| Predicted Trait | |
| Reported Trait | Knee osteoarthritis |
| Mapped Trait(s) | osteoarthritis, knee (EFO_0004616) |
| Score Construction | |
| PGS Name | INTERVENE_MegaPRS_Knee_osteoarthritis |
| Development Method | |
| Name | megaprs.auto |
| Parameters | BayesR, p1=0.69, p2=0.2, p3=0.1, p4=0.01 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 952,133 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000618 |
| Citation (link to publication) | Jermy B et al. Nat Commun (2024) |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST007090 Europe PMC: 30664745 | 403,124 individuals | European | NR |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 404 individuals | European | 1000G | — | — | — | non-Finnish Europeans | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM021238 | PSS011600| European Ancestry| 37,245 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.19 [1.17, 1.22] | C-index: 0.56 [0.55, 0.57] | — | PCs 1-10 | — |
| PPM021239 | PSS011599| European Ancestry| 69,715 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.32 [1.28, 1.35] | C-index: 0.58 [0.57, 0.59] | — | PCs 1-10 | — |
| PPM021240 | PSS011598| European Ancestry| 29,427 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.37 [1.3, 1.44] | C-index: 0.6 [0.58, 0.61] | — | PCs 1-10 | — |
| PPM021241 | PSS011596| European Ancestry| 44,188 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.17 [1.1, 1.24] | — | — | PCs 1-10 | — |
| PPM021242 | PSS011597| European Ancestry| 7,018 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.28 [1.17, 1.39] | C-index: 0.6 [0.57, 0.62] | — | PCs 1-10 | — |
| PPM021243 | PSS011595| European Ancestry| 412,090 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.32 [1.31, 1.34] | C-index: 0.59 [0.58, 0.59] | — | PCs 1-10 | — |
| PPM021244 | PSS011594| European Ancestry| 199,868 individuals | PGP000618 | Jermy B et al. Nat Commun (2024) | Reported Trait: Incident knee osteoarthritis | HR: 1.17 [1.16, 1.18] | C-index: 0.56 [0.56, 0.56] | — | PCs 1-10 | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011594 | — | — | [
| — | European | — | EB | — |
| PSS011595 | — | — | [
| — | European | — | FinnGen | — |
| PSS011596 | — | — | [
| — | European | — | G&H | — |
| PSS011597 | — | — | [
| — | European | — | GS:SFHS | — |
| PSS011598 | — | — | [
| — | European | — | GEL | — |
| PSS011599 | — | — | [
| — | European | — | HUNT | — |
| PSS011600 | — | — | [
| — | European | — | MGBB | — |