PGS Publication: PGP000637

Publication Information (EuropePMC)
Title Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial.
PubMed ID 37264683(Europe PMC)
doi 10.1093/cvr/cvad027
Publication Date Aug. 1, 2023
Journal Cardiovasc Res
Author(s) Kany S, Al-Taie C, Roselli C, Pirruccello JP, Borof K, Reinbold C, Suling A, Krause L, Reissmann B, Schnabel RB, Zeller T, Zapf A, Wegscheider K, Fabritz L, Ellinor PT, Kirchhof P.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000016
(GPS_AF)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Atrial fibrillation atrial fibrillation 6,730,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000016/ScoringFiles/PGS000016.txt.gz - Check Terms/Licenses
PGS000911
(PRS_IS)
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Ischemic stroke Ischemic stroke,
stroke		 530,933
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000911/ScoringFiles/PGS000911.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021351 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident heart failure HR: 1.08 [1.06, 1.1] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021345 PGS000016
(GPS_AF)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Cardiovascular death, stroke, hospitalization for worsening of HF, or acute coronary syndrome HR: 0.99 [0.88, 1.11] — — — —
PPM021346 PGS000016
(GPS_AF)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Stroke HR: 1.1 [0.83, 1.45] — — — —
PPM021347 PGS000016
(GPS_AF)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Recurrent atrial fibrillation HR: 1.08 [1.0, 1.16] — — — —
PPM021348 PGS000911
(PRS_IS)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Cardiovascular death, stroke, hospitalization for worsening of HF, or acute coronary syndrome HR: 1.13 [1.0, 1.27] — — Treatment group —
PPM021349 PGS000911
(PRS_IS)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Stroke HR: 1.0 [0.75, 1.34] — — Treatment group —
PPM021350 PGS000911
(PRS_IS)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Worsening of heart failure HR: 1.23 [1.05, 1.43] — — Treatment group —
PPM021352 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident stroke HR: 1.08 [1.06, 1.11] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021353 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.11 [1.08, 1.14] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021354 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident atrial fibrillation or atrial flutter HR: 1.15 [1.14, 1.67] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011698 — — 1,567 individuals — European — EAST-AFNET4 —
PSS011699 — — 407,311 individuals — European — UKB —