| Publication Information (EuropePMC) | |
| Title | Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation. |
| PubMed ID | 34463125(Europe PMC) |
| doi | 10.1161/circgen.121.003355 |
| Publication Date | Aug. 31, 2021 |
| Journal | Circ Genom Precis Med |
| Author(s) | Khurshid S, Mars N, Haggerty CM, Huang Q, Weng LC, Hartzel DN, Regeneron Genetics Center, Lunetta KL, Ashburner JM, Anderson CD, Benjamin EJ, Salomaa V, Ellinor PT, Fornwalt BK, Ripatti S, Trinquart L, Lubitz SA. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000035 (PRS_AF) |
PGP000022 | Weng LC et al. Circulation (2017) |
Atrial fibrillation | atrial fibrillation | 1,168 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000035/ScoringFiles/PGS000035.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM020778 | PGS000035 (PRS_AF) |
PSS011403| Multi-ancestry (including European)| 3,335 individuals |
PGP000586 | Khurshid S et al. Circ Genom Precis Med (2021) |Ext. |
Reported Trait: Incident atrial fibrillation | HR: 1.49 [1.3, 1.71] | C-index: 0.617 [0.574, 0.66] | R²: 0.016 [0.004, 0.027] | — | — |
| PPM020775 | PGS000035 (PRS_AF) |
PSS011406| Multi-ancestry (including European)| 473,681 individuals |
PGP000586 | Khurshid S et al. Circ Genom Precis Med (2021) |Ext. |
Reported Trait: Incident atrial fibrillation | HR: 1.34 [1.31, 1.37] | C-index: 0.584 [0.577, 0.59] | R²: 0.004 [0.004, 0.005] | — | — |
| PPM020776 | PGS000035 (PRS_AF) |
PSS011404| European Ancestry| 10,560 individuals |
PGP000586 | Khurshid S et al. Circ Genom Precis Med (2021) |Ext. |
Reported Trait: Incident atrial fibrillation | HR: 1.48 [1.31, 1.66] | C-index: 0.615 [0.579, 0.65] | R²: 0.011 [0.004, 0.018] | — | — |
| PPM020777 | PGS000035 (PRS_AF) |
PSS011405| Multi-ancestry (including European)| 55,517 individuals |
PGP000586 | Khurshid S et al. Circ Genom Precis Med (2021) |Ext. |
Reported Trait: Incident atrial fibrillation | HR: 1.28 [1.21, 1.35] | C-index: 0.569 [0.554, 0.584] | R²: 0.003 [0.002, 0.005] | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011403 | Cases were individuals with atrial fibrillation (AF). Individuals were classified as having AF if the arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records. Study investigators reviewed all available records to determine dates of AF. Two physicians adjudicated first-detected AF events. | — | [ ,
44.6 % Male samples |
Mean = 59.4 years Sd = 15.5 years |
European, Not reported | — | FHS | — |
| PSS011404 | Cases were individuals with atrial fibrillation (AF). Cases were identified using ICD-10 code: I48 and ICD-9 code: 427.3. | — | [ ,
47.7 % Male samples |
Mean = 57.0 years Sd = 7.4 years |
European | — | FINRISK | — |
| PSS011405 | Cases were individuals with atrial fibrillation (AF). AF was defined as a clinically reported finding of AF or atrial flutter from a 12- lead ECG or a diagnosis of AF or atrial flutter applied to two or more inpatient or outpatient encounters or on the patient problem list from the institutional electronic health record. Diagnosis codes used to define AF included ICD10: I48.0, I48.1, I48.2, I48.3 and I48.91); ICD9: 427.31; and 92 separate internal codes. | — | [ ,
34.2 % Male samples |
Mean = 47.3 years Sd = 15.2 years |
European, Not reported | — | MyCode | — |
| PSS011406 | Cases were individuals with atrial fibrillation (AF). Cases were identified using using self-report, ICD 9/10 codes, or cause of death records and where available, codes for specific AF-related procedures (e.g., percutaneous transluminal ablation of pulmonary vein) were also utilized in the AF definition. The complete list of clinical factor definitions is shown in supplemental Table I. | — | [ ,
45.3 % Male samples |
Mean = 56.9 years Sd = 8.1 years |
European, Not reported | — | UKB | Possible sample overlap between this dataset and the dataset used to develop/train PGS000035. |