Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_1000786 |
Description | Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old ag... e. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion. [MESH: D015207]Show more |
Trait category |
Other disease
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Synonyms |
10 synonyms
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Mapped terms |
7 mapped terms
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Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
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PGS000967 (GBE_HC1221) | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Coxarthrosis [arthrosis of hip] (time-to-event) | osteoarthritis, hip | 634 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000967/ScoringFiles/PGS000967.txt.gz |
PGS002728 (PRS_hip) | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Hip osteoarthritis | osteoarthritis, hip | 44 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002728/ScoringFiles/PGS002728.txt.gz |
PGS002750 (PRS37_THR) | PGP000362 | Lacaze P et al. Arthritis Rheumatol (2022) | Total hip replacement | total hip arthroplasty, osteoarthritis, hip | 37 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002750/ScoringFiles/PGS002750.txt.gz |
PGS002763 (Hip_osteoarthritis_prscs) | PGP000364 | Mars N et al. Am J Hum Genet (2022) | Hip osteoarthritis | osteoarthritis, hip | 1,052,273 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002763/ScoringFiles/PGS002763.txt.gz |
PGS004478 (disease.M16.score) | PGP000561 | Jung H et al. Commun Biol (2024) | M16 (Coxarthrosis [arthrosis of hip]) | osteoarthritis, hip | 1,059,939 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004478/ScoringFiles/PGS004478.txt.gz |
PGS004548 (meta.M16.score) | PGP000561 | Jung H et al. Commun Biol (2024) | M16 (Coxarthrosis [arthrosis of hip]) | osteoarthritis, hip | 1,059,939 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004548/ScoringFiles/PGS004548.txt.gz |
PGS004882 (INTERVENE_MegaPRS_Hip_osteoarthritis) | PGP000618 | Jermy B et al. Nat Commun (2024) | Hip osteoarthritis | osteoarthritis, hip | 773,587 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004882/ScoringFiles/PGS004882.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
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PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
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PPM007658 | PGS000967 (GBE_HC1221) | PSS004208| African Ancestry| 6,497 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: TTE coxarthrosis [arthrosis of hip] | — | AUROC: 0.63448 [0.57611, 0.69284] | R²: 0.02258 Incremental AUROC (full-covars): 0.01789 PGS R2 (no covariates): 0.0065 PGS AUROC (no covariates): 0.57452 [0.51022, 0.63883] | age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM007659 | PGS000967 (GBE_HC1221) | PSS004209| East Asian Ancestry| 1,704 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: TTE coxarthrosis [arthrosis of hip] | — | AUROC: 0.67991 [0.52221, 0.83761] | R²: 0.03974 Incremental AUROC (full-covars): 0.00141 PGS R2 (no covariates): 0.00044 PGS AUROC (no covariates): 0.52299 [0.39821, 0.64778] | age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM007660 | PGS000967 (GBE_HC1221) | PSS004210| European Ancestry| 24,905 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: TTE coxarthrosis [arthrosis of hip] | — | AUROC: 0.71352 [0.69682, 0.73022] | R²: 0.07227 Incremental AUROC (full-covars): 0.00368 PGS R2 (no covariates): 0.00258 PGS AUROC (no covariates): 0.54164 [0.52116, 0.56213] | age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM007661 | PGS000967 (GBE_HC1221) | PSS004211| South Asian Ancestry| 7,831 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: TTE coxarthrosis [arthrosis of hip] | — | AUROC: 0.72467 [0.66733, 0.78201] | R²: 0.06598 Incremental AUROC (full-covars): -0.00237 PGS R2 (no covariates): 1e-05 PGS AUROC (no covariates): 0.50363 [0.44232, 0.56493] | age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM007662 | PGS000967 (GBE_HC1221) | PSS004212| European Ancestry| 67,425 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: TTE coxarthrosis [arthrosis of hip] | — | AUROC: 0.69051 [0.68108, 0.69995] | R²: 0.06247 Incremental AUROC (full-covars): 0.00918 PGS R2 (no covariates): 0.00628 PGS AUROC (no covariates): 0.5611 [0.55051, 0.57168] | age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM014756 | PGS002728 (PRS_hip) | PSS009891| European Ancestry| 14,926 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.19 [1.1, 1.28] | — | — | — | — |
PPM014757 | PGS002728 (PRS_hip) | PSS009891| European Ancestry| 14,926 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Incident radiographic osteoarthritis | OR: 1.15 [1.05, 1.26] | — | — | — | — |
PPM014758 | PGS002728 (PRS_hip) | PSS009889| European Ancestry| 1,002 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.28 [0.98, 1.65] | — | — | — | — |
PPM014759 | PGS002728 (PRS_hip) | PSS009889| European Ancestry| 1,002 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Incident radiographic osteoarthritis | OR: 0.95 [0.82, 1.11] | — | — | — | — |
PPM014766 | PGS002728 (PRS_hip) | PSS009891| European Ancestry| 14,926 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Prevalent clinical osteoarthritis | OR: 1.3 [1.15, 1.46] | — | — | — | — |
PPM014767 | PGS002728 (PRS_hip) | PSS009891| European Ancestry| 14,926 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Incident clinical osteoarthritis | OR: 1.22 [0.98, 1.51] | — | — | — | — |
PPM014768 | PGS002728 (PRS_hip) | PSS009889| European Ancestry| 1,002 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Incident clinical osteoarthritis | OR: 0.92 [0.74, 1.14] | — | — | — | — |
PPM014773 | PGS002728 (PRS_hip) | PSS009891| European Ancestry| 14,926 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Prevalent total hip replacement | OR: 1.26 [1.12, 1.41] | — | — | — | — |
PPM014774 | PGS002728 (PRS_hip) | PSS009891| European Ancestry| 14,926 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Incident total hip replacement | OR: 1.28 [1.11, 1.48] | — | — | — | — |
PPM014775 | PGS002728 (PRS_hip) | PSS009889| European Ancestry| 1,002 individuals | PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) | Reported Trait: Incident total hip replacement | OR: 1.09 [0.79, 1.47] | — | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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PSS004208 | — | — | [
| — | African unspecified | — | UKB | — |
PSS004209 | — | — | [
| — | East Asian | — | UKB | — |
PSS004210 | — | — | [
| — | European | non-white British ancestry | UKB | — |
PSS004211 | — | — | [
| — | South Asian | — | UKB | — |
PSS004212 | — | — | [
| — | European | white British ancestry | UKB | Testing cohort (heldout set) |
PSS009889 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both jo... ints.In the CHECK cohort, clinical OA was defined as clinically relevant hip or knee osteoarthritis by a group of 36 GPs and secondary care physicians by manually evaluating the study records over the 5-10 years of follow-upShow more | — | 1,002 individuals, 21.0 % Male samples | Mean = 55.9 years Sd = 5.2 years | European | — | NR | CHECK |
PSS009891 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both jo... ints.Clinical OA in Rotterdam Study was defined as reported pain in the last month and a KL score ≥ 2 in that hip or knee joint and the control group was defined as containing all participants who had not been diagnosed with radiographic OA by the end of follow-up time.Show more | — | 14,926 individuals | — | European | — | RS | — |
PSS009935 | — | — | 1,257 individuals | — | European | — | ASPREE | — |
PSS009939 | — | — | 39,444 individuals | — | European (Finnish) | — | FinnGen | — |
PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
PSS011587 | — | — | [
| — | European | — | EB | — |
PSS011588 | — | — | [
| — | European | — | FinnGen | — |
PSS011589 | — | — | [
| — | European | — | G&H | — |
PSS011590 | — | — | [
| — | European | — | GS:SFHS | — |
PSS011591 | — | — | [
| — | European | — | GEL | — |