Trait: total hip arthroplasty

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009806
Description A surgical procedure in which the hip joint is replaced by a prosthetic implant, that is, a hip prosthesis. A total hip replacement (total hip arthroplasty) consists of replacing both the acetabulum and the femoral head.
Trait category
Other trait
Synonyms 4 synonyms
  • Hip Prosthesis Implantation
  • Hip Replacement
  • Hip Replacement Arthroplasty
  • Total Hip Replacement
Mapped terms 2 mapped terms
  • PMID:30794219
  • https://en.wikipedia.org/wiki/Hip_replacement

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002750
(PRS37_THR)
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Total hip replacement total hip arthroplasty,
osteoarthritis, hip		 37
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002750/ScoringFiles/PGS002750.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014940 PGS002750
(PRS37_THR)
 PSS009935|
European Ancestry|
1,257 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Hip replacement OR: 1.23 [1.16, 1.3] — — Age, sex, body mass index, education, and index of relative socioeconomic advantage and disadvantage —
PPM014941 PGS002750
(PRS37_THR)
 PSS009935|
European Ancestry|
1,257 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Hip replacement in men OR: 1.15 [1.06, 1.26] — — Age, body mass index, education, and index of relative socioeconomic advantage and disadvantage —
PPM014942 PGS002750
(PRS37_THR)
 PSS009935|
European Ancestry|
1,257 individuals
 PGP000362 |
Lacaze P et al. Arthritis Rheumatol (2022)
 Reported Trait: Hip replacement in women OR: 1.3 [1.2, 1.4] — — Age, body mass index, education, and index of relative socioeconomic advantage and disadvantage —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009935 — — 1,257 individuals — European — ASPREE —