Trait: Ischemic stroke

Trait Information
Identifier HP_0002140
Description Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured. [PMID: 32054610]
Trait categories
Cardiovascular disease
Neurological disorder
Synonym Ischaemic stroke
Mapped terms 2 mapped terms
  • SNOMEDCT_US:422504002
  • UMLS:C0948008

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000039
(metaGRS_ischaemicstroke)
 PGP000027 |
Abraham G et al. Nat Commun (2019)
 Ischemic stroke stroke,
Ischemic stroke		 3,225,583
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000039/ScoringFiles/PGS000039.txt.gz
PGS000665
(GRS_32)
 PGP000125 |
Marston NA et al. Circulation (2020)
 Ischemic stroke stroke,
Ischemic stroke		 32
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000665/ScoringFiles/PGS000665.txt.gz
PGS000911
(PRS_IS)
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Ischemic stroke stroke,
Ischemic stroke		 530,933
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000911/ScoringFiles/PGS000911.txt.gz
PGS002724
(GIGASTROKE_iPGS_EUR)
 PGP000333 |
Mishra A et al. Nature (2022)
 Ischemic stroke stroke,
Ischemic stroke		 1,213,574
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002724/ScoringFiles/PGS002724.txt.gz
PGS002725
(GIGASTROKE_iPGS_EAS)
 PGP000333 |
Mishra A et al. Nature (2022)
 Ischemic stroke stroke,
Ischemic stroke		 6,010,730
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002725/ScoringFiles/PGS002725.txt.gz
PGS004322
(GRS30_IS)
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Ischemic stroke stroke,
Ischemic stroke		 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004322/ScoringFiles/PGS004322.txt.gz
PGS004597
(PRS32_IS)
 PGP000576 |
Peng H et al. Nutrients (2023)
 Ischemic stroke stroke,
Ischemic stroke		 32
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004597/ScoringFiles/PGS004597.txt.gz
PGS004942
(IS_MetaPRS)
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Ischemic stroke Ischemic stroke 4,765,243
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004942/ScoringFiles/PGS004942.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000091 PGS000039
(metaGRS_ischaemicstroke)
 PSS000058|
European Ancestry|
395,393 individuals
 PGP000027 |
Abraham G et al. Nat Commun (2019)
 Reported Trait: Ischaemic stroke before age 75 HR: 1.26 [1.22, 1.31] C-index: 0.585 [0.574, 0.595] — Sex, genotyping chip, 10 PCs —
PPM002221 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.41 [1.2, 1.65] AUROC: 0.685 [0.64, 0.73] Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.74 [1.19, 2.56] Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. Only 12,405 individuals (171 cases) were used due to missing values. For AUROC values this was 11,385 individuals (158 cases).
PPM002222 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke — — Net reclassification index (NRI): 0.252 [0.175, 0.434] Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. Only 11,385 individuals (158 cases) were used.
PPM002223 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.43 [1.22, 1.68] — — Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin, PCs(1-10) Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. Only 12,405 individuals (171 cases) were used due to missing values.
PPM002224 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.43 [1.22, 1.68] — — Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin, intake of antihypertensive drugs, intake of statin Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. Only 12,405 individuals (171 cases) were used due to missing values.
PPM002225 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.41 [1.2, 1.66] — — Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin, index of relative socio-economic advantage and disadvantage(1-10) Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. Only 12,405 individuals (171 cases) were used due to missing values.
PPM002226 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.4 [1.2, 1.64] — — Age, sex, systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, alcohol consumption (current versus former or never consumption) Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. Only 12,405 individuals (171 cases) were used due to missing values.
PPM002227 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident ischemic stroke — AUROC: 0.582 [0.537, 0.628] — — Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch. For AUROC values only 11,385 individuals (158 cases) were used.
PPM002228 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident large vessel ischemic stroke HR: 1.43 [1.05, 1.94] — — Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch.
PPM002229 PGS000039
(metaGRS_ischaemicstroke)
 PSS001082|
European Ancestry|
12,792 individuals
 PGP000209 |
Neumann JT et al. Stroke (2021)
|Ext.		 Reported Trait: Incident cardiometabolic ischemic stroke HR: 1.74 [1.24, 2.43] — — Age, sex, smoking status (current or former versus never), systolic blood pressure, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, alcohol consumption (current versus former or never consumption), family history of stroke (event occuring before the age of 50 in a first-degree relative), diabetes, randomization to aspirin Only 3,219,276 SNPs from PGS000039 were utilised due to variant identifier mismatch.
PPM012987 PGS000039
(metaGRS_ischaemicstroke)
 PSS009641|
European Ancestry|
3,071 individuals
 PGP000315 |
Hämmerle M et al. Stroke (2022)
|Ext.		 Reported Trait: Stroke — — Odds ratio (OR, top 1% vs. rest): 5.82 [2.08, 14.0] Age, sex, BMI, hypertension, cholesterol, diabetes, smoker —
PPM014737 PGS000039
(metaGRS_ischaemicstroke)
 PSS009879|
European Ancestry|
403,489 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: incident ischemic stroke cases HR: 1.13 [1.1, 1.15] C-index: 0.64 ∆C-index (improvement in C-index over covariates-only model): 0.006 age, sex, 5 PCs —
PPM014739 PGS000039
(metaGRS_ischaemicstroke)
 PSS009876|
European Ancestry|
51,288 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: incident ischemic stroke cases HR: 1.14 [1.06, 1.21] C-index: 0.641 ∆C-index (improvement in C-index over covariates-only model): 0.006 age, sex, 5 PCs —
PPM014741 PGS000039
(metaGRS_ischaemicstroke)
 PSS009878|
African Ancestry|
107,343 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: incident ischemic stroke cases HR: 1.09 [1.04, 1.14] C-index: 0.652 ∆C-index (improvement in C-index over covariates-only model): 0.002 age, sex, 5 PCs —
PPM014748 PGS000039
(metaGRS_ischaemicstroke)
 PSS009881|
East Asian Ancestry|
87,682 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: prevalent ischemic stroke cases OR: 1.1 [1.04, 1.16] AUROC: 0.763 ∆AUROC (improvement in AUROC over covariates-only model): 0.001 age, sex, 5 PCs —
PPM014735 PGS000039
(metaGRS_ischaemicstroke)
 PSS009877|
European Ancestry|
102,099 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: incident ischemic stroke cases HR: 1.19 [1.12, 1.26] C-index: 0.618 ∆C-index (improvement in C-index over covariates-only model): 0.014 age, sex, 5 PCs —
PPM014743 PGS000039
(metaGRS_ischaemicstroke)
 PSS009880|
African Ancestry|
3,434 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: prevalent ischemic stroke cases OR: 1.07 [1.0, 1.15] AUROC: 0.547 ∆AUROC (improvement in AUROC over covariates-only model): 0.006 age, sex, 5 PCs —
PPM014746 PGS000039
(metaGRS_ischaemicstroke)
 PSS009875|
East Asian Ancestry|
41,929 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
|Ext.		 Reported Trait: prevalent ischemic stroke cases OR: 1.17 [1.11, 1.23] AUROC: 0.641 ∆AUROC (improvement in AUROC over covariates-only model): 0.007 age, sex, 5 PCs —
PPM016151 PGS000039
(metaGRS_ischaemicstroke)
 PSS010050|
Ancestry Not Reported|
454,756 individuals
 PGP000401 |
Cho BPH et al. JAMA Neurol (2022)
|Ext.		 Reported Trait: Stroke HR: 1.23 [1.2, 1.26] — — age, sex, ethnicity, exome sequencing batch, and the first 10 principal components of genetic ancestry —
PPM021311 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident cardiovascular disease outcome HR: 1.18 [1.15, 1.21] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021312 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.16, 1.24] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021313 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident stroke HR: 1.19 [1.14, 1.24] — — Age at baseline, stratified by study centre, sex —
PPM021314 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident stroke HR: 1.16 [1.11, 1.21] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021315 PGS000039
(metaGRS_ischaemicstroke)
 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Combination of incident coronary heart disease, stroke and cardiac revascularisation procedures HR: 1.19 [1.16, 1.22] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021765 PGS000039
(metaGRS_ischaemicstroke)
 PSS011789|
European Ancestry|
332 individuals
 PGP000674 |
Lin F et al. Front Stroke (2023)
|Ext.		 Reported Trait: Ischemic stroke OR: 3.0 [0.3, 26.4] — — Age, smoking status —
PPM001373 PGS000665
(GRS_32)
 PSS000602|
European Ancestry|
51,288 individuals
 PGP000125 |
Marston NA et al. Circulation (2020)
 Reported Trait: Incident ischemic stroke — — Hazard Ratio (HR, top vs. bottom tertile): 1.24 [1.05, 1.45]
Hazard Ratio (HR, intermediate vs. bottom tertile): 1.15 [0.98, 1.36]		 age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation —
PPM001374 PGS000665
(GRS_32)
 PSS000602|
European Ancestry|
51,288 individuals
 PGP000125 |
Marston NA et al. Circulation (2020)
 Reported Trait: Incident ischemic stroke — C-index: 0.65 [0.63, 0.66] — Clinical variables from the Revised Framingham Stroke Risk score, geographic region —
PPM001375 PGS000665
(GRS_32)
 PSS000601|
European Ancestry|
11,187 individuals
 PGP000125 |
Marston NA et al. Circulation (2020)
 Reported Trait: Incident ischemic stroke in individuals with atrial fibrillation — — Hazard Ratio (HR, top vs. bottom tertile): 1.29 [1.01, 1.64] age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation, components of CHA2DS2-VASc score —
PPM002960 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 [1.06, 1.23] — — Age at recruitment, sex, UK Biobank array type, PCs(1-10) —
PPM002961 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 [1.06, 1.23] AUROC: 0.605 [0.583, 0.626] — Age at recruitment, sex, UK Biobank array type, PCs(1-10), presence of warfarin prescription —
PPM002962 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases who had not been prescribed warfarin OR: 1.14 [1.05, 1.24] — — Age at recruitment, sex, UK Biobank array type, PCs(1-10) —
PPM002963 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 [1.06, 1.23] — — Age at recruitment, sex, UK Biobank array type, PCs(1-10), cumulative CHA2DS2-VASc score —
PPM002964 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 — — Age at recruitment, sex, UK Biobank array type, PCs(1-10), individual components of CHA2DS2-VASc score —
PPM002965 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases HR: 1.13 [1.04, 1.21] C-index: 0.56 [0.54, 0.58] — Sex, UK Biobank array, PCs(1-10) —
PPM002966 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases HR: 1.14 [1.01, 1.23] C-index: 0.56 [0.54, 0.58] — Sex, age, UK Biobank array, PCs(1-10) —
PPM002967 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases who had not been prescribed warfarin HR: 1.13 [1.04, 1.22] C-index: 0.57 [0.54, 0.59] — Sex, UK Biobank array, PCs(1-10) —
PPM002968 PGS000911
(PRS_IS)
 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases — C-index: 0.61 [0.58, 0.63] — Sex, UK Biobank array, PCs(1-10), cumulative CHA2DS2-VASc score —
PPM021351 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident heart failure HR: 1.08 [1.06, 1.1] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021348 PGS000911
(PRS_IS)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Cardiovascular death, stroke, hospitalization for worsening of HF, or acute coronary syndrome HR: 1.13 [1.0, 1.27] — — Treatment group —
PPM021349 PGS000911
(PRS_IS)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Stroke HR: 1.0 [0.75, 1.34] — — Treatment group —
PPM021350 PGS000911
(PRS_IS)
 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Worsening of heart failure HR: 1.23 [1.05, 1.43] — — Treatment group —
PPM021352 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident stroke HR: 1.08 [1.06, 1.11] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021353 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.11 [1.08, 1.14] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021354 PGS000911
(PRS_IS)
 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident atrial fibrillation or atrial flutter HR: 1.15 [1.14, 1.67] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM014736 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS009879|
European Ancestry|
403,489 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: incident ischemic stroke cases HR: 1.19 [1.16, 1.21] C-index: 0.645 ∆C-index (improvement in C-index over covariates-only model): 0.01 age, sex, 5 PCs —
PPM014738 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS009876|
European Ancestry|
51,288 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: incident ischemic stroke cases HR: 1.19 [1.11, 1.27] C-index: 0.644 ∆C-index (improvement in C-index over covariates-only model): 0.008 age, sex, 5 PCs —
PPM014740 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS009878|
African Ancestry|
107,343 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: incident ischemic stroke cases HR: 1.11 [1.06, 1.17] C-index: 0.653 ∆C-index (improvement in C-index over covariates-only model): 0.003 age, sex, 5 PCs —
PPM014742 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS009880|
African Ancestry|
3,434 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: prevalent ischemic stroke cases OR: 1.09 [1.02, 1.17] AUROC: 0.548 ∆AUROC (improvement in AUROC over covariates-only model): 0.007 age, sex, 5 PCs —
PPM014745 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS009875|
East Asian Ancestry|
41,929 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: prevalent ischemic stroke cases OR: 1.18 [1.12, 1.25] AUROC: 0.643 ∆AUROC (improvement in AUROC over covariates-only model): 0.009 age, sex, 5 PCs —
PPM014734 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS009877|
European Ancestry|
102,099 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: incident ischemic stroke cases HR: 1.26 [1.19, 1.34] C-index: 0.631 ∆C-index (improvement in C-index over covariates-only model): 0.027 age, sex, 5 PCs —
PPM020273 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS011318|
African Ancestry|
18,505 individuals
 PGP000536 |
Vassy JL et al. JAMA Cardiol (2023)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.05 [0.95, 1.17] — — age, sex, and principal components of genetic ancestry —
PPM020274 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS011319|
Hispanic or Latin American Ancestry|
6,785 individuals
 PGP000536 |
Vassy JL et al. JAMA Cardiol (2023)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.08 [0.85, 1.36] — — age, sex, and principal components of genetic ancestry —
PPM020275 PGS002724
(GIGASTROKE_iPGS_EUR)
 PSS011320|
European Ancestry|
53,861 individuals
 PGP000536 |
Vassy JL et al. JAMA Cardiol (2023)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.15 [1.08, 1.21] — — age, sex, and principal components of genetic ancestry —
PPM014747 PGS002725
(GIGASTROKE_iPGS_EAS)
 PSS009881|
East Asian Ancestry|
87,682 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: prevalent ischemic stroke cases OR: 1.18 [1.12, 1.25] AUROC: 0.765 ∆AUROC (improvement in AUROC over covariates-only model): 0.003 age, sex, 5 PCs —
PPM014744 PGS002725
(GIGASTROKE_iPGS_EAS)
 PSS009875|
East Asian Ancestry|
41,929 individuals
 PGP000333 |
Mishra A et al. Nature (2022)
 Reported Trait: prevalent ischemic stroke cases OR: 1.33 [1.26, 1.4] AUROC: 0.653 ∆AUROC (improvement in AUROC over covariates-only model): 0.019 age, sex, 5 PCs —
PPM020429 PGS004322
(GRS30_IS)
 PSS011358|
European Ancestry|
454,493 individuals
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Reported Trait: Incident ischaemic stroke HR: 1.26 [1.17, 1.35] — — age, gender, 10-yr ASCVD Risk by PCE, genetic background, and sepsis —
PPM020430 PGS004322
(GRS30_IS)
 PSS011358|
European Ancestry|
454,493 individuals
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Reported Trait: Any incident myocardial infarction, ischaemic stroke, or venous thromboembolism HR: 1.05 [1.01, 1.1] — — age, gender, 10-yr ASCVD Risk by PCE, genetic background, and sepsis —
PPM020749 PGS004597
(PRS32_IS)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident ischaemic stroke in breast cancer survivors — — Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.25 [0.91, 1.72] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020752 PGS004597
(PRS32_IS)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident ischaemic stroke in breast cancer survivors with lifestyle — — Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.37 [0.15, 0.93] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM021740 PGS004942
(IS_MetaPRS)
 PSS011774|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident ischemic stroke HR: 1.18 [1.16, 1.21] C-index: 0.733 [0.727, 0.738] — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011774 ICD10: I63 Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —
PSS011698 — — 1,567 individuals — European — EAST-AFNET4 —
PSS011699 — — 407,311 individuals — European — UKB —
PSS001082 Cases were individuals who had experienced an ischemic stroke (IS) event. IS was defined according to the World Health Organization definition and included imaging by computed tomography or magnetic resonance imaging in the majority of cases. All cases of IS were further divided into subtypes of large vessel (n=49), small vessel (n=43), cardioembolic (n=36), and undetermined. Undetermined strokes had undetermined causes, multiple causes identified, or an incomplete evaluation made. All stroke events were assessed by an adjudication committee, blinded to the identity of participants and study treatment group assignment. Median = 4.7 years
IQR = [3.6, 5.7] years
[
  • 173 cases
  • , 12,619 controls
]
,
45.1 % Male samples
 Mean = 75.1 years
Sd = 4.2 years		 European — ASPREE —
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 12,780 individuals,
0.0 % Male samples
 — European — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 568 individuals,
0.0 % Male samples
 — Not reported — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS011789 — —
[
  • 136 cases
  • , 196 controls
]
,
0.0 % Male samples
 — European — GEOS —
PSS009641 A stroke event was defined as hospitalization due to stroke which was self-reported in a structured and standardized inter- view performed by certified and supervised personnel. — 3,071 individuals,
49.0 % Male samples
 Mean = 57.4 years
Sd = 12.9 years		 European — KORA —
PSS009875 Ischemic stroke —
[
  • 1,470 cases
  • , 40,459 controls
]
 — East Asian
(Japanese)		 — BBJ % Male: 70.0% for cases and 53.1% for controls. Age information: Mean (cases) = 69.2 years, sd (cases) = 10.8; Mean (controls) = 66.5 years, sd (controls) = 12.5
PSS009876 Ischemic stroke —
[
  • 960 cases
  • , 50,328 controls
]
 — European — NR ClinicalTrials_EUR
PSS009877 Ischemic stroke Mean = 4.6 years
Sd = 4.8 years
[
  • 1,128 cases
  • , 100,971 controls
]
,
37.8 % Male samples
 Mean = 44.0 years
Sd = 15.7 years		 European
(Estonian)		 — EB —
PSS009878 Ischemic stroke —
[
  • 2,227 cases
  • , 105,116 controls
]
 — African American or Afro-Caribbean
(African American)		 — MVP —
PSS009879 Ischemic stroke —
[
  • 8,392 cases
  • , 395,097 controls
]
 — European
(European)		 — MVP —
PSS009880 Ischemic stroke —
[
  • 1,691 cases
  • , 1,743 controls
]
 — Sub-Saharan African
(Nigerian)		 — NR Stroke Investigative Research & Educational Network (SIREN)
PSS009881 Ischemic stroke —
[
  • 1,399 cases
  • , 86,283 controls
]
 — East Asian
(Taiwanese)		 — TWB —
PSS000058 Prevalent and incident Ischaemic stroke; defined in http://biobank.ndph.ox.ac.uk/showcase/docs/alg_outcome_stroke.pdf Mean = 6.3 years
Sd = 1.9 years
[
  • 3,075 cases
  • , 392,318 controls
]
,
45.7 % Male samples
 Mean = 54.3 years European — UKB Validation set
PSS011358 ICD-10 codes (I21, I22, I23, I24.1, and I25.2), ICD-9 codes (410, 411, 412, and 429.79) for MI, ICD-10 (I63, I64), ICD-9 (434 and 436) for IS — 454,493 individuals — European — UKB Mean age of full combined ancestry cohort = 56.9 years
PSS000601 All patients with atrial fibrillation and CHADS2 score of 2 or higher who were treated with anticoagulation. The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. Median = 2.8 years
[
  • 395 cases
  • , 10,792 controls
]
,
60.78 % Male samples
 Mean = 70.8 years
Sd = 9.1 years		 European — ENGAGE_AF-TIMI_48 —
PSS000602 The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. Median = 2.5 years
[
  • 960 cases
  • , 50,328 controls
]
,
71.7 % Male samples
 Mean = 65.9 years
Sd = 9.2 years		 European — ENGAGE_AF-TIMI_48, FOURIER, PEGASUS-TIMI_54, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS011318 — — 18,505 individuals,
81.9 % Male samples
 Mean = 55.4 years
Sd = 11.8 years		 African American or Afro-Caribbean — MVP —
PSS011681 The primary outcome was a first-onset cardiovascular disease event, defined as the composite of CHD (i.e., myocardial infarction or fatal CHD) or any stroke. Secondary outcomes included each of CHD and stroke separately, and a combination of CHD, stroke, and cardiac revascularisation procedures (i.e., percutaneous transluminal cor- onary angioplasty [PTCA] and coronary artery bypass grafting [CABG]). 3333 Cases are CHD events and 2347 are stroke events Median = 8.1 years
[
  • 5,680 cases
  • , 300,974 controls
]
,
43.01 % Male samples
 Mean = 56.0 years
Sd = 8.0 years		 European — UKB —
PSS010050 Participants without history of stroke, coronary heart disease, peripheral vascular disease, or congestive heart failure at recruitment — 454,756 individuals — Not reported — UKB —
PSS011319 — — 6,785 individuals,
86.5 % Male samples
 Mean = 52.6 years
Sd = 14.8 years		 Hispanic or Latin American — MVP —
PSS011320 — — 53,861 individuals,
88.2 % Male samples
 Mean = 59.3 years
Sd = 13.8 years		 European — MVP —
PSS001445 All individuals had a history of incident atrial fibrillation (AF) following enrollment. 2,310 individuals were taking warfarin. Cases were individuals with ischemic stroke (IS). IS was defined uisng the UKB codes: 131368, 42008. Of the 2,310 individuals taking warfarin, 93 were individuals with ischemic stroke (cases). Median = 7.0 years
[
  • 684 cases
  • , 15,245 controls
]
,
66.7 % Male samples
 European — UKB —