PGS Publication: PGP000484

Publication Information (EuropePMC)
Title Associations of risk factor burden and genetic predisposition with the 10-year risk of atrial fibrillation: observations from a large prospective study of 348,904 participants.
PubMed ID 36882748(Europe PMC)
doi 10.1186/s12916-023-02798-7
Publication Date March 8, 2023
Journal BMC Med
Author(s) Zhang J, Chen G, Wang C, Wang X, Qian ZM, Cai M, Vaughn MG, Bingheim E, Li H, Gao Y, Lip GYH, Lin H.
Released in PGS Catalog: Aug. 4, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
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Greater Middle Eastern
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS003761
(PRS165_AF)
PGP000484 |
Zhang J et al. BMC Med (2023)
Atrial fibrillationatrial fibrillation165
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003761/ScoringFiles/PGS003761.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM018558PGS003761
(PRS165_AF)
PSS011022|
Multi-ancestry (including European)|
84,206 individuals
PGP000484 |
Zhang J et al. BMC Med (2023)
Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden——Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 7.32 [3.02, 17.7]sex—
PPM018559PGS003761
(PRS165_AF)
PSS011023|
Multi-ancestry (including European)|
117,520 individuals
PGP000484 |
Zhang J et al. BMC Med (2023)
Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden——Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 8.41 [4.37, 16.2]sex—
PPM018560PGS003761
(PRS165_AF)
PSS011024|
Multi-ancestry (including European)|
147,178 individuals
PGP000484 |
Zhang J et al. BMC Med (2023)
Reported Trait: 10-year risk of atrial fibrillation with elevated risk burden——Hazard ratio (elevated risk factor burden and high PRS vs optimal risk factor burden and low PRS): 4.12 [2.76, 6.14]sex—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011022——75,886 individualsEuropean—UKB—
PSS011022——8,320 individualsNot reported—UKB—
PSS011023——6,783 individualsNot reported—UKB—
PSS011023——110,737 individualsEuropean—UKB—
PSS011024——142,614 individualsEuropean—UKB—
PSS011024——4,564 individualsNot reported—UKB—
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