| Predicted Trait | |
| Reported Trait | Hip osteoarthritis |
| Mapped Trait(s) | osteoarthritis, hip (EFO_1000786) |
| Score Construction | |
| PGS Name | PRS_hip |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | p<1.3E–8 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 44 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000336 |
| Citation (link to publication) | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 353,388 individuals (100%) |
| PGS Evaluation | European: 100% 2 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST90034522 Europe PMC: 34450027 |
353,388 individuals | European | 8 cohorts
|
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM014781 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident severe radiographic osteoarthritis | OR: 1.33 [1.12, 1.59] | — | — | — | — |
| PPM014756 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.19 [1.1, 1.28] | — | — | — | — |
| PPM014757 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident radiographic osteoarthritis | OR: 1.15 [1.05, 1.26] | — | — | — | — |
| PPM014758 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.28 [0.98, 1.65] | — | — | — | — |
| PPM014759 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident radiographic osteoarthritis | OR: 0.95 [0.82, 1.11] | — | — | — | — |
| PPM014766 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent clinical osteoarthritis | OR: 1.3 [1.15, 1.46] | — | — | — | — |
| PPM014767 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident clinical osteoarthritis | OR: 1.22 [0.98, 1.51] | — | — | — | — |
| PPM014768 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident clinical osteoarthritis | OR: 0.92 [0.74, 1.14] | — | — | — | — |
| PPM014773 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent total hip replacement | OR: 1.26 [1.12, 1.41] | — | — | — | — |
| PPM014774 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident total hip replacement | OR: 1.28 [1.11, 1.48] | — | — | — | — |
| PPM014775 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident total hip replacement | OR: 1.09 [0.79, 1.47] | — | — | — | — |
| PPM014779 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis progression | OR: 1.18 [1.09, 1.28] | — | — | — | — |
| PPM014783 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis | — | AUROC: 0.59 [0.56, 0.61] | — | Age, sex | — |
| PPM014784 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis | — | AUROC: 0.62 [0.58, 0.65] | — | Age, sex | — |
| PPM014785 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Clinical osteoarthritis | — | AUROC: 0.62 [0.56, 0.68] | — | Age, sex | — |
| PPM014786 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Clinical osteoarthritis | — | AUROC: 0.53 [0.47, 0.59] | — | Age, sex | — |
| PPM014787 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Total hip replacement | — | AUROC: 0.66 [0.62, 0.70] | — | Age, sex | — |
| PPM014788 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Total hip replacement | — | AUROC: 0.64 [0.55, 0.73] | — | Age, sex | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009889 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both joints.In the CHECK cohort, clinical OA was defined as clinically relevant hip or knee osteoarthritis by a group of 36 GPs and secondary care physicians by manually evaluating the study records over the 5-10 years of follow-up | — | 1,002 individuals, 21.0 % Male samples |
Mean = 55.9 years Sd = 5.2 years |
European | — | NR | CHECK |
| PSS009891 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both joints.Clinical OA in Rotterdam Study was defined as reported pain in the last month and a KL score ≥ 2 in that hip or knee joint and the control group was defined as containing all participants who had not been diagnosed with radiographic OA by the end of follow-up time. | — | 14,926 individuals | — | European | — | RS | — |