| Publication Information (EuropePMC) | |
| Title | Genetic risk and atrial fibrillation in patients with heart failure. |
| PubMed ID | 31919934(Europe PMC) |
| doi | 10.1002/ejhf.1735 |
| Publication Date | Jan. 9, 2020 |
| Journal | Eur J Heart Fail |
| Author(s) | Kloosterman M, Santema BT, Roselli C, Nelson CP, Koekemoer A, Romaine SPR, Van Gelder IC, Lam CSP, Artola VA, Lang CC, Ng LL, Metra M, Anker S, Filippatos G, Dickstein K, Ponikowski P, van der Harst P, van der Meer P, van Veldhuisen DJ, Benjamin EJ, Voors AA, Samani NJ, Rienstra M. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000338 (GRS97_AF) |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Atrial fibrillation | atrial fibrillation | 97 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000338/ScoringFiles/PGS000338.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000916 | PGS000338 (GRS97_AF) |
PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | OR: 2.13 [1.86, 2.44] | — | — | age, sex, PCs (1-10) of ancestry | — |
| PPM000913 | PGS000338 (GRS97_AF) |
PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | OR: 2.12 [1.84, 2.45] | — | — | age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry | — |
| PPM000917 | PGS000338 (GRS97_AF) |
PSS000461| European Ancestry| 2,262 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction | OR: 2.12 [1.77, 2.54] | — | — | age, sex, PCs (1-10) of ancestry | — |
| PPM000915 | PGS000338 (GRS97_AF) |
PSS000460| European Ancestry| 530 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction | OR: 2.02 [1.37, 2.99] | — | — | age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry | — |
| PPM000914 | PGS000338 (GRS97_AF) |
PSS000461| European Ancestry| 2,262 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction | OR: 2.08 [1.72, 2.5] | — | — | age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry | — |
| PPM000920 | PGS000338 (GRS97_AF) |
PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | — | AUROC: 0.721 [0.704, 737.0] | — | PCs (1-10) of ancestry, CHARGE-AF risk factors (age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, myocardial infarction, diabetes) | — |
| PPM000919 | PGS000338 (GRS97_AF) |
PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | — | AUROC: 0.606 [0.588, 0.624] | — | PCs (1-10) of ancestry | — |
| PPM000918 | PGS000338 (GRS97_AF) |
PSS000460| European Ancestry| 530 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction | OR: 1.82 [1.28, 2.59] | — | — | age, sex, PCs (1-10) of ancestry | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000460 | Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. HFpEF defined as LVEF >/= 50% | — | [
|
— | European | — | BIOSTAT-CHF | BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014 |
| PSS000461 | Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.HFrEF defined as LVEF <40% | — | [
|
— | European | — | BIOSTAT-CHF | BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014 |
| PSS000462 | Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. | — | [ ,
70.0 % Male samples |
Mean = 72.8 years Sd = 11.5 years |
European | — | BIOSTAT-CHF | BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014 |