Polygenic Score (PGS) ID: PGS004871

Predicted Trait
Reported Trait Gout
Mapped Trait(s) gout (EFO_0004274)
Released in PGS Catalog: June 27, 2024
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Score Details

Score Construction
PGS Name INTERVENE_MegaPRS_Gout
Development Method
Name megaprs.auto
Parameters bolt, p=0.45, f2=0.15
Variants
Original Genome Build GRCh37
Number of Variants 762,621
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000618
Citation (link to publication) Jermy B et al. Nat Commun (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 63.1%
East Asian: 27.5%
African: 7.4%
South Asian: 2%
Hispanic or Latin American: 0.1%
457,690 individuals (100%)
Score Development/Training
European: 100%
404 individuals (100%)
PGS Evaluation
European: 100%
8 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008972
Europe PMC: 31578528
 288,649 individuals European NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 125,725 individuals East Asian NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 33,671 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 9,037 individuals South Asian NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 608 individuals Hispanic or Latin American NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 404 individuals European 1000G — — — non-Finnish Europeans —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021149 PSS011667|
European Ancestry|
447,332 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.87 [1.83, 1.91] — — PCs 1-10 —
PPM021150 PSS011666|
European Ancestry|
31,218 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.54 [1.48, 1.6] C-index: 0.63 [0.61, 0.64] — PCs 1-10 —
PPM021151 PSS011586|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.74 [1.63, 1.86] C-index: 0.66 [0.64, 0.68] — PCs 1-10 —
PPM021153 PSS011583|
European Ancestry|
44,188 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 2.0 [1.77, 2.26] — — PCs 1-10 —
PPM021154 PSS011584|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.23 [0.98, 1.55] C-index: 0.64 [0.57, 0.71] — PCs 1-10 —
PPM021155 PSS011582|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.62 [1.58, 1.66] C-index: 0.64 [0.64, 0.65] — PCs 1-10 —
PPM021156 PSS011581|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.55 [1.52, 1.58] C-index: 0.63 [0.62, 0.64] — PCs 1-10 —
PPM021152 PSS011585|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Gout HR: 1.92 [1.76, 2.09] C-index: 0.68 [0.66, 0.71] — PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011581 — —
[
  • 10,237 cases
  • , 189,631 controls
]
 — European — EB —
PSS011582 — —
[
  • 8,264 cases
  • , 403,826 controls
]
 — European — FinnGen —
PSS011583 — —
[
  • 267 cases
  • , 43,921 controls
]
 — European — G&H —
PSS011584 — —
[
  • 73 cases
  • , 6,945 controls
]
 — European — GS:SFHS —
PSS011585 — —
[
  • 564 cases
  • , 28,863 controls
]
 — European — GEL —
PSS011586 — —
[
  • 917 cases
  • , 68,798 controls
]
 — European — HUNT —
PSS011666 — —
[
  • 2,576 cases
  • , 28,642 controls
]
 — European — MGBB —
PSS011667 — —
[
  • 7,945 cases
  • , 439,387 controls
]
 — European — UKB —