| Publication Information (EuropePMC) | |
| Title | Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank. |
| PubMed ID | 36839222(Europe PMC) |
| doi | 10.3390/nu15040864 |
| Publication Date | Feb. 8, 2023 |
| Journal | Nutrients |
| Author(s) | Peng H, Wang S, Wang M, Wang X, Guo H, Huang J, Wu T. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS004598 (PRS12_HF) |
PGP000576 | Peng H et al. Nutrients (2023) |
Heart failure | heart failure | 12 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004598/ScoringFiles/PGS004598.txt.gz |
| PGS004597 (PRS32_IS) |
PGP000576 | Peng H et al. Nutrients (2023) |
Ischemic stroke | stroke, Ischemic stroke |
32 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004597/ScoringFiles/PGS004597.txt.gz |
| PGS004596 (PRS64_CHD) |
PGP000576 | Peng H et al. Nutrients (2023) |
Coronary heart disease | coronary artery disease | 64 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004596/ScoringFiles/PGS004596.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM020747 | PGS004598 (PRS12_HF) |
PSS011390| Multi-ancestry (including European)| 13,348 individuals |
PGP000576 | Peng H et al. Nutrients (2023) |
Reported Trait: Incident heart failure in breast cancer survivors | — | — | Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.4 [1.06, 1.84] | Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs | — |
| PPM020748 | PGS004596 (PRS64_CHD) |
PSS011390| Multi-ancestry (including European)| 13,348 individuals |
PGP000576 | Peng H et al. Nutrients (2023) |
Reported Trait: Incident coronary artery disease in breast cancer survivors | — | — | Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.36 [1.1, 1.67] | Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs | — |
| PPM020749 | PGS004597 (PRS32_IS) |
PSS011390| Multi-ancestry (including European)| 13,348 individuals |
PGP000576 | Peng H et al. Nutrients (2023) |
Reported Trait: Incident ischaemic stroke in breast cancer survivors | — | — | Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.25 [0.91, 1.72] | Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs | — |
| PPM020750 | PGS004598 (PRS12_HF) |
PSS011390| Multi-ancestry (including European)| 13,348 individuals |
PGP000576 | Peng H et al. Nutrients (2023) |
Reported Trait: Incident heart failure in breast cancer survivors with lifestyle | — | — | Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.39 [0.21, 0.73] | Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs | — |
| PPM020751 | PGS004596 (PRS64_CHD) |
PSS011390| Multi-ancestry (including European)| 13,348 individuals |
PGP000576 | Peng H et al. Nutrients (2023) |
Reported Trait: Incident coronary artery disease in breast cancer survivors with lifestyle | — | — | Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.37 [0.24, 0.56] | Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs | — |
| PPM020752 | PGS004597 (PRS32_IS) |
PSS011390| Multi-ancestry (including European)| 13,348 individuals |
PGP000576 | Peng H et al. Nutrients (2023) |
Reported Trait: Incident ischaemic stroke in breast cancer survivors with lifestyle | — | — | Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.37 [0.15, 0.93] | Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011390 | CVD ICD-10: I20-I25, I60-I64, G45 | — | 12,780 individuals, 0.0 % Male samples |
— | European | — | UKB | Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1) |
| PSS011390 | CVD ICD-10: I20-I25, I60-I64, G45 | — | 568 individuals, 0.0 % Male samples |
— | Not reported | — | UKB | Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1) |