| Predicted Trait | |
| Reported Trait | Lung cancer |
| Mapped Trait(s) | lung carcinoma (EFO_0001071) |
| Score Construction | |
| PGS Name | INTERVENE_MegaPRS_Lung_cancer |
| Development Method | |
| Name | megaprs.auto |
| Parameters | BayesR, p1=0.995, p2=0.005, p3=0, p4=0 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 655,479 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000618 |
| Citation (link to publication) | Jermy B et al. Nat Commun (2024) |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST90018875 Europe PMC: 34594039 | 492,803 individuals | European | NR |
GWAS Catalog: GCST90018875 Europe PMC: 34594039 | 178,726 individuals | East Asian | NR |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 404 individuals | European | 1000G | — | — | — | non-Finnish Europeans | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM021245 | PSS011607| European Ancestry| 38,448 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.13 [1.07, 1.19] | C-index: 0.54 [0.52, 0.56] | — | PCs 1-10 | — |
| PPM021246 | PSS011606| European Ancestry| 69,715 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.32 [1.24, 1.4] | C-index: 0.59 [0.57, 0.61] | — | PCs 1-10 | — |
| PPM021247 | PSS011605| European Ancestry| 29,427 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.26 [1.2, 1.33] | C-index: 0.6 [0.58, 0.62] | — | PCs 1-10 | — |
| PPM021248 | PSS011603| European Ancestry| 44,187 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.43 [1.06, 1.93] | — | — | PCs 1-10 | — |
| PPM021249 | PSS011604| European Ancestry| 7,018 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.21 [1.03, 1.41] | C-index: 0.62 [0.57, 0.67] | — | PCs 1-10 | — |
| PPM021250 | PSS011602| European Ancestry| 277,400 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.24 [1.2, 1.28] | C-index: 0.62 [0.61, 0.63] | — | PCs 1-10 | — |
| PPM021251 | PSS011601| European Ancestry| 199,868 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident lung cancer | HR: 1.08 [1.01, 1.16] | C-index: 0.57 [0.54, 0.59] | — | PCs 1-10 | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011601 | — | — | [
| — | European | — | EB | — |
| PSS011602 | — | — | [
| — | European | — | FinnGen | — |
| PSS011603 | — | — | [
| — | European | — | G&H | — |
| PSS011604 | — | — | [
| — | European | — | GS:SFHS | — |
| PSS011605 | — | — | [
| — | European | — | GEL | — |
| PSS011606 | — | — | [
| — | European | — | HUNT | — |
| PSS011607 | — | — | [
| — | European | — | MGBB | — |