PGS Publication: PGP000652

Publication Information (EuropePMC)
Title Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.
PubMed ID 34374755(Europe PMC)
doi 10.1093/eurheartj/ehab505
Publication Date Oct. 1, 2021
Journal Eur Heart J
Author(s) Wang N, Sun Y, Zhang H, Wang B, Chen C, Wang Y, Chen J, Tan X, Zhang J, Xia F, Qi L, Lu Y.
Released in PGS Catalog: June 27, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004920
(GRS166_AF)
 PGP000652 |
Wang N et al. Eur Heart J (2021)
 Atrial fibrillation atrial fibrillation 166
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004920/ScoringFiles/PGS004920.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021391 PGS004920
(GRS166_AF)
 PSS011724|
European Ancestry|
193,819 individuals
 PGP000652 |
Wang N et al. Eur Heart J (2021)
 Reported Trait: Atrial fibrillation HR: 2.68 [2.53, 2.84] — — Age, sex, ethnicity, Townsend index, education, smoking status, BMI <25.0 kg/m2, physical activity goal (≥150 min/week of moderate intensity, ≥75 min/week of vigorous intensity, or an equivalent combination), dietary score ≥4 proposed in previous studies, total cholesterol <5.18 mmol/L without using lipid-lowering medication, glycated haemoglobin <5.7% (39 mmol/mol) and no history of diabetes, blood pressure <120/<80 mmHg without using blood pressure-lowering medication —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011724 — —
[
  • 3,832 cases
  • , 189,987 controls
]
 — European — UKB —