Trait: osteoarthritis, hip

Experimental Factor Ontology (EFO) Information
Identifier EFO_1000786
Description Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old ag... e. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion. [MESH: D015207]Show more
Trait category
Other disease
Synonyms 10 synonyms
  • Coxarthroses
  • Coxarthrosis
  • Hip Osteoarthritides
  • Hip Osteoarthritis
  • Osteoarthritides, Hip
  • Osteoarthritis Of Hip
  • Osteoarthritis Of Hips
  • hip osteoarthritis
  • osteoarthritis of the hip
  • osteoarthritis, hip
Mapped terms 7 mapped terms
  • ICD10:M16
  • MEDGEN:14530
  • MESH:D015207
  • MONDO:0006629
  • MeSH:D015207
  • NCIT:C34876
  • UMLS:C0029410

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000967
(GBE_HC1221)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Coxarthrosis [arthrosis of hip] (time-to-event)osteoarthritis, hip634
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000967/ScoringFiles/PGS000967.txt.gz
PGS002728
(PRS_hip)
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Hip osteoarthritisosteoarthritis, hip44
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002728/ScoringFiles/PGS002728.txt.gz
PGS002750
(PRS37_THR)
PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
Total hip replacementtotal hip arthroplasty,
osteoarthritis, hip		37
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002750/ScoringFiles/PGS002750.txt.gz
PGS002763
(Hip_osteoarthritis_prscs)
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Hip osteoarthritisosteoarthritis, hip1,052,273
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002763/ScoringFiles/PGS002763.txt.gz
PGS004478
(disease.M16.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
M16 (Coxarthrosis [arthrosis of hip])osteoarthritis, hip1,059,939
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004478/ScoringFiles/PGS004478.txt.gz
PGS004548
(meta.M16.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
M16 (Coxarthrosis [arthrosis of hip])osteoarthritis, hip1,059,939
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004548/ScoringFiles/PGS004548.txt.gz
PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Hip osteoarthritisosteoarthritis, hip773,587
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004882/ScoringFiles/PGS004882.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM007658PGS000967
(GBE_HC1221)
PSS004208|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE coxarthrosis [arthrosis of hip]—AUROC: 0.63448 [0.57611, 0.69284]R²: 0.02258
Incremental AUROC (full-covars): 0.01789
PGS R2 (no covariates): 0.0065
PGS AUROC (no covariates): 0.57452 [0.51022, 0.63883]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM007659PGS000967
(GBE_HC1221)
PSS004209|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE coxarthrosis [arthrosis of hip]—AUROC: 0.67991 [0.52221, 0.83761]R²: 0.03974
Incremental AUROC (full-covars): 0.00141
PGS R2 (no covariates): 0.00044
PGS AUROC (no covariates): 0.52299 [0.39821, 0.64778]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM007660PGS000967
(GBE_HC1221)
PSS004210|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE coxarthrosis [arthrosis of hip]—AUROC: 0.71352 [0.69682, 0.73022]R²: 0.07227
Incremental AUROC (full-covars): 0.00368
PGS R2 (no covariates): 0.00258
PGS AUROC (no covariates): 0.54164 [0.52116, 0.56213]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM007661PGS000967
(GBE_HC1221)
PSS004211|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE coxarthrosis [arthrosis of hip]—AUROC: 0.72467 [0.66733, 0.78201]R²: 0.06598
Incremental AUROC (full-covars): -0.00237
PGS R2 (no covariates): 1e-05
PGS AUROC (no covariates): 0.50363 [0.44232, 0.56493]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM007662PGS000967
(GBE_HC1221)
PSS004212|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE coxarthrosis [arthrosis of hip]—AUROC: 0.69051 [0.68108, 0.69995]R²: 0.06247
Incremental AUROC (full-covars): 0.00918
PGS R2 (no covariates): 0.00628
PGS AUROC (no covariates): 0.5611 [0.55051, 0.57168]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM014756PGS002728
(PRS_hip)
PSS009891|
European Ancestry|
14,926 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Prevalent radiographic osteoarthritisOR: 1.19 [1.1, 1.28]————
PPM014757PGS002728
(PRS_hip)
PSS009891|
European Ancestry|
14,926 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Incident radiographic osteoarthritisOR: 1.15 [1.05, 1.26]————
PPM014758PGS002728
(PRS_hip)
PSS009889|
European Ancestry|
1,002 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Prevalent radiographic osteoarthritisOR: 1.28 [0.98, 1.65]————
PPM014759PGS002728
(PRS_hip)
PSS009889|
European Ancestry|
1,002 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Incident radiographic osteoarthritisOR: 0.95 [0.82, 1.11]————
PPM014766PGS002728
(PRS_hip)
PSS009891|
European Ancestry|
14,926 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Prevalent clinical osteoarthritisOR: 1.3 [1.15, 1.46]————
PPM014767PGS002728
(PRS_hip)
PSS009891|
European Ancestry|
14,926 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Incident clinical osteoarthritisOR: 1.22 [0.98, 1.51]————
PPM014768PGS002728
(PRS_hip)
PSS009889|
European Ancestry|
1,002 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Incident clinical osteoarthritisOR: 0.92 [0.74, 1.14]————
PPM014773PGS002728
(PRS_hip)
PSS009891|
European Ancestry|
14,926 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Prevalent total hip replacementOR: 1.26 [1.12, 1.41]————
PPM014774PGS002728
(PRS_hip)
PSS009891|
European Ancestry|
14,926 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Incident total hip replacementOR: 1.28 [1.11, 1.48]————
PPM014775PGS002728
(PRS_hip)
PSS009889|
European Ancestry|
1,002 individuals
PGP000336 |
Sedaghati-Khayat B et al. Arthritis Rheumatol (2022)
Reported Trait: Incident total hip replacementOR: 1.09 [0.79, 1.47]————
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS004208——
[
  • 85 cases
  • , 6,412 controls
]
—African unspecified—UKB—
PSS004209——
[
  • 16 cases
  • , 1,688 controls
]
—East Asian—UKB—
PSS004210——
[
  • 779 cases
  • , 24,126 controls
]
—Europeannon-white British ancestryUKB—
PSS004211——
[
  • 74 cases
  • , 7,757 controls
]
—South Asian—UKB—
PSS004212——
[
  • 2,783 cases
  • , 64,642 controls
]
—Europeanwhite British ancestryUKBTesting cohort (heldout set)
PSS009889Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both jo... ints.In the CHECK cohort, clinical OA was defined as clinically relevant hip or knee osteoarthritis by a group of 36 GPs and secondary care physicians by manually evaluating the study records over the 5-10 years of follow-upShow more—1,002 individuals,
21.0 % Male samples
Mean = 55.9 years
Sd = 5.2 years		European—NRCHECK
PSS009891Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both jo... ints.Clinical OA in Rotterdam Study was defined as reported pain in the last month and a KL score ≥ 2 in that hip or knee joint and the control group was defined as containing all participants who had not been diagnosed with radiographic OA by the end of follow-up time.Show more—14,926 individuals—European—RS—
PSS009935——1,257 individuals—European—ASPREE—
PSS009939——39,444 individuals—European
(Finnish)		—FinnGen—
PSS011364——56,192 individuals—European—UKB—
PSS011587——
[
  • 21,639 cases
  • , 178,229 controls
]
—European—EB—
PSS011588——
[
  • 22,634 cases
  • , 389,456 controls
]
—European—FinnGen—
PSS011589——
[
  • 96 cases
  • , 44,092 controls
]
—European—G&H—
PSS011590——
[
  • 516 cases
  • , 6,502 controls
]
—European—GS:SFHS—
PSS011591——
[
  • 839 cases
  • , 28,588 controls
]
—European—GEL—
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