCs 1-10 —
PPM021191 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011547|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.06 [0.97, 1.16] — — PCs 1-10 —
PPM021192 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011548|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.1 [1.01, 1.2] C-index: 0.57 [0.54, 0.59] — PCs 1-10 —
PPM021193 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011546|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.07 [1.06, 1.08] C-index: 0.53 [0.52, 0.53] — PCs 1-10 —
PPM021194 PGS004876
(INTERVENE_MegaPRS_Appendicitis)
 PSS011545|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Appendicitis HR: 1.05 [1.03, 1.07] C-index: 0.54 [0.53, 0.54] — PCs 1-10 —
PPM021195 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011664|
European Ancestry|
33,589 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.27 [1.24, 1.3] C-index: 0.57 [0.57, 0.58] — PCs 1-10 —
PPM021196 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011663|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.48 [1.43, 1.52] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021197 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011662|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.47 [1.43, 1.52] C-index: 0.61 [0.6, 0.62] — PCs 1-10 —
PPM021198 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011660|
European Ancestry|
44,187 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.39 [1.35, 1.43] — — PCs 1-10 —
PPM021200 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011659|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.42 [1.41, 1.44] C-index: 0.61 [0.61, 0.62] — PCs 1-10 —
PPM021201 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011658|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.35 [1.33, 1.37] C-index: 0.6 [0.6, 0.6] — PCs 1-10 —
PPM021202 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011544|
European Ancestry|
32,089 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.36 [1.32, 1.39] C-index: 0.59 [0.58, 0.6] — PCs 1-10 —
PPM021203 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011543|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.68 [1.64, 1.73] C-index: 0.65 [0.64, 0.65] — PCs 1-10 —
PPM021206 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011541|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.62 [1.5, 1.75] C-index: 0.66 [0.63, 0.68] — PCs 1-10 —
PPM021207 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011539|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.61 [1.6, 1.63] C-index: 0.62 [0.62, 0.62] — PCs 1-10 —
PPM021209 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011573|
European Ancestry|
38,448 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.18 [1.16, 1.2] C-index: 0.55 [0.55, 0.56] — PCs 1-10 —
PPM021210 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011572|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.39 [1.36, 1.42] C-index: 0.6 [0.59, 0.6] — PCs 1-10 —
PPM021211 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011571|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.32 [1.27, 1.38] C-index: 0.6 [0.58, 0.61] — PCs 1-10 —
PPM021212 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011569|
European Ancestry|
44,168 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.27 [1.23, 1.32] — — PCs 1-10 —
PPM021213 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011570|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.13 [1.07, 1.19] C-index: 0.56 [0.54, 0.57] — PCs 1-10 —
PPM021214 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011568|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.41 [1.4, 1.43] C-index: 0.62 [0.62, 0.62] — PCs 1-10 —
PPM021215 PGS004879
(INTERVENE_MegaPRS_CHD)
 PSS011567|
European Ancestry|
148,312 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident CHD HR: 1.18 [1.16, 1.21] C-index: 0.58 [0.57, 0.58] — PCs 1-10 —
PPM021216 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011566|
European Ancestry|
38,448 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.28 [1.21, 1.35] C-index: 0.57 [0.56, 0.59] — PCs 1-10 —
PPM021217 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011565|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.34 [1.27, 1.41] C-index: 0.58 [0.57, 0.6] — PCs 1-10 —
PPM021218 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011564|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.44 [1.38, 1.5] C-index: 0.6 [0.59, 0.62] — PCs 1-10 —
PPM021220 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011563|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.59 [1.41, 1.79] C-index: 0.64 [0.61, 0.68] — PCs 1-10 —
PPM021221 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011561|
European Ancestry|
407,920 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.54 [1.5, 1.58] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021222 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011560|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.44 [1.37, 1.51] C-index: 0.61 [0.59, 0.63] — PCs 1-10 —
PPM021223 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011665|
European Ancestry|
447,332 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.12 [1.09, 1.14] — — PCs 1-10 —
PPM021224 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011580|
European Ancestry|
20,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.07 [1.02, 1.11] C-index: 0.54 [0.53, 0.55] — PCs 1-10 —
PPM021225 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011579|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.1 [1.05, 1.16] C-index: 0.55 [0.54, 0.57] — PCs 1-10 —
PPM021226 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011578|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.1 [1.02, 1.19] C-index: 0.54 [0.52, 0.56] — PCs 1-10 —
PPM021227 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011576|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.17 [1.04, 1.32] — — PCs 1-10 —
PPM021228 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011577|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 0.98 [0.86, 1.13] C-index: 0.59 [0.55, 0.63] — PCs 1-10 —
PPM021230 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011574|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.11 [1.08, 1.14] C-index: 0.55 [0.54, 0.56] — PCs 1-10 —
PPM021231 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011593|
European Ancestry|
37,024 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.16 [1.13, 1.2] C-index: 0.55 [0.54, 0.56] — PCs 1-10 —
PPM021232 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011592|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.33 [1.29, 1.37] C-index: 0.58 [0.57, 0.59] — PCs 1-10 —
PPM021233 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011591|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.46 [1.36, 1.56] C-index: 0.6 [0.58, 0.63] — PCs 1-10 —
PPM021234 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011589|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.07 [0.88, 1.31] — — PCs 1-10 —
PPM021235 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011590|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.35 [1.24, 1.48] C-index: 0.6 [0.57, 0.63] — PCs 1-10 —
PPM021236 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011588|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.4 [1.38, 1.42] C-index: 0.6 [0.6, 0.6] — PCs 1-10 —
PPM021238 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011600|
European Ancestry|
37,245 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.19 [1.17, 1.22] C-index: 0.56 [0.55, 0.57] — PCs 1-10 —
PPM021239 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011599|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.32 [1.28, 1.35] C-index: 0.58 [0.57, 0.59] — PCs 1-10 —
PPM021240 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011598|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.37 [1.3, 1.44] C-index: 0.6 [0.58, 0.61] — PCs 1-10 —
PPM021241 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011596|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.17 [1.1, 1.24] — — PCs 1-10 —
PPM021242 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011597|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.28 [1.17, 1.39] C-index: 0.6 [0.57, 0.62] — PCs 1-10 —
PPM021243 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011595|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.32 [1.31, 1.34] C-index: 0.59 [0.58, 0.59] — PCs 1-10 —
PPM021244 PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
 PSS011594|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident knee osteoarthritis HR: 1.17 [1.16, 1.18] C-index: 0.56 [0.56, 0.56] — PCs 1-10 —
PPM021245 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011607|
European Ancestry|
38,448 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.13 [1.07, 1.19] C-index: 0.54 [0.52, 0.56] — PCs 1-10 —
PPM021246 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011606|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.32 [1.24, 1.4] C-index: 0.59 [0.57, 0.61] — PCs 1-10 —
PPM021247 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011605|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.26 [1.2, 1.33] C-index: 0.6 [0.58, 0.62] — PCs 1-10 —
PPM021248 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011603|
European Ancestry|
44,187 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.43 [1.06, 1.93] — — PCs 1-10 —
PPM021249 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011604|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.21 [1.03, 1.41] C-index: 0.62 [0.57, 0.67] — PCs 1-10 —
PPM021250 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011602|
European Ancestry|
277,400 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.24 [1.2, 1.28] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021251 PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
 PSS011601|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident lung cancer HR: 1.08 [1.01, 1.16] C-index: 0.57 [0.54, 0.59] — PCs 1-10 —
PPM021252 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011614|
European Ancestry|
37,136 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.18 [1.16, 1.2] C-index: 0.56 [0.55, 0.56] — PCs 1-10 —
PPM021253 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011613|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.27 [1.23, 1.31] C-index: 0.57 [0.56, 0.58] — PCs 1-10 —
PPM021254 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011612|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.27 [1.23, 1.32] C-index: 0.58 [0.57, 0.59] — PCs 1-10 —
PPM021255 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011610|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.17 [1.12, 1.22] — — PCs 1-10 —
PPM021256 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011611|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.36 [1.21, 1.53] C-index: 0.62 [0.58, 0.65] — PCs 1-10 —
PPM021257 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011609|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.24 [1.23, 1.25] C-index: 0.58 [0.58, 0.58] — PCs 1-10 —
PPM021258 PGS004885
(INTERVENE_MegaPRS_MDD)
 PSS011608|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident MDD HR: 1.15 [1.14, 1.16] C-index: 0.55 [0.55, 0.55] — PCs 1-10 —
PPM021259 PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PSS011668|
European Ancestry|
38,448 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Melanoma HR: 1.18 [1.15, 1.21] C-index: 0.58 [0.57, 0.59] — PCs 1-10 —
PPM021261 PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PSS011618|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Melanoma HR: 1.35 [1.23, 1.49] C-index: 0.58 [0.54, 0.61] — PCs 1-10 —
PPM021262 PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PSS011617|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Melanoma HR: 1.43 [1.14, 1.79] C-index: 0.65 [0.59, 0.72] — PCs 1-10 —
PPM021263 PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PSS011616|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Melanoma HR: 1.37 [1.32, 1.42] C-index: 0.59 [0.58, 0.61] — PCs 1-10 —
PPM021264 PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PSS011615|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Melanoma HR: 1.18 [1.12, 1.24] C-index: 0.55 [0.54, 0.57] — PCs 1-10 —
PPM021186 PGS004875
(INTERVENE_MegaPRS_AllCancers)
 PSS011652|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Cancer HR: 1.17 [1.16, 1.17] C-index: 0.54 [0.54, 0.55] — PCs 1-10 —
PPM021229 PGS004881
(INTERVENE_MegaPRS_Epilepsy)
 PSS011575|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Epilepsy HR: 1.11 [1.09, 1.13] C-index: 0.55 [0.55, 0.56] — PCs 1-10 —
PPM021199 PGS004877
(INTERVENE_MegaPRS_Asthma)
 PSS011661|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.41 [1.32, 1.5] C-index: 0.6 [0.58, 0.62] — PCs 1-10 —
PPM021237 PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
 PSS011587|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.15 [1.13, 1.16] C-index: 0.57 [0.56, 0.57] — PCs 1-10 —
PPM021260 PGS004886
(INTERVENE_MegaPRS_Melanoma)
 PSS011619|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Melanoma HR: 1.32 [1.23, 1.4] C-index: 0.58 [0.56, 0.6] — PCs 1-10 —
PPM021177 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011638|
European Ancestry|
44,187 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 1.05 [0.95, 1.15] — — PCs 1-10 —
PPM021178 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011639|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 1.56 [1.14, 2.12] C-index: 0.73 [0.67, 0.78] — PCs 1-10 —
PPM021134 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011559|
European Ancestry|
242,571 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.67 [1.64, 1.7] — — PCs 1-10 —
PPM021135 PGS004869
(INTERVENE_MegaPRS_breast_cancer)
 PSS011558|
European Ancestry|
21,171 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Breast Cancer HR: 1.55 [1.49, 1.63] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021152 PGS004871
(INTERVENE_MegaPRS_Gout)
 PSS011585|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.92 [1.76, 2.09] C-index: 0.68 [0.66, 0.71] — PCs 1-10 —
PPM021162 PGS004872
(INTERVENE_MegaPRS_Prostate_cancer)
 PSS011623|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Prostate Cancer HR: 1.61 [1.42, 1.83] C-index: 0.66 [0.62, 0.7] — PCs 1-10 —
PPM021172 PGS004873
(INTERVENE_MegaPRS_RA)
 PSS011628|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident RA HR: 1.43 [1.38, 1.49] C-index: 0.61 [0.6, 0.62] — PCs 1-10 —
PPM021180 PGS004874
(INTERVENE_MegaPRS_T1D)
 PSS011636|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident T1D HR: 1.64 [1.5, 1.79] C-index: 0.68 [0.65, 0.7] — PCs 1-10 —
PPM021208 PGS004878
(INTERVENE_MegaPRS_Atrial_fibrillation)
 PSS011538|
European Ancestry|
148,312 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident AF HR: 1.56 [1.52, 1.6] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021219 PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
 PSS011562|
European Ancestry|
44,186 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Colorectal Cancer HR: 1.37 [1.12, 1.68] — — PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011538 — —
[
  • 5,454 cases
  • , 142,858 controls
]
 — European — EB —
PSS011539 — —
[
  • 42,166 cases
  • , 369,924 controls
]
 — European — FinnGen —
PSS011540 — —
[
  • 401 cases
  • , 43,785 controls
]
 — European — G&H —
PSS011541 — —
[
  • 656 cases
  • , 6,362 controls
]
 — European — GS:SFHS —
PSS011542 — —
[
  • 1,852 cases
  • , 27,575 controls
]
 — European — GEL —
PSS011543 — —
[
  • 4,962 cases
  • , 64,753 controls
]
 — European — HUNT —
PSS011544 — —
[
  • 5,982 cases
  • , 26,107 controls
]
 — European — MGBB —
PSS011545 — —
[
  • 13,442 cases
  • , 186,426 controls
]
 — European — EB —
PSS011546 — —
[
  • 31,397 cases
  • , 380,693 controls
]
 — European — FinnGen —
PSS011547 — —
[
  • 453 cases
  • , 43,735 controls
]
 — European — G&H —
PSS011548 — —
[
  • 519 cases
  • , 6,499 controls
]
 — European — GS:SFHS —
PSS011549 — —
[
  • 586 cases
  • , 28,841 controls
]
 — European — GEL —
PSS011550 — —
[
  • 1,768 cases
  • , 67,947 controls
]
 — European — HUNT —
PSS011551 — —
[
  • 527 cases
  • , 37,664 controls
]
 — European — MGBB —
PSS011552 — —
[
  • 2,610 cases
  • , 128,375 controls
]
 — European — EB —
PSS011553 — —
[
  • 18,037 cases
  • , 212,239 controls
]
 — European — FinnGen —
PSS011554 — —
[
  • 195 cases
  • , 24,192 controls
]
 — European — G&H —
PSS011555 — —
[
  • 510 cases
  • , 6,508 controls
]
 — European — GS:SFHS —
PSS011556 — —
[
  • 2,744 cases
  • , 14,626 controls
]
 — European — GEL —
PSS011557 — —
[
  • 1,596 cases
  • , 35,290 controls
]
 — European — HUNT —
PSS011558 — —
[
  • 2,114 cases
  • , 19,057 controls
]
 — European — MGBB —
PSS011559 — —
[
  • 15,232 cases
  • , 227,339 controls
]
 — European — UKB —
PSS011560 — —
[
  • 1,552 cases
  • , 198,316 controls
]
 — European — EB —
PSS011561 — —
[
  • 5,916 cases
  • , 402,004 controls
]
 — European — FinnGen —
PSS011562 — —
[
  • 101 cases
  • , 44,085 controls
]
 — European — G&H —
PSS011563 — —
[
  • 270 cases
  • , 6,748 controls
]
 — European — GS:SFHS —
PSS011564 — —
[
  • 2,390 cases
  • , 27,037 controls
]
 — European — GEL —
PSS011565 — —
[
  • 1,552 cases
  • , 68,163 controls
]
 — European — HUNT —
PSS011566 — —
[
  • 1,599 cases
  • , 36,849 controls
]
 — European — MGBB —
PSS011567 — —
[
  • 8,099 cases
  • , 140,213 controls
]
 — European — EB —
PSS011568 — —
[
  • 41,144 cases
  • , 370,946 controls
]
 — European — FinnGen —
PSS011569 — —
[
  • 3,014 cases
  • , 41,154 controls
]
 — European — G&H —
PSS011570 — —
[
  • 1,260 cases
  • , 5,758 controls
]
 — European — GS:SFHS —
PSS011571 — —
[
  • 2,267 cases
  • , 27,160 controls
]
 — European — GEL —
PSS011572 — —
[
  • 9,039 cases
  • , 60,676 controls
]
 — European — HUNT —
PSS011573 — —
[
  • 11,491 cases
  • , 26,957 controls
]
 — European — MGBB —
PSS011574 — —
[
  • 4,887 cases
  • , 194,981 controls
]
 — European — EB —
PSS011575 — —
[
  • 12,248 cases
  • , 399,842 controls
]
 — European — FinnGen —
PSS011576 — —
[
  • 297 cases
  • , 43,891 controls
]
 — European — G&H —
PSS011577 — —
[
  • 200 cases
  • , 6,818 controls
]
 — European — GS:SFHS —
PSS011578 — —
[
  • 750 cases
  • , 28,677 controls
]
 — European — GEL —
PSS011579 — —
[
  • 1,523 cases
  • , 68,192 controls
]
 — European — HUNT —
PSS011580 — —
[
  • 2,388 cases
  • , 17,800 controls
]
 — European — MGBB —
PSS011581 — —
[
  • 10,237 cases
  • , 189,631 controls
]
 — European — EB —
PSS011582 — —
[
  • 8,264 cases
  • , 403,826 controls
]
 — European — FinnGen —
PSS011583 — —
[
  • 267 cases
  • , 43,921 controls
]
 — European — G&H —
PSS011584 — —
[
  • 73 cases
  • , 6,945 controls
]
 — European — GS:SFHS —
PSS011585 — —
[
  • 564 cases
  • , 28,863 controls
]
 — European — GEL —
PSS011586 — —
[
  • 917 cases
  • , 68,798 controls
]
 — European — HUNT —
PSS011587 — —
[
  • 21,639 cases
  • , 178,229 controls
]
 — European — EB —
PSS011588 — —
[
  • 22,634 cases
  • , 389,456 controls
]
 — European — FinnGen —
PSS011589 — —
[
  • 96 cases
  • , 44,092 controls
]
 — European — G&H —
PSS011590 — —
[
  • 516 cases
  • , 6,502 controls
]
 — European — GS:SFHS —
PSS011591 — —
[
  • 839 cases
  • , 28,588 controls
]
 — European — GEL —
PSS011592 — —
[
  • 4,219 cases
  • , 65,496 controls
]
 — European — HUNT —
PSS011593 — —
[
  • 5,536 cases
  • , 31,488 controls
]
 — European — MGBB —
PSS011594 — —
[
  • 38,047 cases
  • , 161,821 controls
]
 — European — EB —
PSS011595 — —
[
  • 46,914 cases
  • , 365,176 controls
]
 — European — FinnGen —
PSS011596 — —
[
  • 1,053 cases
  • , 43,135 controls
]
 — European — G&H —
PSS011597 — —
[
  • 538 cases
  • , 6,480 controls
]
 — European — GS:SFHS —
PSS011598 — —
[
  • 1,600 cases
  • , 27,827 controls
]
 — European — GEL —
PSS011599 — —
[
  • 5,041 cases
  • , 64,674 controls
]
 — European — HUNT —
PSS011600 — —
[
  • 8,184 cases
  • , 29,061 controls
]
 — European — MGBB —
PSS011601 — —
[
  • 798 cases
  • , 199,070 controls
]
 — European — EB —
PSS011602 — —
[
  • 4,018 cases
  • , 273,382 controls
]
 — European — FinnGen —
PSS011603 — —
[
  • 44 cases
  • , 44,143 controls
]
 — European — G&H —
PSS011604 — —
[
  • 162 cases
  • , 6,856 controls
]
 — European — GS:SFHS —
PSS011605 — —
[
  • 1,388 cases
  • , 28,039 controls
]
 — European — GEL —
PSS011606 — —
[
  • 962 cases
  • , 68,753 controls
]
 — European — HUNT —
PSS011607 — —
[
  • 1,375 cases
  • , 37,073 controls
]
 — European — MGBB —
PSS011608 — —
[
  • 51,443 cases
  • , 148,425 controls
]
 — European — EB —
PSS011609 — —
[
  • 46,909 cases
  • , 365,181 controls
]
 — European — FinnGen —
PSS011610 — —
[
  • 2,526 cases
  • , 41,662 controls
]
 — European — G&H —
PSS011611 — —
[
  • 273 cases
  • , 6,745 controls
]
 — European — GS:SFHS —
PSS011612 — —
[
  • 3,349 cases
  • , 26,078 controls
]
 — European — GEL —
PSS011613 — —
[
  • 4,671 cases
  • , 65,044 controls
]
 — European — HUNT —
PSS011614 — —
[
  • 12,774 cases
  • , 24,362 controls
]
 — European — MGBB —
PSS011615 — —
[
  • 1,329 cases
  • , 198,539 controls
]
 — European — EB —
PSS011616 — —
[
  • 2,969 cases
  • , 409,121 controls
]
 — European — FinnGen —
PSS011617 — —
[
  • 78 cases
  • , 6,940 controls
]
 — European — GS:SFHS —
PSS011618 — —
[
  • 400 cases
  • , 29,027 controls
]
 — European — GEL —
PSS011619 — —
[
  • 929 cases
  • , 68,786 controls
]
 — European — HUNT —
PSS011620 — —
[
  • 2,142 cases
  • , 66,741 controls
]
 — European — EB —
PSS011621 — —
[
  • 13,697 cases
  • , 168,117 controls
]
 — European — FinnGen —
PSS011622 — —
[
  • 86 cases
  • , 19,712 controls
]
 — European — G&H —
PSS011623 — —
[
  • 226 cases
  • , 6,792 controls
]
 — European — GS:SFHS —
PSS011624 — —
[
  • 854 cases
  • , 11,204 controls
]
 — European — GEL —
PSS011625 — —
[
  • 1,987 cases
  • , 30,760 controls
]
 — European — HUNT —
PSS011626 — —
[
  • 2,332 cases
  • , 14,938 controls
]
 — European — MGBB —
PSS011627 — —
[
  • 11,638 cases
  • , 193,123 controls
]
 — European — UKB —
PSS011628 — —
[
  • 2,348 cases
  • , 197,520 controls
]
 — European — EB —
PSS011629 — —
[
  • 9,610 cases
  • , 402,480 controls
]
 — European — FinnGen —
PSS011630 — —
[
  • 58 cases
  • , 44,130 controls
]
 — European — G&H —
PSS011631 — —
[
  • 18 cases
  • , 7,000 controls
]
 — European — GS:SFHS —
PSS011632 — —
[
  • 71 cases
  • , 29,356 controls
]
 — European — GEL —
PSS011633 — —
[
  • 1,072 cases
  • , 68,643 controls
]
 — European — HUNT —
PSS011634 — —
[
  • 384 cases
  • , 37,602 controls
]
 — European — MGBB —
PSS011635 — —
[
  • 994 cases
  • , 446,338 controls
]
 — European — UKB —
PSS011636 — —
[
  • 497 cases
  • , 199,371 controls
]
 — European — EB —
PSS011637 — —
[
  • 4,310 cases
  • , 407,780 controls
]
 — European — FinnGen —
PSS011638 — —
[
  • 434 cases
  • , 43,753 controls
]
 — European — G&H —
PSS011639 — —
[
  • 78 cases
  • , 6,940 controls
]
 — European — GS:SFHS —
PSS011640 — —
[
  • 397 cases
  • , 29,030 controls
]
 — European — GEL —
PSS011641 — —
[
  • 342 cases
  • , 69,373 controls
]
 — European — HUNT —
PSS011642 — —
[
  • 103 cases
  • , 32,676 controls
]
 — European — MGBB —
PSS011643 — —
[
  • 992 cases
  • , 446,340 controls
]
 — European — UKB —
PSS011644 — —
[
  • 6,813 cases
  • , 141,499 controls
]
 — European — EB —
PSS011645 — —
[
  • 62,413 cases
  • , 349,677 controls
]
 — European — FinnGen —
PSS011646 — —
[
  • 6,537 cases
  • , 37,646 controls
]
 — European — G&H —
PSS011647 — —
[
  • 613 cases
  • , 6,405 controls
]
 — European — GS:SFHS —
PSS011648 — —
[
  • 2,423 cases
  • , 27,004 controls
]
 — European — GEL —
PSS011649 — —
[
  • 3,129 cases
  • , 66,586 controls
]
 — European — HUNT —
PSS011650 — —
[
  • 5,430 cases
  • , 32,913 controls
]
 — European — MGBB —
PSS011651 — —
[
  • 16,701 cases
  • , 183,167 controls
]
 — European — EB —
PSS011652 — —
[
  • 72,760 cases
  • , 339,330 controls
]
 — European — FinnGen —
PSS011653 — —
[
  • 912 cases
  • , 43,265 controls
]
 — European — G&H —
PSS011654 — —
[
  • 2,002 cases
  • , 5,016 controls
]
 — European — GS:SFHS —
PSS011655 — —
[
  • 12,187 cases
  • , 17,240 controls
]
 — European — GEL —
PSS011656 — —
[
  • 10,696 cases
  • , 59,019 controls
]
 — European — HUNT —
PSS011657 — —
[
  • 15,217 cases
  • , 23,231 controls
]
 — European — MGBB —
PSS011658 — —
[
  • 23,157 cases
  • , 176,711 controls
]
 — European — EB —
PSS011659 — —
[
  • 45,188 cases
  • , 366,902 controls
]
 — European — FinnGen —
PSS011660 — —
[
  • 4,032 cases
  • , 40,155 controls
]
 — European — G&H —
PSS011661 — —
[
  • 989 cases
  • , 6,029 controls
]
 — European — GS:SFHS —
PSS011662 — —
[
  • 4,346 cases
  • , 25,081 controls
]
 — European — GEL —
PSS011663 — —
[
  • 3,679 cases
  • , 66,036 controls
]
 — European — HUNT —
PSS011664 — —
[
  • 8,184 cases
  • , 25,405 controls
]
 — European — MGBB —
PSS011665 — —
[
  • 5,886 cases
  • , 441,446 controls
]
 — European — UKB —
PSS011666 — —
[
  • 2,576 cases
  • , 28,642 controls
]
 — European — MGBB —
PSS011667 — —
[
  • 7,945 cases
  • , 439,387 controls
]
 — European — UKB —
PSS011668 — —
[
  • 5,768 cases
  • , 32,680 controls
]
 — European — MGBB —