Polygenic Score (PGS) ID: PGS004882

Predicted Trait
Reported Trait Hip osteoarthritis
Mapped Trait(s) osteoarthritis, hip (EFO_1000786)
Released in PGS Catalog: June 27, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name INTERVENE_MegaPRS_Hip_osteoarthritis
Development Method
Name megaprs.auto
Parameters BayesR, p1=0.74, p2=0.2, p3=0.05, p4=0.01
Variants
Original Genome Build GRCh37
Number of Variants 773,587
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000618
Citation (link to publication) Jermy B et al. Nat Commun (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
393,873 individuals (100%)
Score Development/Training
European: 100%
404 individuals (100%)
PGS Evaluation
European: 100%
7 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007091
Europe PMC: 30664745
 393,873 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 404 individuals European 1000G — — — non-Finnish Europeans —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021231 PSS011593|
European Ancestry|
37,024 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.16 [1.13, 1.2] C-index: 0.55 [0.54, 0.56] — PCs 1-10 —
PPM021232 PSS011592|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.33 [1.29, 1.37] C-index: 0.58 [0.57, 0.59] — PCs 1-10 —
PPM021233 PSS011591|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.46 [1.36, 1.56] C-index: 0.6 [0.58, 0.63] — PCs 1-10 —
PPM021234 PSS011589|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.07 [0.88, 1.31] — — PCs 1-10 —
PPM021235 PSS011590|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.35 [1.24, 1.48] C-index: 0.6 [0.57, 0.63] — PCs 1-10 —
PPM021236 PSS011588|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.4 [1.38, 1.42] C-index: 0.6 [0.6, 0.6] — PCs 1-10 —
PPM021237 PSS011587|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident hip osteoarthritis HR: 1.15 [1.13, 1.16] C-index: 0.57 [0.56, 0.57] — PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011587 — —
[
  • 21,639 cases
  • , 178,229 controls
]
 — European — EB —
PSS011588 — —
[
  • 22,634 cases
  • , 389,456 controls
]
 — European — FinnGen —
PSS011589 — —
[
  • 96 cases
  • , 44,092 controls
]
 — European — G&H —
PSS011590 — —
[
  • 516 cases
  • , 6,502 controls
]
 — European — GS:SFHS —
PSS011591 — —
[
  • 839 cases
  • , 28,588 controls
]
 — European — GEL —
PSS011592 — —
[
  • 4,219 cases
  • , 65,496 controls
]
 — European — HUNT —
PSS011593 — —
[
  • 5,536 cases
  • , 31,488 controls
]
 — European — MGBB —