PGS Publication: PGP000668

Publication Information (EuropePMC)
Title Joint impact of polygenic risk score and lifestyles on early- and late-onset cardiovascular diseases.
PubMed ID 38987358(Europe PMC)
doi 10.1038/s41562-024-01923-7
Publication Date July 10, 2024
Journal Nat Hum Behav
Author(s) China Kadoorie Biobank Collaborative Group.
Released in PGS Catalog: Aug. 29, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004942
(IS_MetaPRS)
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Ischemic stroke Ischemic stroke 4,765,243
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004942/ScoringFiles/PGS004942.txt.gz
PGS004943
(ICH_MetaPRS)
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Intracerebral hemorrhage intracerebral hemorrhage 2,124,631
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004943/ScoringFiles/PGS004943.txt.gz
PGS004941
(CAD_MetaPRS)
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Coronary artery disease coronary artery disease 3,711,629
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004941/ScoringFiles/PGS004941.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021739 PGS004941
(CAD_MetaPRS)
 PSS011772|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident coronary artery disease HR: 1.42 [1.36, 1.49] C-index: 0.809 [0.799, 0.819] — age, sex —
PPM021740 PGS004942
(IS_MetaPRS)
 PSS011774|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident ischemic stroke HR: 1.18 [1.16, 1.21] C-index: 0.733 [0.727, 0.738] — age, sex —
PPM021741 PGS004943
(ICH_MetaPRS)
 PSS011773|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident intracerebral hemorrhage HR: 1.31 [1.24, 1.39] C-index: 0.748 [0.734, 0.761] — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011773 ICD10: I61 Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —
PSS011774 ICD10: I63 Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —
PSS011772 Including death resulting from ischemic heart disease [ICD10: I20-I25], nonfatal myocardial infarction [ICD10: I21-I23], and coronary revascularization Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —